检索结果-南通市图书馆

Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： chang-Jun Zhang Zi-Bing jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

Self-adaptive gas flow and phase change behaviors during hydrate exploitation by alternate injection of N_(2. and CO_(2.

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 2120-2129页

作者： Bo-Jian Cao Yi-Fei Sun Hong-Nan Chen jin-Rong Zhong Ming-Long Wang Ming Wang chang-Yu Sun Guang-jin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha410114HunanChina

Since hydrate resources play a part of the stratigraphic framework structure in sediments,establishing a safe and economic method for hydrates exploitation remains the primary challenge to this *** the proposed methods,the spontaneous displacement of CH_(4) from hydrate cages by CO_(2. seems to be a perfect mechanism to address gas production and CO_(2. storage,especially in today's strong demand for carbon reduction and replacing clean *** extensive lab researches,in the past decade,injecting a mixture of CO_(2. and small molecule gas has become a key means to enhance displacement efficiency and has great potential for ***,there is a lack of in-depth research on gas flow in the reservoir,while the injected gas always passes through low-saturated hydrate areas with high permeability and then occurs gas channel in a short term,finally resulting in the decreases in gas production efficiency and produced gas ***,we explored a new injection-production mode of alternate injection of N2.and CO_(2. in order to fully coordinate the advantages of N_(2. in enhanced hydrate decomposition and CO_(2. in solid storage and heat *** alternate"taking"and"storing"processes perfectly repair the problem of the gas channel,achieving self-regulation effect of CH_(4) recovery and CO_(2. *** 3-D experimental results show that compared to the mixed gas injection,CH_(4) recovery is increased by>50%and CO_(2. storage is increased by>70%.Additionally,this alternate injection mode presented a better performance in CH_(4) concentration of produced gas and showed outstanding N_(2. utilization ***,we analyzed its self-adaptive gas flow mechanism and proposed an application model of"one injection and multiple production".We look forward to this study accelerating the application of CO_(2.-CH_(4) replacement technology.

关键词： Hydrate Replacement CH_(4)recovery CO_(2.storage Reservoir remediation

Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 348-360页

作者： jin Wang Ke Wan Xin chang Rui-Feng Mao Department of Ultrasound Medicine Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Faculty of Medicine and Health The University of SydneyCamperdown NSW 2050Australia School of Life Science Huaiyin Normal UniversityHuai'an 223300Jiangsu ProvinceChina

As a common hyperglycemic disease,type 1 diabetes mellitus(T1DM)is a complicated disorder that requires a lifelong insulin supply due to the immunemediated destruction of pancreaticβ*** it is an organ-specific autoimmune disorder,T1DM is often associated with multiple other autoimmune *** most prevalent concomitant autoimmune disorder occurring in T1DM is autoimmune thyroid disease(AITD),which mainly exhibits two extremes of phenotypes:hyperthyroidism[Graves'disease(GD)]and hypothyroidism[Hashimoto's thyroiditis,(HT)].However,the presence of comorbid AITD may negatively affect metabolic management in T1DM patients and thereby may increase the risk for potential diabetes-related ***,routine screening of thyroid function has been recommended when T1DM is ***,first,we summarize current knowledge regarding the etiology and pathogenesis mechanisms of both ***,an updated review of the association between T1DM and AITD is ***,we provide a relatively detailed review focusing on the application of thyroid ultrasonography in diagnosing and managing HT and GD,suggesting its critical role in the timely and accurate diagnosis of AITD in T1DM.

关键词： Type 1 diabetes mellitus Autoimmunity Autoimmune thyroid disease Ultrasonography Diagnosis

Insect-specific RNA virus affects the stylet penetration activity of brown citrus aphid(Aphis citricidus)to facilitate its transmission

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 255-270页

作者： Xin An Qiaoying Gu jing Wang Tengyu chang Wei Zhang jin-Jun Wang jinzhi Niu Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural ScienceSouthwest UniversityChongqingChina

Sap-sucking insects often transmit plant viruses but also carry insect viruses,which infect insects but not *** impact of such insect viruses on insect host biology and ecology is largely ***,we identified a novel insect-specific virus carried by brown citrus aphid(Aphis citricidus),which we tentatively named Aphis citricidus picornavirus(AcPV).Phylogenetic analysis discovered a monophyletic cluster with AcPV and other unassigned viruses,suggesting that these viruses represent a new family in order *** infection with AcPV triggered aphid antiviral immunity mediated by RNA interference,resulting in asymptomatic ***,we found that AcPV was transmitted horizontally by secretion of the salivary gland into the feeding sites of *** influenced aphid stylet behavior during feeding and increased the time required for intercellular penetration,thus promoting its transmission among aphids with plants as an intermediate *** gene expression results suggested that this mechanism was linked with transcription of salivary protein genes and plant defense hormone ***,our results show that the horizontal transmission of AcPV in brown citrus aphids evolved in a manner similar to that of the circulative transmission of plant viruses by insect vectors,thus providing a new ecological perspective on the activity of insect-specific viruses found in aphids and improving the understanding of insect virus ecology.

