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运动干预与细胞焦亡在骨关节炎中的作用

中国组织工程研究 2025年第8期29卷 1667-1675页

作者：王秋月靳攀蒲锐长江大学教育与体育学院湖北省荆州市434023 长江大学医学部湖北省荆州市434023 长江大学运动人体科学实验室湖北省荆州市434023

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞... 详细信息

背景:细胞焦亡参与软骨细胞外基质降解、滑膜炎症以及疼痛,在骨关节炎防治中发挥重要作用。此外,运动可通过抑制细胞焦亡调控骨关节炎的发生,已成为防治骨关节炎的研究热点。目的:总结细胞焦亡在骨关节炎中的调控作用,以及运动介导细胞焦亡在改善骨关节炎中的机制。方法:以“pyroptosis,osteoarthritis,chondrocyte pyroptosis,synovial cell pyroptosis,exercise”和“细胞焦亡,骨关节炎,软骨细胞焦亡,滑膜细胞焦亡,运动”为关键词,检索PubMed与中国知网数据库1992-2024年间发表的相关文献,根据纳入及排除标准选择71篇文献进行综述。结果与结论:①骨关节炎是以软骨细胞外基质降解、滑膜炎症和软骨下骨重塑等为特点的慢性退行性关节疾病,易引起骨的器质性病变、疼痛并引发功能障碍。②细胞焦亡作为一种特殊的程序性死亡机制,其特征为细胞裂解死亡释放炎症因子引发强烈的炎症反应,与骨关节炎的发生发展关系密切。细胞焦亡可导致大量炎症因子释放,进而激活核因子κB转录,增加焦亡蛋白的产生,进而加剧骨关节炎的发生发展,因此细胞焦亡可作为骨关节炎防治的新方向。③运动可通过下调焦亡蛋白信号通路和抑制相关炎症因子表达等途径抑制软骨细胞和滑膜细胞的焦亡,从而在骨关节炎防治中发挥重要作用。有氧和无氧运动可通过抑制细胞焦亡的发生延缓骨关节炎的病理进程,中等强度的有氧运动通过抑制细胞焦亡信号通路改善骨关节炎的效果较好,无氧运动可通过提高肌肉质量进而对骨关节炎产生有益效应。

关键词：细胞焦亡骨关节炎运动运动调控信号通路综述

Geometric nonlinear dynamic analysis of curved beams using curved beam element

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Acta Mechanica Sinica 2011年第6期27卷 1023-1033页

作者： Ke-Qi pan jin-Yang Liu School of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University 200240 Shanghai China

Instead of using the previous straight beam element to approximate the curved beam,in this paper,a curvilinear coordinate is employed to describe the deformations,and a new curved beam element is proposed to model the curved *** on exact nonlinear strain-displacement relation,virtual work principle is used to derive dynamic equations for a rotating curved beam,with the effects of axial extensibility,shear deformation and rotary inertia taken into *** constant matrices are solved numerically utilizing the Gauss quadrature integration *** and Newton-Raphson iteration methods are adopted to solve the differential equations of the rigid-flexible coupling *** present results are compared with those obtained by commercial programs to validate the present finite *** order to further illustrate the convergence and efficiency characteristics of the present modeling and computation formulation,comparison of the results of the present formulation with those of the ADAMS software are ***,the present results obtained from linear formulation are compared with those from nonlinear formulation,and the special dynamic characteristics of the curved beam are concluded by comparison with those of the straight beam.

关键词： Curved beam element. Geometric nonlinear formulation Rigid-flexible coupling

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钙钛矿体材料的合成及量子点光转换膜制备

化工管理 2025年第2期 144-147页

作者：佟峰潘锦顾修全中国矿业大学江苏徐州221000 徐州绿肯环保科技有限公司江苏徐州221000

钙钛矿材料因其独特的晶体结构和优异的光电性能,在太阳能电池、发光二极管(LED)、光探测器等领域展现出广阔的应用前景。文章综述了钙钛矿体材料的多种合成方法,并详细介绍了钙钛矿量子点光转换膜的制备技术。通过对溶胶-凝胶法、水热... 详细信息

钙钛矿材料因其独特的晶体结构和优异的光电性能,在太阳能电池、发光二极管(LED)、光探测器等领域展现出广阔的应用前景。文章综述了钙钛矿体材料的多种合成方法,并详细介绍了钙钛矿量子点光转换膜的制备技术。通过对溶胶-凝胶法、水热合成法、高能球磨法以及热注射法等合成方法的探讨,为钙钛矿材料的制备提供了全面视角。同时,结合量子点光转换膜的原位制备技术和应用实例,展示了钙钛矿量子点在提升显示器件性能方面的巨大潜力。

