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Perivascular epithelioid cell tumor of the cecum： a case report and review of literatures

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Chinese Medical Journal 2009年第14期122卷 1713-1715页

作者： QU Gui-mei HU jin-chen cai Li LANG Zhi-qiang Department of Pathology Yantai Yuhuangding Hospital Medical College of Qingdao University Yantai Shandong 264000 China

Perivascular epithelioid cell tumors （PEComas） are a group of rare mesenchymal neoplasms which composed of histologically and immunohistochemically distinctive perivascular epithelioid cells （PECs）. In recent years, PEComas have been manily reported in liver, kidney, lung, uterus and adnexa,1 but rare in small or large intestine.2-6 Here, we describe a case of PEComa restricted in the cecal mucosa, which displayed histological characteristics of epithelioid clear cells.

关键词： perivascular epithelioid cell tumors cecum melanoma

GC-MS分析王不留行、决明子、酸枣仁炒制前后脂肪油成分的变化

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中国实验方剂学杂志 2017年第15期23卷 31-34页

作者：蔡瑾瑾陈璐成都中医药大学临床医学院和附属医院成都610075 成都中医药大学中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室--省部共建国家重点实验室培育基地成都611137

目的:分析和鉴定王不留行、决明子、酸枣仁3种药材炒制前后脂肪油类成分的变化,为探索种子类药材"逢子必炒"的炮制机制奠定基础。方法:以石油醚为溶剂,采取索氏提取器提取脂肪油,甲酯化后用气相色谱-质谱联用技术(GCMS)分离、鉴定其组... 详细信息

目的:分析和鉴定王不留行、决明子、酸枣仁3种药材炒制前后脂肪油类成分的变化,为探索种子类药材"逢子必炒"的炮制机制奠定基础。方法:以石油醚为溶剂,采取索氏提取器提取脂肪油,甲酯化后用气相色谱-质谱联用技术(GCMS)分离、鉴定其组成和相对质量分数。HP-5毛细管柱(0.25 mm×30 m,0.25μm),载气99.999%高纯氮,流速1 mL·min^(-1),采用程序升温方式(初始温度50℃,以5℃·min^(-1)升至170℃,停留4 min,5℃·min^(-1)升至190℃,0.5℃·min^(-1)升至200℃,10℃·min^(-1)升至240℃,保持4 min),进样量1μL,电子轰击离子源(EI),离子源温度220℃,电子能量70 eV。结果:王不留行、决明子、酸枣仁3种药材生品脂肪油提取率分别为3.34%,6.16%,20.66%,炒制品脂肪油提取率分别为4.67%,7.40%,26.35%。王不留行生品鉴定出7个化合物,炒制品鉴定出10个化合物;决明子生品鉴定出8个化合物,炒制品鉴定出9个化合物;酸枣仁生品鉴定出10个化合物,炒制品鉴定出14个化合物。结论:炒制能提高脂肪油的提取效率,炒制后3种药材脂肪油的组成出现了一些共性变化。

关键词：王不留行决明子酸枣仁脂肪油气相色谱-质谱联用技术油酸硬脂酸

Relationship between the expression of Toll-like receptor 2 and 4 in mononuclear cells and postoperative acute lung injury in orthotopic liver transplantation

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Chinese Medical Journal 2009年第8期122卷 895-899页

作者： CHI Xin-jin cai Jun LUO chen-fang chenG Nan HEI Zi-qing LI Shang-rong LUO Gang-jian Department of Anesthesiology Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background The aim of this study was to investigate the potential relationship between the dynamic expression of Toll-like receptor 2 and 4 （TLR2/4） in peripheral blood mononuclear cells as well as changes in serum concentration of inflammatory factors and acute lung injury （ALl） in patients after orthotopic liver transplantation （OLT）. Methods The peripheral blood samples of 27 patients （23 men and 4 women with ASA Ⅲ to Ⅳ） who received OLT were collected for measurement of TLR2/4 at T1 （after induction of anesthesia）, T2 （25 minutes after anhepatic phase）, T3 （3 hours after graft reperfusion） and T4 （24 hours after graft reperfusion）. The expression of TLR2/4 in mononuclear cells was measured by flow cytometry. The serum concentrations of tumor necrosis factor （TNF）-α, interleukin （IL）-1β and IL-8 were measured by enzyme-linked immunosorbent assay （ELISA）. Twenty-seven patients were assigned to ALl group （n=-9） and non-ALl group （n=-18） according to the diagnostic criteria of ALl. The expression of TLR2/4 in the ALl group or non-ALl group was analyzed. Results Compared to the non-ALl group, the volumes of blood loss, ascites, total output and transfused red blood cells were higher in the ALl group, and the anhepatic phase lasted longer （P 〈0.05, P 〈0.01）. The expression of TLR2/4 in mononuclear cells increased significantly at T3 and T4, and serum concentrations of TNF-α, IL-1β and IL-8 increased significantly too. There was no significant difference in Child-Turcotte-Pugh （CTP） scores between the ALl group and non-ALl group （P 〉0.05）. The expression of TLR2/4 in mononuclear cells increased significantly at T3 and T4 in the ALl group （P 〈0.05, P〈0.01）. A positive correlation was noted between the expression of TLR4 in mononuclear cells and the serum concentrations of TNF-α, IL-1β （P=0.041, P=0.046） in the ALl group. In the non-ALl group, statistical results showed that the expression level of TLR2/4 in mononuclear cells was not significantly different during the pe

