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Bacteriophage cocktail supplementation improves growth performance,gut microbiome and production traits in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1339-1350页

作者： Santi Devi Upadhaya Je Min Ahn Jae hyoung Cho jin young kim Dae kyung kang Sung Woo kim Hyeun Bum kim In Ho kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea Department of Animal Science North Carolina State University116 Polk HallBox 7621120 W Broughton DrRaleighNC 27695USA

Background:Effective antibiotic alternatives are urgently needed in the poultry industry to control disease *** therapy mainly utilizes lytic phages to kill their respective bacterial hosts and can be an attractive solution to combating the emergence of antibiotic resistance in ***:Five hundred and four,one-day-old broilers(Ross 308)were allotted to 1 of 4 treatment groups in a completely randomized *** consisted of CON(basal diet),PC(CON+0.025%Avilamax®),BP 0.05(CON+0.05%bacteriophage),and BP 0.10(CON+0.10%bacteriophage).Results:A significant linear effect on body weight gain(BWG)was observed during days 1–7,days 22–35,and cumulatively in bacteriophage(BP)supplemented *** BWG tended to be higher(P=0.08)and the feed intake(FI)was increased(P=0.017)in the PC group over CON group.A greater(P=0.016)BWG and trends in increased FI(P=0.06)were observed in the experiment in birds fed PC than CON *** the genus level,the relative abundance of Lactobacillus was decreased in PC(65.28%),while it was similar in BP 0.05 and BP 0.10(90.65%,86.72%)compared to CON(90.19%).At the species level,the relative abundance of Lactobacillus salivarus was higher in BP 0.05(40.15%)and BP 0.10(38.58%)compared to the CON(20.04%)and PC(18.05%).A linear reduction in the weight of bursa of Fabricius(P=0.022)and spleen(P=0.052)was observed in birds fed graded level of BP and an increase(P=0.059)in the weight of gizzard was observed in birds fed PC over BP *** and quadratic responses were observed in redness of breast muscle color in birds fed graded level of ***:The inclusion of the 0.05%and 0.1%BP cocktail linearly improved broiler weight during the first 7 days,22–35 days and cumulatively,whereas 0.05%BP addition was sufficient for supporting immune organs,bursa and spleen as well as enhancing gut microbiome,indicating the efficacy of 0.05%BP as a substitute antibiotic growth promoter in broiler diets.

关键词： Bacteriophage Broiler chickens Gut microbiome Performance

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Effect of prenatal antioxidant intake on infants' respiratory infection is modified by a CD14 polymorphism

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World Journal of Pediatrics 2017年第2期13卷 173-182页

作者： Seo Ah hong Eun Lee Sung Ok Kwon kyung won kim Youn Ho Shin kang Mo Ahn Eun-jin kim Jeom-Gyu Lee Se-young oh Soo-Jong hong ASEAN Institute for Health Development Mahidol UniversitySalayaPhutthamonthonNakhonpathomThailand Department of Pediatrics Inje University Haeundae Paik HospitalBusanKorea Department of Food and Nutrition Research Institute of Human EcologyKyung Hee UniversitySeoulKorea Department of Pediatrics Severance Children's HospitalCollege of MedicineYonsei UniversitySeoulKorea Department of Pediatrics CHA Medical CenterCHA University School of MedicineSeoulKorea Department of Pediatrics Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Allergy and Respiratory Diseases Korea National Institute of HealthOsong Health Technology Administration ComplexKorea Department of Pediatrics Childhood Asthma Atopy CenterEnvironmental Health CenterAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic *** hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of ***:This study included 550 *** the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study,prenatal maternal diet was assessed by administering a food frequency ***' cord blood was genotyped for CD14 (rs2569190),TLR4 (rs1927911),and GSDMB (rs4794820) polymorphisms by the TaqMan ***:Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430).In children with TT genotype at rs2569190,a higher prenatal intake of vitamins A and C,fruits,and total FV decreased RTI risk (P-trend <0.05),while in infants with TC+CC genotype,a higher prenatal intake of fruit increased RTI risk (P-trend <0.05).When analyzing the 3 genotypes,children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30,respectively].In children with CC genotype at rs1927911,RTI risk showed a dose-response association with a higher prenatal intake of vitamin C (P for interaction<0.05).A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction<0.05).Conclusion:Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14,TLR4,and GSDMB polymorphisms.