关键词：钙钛矿体材料化学合成量子点光转换膜材料制备

TOPOLOGY OPTIMIZATION OF TRUSS STRUCTURE WITH FUNDAMENTAL FREQUENCY AND FREQUENCY DOMAIN DYNAMIC RESPONSE CONSTRAINTS

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Acta Mechanica Solida Sinica 2006年第3期19卷 231-240页

作者： pan jin Wang De-yu State Key Lab of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200030 China

In this paper, adaptive genetic algorithm （AGA） is applied to topology optimization of truss structure with frequency domain excitations. The optimization constraints include fundamental frequency, displacement responses under force excitations and acceleration responses under foundation acceleration excitations. The roulette wheel selection operator, adaptive crossover and mutation operators are used as genetic operators. Some heuristic strategies are put forward to direct the deletion of the extra bars and nodes on truss structures. Three examples demonstrate that the proposed method can yield the optimum structure form and the lightest weight of the given ground structure while satisfying dynamic response constraints.

关键词： fundamental frequency dynamic response adaptive genetic algorithm topology optimization truss structure

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论马克思问题意识的人民性向度

北方论丛 2025年第1期 73-82页

作者：潘金倩孙迪亮曲阜师范大学马克思主义学院日照276826

马克思在毕生的理论创建和革命实践中都表现出强烈的问题意识,能够以深邃的历史洞察力在他人不疑之处展开自己的质疑和追问。马克思的问题意识缘于对时代发展形势的分析研判和对社会焦点问题的深刻认识,其根本出发点和落脚点在于人民群... 详细信息

马克思在毕生的理论创建和革命实践中都表现出强烈的问题意识,能够以深邃的历史洞察力在他人不疑之处展开自己的质疑和追问。马克思的问题意识缘于对时代发展形势的分析研判和对社会焦点问题的深刻认识,其根本出发点和落脚点在于人民群众的物质生活实践,因而具有鲜明的人民性特征,这集中体现为:发现问题须源于人民,研究问题是为了人民,破解问题应依靠人民。深入领会并体悟马克思问题意识的人民性向度,对于我们在新形势下坚持以人民为中心的发展思想,更好地为民解忧、为民纾困、为民谋利,进而满足人民日益增长的美好生活需要,具有重要的现实意义。

关键词：马克思问题意识人民性

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肠道菌群、运动干预与呼吸系统疾病

中国组织工程研究 2025年第14期29卷 3034-3042页

作者：殷月冷思逸靳攀陈子扬蒲锐长江大学教育与体育学院湖北省荆州市 4340232 长江大学医学部湖北省荆州市 4340232 长江大学教育与体育学院湖北省荆州市 4340232 长江大学运动人体科学实验室湖北省荆州市 434023

背景:肠道菌群是位于人体胃肠道中的一种多样化和动态的微生物群落总称,对维持人体免疫和健康有着至关重要的作用.近年提出"肠-肺轴"概念,提示肠道菌群与肺密切相关,且运动可通过维持肠道菌群平衡调节呼吸系统疾病.目的:综述了肠道菌群... 详细信息

背景:肠道菌群是位于人体胃肠道中的一种多样化和动态的微生物群落总称,对维持人体免疫和健康有着至关重要的作用.近年提出"肠-肺轴"概念,提示肠道菌群与肺密切相关,且运动可通过维持肠道菌群平衡调节呼吸系统疾病.目的:综述了肠道菌群与肺炎、肺癌、哮喘病和慢性肺阻塞疾病等不同呼吸系统疾病的关系、不同运动方式对肠道菌群和呼吸系统疾病的影响,为深入探讨运动调控肠道菌群在呼吸系统疾病中的作用机制提供新的思路.方法:检索1944-2024年间CNKI和PubMed数据库相关文献,中文检索词包括"肠道菌群、肠道细菌、呼吸系统疾病、肺炎、肺癌、哮喘病和慢性肺阻塞疾病、有氧运动、抗阻运动"等;英文检索词包括"Intestinal flora,Gut bacteria,Respiratory illness,Pneumonia,Lung cancer,Asthma,Chronic obstructive pulmonary diseases,Aerobic exercise、Resistance training"等,根据纳入和排除标准选择101篇文献进行归纳总结.结果与结论:①肠道菌群在肺炎、肺癌、哮喘病和慢性肺阻塞疾病等多种呼吸系统疾病中发挥着重要的调节作用.②不同运动方式与肠道菌群密切相关:有氧运动可通过改善胰岛素敏感性、增加菌群多样性和抑制全身慢性炎症在肠道菌群的调控中发挥有益效应;抗阻运动可降低肠黏膜通透性并促进短链脂肪酸的产生;有氧联合抗阻运动也可提升肠道菌群多样性、影响肠道菌群组成.③运动可通过调节炎症反应和减轻氧化应激损伤,提高心肺功能和运动表现进而改善呼吸系统疾病.④运动通过调控肠道菌群抑制炎症反应、调节氧化应激、改善肠屏障通透性和维持肠道菌群稳态,在防治呼吸系统疾病中发挥关键作用.

