检索结果-南通市图书馆

Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation

Cellular & Molecular Immunology 2018年第7期15卷 697-709页

作者： Yuan Zhang Tae-jin kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu Department of Pathology University of ChicagoChicagoIL 60637USA Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Korea Committee on Immunology Department of PathologyUniversity of ChicagoChicagoIL 60637USA Department of Radiation and Cellular Oncology and The Ludwig Center for Metastasis Research University of ChicagoChicagoIL 60637USA Department of Microbiology Immunology and Molecular GeneticsUniversity of Texas Health Science Center San AntonioSan AntonioTX 78229USA Chinese Academy of Sciences Key Laboratory for Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Immunology Tsinghua University School of MedicineBeijing 100084China Department of Pathology University of Texas Southwestern Medical CenterDallasTX 75390USA

Splenomegaly is a well-known phenomenon typically associated with ***,the underlying cause of this phenotype has not been well ***,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic ***,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient *** now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent *** administration to LTα1β2-or LTβR-deficient mice reduces ***,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−*** using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of ***,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota.

关键词： germ-free lymphotoxin microbiota splenomegaly type 3 innate lymphoid cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein Expression of STAT3, pSTAT3, MMP-7 and VEGF in Colorectal Adenocarcinoma: An Immunohistochemical Study

引用

Journal of Cancer Therapy 2014年第13期5卷 1175-1185页

作者： Rakesh Naidu Lim Vin Nee Mak Joon Wah Kevin Moissinac A. Rahman A. Jamal Isa Mohd Rose Yunus Gul Alif Gul Patricia Lim kim Chooi Gregory Tan jin san School of Medicine and Health Sciences Monash University Malaysia Selangor Malaysia International Medical University Kuala Lumpur Malaysia Department of Surgery Penang Medical College Pulau Pinang Malaysia Department of Paediatrics Faculty of Medicine Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Department of Pathology Faculty of Medicine Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Department of Surgery Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia School of Health Sciences The University of Notre Dame Australia Fremantle Australia

Background: The purpose of the present study is to investigate the expression levels of STAT3, pSTAT3, MMP-7 and VEGF in colorectal adenocarcinoma, and also to determine association with the clinico-pathological parameters and?co-expression of these genes. Methods: An immunohistochemical method was used to evaluate the expression of MMP-7 and VEGF genes in 93 archival tissues whereas STAT3 and pSTAT3 expression was determined in 75 cases. Results: Overexpression of STAT3 was detected in 26.7% (20/75), pSTAT3 in 13.4% (10/75), MMP-7 in 38.8% (36/93) and VEGF in 59.2% (55/93) of the colorectal carcinomas. STAT3, MMP-7 and VEGF immunopositivity were significantly correlated with poorly-differentiated tumors (P = 0.004;P = 0.03;P = 0.002, respectively) but not with other parameters. However, pSTAT3 immunostaining was not significantly associated with the clinico-pathological characteristics. Significant relationship was noted between overexpression of pSTAT3 and STAT3 (P < 0.001), pSTAT3 and VEGF (P = 0.044), pSTAT3 and MMP-7 (P = 0.003), and STAT3 and VEGF (P = 0.037) but marginal association was detected between STAT3 and MMP-7 (P = 0.057), and MMP-7 and VEGF (P = 0.052). Conclusion:?Our data suggest that expression of these genes?may have an important role in tumor dedifferentiation and?may be useful as indicators of biologic aggressiveness. Co-expression of the biomarkers by cancer cells?may have important implications in colorectal cancer biology and?could be useful biological markers of the malignant phenotype.

关键词： STAT3 pSTAT3 MMP-7 VEGF Colorectal Adenocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Banxia Xiexin Decoction (半夏泻心汤) on Cisplatin-Induced Apoptosis of Human A549 Lung Cancer Cells

引用

Chinese Journal of Integrative Medicine 2018年第6期24卷 436-441页

作者： Ha-Rim kim Guem-san Lee Mi-Seong kim Do-Gon Ryu Hong-Seob So Hyoung-Chul Moon Young-Rae Lee Sei-Hoon Yang Kang-Beom Kwon Center for Metabolic Function Regulation Wonkwang University School of Medicine Iksan Jeonbuk 54538 South Korea Department of Herbology Wonkwang University School of Korean Medicine Iksan Jeonbuk 54538 South Korea Department of Korean Physiology Wonkwang University School of Korean Medicine Iksan Jeonbuk 54538 South Korea Institute of Customized Physical Therapy Gwanju 62279 South Korea Department of Oral Biochemistry Wonkwang University School of Dentistry Iksan Jeonbuk 54538 South Korea Department of Internal Medicine Wonkwang University School of Medicine Iksan Jeonbuk 54538 South Korea

