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Evaluation of transarterial chemoembolization combined with percutaneous ethanol ablation for large hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第26期17卷 3145-3150页

作者： Fei Gao Yang-Kui Gu Wei-Jun Fan Liang Zhang jin-hua huang State Key Laboratory of Oncology in South China Cancer Center Sun Yat-Sen University Guangzhou 510060Guangdong Province China Department of Medical Imaging and InterventionalRadiology Cancer Center Sun Yat-Sen University Guangzhou510060 Guangdong Province China

AIM： To assess the effects of combined transcatheter arterial chemoembolization （TACE） and percutaneous ethanol ablation （PEA） in patients with large hepatocellular carcinoma （HCC）.METHODS： A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed.RESULTS： The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively （a median survival of 27.7 too）. Tumor area was reduced by more than 50% in 30 （47.6%） cases. In 56 cases with increased α-fetoprotein （AFP） values, AFP level was declined by more than 75%. The combined thera- py was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the num- ber of tumors, the tumor margin and the ethanol dose were independent prognostic factors. CONCLUSION： The combined TACE and PEA therapy is a promising approach for unresectable large HCC.

关键词： Hepatocellular carcinoma Chemoembolizaion Ethanol ablation Combination therapy

Growth and properties of hydrogenated microcrystalline silicon thin films prepared by magnetron sputtering with different substrate temperatures

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Rare Metals 2022年第3期41卷 1037-1042页

作者： Lin-Qing Wang Wei-Yan Wang jin-hua huang Rui-Qin Tan Wei-Jie Song Jian-Min Chen State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Ningbo Institute of Material Technology and Engineering Chinese Academy of SciencesNingbo 315201China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China

Hydrogenated microcrystalline silicon (μcSi:H) thin films were deposited by an radio frequency (RF)(13.56 MHz) magnetron sputtering at different substrate temperatures (100–300℃), and the influences of substrate temperature on the growth and properties ofμc-Si:H thin films were investigated. Surface roughness and crystallinity of the thin films increase as substrate temperature increases. And all thin films are at the transition region(X_(c)=49.2%~61.0%). Theμc-Si:H thin films deposited at lower substrate temperature (≤200℃) represent a weak(220) preferred orientation, while the thin films deposited at higher substrate temperature (≥250℃) exhibit a weak(111) preferred orientation. The μc-Si:H thin films have a dense structure, and the structural compactness of the thin films slightly increases with substrate temperature increasing. The Fourier transform infrared spectroscopy (FTIR) results indicate that theμc-Si:H thin films have a low hydrogen content (3.9 at%–5.6 at%), which is in favor of reducing light-induced degradation effect.

关键词： μc-Si:H thin films Magnetron sputtering Substrate temperature Hydrogen content

Combined treatment of hepatocellular carcinoma with partial splenic embolization and transcatheter hepatic arterial chemoembolization

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World Journal of Gastroenterology 2007年第48期13卷 6593-6597页

作者： jin-hua huang Fei Gao Yang-Kui Gu Wen-Quan Li Lian-Wei Lu Department of Imaging and Interventional Radiology Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM: To prospectively evaluate the effi cacy and safety of partial splenic embolization (PSE) combined with transcatheter hepatic arterial chemoembolization (TACE) in treatment of hepatocellular carcinoma (HCC). METHODS: Fifty patients suffering from primary HCC associated with hypersplenism caused by cirrhosis were randomly assigned to 2 groups: group A receiving PSE combined with TACE (n = 26) and group B receiving TACE alone (n = 24). Follow-up examinations included calculation of peripheral blood cells (leukcytes, platelets and red blood cells) and treatment-associated complications. RESULTS: Prior to treatment, there was no signifi cant difference in sex, age, Child-Pugh grade, tumor diameter, mass pathology type and peripheral blood cell counts between the 2 groups. After treatment, leukocyte and platelet counts were significantly higher in group A during the 3-mo follow-up period (P 0.05). CONCLUSION: PSE combined with TACE is more effective and safe than TACE alone for patients with HCC associated with hypersplenism caused by cirrhosis.