关键词： antioxidants CD14 fruit polymorphism respiratory tract infection

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Acoustic radiation force impulse elastography for hepatocellular carcinoma-associated radiofrequency ablation

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World Journal of Gastroenterology 2011年第14期17卷 1874-1878页

作者： Hee-jin Kwon Myong-jin kang jin-Han Cho Jong-young oh kyung-jin Nam Sang-Yeong Han Sung Wook Lee Department of Radiology Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea Department of Internal Medicine Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea

AIM:To evaluate the potential usefulness of acoustic radiation force impulse (ARFI) images for evaluation of hepatocellular carcinomas (HCC)-associated radiofrequency ablation. METHODS:From January 2010 to June 2010,a total of 38 patients with HCC including recurred HCCs after RFA underwent ARFI elastography. The brightness of tumor was checked and the shear wave velocity was measure-d for the-quantification of stiffne-ss. According to theb-rightne-ss,the-tumors we-re-classifie-d as b-righte-r,samecolor and darker compared with adjacent parenchyma. Using the same methods,8 patients with recurred HCCs after RFA state were evaluated about the brightness compared with adjacent RFA ablation area. RESULTS:In the 38 patients with HCCs,20 (52.6%)were brighter than surrounding cirrhotic parenchyma. Another 13 (34.2%) were darker. The others (5 cases,13.2%) were seen as the same color as the adjacent liver parenchyma. Post-RFA lesions were darker than previous tumor and surrounding parenchyma in all 38 cases. However,recurred HCCs were brighter than the treated site in all 8 cases. CONCLUSION:Using ARFI technique is helpful for differential diagnosis in order to detect recurred HCCs more easily in patients with confusing status.

关键词：射频消融辐射力肝癌成像弹性治疗 RFA 亮度比

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Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial

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Chinese Journal of Cancer 2017年第11期36卷 609-617页

作者： kyung-Hee Lee Tae won kim Jung-Hun kang jin-Soo kim jin-Seok Ahn Sun-young kim Hwan-Jung Yun young-Jun Eum Sung Ae Koh Min Kyoung kim Yong Sang hong Jeong Eun kim Gyeong-won Lee Department of Hematology-Oncology Yeungnam University Medical Center Daegu 42415 South Korea Department of Oncology Asan Medical Center University of Ulsan Seoul 05505 South Korea Department of Hematology-Oncology Gyeongsang National University Hospital Jinju 52727 South Korea Department of Internal Medicine SMG-SNU Boramae Medical Center Seoul 07061 South Korea Division of Hematology-Oncology Department of Medicine Samsung Medical Center Seoul 06351 South Korea Department of Hematology.Oncology National Cancer Center Ilsan 10408 South Korea Department of Hematology-Oncology Chungnam National University Hospital Daejeon 35015 South Korea Medical Affairs Mundipharma Korea Ltd Seoul 04637 South Korea Department of Oncology Asan Medical Center University of Ulsan College of Medicine 388.1 Pungnap-dong Songpa-gu Seoul 138.736 South Korea

Background: Controlled-release oxycodone/naloxone(OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone(OX-CR) for the control of cancer-related pain in Korean ***: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale(NRS) pain score ≥4] from seven Korean oncology/hematology centers. Patients in the intention-to-treat(ITT) population were randomized(1:1) to OXNCR or OX-CR groups. OXN-CR was administered starting at 20 mg/10 mg per day and up-titrated to a maximum of80 mg/40 mg per day for 4 weeks, and OX-CR was administered starting at 20 mg/day and up-titrated to a maximum of 80 mg/day for 4 *** primary efficacy endpoint was the change in NRS pain score from baseline to week4, with non-inferiority margin of-1.5. Secondary endpoints included analgesic rescue medication intake, patientreported change in bowel habits, laxative intake, quality of life(QoL), and safety ***: Of the ITT population comprising 128 patients, 7 with missing primary efficacy data and 4 who violated the eligibility criteria were excluded from the efficacy analysis. At week 4, the mean change in NRS pain scores was not significantly different between the OXN-CR group(n = 58) and the OX-CR group(n = 59)(-1.586 vs.-1.559,P = 0.948). The lower limit of the one-sided 95% confidence interval(-0.776 to 0.830) for the difference exceeded the non-inferiority margin(P < 0.001). The OXN-CR and OX-CR groups did not differ significantly in terms of analgesic rescue medication intake, change in bowel habits, laxative intake, QoL, and safety ***: OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatmen

关键词： Constipation Naloxone Oxycodone Quality of life Safety

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Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： Sungbae Moon Hyun Wook Ryoo Jae Yun Ahn Jung Bae Park kang Suk Seo Sang Do Shin Kyoung Jun Song kang Hyun Lee In Sool Yoo jin seong Cho Hyun Ho Ryu Tae oh Jeong Seok Ran Yeom young taek kim Sung Ok hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using Chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.