关键词： electrical penetration graph feeding behavior insect virus transmission Picornavirales salivary protein

Implications for fault reactivation and seismicity induced by hydraulic fracturing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1081-1098页

作者： Zi-Han Sun Ming-Guang Che Li-Hong Zhu Shu-Juan Zhang Ji-Yuan Lu chang-Yu jin Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil Engineering and Key Laboratory of Liaoning Province on Deep Engineering and Intelligent TechnologyNortheastern UniversityShenyang110819LiaoningChina Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100084China The Exploration and Development Research Institute of Daqing Oilfield Limited Company Daqing163458HeilongjiangChina

Evaluating the physical mechanisms that link hydraulic fracturing(HF) operations to induced earthquakes and the anticipated form of the resulting events is significant in informing subsurface fluid injection operations. Current understanding supports the overriding role of the effective stress magnitude in triggering earthquakes, while the impact of change rate of effective stress has not been systematically addressed. In this work, a modified critical stiffness was brought up to investigate the likelihood, impact,and mitigation of induced seismicity during and after hydraulic fracturing by developing a poroelastic model based on rate-and-state fraction law and linear stability analysis. In the new criterion, the change rate of effective stress was considered a key variable to explore the evolution of this criterion and hence the likelihood of instability slip of fault. A coupled fluid flow-deformation model was used to represent the entire hydraulic fracturing process in COMSOL Multiphysics. The possibility of triggering an earthquake throughout the entire hydraulic fracturing process, from fracturing to cessation, was investigated considering different fault locations, orientations, and positions along the fault. The competition between the effects of the magnitude and change rate of effective stress was notable at each fracturing stage. The effective stress magnitude is a significant controlling factor during fracturing events, with the change rate dominating when fracturing is suddenly started or stopped. Instability dominates when the magnitude of the effective stress increases(constant injection at each fracturing stage) and the change rate of effective stress decreases(the injection process is suddenly stopped). Fracturing with a high injection rate, a fault adjacent to the hydraulic fracturing location and the position of the junction between the reservoir and fault are important to reduce the Coulomb failure stress(CFS) and enhance the critical stiffness as

关键词： Hydraulic fracturing Coulomb failure stress Rate-and-state fraction model Linear stability analysis Critical stiffness Seismically induced fault

Dynamic Analysis of A Deepwater Drilling Riser with A New Hang-off System

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第1期38卷 29-41页

作者： LI Yan-wei LIU Xiu-quan WANG jin-long CHEN Guo-ming chang Yuan-jiang SHENG Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drilling riser new hang-off system dynamic analysis finite element method penalty function method

Dual modification of LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2. cathode materials by K^(+) doping and Li_(3)PO_(4) coating for lithium ions batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3007-3018页

作者： Wei Xiao Jia-Le Wang Zhi-Cheng Yi Cheng-jin Liu chang Miao Yu Xin Shu-Qing Nie College of Chemistry and Environmental Engineering Yangtze UniversityJingzhou 434023China

Li_(3)PO_(4)@Li_(0.99)K_(0.01)Ni_(0.83)Co_(0.11)Mn_(O.06)O_(2.(NCM-KP) cathode powders are synthesized via K^(+)doping in calcination processes and H_3PO_4 coating in sol-gel processes.K^(+) precisely enters into the lattice to widen the(003) plane to 0.4746 nm with a lower cationic disordered degree of 1.87%.Moreover,the surface residual lithium salts are treated by H_3PO_4 to generate a uniform Li_(3)PO_(4) coating layer of approximately 11.41 nm,which completely covers on the surface of secondary spherical particles to improve the interfacial *** 2.℃,the NCM-KP electrode delivers a discharge specific capacity of 148.9 mAh·g^(-1) with a remarkable capacity retention ratio of 84.1% after 2.0 cycles at 1.0C and retains a high reversible specific capacity of 154.4 mAh·g^(-1) at *** at 1.0C and 60℃,it can maintain a reversible discharge specific capacity of 114.6 mAh·g^(-1) with 0.2.% of capacity decay per cycle after 2.0 cycles,which is significantly lower than 0.40% for the pristine NCM ***,the charge transfer resistance of 2.8.89 Ω for the NCM-KP electrode is significantly lower than 947.41 Ω for the pristine NCM one by restricting the interfacial side ***,combining K+doping and Li_(3)PO_(4) coating is an effective strategy to enable the significant improvement of the electrochemical property of high-nickel cathode materials,which may be mainly attributed to the widened diffusion pathway and the formed Li_(3)PO_(4) protective layer,thus promoting Li~+diffusion rate and preventing the erosion of HF.

关键词： High-nickel cathode material Residual lithium K^(+)doping Li_(3)PO_(4)coating Lithium ions battery

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2.18–2.2.

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan jin Yi Chen CAI chang TANG Hou Lin QIN Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2.18 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2.18 to 2.2.,were collected using the *** tests and spatial analyses were also *** Between 2.18 and 2.2.,2.7,72. HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.2.%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

Targeting methyltransferase-like 5-mediated sphingomyelin metabolism:A novel therapeutic approach in gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4060-4063页

作者： jin-Juan Zhang chang Yuan Sheng-Chun Dang Department of General Surgery The Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina

Gastric cancer(GC)is a global health problem and a leading cause of cancerrelated deaths,with its mortality rate ranking third among all *** etiology and progression of GC are characterized by a complex interplay of genetic and epigenetic changes,which present challenges for its early diagnosis and effective *** the mechanisms underlying the occurrence and development of GC and identifying novel biomarkers for early detection and prognosis are crucial to improving patient *** editorial examines the role of methyltransferase-like 5(METTL5)in the progression of GC through sphingomyelin metabolism by considering an article published by Zhang et al in the World Journal of Gastrointestinal Oncology in 2.2.,which is entitled“METTL5 promotes GC progression via sphingomyelin metabolism”.These authors investigated the biological behavior of METTL5 in GC by examining its expression patterns,clinical relevance,functional effect,and potential mechanisms,as well as its response to *** editorial provides valuable insights into the role of METTL5 in the progression of GC and its potential as a therapeutic target.

关键词： Gastric cancer Methyltransferase-like 5 Sphingomyelin metabolism Biomarkers Chemotherapy response