Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts
作者机构：Clinical Data CenterGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of GastroenterologyGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Internal MedicineGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Infectious DiseasesGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Information DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China School of PediatricsGuangzhou Medical UniversityGuangzhou 510623China Imaging DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Respiratory DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Pediatric Intensive Care UnitGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510623China Neonatal Intensive Care UnitGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Rehabilitation DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China General PediatricsGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou510623China Emergency DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of NeurologyGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Key Laboratory of Structural Birth Defects Research in Guangdong ProvinceGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Cardiovascular DepartmentGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2024年第20卷第10期
页 面：1079-1089页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：supported by the Science and Technology Planning Project of Guangdong Province(No.2020B1111170001) The funder had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript
主 题：Body temperature Brain damage:Children:Convulsion Omicron BA.5.Vaccination
摘 要：Background SARS-CoV-2 continues to mutate over time,and reports on children infected with Omicron BA.5 are *** aimed to analyze the specific symptoms of Omicron-infected children and to improve patient *** We selected 315 consecutively hospitalized children with Omicron BA.5 and 16,744 non-Omicron-infected febrile children visiting the fever clinic at our hospital between December 8 and 30,*** convulsions and body temperatures were compared between the two *** analyzed potential associations between convulsions and vaccination,and additionally evaluated the brain damage among severe Omicron-infected *** Convulsion rates(97.5%vs.4.3%,P0.001)and frequencies(median:2.0 vs.1.6,P0.001)significantly differed between Omicron-infected and non-Omicron-infected febrile *** body temperatures of Omicron-infected children were significantly higher during convulsions than when they were not convulsing and those of non-Omicron-infected febrile children during convulsions(median:39.5 vs.38.2 and 38.6℃,both P0.001).In the three Omicron-subgroups,the temperature during convulsions was proportional to the percentage of patients and significantly differed(P0.001),while not in the three non-Omicron-subgroups(P=0.244).The convulsion frequency was lower in the 55 vaccinated children compared to the 260 non-vaccinated children(average:1.8 vs.2.1,P0.001).The vaccination dose and convulsion frequency in Omicron-infected children were significantly correlated(P0.001).Fifteen of the 112 severe Omicron cases had brain *** Omicron-infected children experience higher body temperatures and frequencies during convulsions than those of non-Omicron-infected febrile *** additionally found evidence of brain damage caused by infection with omicron *** and prompt fever reduction may relieve symptoms.
维普期刊数据库