Objective： To examinie the synergistic effects of Banxia Xiexin Decoction （半夏泻心汤, Known as Banhasasim-tang in Korean） extract （BXDE） on cisplatin-induced cytotoxicity in the A549 human lung cancer ceil lines. Methods： A549 cells were treated with varying concentrations （50-200μg/mL） of cisplatin and BXDE alone or in combination for 96 h. We used 1-（4,5-dimethylthiazol-2-yl）-3,5-diphenylformazan assay and flow cytometry to analyze cell viability and apoptosis, respectively. Results： The exposure of cells to cispiatin and BXDE alone or in combination decreased ceil viability dose- and time-dependently （P〈0.05）, which was found to be mediated by the apoptotic pathway as confirmed by the increase in the annexin V^＋/propidium iodide stained cell population and a ladder pattern of discontinuous DNA fragments. Furthermore, the apoptosis was inhibited by the pan-caspase inhibitor, benzyloxycarbonyI-Val-Ala-Asp （OMe） fluoromethylketone （z-VAD-FMK）. Conclusions： BXDE significantly potentiated apoptotic effects of cisplatin in A549 cells. Moreover, apoptosis induced by BXDE might be the pivotal mechanism mediating its chemopreventative action against cancer.

关键词： Banxia Xiexin Decoction cisplatin A549 cells apoptosis anticancer synergism Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear Finite Element Analysis of Ocean Cables

引用

海洋工程：英文版 2004年第4期18卷 537-550页

作者： Nam-Il kim sang-Soo JEON Moon-Young kim Department of Civil-Environmental Engineering SungKyunKwan University Jangan-Gu Suwon Kyongki-Do 440-746 S. Korea Highway and Transportation Technology Institute Korea Highway Corporation San 28-1 Sancheok-Ri Dongtan-Myeon Hwaseong City S. Korea Department of Civil-Environmental Engineering SungKyunKwan University Jangan-Gu Suwon Kyongki-Do 440-746 S. Korea

This study has focused on developing numerical procedures for the dynamic nonlinear analysis of cable structures subjected to wave forces and ground motions in the ocean. A geometrically nonlinear finite element procedure using the isoparametric curved cable element based on the Lagrangian formulation is briefly summarized. A simple and accurate method to determine the initial equilibrium state of cable systems associated with self-weights, buoyancy and the motion of end points is presented using the load incremental method combined with penalty method. Also the Newmark method is used for dynamic nonlinear analysis of ocean cables. Numerical examples are presented to validate the present numerical method.

关键词： nonlinear cable wave finite element analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

聚L－乳酸与聚乙烯醇的反应混合物

引用

维纶通讯 2007年第1期27卷 51-54页

作者： Choon Mee Lee Eung Su kim jin - san Yoon 王大仁（译）韩国Inha大学高分子科学工程系不详

在酯化催化剂的存在下使聚L-乳酸（2-羟基丙酸）（PLLA）与聚乙烯乙烯醇（EVOH）混合．该EVOH的羟基则与PLLA分子末端的羧基发生反应。直接得自L-乳酸本体缩聚反应的初生的低分子量的PLLA就用在了混合物中。在接枝共聚物中PLLA相所占有... 详细信息

在酯化催化剂的存在下使聚L-乳酸（2-羟基丙酸）（PLLA）与聚乙烯乙烯醇（EVOH）混合．该EVOH的羟基则与PLLA分子末端的羧基发生反应。直接得自L-乳酸本体缩聚反应的初生的低分子量的PLLA就用在了混合物中。在接枝共聚物中PLLA相所占有的界域大小要远远小于单纯的PLLA／EVOH混合物中PLLA所对应的界域。接枝共聚物的机械性能远远优于单纯混合物的性能，即使在生物降解方面实际上也具有超级的渗滤水平。接枝的PuA降低了EVOH部分的结晶率。PLLA的含量在接枝介质中未达到60％（wt）时是观察不到PLLA相的熔融峰温（Tm）的。改进的Sturm试验结果论证了EVOH—g—IPLLA的生物降解要比单纯的EVOH／PLLA混合物的生物降解缓慢得多，这表明化学健合的PLLA部分对待微生物的进攻要比单纯混合物中的PLLA不那么敏锐。

关键词：生物降解高聚物接枝进行链的延伸聚乙烯乙烯醇聚L-乳酸

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Nozzle Geometry on the Flow Characteristics of Spiral Flow Generated through an Annular Slit

引用

Journal of Thermal Science 2007年第2期16卷 149-154页

作者： Shigeru MATSUO Tae-Hun kim Toshiaki SETOGUCHI Heuy Dong kim Yeon-Won LEE Department of Mechanical Engineering Saga University1Honjo-machiSaga-shiSaga 840-8502Japan Graduate school of Science and Technology Saga University1Honjo-machiSaga shiSaga 840-8502Japan School of Mechanical Engineering Andong National University388Songchun-dongAndong 760749Korea School of Mechanical Engineering College of EngineeringPukyong National UniversitySan 100Young-Dang DongBusanKorea

In comparison with previous researches of swirling flow, spiral flow generated in the spiral nozzle has some different flow characteristics. It does not need a forced tangential momentum to generate its velocity and has some different merits from the swirling flow such as long potential core and low tangential velocity. In this study, the effect of nozzle geometry on the flow characteristics in spiral nozzle was investigated by experiment and computation. As a result, the flow characteristics obtained by experiment has a satisfactory agreement with computational results, quantitatively and qualitatively.