关键词： Hepatocellular carcinoma Hypersplenism Cirrhosis Partial splenic embolization Transcatheter hepatic arterial chemoembolization

Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： Ming-hua Yang Si-ming huang jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

Experimental study of destruction to porcine spleen in vivo by microwave ablation

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World Journal of Gastroenterology 2011年第45期17卷 5014-5020页

作者： Fei Gao Yang-Kui Gu jing-Xian Shen Chang-Lun Li Xiong-Ying Jiang jin-hua huang State Key Laboratory of Oncology in South China Guangzhou 510060 Guangdong Province China Medical Imaging and Interventional Center Cancer Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM: To discuss the safety, feasibility and regularity of destruction to porcine spleen in vivo with congestion and tumescence by microwave ablation (MWA). METHODS: Ligation of the splenic vein was used to induce congestion and tumescence in vivo in five porcine spleens, and microwave ablation was performed 2-4 h later. A total of 56 ablation points were ablated and the ablation powers were 30-100 W. The ablation time (1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 min) was performed at a power of 60 W. After ablation, the ablation size was measured in pigs A, C, D and E and spleen resection. In pig B, the ablation size was measuredand 2 ablation points were sent for pathology analysis and all tissues were sutured following ablation. Pig B was killed 1 wk later and the ablation points were sent for pathology analysis. Bleeding, tissue carbonization surrounding electrodes, and pathological changes were observed, and the effect on destruction volume relative to different ablation powers, times and positions was analyzed. RESULTS: The incidence of bleeding (only small amounts, < 20 mL) in the course of ablation was 5.4% (3/56) and was attributed to tissue carbonization surrounding electrodes, which also exhibited an incidence of 5.4% (3/56). The destruction volume was influenced by different ablation powers, times and points. It showed that the ablation lesion size increased with increased ablation time, from 1 to 10 min, when the ablation power was 60 W. Also, the ablation lesion size increased with the increase of ablation power, ranging from 30 to 100 W when the ablation time was set to 3 min. A direct correlation was seen between the destruction volume and ablation time by the power of 60 W (r = 0.97542, P < 0.0001, and also between the destruction volume and ablation powers at an ablation time of 3 min (r = 0.98258, P < 0.0001). The destruction volume of zone Ⅱ (the extra-2/3 part of the spleen, relative to the fi rst or second class vascular branches), which was near the hilum

关键词： Experimental study Microwave ablation Porcine spleen In vivo Water-cooled antenna

Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase Ⅱ study

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5556-5562页

作者： Tian-Qi Zhang Zhi-Jun Geng Meng-Xuan Zuo Ji-Bin Li jin-hua huang Zi-Lin huang Pei-Hong Wu Yang-Kui Gu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhouP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhouP.R.China Department of Radiology Sun Yat-sen University Cancer CenterGuangzhouP.R.China Department of Clinical Research Sun Yat-sen University Cancer CenterGuangzhouP.R.China

Hepatic arterial infusion chemotherapy(HAIC)using a combination of oxaliplatin,fluorouracil,and leucovorin(FOLFOX)has shown promise for hepatocellular carcinoma(HCC)patients classified under Barcelona Clinic Liver Cancer(BCLC)stage *** China,the combined therapy of camrelizumab and apatinib is now an approved first-line approach for inoperable *** study(NCT04191889)evaluated the benefit of combining camrelizumab and apatinib with HAIC-FOLFOX for HCC patients in BCLC stage *** patients were given a maximum of six cycles of HAIC-FOLFOX,along with camrelizumab and apatinib,until either disease progression or intolerable toxicities *** primary outcome measured was the objective response rate(ORR)based on the Response Evaluation Criteria in Solid Tumors(RECIST)***-five patients were *** on RECIST v1.1 criteria,the confirmed ORR stood at 77.1%(95%CI:59.9%to 89.6%),with a disease control rate of 97.1%(95%CI:85.1%to 99.9%).The median progression-free survival was 10.38 months(95%CI:7.79 to 12.45).Patient quality of life had a transient deterioration within four cycles of treatment,and generally recovered *** most frequent grade≥3 or above treatment-related adverse events included reduced lymphocyte count(37.1%)and diminished neutrophil count(34.3%).The combination of camrelizumab,apatinib,and HAIC demonstrated encouraging results and manageable safety concerns for HCC at BCLC stage C.