关键词： orthotopic liver transplantation Toll-like receptor 2 Toll-like receptor 4 acute lung injury

Status report on SLEGS

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Status report on SLEGS

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

The 6th China-Nuclear Physics Symposium

作者： Xiang-Zhou cai, jin-Geng chen, Wei Guo, Wen-Qing Shen, Wang Xu, Hong-Wei Wang, Yu-Gang Ma (SINAP)

SLEGS (Shanghai Laser Electron Gamma Source) is a high intensity MeV gamma source & highly polarized gamma source, which is generated by laser beam Compton back scattering on 3.5 GeV electron at a straight of the electron storage ring of SSRF. The total flux of SLEGS is about 10^7-8/Ws and the energy of a gamma ray will be less than 23 MeV with CO2 laser, a high power infrared laser. SLEGS is a nearly 100% polarized gamma source as laser beam is fully polarized. Low energy photon scattering

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali chen Yiyong Wei jin Liu Tao Zhu cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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基于FSM的联合收割机多按键控制系统设计

电子科技 2017年第1期30卷 154-156,160页

作者：陈进蔡阳阳陈璇江苏大学机械工程学院江苏镇江212013

针对联合收割机传统操控方式繁琐、危险系数高的问题,设计了一种以按键调节各工作部件的控制系统,改变了联合收割机用操纵杆或机械结构的操控方式。针对按键控制过程中按键抖动对控制系统带来的影响以及多按键情况下代码的复杂性,提出... 详细信息

针对联合收割机传统操控方式繁琐、危险系数高的问题,设计了一种以按键调节各工作部件的控制系统,改变了联合收割机用操纵杆或机械结构的操控方式。针对按键控制过程中按键抖动对控制系统带来的影响以及多按键情况下代码的复杂性,提出了基于有限状态机的按键嵌入式程序设计方法。试验表明,有限状态机应用于按键系统设计能获得稳定的控制效果与功能要求。

关键词：联合收割机操纵杆 ARM嵌入式多按键控制系统有限状态机

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu Yi-Sheng chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang chengyihan Gu Yinghan chen Wencheng Yan Yong Liang Weipeng Li chengjian Zhu Jie Han jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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胃肠道间质瘤的多层螺旋CT诊断及误诊原因分析

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中国现代医学杂志 2015年第20期25卷 101-105页

作者：陈金才于共泉侯佩国季伟伟山东省商河县人民医院放射科山东商河251600 山东省商河县人民医院外科山东商河251600 齐鲁医院影像科山东济南250012

目的探讨胃肠道间质瘤(GIST)的多层螺旋CT诊断,分析其误诊原因。方法收集两家医院经多层螺旋CT检查,拟诊为GIST的38例患者资料,结合手术及病理结果回顾性分析其多层螺旋CT影像表现。结果术后病理证实30例为GIST,8例误诊;30例GIST的多层... 详细信息

目的探讨胃肠道间质瘤(GIST)的多层螺旋CT诊断,分析其误诊原因。方法收集两家医院经多层螺旋CT检查,拟诊为GIST的38例患者资料,结合手术及病理结果回顾性分析其多层螺旋CT影像表现。结果术后病理证实30例为GIST,8例误诊;30例GIST的多层螺旋CT表现:25例呈类圆形肿块,5例呈分叶状;14例肿瘤内见液化坏死;增强扫描28例为中等或中等程度以上强化;强化方式为动脉期肿瘤实质部分强化,门脉期持续强化,平衡期无明显减退,以门脉期强化最明显。结论 GIST多层螺旋CT三期增强扫描有一定的特点,有助于诊断和鉴别诊断。

关键词：胃肠道间质瘤多层螺旋CT成像增强扫描误诊