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Influence of tool plunge depth and welding distance on friction stir lap welding of AA5454-O aluminum alloy plates with different thicknesses

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中国有色金属学会会刊：英文版 2012年第S3期22卷 624-628页

作者： Jun-won Kwon Myoung-Soo kang Sung-Ook YOON Yong-Jai Kwon Sung-Tae hong Dae-Il kim Kwang-Hak LEE Jong-Dock SEO jin-Soo MOON kyung-Sik HAN School of Materials Science and Engineering University of Ulsan School of Mechanical Engineering University of Ulsan Technical Research Laboratories Shin Young Co.Ltd. Automotive Parts Innovation Center Ulsan Technopark

AA5454-O aluminum alloy plates with thicknesses of 1.4 and 1.0 mm were friction-stir-lap-welded (FSLWed).The influences of the tool plunge depth and welding distance on surface appearance,macrostructure and mechanical properties of the FSLWed plates were experimentally *** tensile shear load of the FSLWed plates was compared with that of the adhesive-bonded ***-free FSLWed zones were successfully obtained in all the tool plunge depths and the welding *** FSLWed zones exhibited the relatively smooth surface *** all the FSLWed conditions,the FSLWed zone exhibited higher average hardness than the base *** addition,the upper plate exhibited a higher average hardness than the lower plate,although there was no special tendency in spite of the change in the tool plunge depth and the welding *** maximum tensile shear load of the FSLWed plates was much higher than that of the adhesive-bonded aluminum alloy ***,under the FSLW condition of the plunge depth of 1.8 mm and the welding distance of 40 mm,the tensile shear load of the FSLWed plate reached a level about 41% greater than that of the adhesive-bonded aluminum alloy *** addition,the maximum tensile shear load of the FSLWed plate was increased with the increase of the welding distance.

关键词： friction stir lap welding AA5450-O aluminum alloy tool plunge depth welding distance mechanical properties

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Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

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World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： Joon Mee kim Mee-Yon Cho jin Hee Sohn Dae young kang Cheol Keun Park Woo Ho kim So-young jin Kyoung Mee kim Hee kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha kim Do Youn Park Yun kyung kang Sun Hoo Park Hye Seung Han young Bae kim Ho Sung Park Yang Seok Chae Kye won Kwon Hee jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词：病理诊断粘膜上皮理学家胃粘膜韩国学术交流活动发育不良细胞学

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Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acid

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International Journal of Oral Science 2014年第3期6卷 150-153页

作者： jin Man kim Sang Wook kang Su-Mi Shin Duck Su kim Kyong-Kyu Choi Eun-Cheol kim Sun-young kim Department of Conservative Dentistry School of Dentistry Kyung Hee University Department of Maxillofacial Tissue Regeneration School of Dentistry Kyung Hee University

All-trans retinoic acid（ATRA） inhibits matrix metalloproteinase（MMP）-2 and MMP-9 in synovial fibroblasts, skin fibroblasts,bronchoalveolar lavage cells and cancer cells, but activates MMP-9 in neuroblast and leukemia cells. Very little is known regarding whether ATRA can activate or inhibit MMPs in human dental pulp cells（HDPCs）. The purpose of this study was to determine the effects of ATRA on the production and secretion of MMP-2 and-9 in HDPCs. The productions and messenger RNA（mRNA） expressions of MMP-2 and-9 were accessed by gelatin zymography and real-time polymerase chain reaction（PCR）, respectively. ATRA was found to decrease MMP-2 level in a dose-dependent manner. Significant reduction in MMP-2 mRNA expression was also observed in HDPCs treated with 25 mmol？L21ATRA. However, HDPCs treated with ATRA had no effect on the pattern of MMP-9 produced or secreted in either cell extracts or conditioned medium fractions. Taken together, ATRA had an inhibitory effect on MMP-2 expression in HDPCs,which suggests that ATRA could be a candidate as a medicament which could control the inflammation of pulp tissue in vital pulp therapy and regenerative endodontics.