关键词： infusion transient Barcelona

Temporal Change in Treatment Patterns of Metastatic Colorectal Cancer and Its Association with Patient Survival:A Retrospective Cohort Study Based on an Intelligent Big-Data Platform

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Engineering 2021年第4期7卷 526-533页

作者： Zi-Xian Wang Yi-Chen Yao Zong-Jiong Mai Wu-Hao Lin You-Sheng huang Ying jin Hui-Yan Luo Dong-Sheng Zhang Feng-hua Wang Feng Wang Gong Chen Pei-Rong Ding Yun-Fei Yuan Yu-Hong Li jin-hua huang Zhi-Zhong Pan Rui-hua Xu Department of Medical Oncology State Key Laboratory of Oncology in South China&Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Artificial Intelligence Laboratory Sun Yat-sen University Cancer CenterGuangzhou 510060China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhou 510060China Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Hepatobiliary Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Minimally Invasive Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060China

There is a lack of high-quality,large-scale,real-world evidence from patients with metastatic colorectal cancer(mCRC),especially in *** remains unclear whether efforts to improve the quality of care for mCRC would improve patient survival outcomes in real-world *** the basis of an intelligent bigdata platform,we established a large-scale retrospective cohort of mCRC *** investigated the temporal changes in the systemic and local treatment(resection,ablation,or radiation to liver,lung,or extrahepatic and/or extrapulmonary metastases)patterns of mCRC,and whether these changes were associated with improved overall survival(OS)over *** July 2012 and December 2018,3403 eligible patients were included in this *** median OS was 42.8 months(95%confidence interval(CI),40.7–46.6)for the entire cohort,25.6 months(95%CI,24.7–26.9)for those treated with systemic therapy only,and not reached(95%CI,78.6 months–not reached)for those receiving local *** utility rate of local therapy increased continuously from 37.9%in 2012–2014 to 46.9%in 2017–2018.A dramatic increase in the utility rate of either cetuximab or bevacizumab was observed since 2017(39.9%,43.2%,and 60.3%in 2012–2014,2015–2016,and 2017–2018,respectively).Compared with 2012–2014,the OS of the entire population significantly improved in 2015–2016(hazard ratio(HR)=0.87(95%CI,0.78–0.99);P=0.034),but not for patients receiving systemic therapy only(HR=0.99(95%CI,0.86–1.14);P=0.889),whereas an improved OS was found in 2015–2018 for both the entire population(HR=0.75(95%CI,0.70–0.81);P<0.001)and for patients receiving systemic therapy only(HR=0.83(95%CI,0.77–0.91);P<0.001).In summary,the quality of care for mCRC,as indicated by the utility rate of targeted and local therapies,has been continuously improving over time in this study cohort,which is associated with continuously improving survival outcomes for these patients.

关键词： Metastatic colorectal cancer Real-world evidence Treatment pattern Survival Big-data platform

Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells

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Chinese Medical Journal 2017年第5期130卷 594-599页

作者： Dan Wang jin-hua huang Qing-Hai Zeng Can Gu Shu Ding Jian-Yun Lu jing Chen Sheng-Bo Yang Department of Dermatology Third Xiangya Hospital Central South University Changsha Hunan 410013 China Department of Community Nursing Xiangya School of Nursing Central South University Changsha Hunan 410013 China