关键词：肠道菌群呼吸系统疾病肺炎肺癌哮喘病慢性肺阻塞疾病有氧运动抗阻运动综述

Multi-scale simulation model of air system based on cross-dimensional data transmission method

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Chinese Journal of Aeronautics 2023年第5期36卷 157-174页

作者： Lei WANG Junkui MAO Song WEI Longfei WANG jin pan AECC Aeroengine Control System Institute Wuxi 214063China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The Secondary Air System(SAS)plays an important role in the safe operation and performance of *** traditional 1D-3D coupling method loses information when used for secondary air systems,which affects the calculation *** this paper,a Cross-dimensional Data Transmission method(CDT)from 3D to 1D is proposed by introducing flow field uniformity into the data ***,a uniformity index was established to quantify the flow field parameter distribution characteristics,and a uniformity index prediction model based on the locally weighted regression method(Lowess)was established to quickly obtain the flow field ***,an information selection criterion in 3D to 1D data transmission was established based on the Spearman rank correlation coefficient between the uniformity index and the accuracy of coupling calculation,and the calculation method was automatically determined according to the established ***,a modified function was obtained by fitting the ratio of the 3D mass-average parameters to the analytical solution,which are then used to modify the selected parameters at the 1D-3D *** a typical disk cavity air system as an example,the results show that the calculation accuracy of the CDT method is greatly improved by a relative 53.88%compared with the traditional 1D-3D coupling ***,the CDT method achieves a speedup of 2 to 3 orders of magnitude compared to the 3D calculation.

关键词： Air system Data transmission Disk cavity Multi-scale simulation 1D-3D coupling

Reaction behaviors of Pb and Zn sulfates during reduction roasting of Zn leaching residue and flotation of artificial sulfide minerals

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 358-366页

作者： Yong-xing Zheng Jilai Ning Wei Liu pan-jin Hu jin-fang Lü Jie pang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

To evaluate the feasibility of recovering Pb and Zn sulfides and Ag-containing minerals from Zn leaching residue by the process of reduction roasting followed by flotation,the reaction behaviors of Pb and Zn sulfates during this process were *** analysis showed that the transformation ratios of PbSO4 and ZnSO4 could reach 65.51%and 52.12%,respectively,after reduction roasting,and the introduction of a sulfidation agent could improve the transformation ratios of these *** electron microscopy-energy dispersive spectroscopy(SEM-EDS)revealed that temperature obviously affects the particle size,crystal growth,and morphology of the artificial Pb and Zn sulfide *** size analysis demonstrated that the particle size of the materials increases after *** tests revealed that a flotation concentrate composed of 12.01wt%Pb,27.78wt%Zn,and 6.975×10^(−2)wt%Ag with recoveries of 60.54%,29.24%,and 57.64%,respectively,could be obtained after roasting.

关键词： zinc leaching residue reduction roasting flotation Pb and Zn sulfates artificial sulfides

MECHANICAL PROPERTIES AND INTERFACIAL STRUCTURES OF ALUMINIUM BORATE WHISKER REINFORCED ALUMINIUM COMPOSITES

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Acta Metallurgica Sinica(English Letters) 1993年第12期6卷 465-471页

作者： pan jin NING Xiaoguang HU Kuiyi YE Hengqiang Changsha Institute of Technology ChangshaChina Laboratory of Atomic Imaging of Solids Institute of Metal ResearchAcademia SinicaShenyangChina

Quality 9Al_2O_3-2B_2O_3 whisker reinforced 6061Al or Al composites have been prepared by technique of squeeze *** mechanical properties of the 9Al_2O_3·2B_2O_3(w)/6061Al composites could be hardly improved by T6 treatment,owing to cause the remarkable interracial *** observation under high resolution trans- mission electron microscope on interfaces shows that the serious chemical reaction occurs and the product is Al_2MgO_*** no such reaction is found at the interfaces of 9Al_2O_3. 2B_2O_3(w)/Al *** analysis on the interfaces shows that above mentioned interracial reaction may be resulted from the interracial segregation of Mg atoms in 6061Al matrix during sequeeze casting.

关键词： aluminium borate whisker Al matrix composite strength interracial structure