关键词： all-trans retinoic acid human dental pulp cell matrix metalloproteinase zymography

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High-throughput discovery of plastid genes causing albino phenotypes in ornamental chimeric plants

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Horticulture Research 2023年第1期10卷 249-259页

作者： Hyun-Seung Park Jae-Hyeon Jeon Woohyeon Cho Yeonjeong Lee Jee young Park Jiseok kim young Sang Park Hyun Jo Koo Jung Hwa kang taek Joo Lee Sang Hoon kim jin-Baek kim Hae-Yun Kwon Suk-Hwan kim Nam-Chon Paek Geupil Jang Jeong-Yong Suh Tae-jin Yang Department of Agriculture Forestry and BioresourcesResearch Institute of Agriculture and Life Sciencesand Plant Genomics and Breeding InstituteCollege of Agriculture and Life SciencesSeoul National UniversitySeoul08826Republic of Korea Department of Integrative Biological Sciences and Industry Sejong UniversitySeoul 05006Korea Hantaek Botanical Garden YonginGyeonggi-do17183Republic of Korea Radiation Breeding Research Team Advanced Radiation Technology InstituteKorea Atomic Energy Research InstituteJeongeup 56212Korea Special Forest Resources Division National Institute of Forest ScienceSuwon 16631Korea School of Biological Sciences and Technology Chonnam National UniversityGwangjuSouth Korea Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826Korea

Chimeric plants composed of green and albino tissues have great ornamental *** unveil the functional genes responsible for albino phenotypes in chimeric plants,we inspected the complete plastid genomes(plastomes)in green and albino leaf tissues from 23 ornamental chimeric plants belonging to 20 species,including monocots,dicots,and *** nine chimeric plants,plastomes were identical between green and albino ***,another 14 chimeric plants were heteroplasmic,showing a mutation between green and albino *** identified 14 different point mutations in eight functional plastid genes related to plastid-encoded RNA polymerase(rpo)or photosystems which caused albinism in the chimeric *** them,12 were deleterious mutations in the target genes,in which early termination appeared due to small deletion-mediated frameshift or single nucleotide *** was single nucleotide substitution in an intron of the ycf3 and the other was a missense mutation in coding region of the rpoC2 *** inspected chlorophyll structure,protein functional model of the rpoC2,and expression levels of the related genes in green and albino tissues of Reynoutria japonica.A single amino acid change,histidine-to-proline substitution,in the rpoC2 protein may destabilize the peripheral helix of plastid-encoded RNA polymerase,impairing the biosynthesis of the photosynthesis system in the albino tissue of *** chimera plant.

关键词： plast substitution ornamental

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Expression Pattern of the Hippo Pathway Effector TAZ in Cellular and Fibrotic Nonspecific Interstitial Pneumonia

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Chinese Medical Journal 2018年第5期131卷 626-628页

作者： Min-kyung Yeo Hee Sun Park Yeon Hee Park Choong-Sik Lee Geon Yoo Dong II Park Jeong Eun Lee Jae young Moon Sung Soo Jung Ju Ock kim Dahyun kang Hyun jin Cho Min-Woong kang jin-Whan kim Song-Soo kim Chaeuk Chung Department of Pathology Chungnam National University School of Medicine Daejeon 35015 South Korea Division of Pulmonology Department of Internal Medicine Chungnam National University 282 Munhwaro Jung-gu Daejeon 35015 South Korea Department of Internal Medicine Daejeonst Mary's Hospital College of Medicine Catholic University Daejeon 34943 South Korea ~Department of Toxicological Evaluation and Research Korea Institute of Toxicology 141 Gajeong-ro Yuseong-gu Daejeon 34114 South Korea Department of Thoracic Surgery College of Medicine Chungnam National University Daejeon 35015 South Korea Department of Radiology College of Medicine Chungnam National University Daejeon 35015 South Korea Infection Control Convergence Research Center College of Medicine Chungnam National University Jung-guMunhwa-ro 266 Daejeon 35015 South Korea

Interstitial lung disease （ILD） is a comprehensive term referring to a group of lung diseases affecting the interstitium of the lung. Idiopathic pulmonary fibrosis （IPF） is the most common idiopathic ILD, and nonspecific interstitial pneumonia （NSIP） is the second most common. As the name suggests, NSIP is diagnosed atter many other diseases are excluded. The main pathological finding in NSIP is homogeneous interstitial inflammation with or without fibrosis. NSIP can be categorized by cellular type or fibrotic type, according to the grade of inflammation and fibrosis. The cellular type has mostly inflammatory lesions with good responses to steroid, but the fibrotic type has a large proportion of fibrosis mixed with inflammatory lesions and a relatively poor response to steroid treatment So far, the exact mechanism underlying idiopathic lED has not been clarified. Determining key regulators of these ILDs will be helpful in the diagnosis and development of novel drugs for ILD.

关键词： YAP

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