Background： DNA hydroxymethylation refers to a chemical modification process in which 5-methylcytosine （5mC） is catalyzed to 5-hydroxymethylcytosine （5hmC） by ten-eleven translocation （TET） family proteins. Recent studies have revealed that aberrant TETs expression or 5hmC level may play important roles in the occurrence and development of various pathological and physiological processes including cancer and aging. This study aimed to explore the relation between aberrant DNA hydroxymethylation with skin photoaging and to investigate the levels of TETs, 5mC, and 5hmC expression 24 h after 40 mJ/cm^2 and 80 mJ/cm^2 doses of ultraviolet B （UVB） irradiation to HaCaT cells. Methods： To explore whether aberrant DNA hydroxymethylation is also related to skin photoaging, 40 mJ/cm^2 and 80 mJ/cm^2 doses of UVB were chosen to treat keratinocytes （HaCaT cells）. After 24 h of UVB irradiation, 5mC and 5hmC levels were determined by immunohistochemistry （IHC） and immunofluorescence （IF）, and at the same time, the expression levels of matrix metalloproteinase 1 （MMP-1） and TETs were assessed by reverse transcription-polymerase chain reaction or Western blot analysis. Results： After 40 mJ/cm^2 and 80 mJ/cm^2 doses of UVB exposure, both IHC and IF results showed that 5hmC levels increased significantly, while the 5mC levels did not exhibit significant changes in HaCaT cells, compared with HaCat cells without UVB exposure. Moreover, compared with HaCat cells without UVB exposure, the levels ofTET1, TET2, and TET3 mRNA and protein expression were significantly upregulated （mRNA： P = 0.0022 and 0.0043 for TET1; all P 〈 0.0001 for TET2; all P = 0.0006 for TET3; protein： P = 0.0012 and 0.0006 tbr TET 1 ; all P = 0.0022 for TET2; and all P = 0.0002 for TET3）, and the levels of MMP- 1 mRNA expression increased dose dependently in 40 mJ/cm^2 and 80 mJ/cm^2 UVB-irradiated groups. Conclusion： UVB radiation could cause increased 5hmC and TET expression, which might become a novel biomarker in

关键词： 5-hydroxymethylcytosine 5-methylcytosine DNA Hydroxymethylation Ten-eleven Translocation Ultraviolet B

Radiofrequency ablation as a treatment for hilar cholangiocarcinoma

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World Journal of Gastroenterology 2008年第28期14卷 4540-4545页

作者： Wei-Jun Fan Pei-Hong Wu Liang Zhang jin-hua huang Fu-Jun Zhang Yang-Kui Gu Ming Zhao Xiang-Long huang Chang-Yu Guo Cancer Center of Sun Yat-Sen University 651# Dong Feng Dong Road Guangzhou 510060 Guangdong Province China Radiology Department Centro Hospitalar Conde de Sao Januario (CHCSJ) Macao SAR CP3002 China

AIM: To explore the role of radio-frequency ablation (RFA) as a treatment for hilar cholangiocarcinoma. METHODS: Eleven patients with obstructive cholestasis underwent Computed Tomography (CT) examination, occupying lesions were observed in the hepatic hilar region in each patient. All lesions were confirmed as cholangioadenocarcinoma by biopsy and were classified as type or by percutaneous transhepatic cholangiography. Patients were treated with multiple electrodes RFA combined with other adjuvant therapy. The survival rate, change of CT attenuation coefficient of the tumor and tumor size were studied in these patients after RFA. RESULTS: In a follow-up CT scan one month after RFA, a size reduction of about 30% was observed in six masses, and two masses were reduced by about 20% in size, three of the eleven masses remained unchanged. In a follow-up CT scan 6 mo after RFA, all the masses were reduced in size (overall 35%), in which the most significant size reduction was 60%. The survival follow-up among these eleven cases was 18 mo in average. Ongoing follow-up showed that the longest survival case was 30 mo and the shortest case was 10 mo. CONCLUSION: RFA is a microinvasive and effective treatment for hilar cholangiocarcinoma.

关键词： Radio-frequency ablation Cholangiocarcinoma Computed tomography