关键词： nozzle flow characteristics momentum numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Weaving Laser on Weld Microstructure and Crack for Al 6k21-T4 Alloy

引用

Journal of Materials Science & Technology 2011年第1期27卷 93-96页

作者： B.H.kim N.H.Kang W.T.Oh C.H.kim J.H.kim Y.S.kim Y.H.Park Department of Materials Science and Engineering Pusan National UniversitySan30Jangjeon-dongGeumjeong-guBusan 609-735Korea Department of Materials and Components Engineering Dong-Eui UniversityBusan 614-714Korea Advanced Joining Technology Team KITECH7-47Songdo-dongYeonsu-guIncheon 406-840Korea Division for Dongnam Area Technology Service KITECHJisa-dongGanseo-guBusan 618-230Korea

For Al 6k21-T4 overlap weld joint,the shear-tensile strength by using the weaving laser was improved as compared to the case of linear *** the specimen of low strength,the porosity was distributed continuously along the intersection between the plates and fusion ***,for the optimized welding condition,large oval-shaped porosities were located only in the advancing track of the concave ***,the continuity of cracks and porosities played a key role to determine the ***,the weaving width was also the important parameter to control the ***,the concave part had more significant hot and cold cracking in the weld and heat-affected zone（HAZ）,respectively,than the convex part.

关键词： Weaving laser Weld microstructure Void Al alloy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence

引用

World Journal of Hepatology 2018年第6期10卷 433-447页

作者： Ye Xin Koh Hwee Leong Tan Weng Kit Lye Juinn Huar Kam Adrian Kah Heng Chiow Siong san Tan Su Pin Choo Alexander Yaw Fui Chung Brian kim Poh Goh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingapore 169608Singapore Center for Quantitative Medicine Duke-NUS Graduate Medical SchoolSingapore 169857Singapore Department of General Surgery Hepatopancreatobiliary ServiceChangi General HospitalSingapore 529889Singapore Department of Medical Oncology National Cancer Centre SingaporeSingapore 169610Singapore Duke-NUS Graduate Medical School Singapore 169857Singapore

AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal *** We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection.

关键词： Barcelona Clinic Liver Cancer Hepatocellular carcinoma Hepatectomy Milan criteria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stress Oriented Hydrogen Induced Cracking of Linepipe Steel

引用

Journal of Iron and Steel Research International 2011年第S1期18卷 121-128页

作者： Wan Keun kim Gyu Tae Park Kyoo Young kim Pohang University of Science and Technology Graduate Institute of Ferrous Technology San 31Hyoja-DongPohang 790-784Korea

The stress oriented hydrogen induced cracking (SOHIC) is a typical hydrogen embrittlement phenomenon occurring in the linepipe steels exposed to sour environment containing H 2 S ***,even recently,the cracking mechanism of SOHIC has not been clarified because of lacking in the empirical data on the actual failure mode of SOHIC *** factors affecting SOHIC are discussed in terms of metallurgy of high strength linepipe steel and hydrogen *** cracking mechanisms of SOHIC are examined by comparing them with the empirical failure mode of SOHIC which is developed by observation of the actual fracture sites of the hydrogen induced blister cracking (HIBC) and secondary ***,the correlation between SOHIC and HIC is discussed.

关键词： linepipe steel stress oriented hydrogen induced cracking hydrogen induced cracking metallurgical factor diffusible hydrogen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Properties of the ZnO:Al Thin Film Deposited on the Flexible Substrate

Properties of the ZnO:Al Thin Film Deposited on the Flexible...

引用

2006年上海电子电镀学术报告会

作者： kim KYUNG-HWAN CHO BUM-jin Dept. of Electrical ＆ Information Engineering Kyungwon University San 65 Bokjung Sujung SongNam GyeongGi Korea Dept. of Electrical ＆ Information Engineering Kyungwon University San 65 Bokjung Sujung SongNam GyeongGi Korea

＜正＞Submission ZnO:Al（AZO） thin film was prepared by Facing Targets Sputtering（FTS） apparatus[1]. Because the flexible substrate has advantages as a light weight, easy deformation, the study about deposition on the flexible substrate is necessary. In this study, we used the flexible substrate polycarbonate （PC） which its thickness is

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：