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Outcome of Stretta radiofrequency and fundoplication for GERD- related severe asthmatic symptoms

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Frontiers of Medicine 2015年第4期9卷 437-443页

作者： Zhiwei Hu jimin wu Zhonggao Wang Yu Zhang Weitao Liang Chao Yan Department of Gastroesophageal Reflux Disease the Second Artillery General Hospital PLA Beijing 100088 China

This study aimed to investigate the outcome of treatment with Stretta radiofrequency （SRF） or laparoscopic Nissen fundoplication （LNF）. A total of 137 gastroesophageal reflux disease （GERD） patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma were investigated. The patients were followed up 1 year and 5 years after SRF （n = 82） or LNF （n = 55） treatment. A questionnaire covering 29 related symptoms and medication use was employed. Digestive, respiratory, and ear-nose-throat （ENT） symptom scores significantly decreased after antireflux treatment. Symptom scores respectively changed from 17.2 ± 10.1, 31.9 ± 6.6, and 21.1± 11.8 to 5.0 ±6.2, 11.5 ±10.2, and 6.3± 6.8 at 1 year and to 5.6 ± 6.5, 13.1± 10.1, and 7.8 ± 7.2 at 5 years （P 〈 0.001）. The outcome of LNF was significantly better than that of SRF in terms of digestive （P 〈 0.001, P = 0.001）, respiratory （P = 0.006, P = 0.001）, and ENT symptoms （P = 0.006, P = 0.003） at both 1 year and 5 years. SRF and LNF were both effective against the digestive symptoms of GERD as well as GERD-related severe asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group. Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.

关键词： asthma gastroesophageal reflux Stretta radiofrequency laparoscopic Nissen fundoplication

Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease

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Frontiers of Medicine 2017年第1期11卷 68-73页

作者： Zhiwei Hu Meiping Chen jimin wu Qing Song Chao Yan Xing Du Zhonggao Wang Department of Gastroesophageal Reflux Disease PLA Rocket Force General Hospital Beijing 100088 China Department of Vascular Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease （GERD） can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery. Wilcoxon signed-ranks test was used for the statistical analyses. Seventy GERD patients were included in the analysis and followed up for a mean period of 3.5± 1.4 years. Prior to surgery, all participating patients were taking at least one class of antihypertensive medication, and 56 patients （80%） had intermittently high blood pressure. After surgery, the mean number of antihypertensive medication classes per patient was significantly reduced from 1.61 ± 0.77 pre-procedure to 1.27 ± 0.88 post-procedure （P 〈 0.001）. The blood pressure of 48 of the 56 cases （86±） with preoperative intermittent high blood pressure returned to normal post procedure. A total of 50 patients （71%） recorded improvements on the hypertension control scale, with the overall mean score decreasing from 3.1 ± 1.0 pre- procedure to 1.4 ± 1.0 post-procedure （P 〈 0.001）. Therefore, successful laparoscopic fundoplication may result in better blood pressure control in some hypertensive GERD patients. This result suggests a possible connection between gastroesophageal reflux and hypertension.

关键词： gastroesophageal reflux disease hypertension blood pressure laparoscopic fundoplication

Autophagy mediates the secretion of macrophage migration inhibitory factor from cardiomyocytes upon serum-starvation

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Science China(Life Sciences) 2019年第8期62卷 1038-1046页

作者： jimin wu Xiangning Deng Juan Gao Wei Gao Han Xiao Xinyu Wang Youyi Zhang Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors Research

Macrophage migration inhibitory factor(MIF) is an inflammatory cytokine. It is elevated early in the blood of acute myocardial infarction patients. However, it is unclear whether and how MIF is released. This study investigated the cellular source and mechanism of MIF release from hearts. An ischemia-mimic treatment induced the secretion of MIF from neonatal rat cardiomyocytes but not from fibroblasts. The treatment did not cause significant leakage of lactate dehydrogenase, suggesting that ischemia induced the MIF secretion without causing severe cell damage. Plasma samples from patients with acute chest pain at the emergency department were collected for the detection of MIF. MIF levels in patients with acute coronary syndrome(ACS)increased early, when cardiac injury markers were not yet elevated, suggesting that ischemia can induce MIF secretion before the occurrence of severe myocardial damage. Serum-starvation caused MIF secretion from rat cardiomyocytes and Langendorffperfused rat hearts. The secretion was suppressed by the inhibition of autophagy by inhibitors or by silencing of Atg5. In conclusion, serum-starvation induces the secretion of MIF from cardiomyocytes via autophagy dependent pathway. Clarifying the mechanism of MIF secretion will be helpful for its application in the early diagnosis and treatment of ACS.

关键词： macrophage migration inhibitory factor cardiomyocyte ischemia autophagy secretion

Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β_2-adrenergic receptor

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Science China Chemistry 2017年第10期60卷 1310-1317页

作者： Mingliang Zhang Kangmin He jimin wu Nan Li Jinghe Yuan Wei Zhou Zi Ye Zijian Li Han Xiao Zhizhen Lv Youyi Zhang Xiaohong Fang Institute of Vascular Medicine of Third Hospital Ministry of Health Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors and Academy for Advanced Interdisciplinary Studies Peking University Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructures and Nanotechnology Institute of ChemistryChinese Academy of Sciences

Stimulation of G protein-coupled receptors(GPCRs) can lead to the transactivation of the epidermal growth factor receptors(EGFR). The cross-communication between the two signaling pathways regulates several important physiological or pathological processes. However, the molecule mechanism underlying EGFR transactivation remains poorly understood. Here, we aim to study the GPCR-mediated EGFR transactivation process using the single-molecule fluorescence imaging and tracking *** found that although EGFR existed as monomers at the plasma membrane of resting cells, they became dimers and thus diffused slower following the activation of β2-adrenergic receptor(β2-AR) by isoproterenol(ISO). We further proved thatβ2-AR-mediated changes of EGFR in stoichiometry and dynamics were mediated by Src kinase. Thus, the observations obtained via the single-molecule imaging and tracking methods shed new insights into the molecular mechanism of EGFR transactivation at single molecule level.

关键词： transactivation epidermal growth factor receptor(EGFR) β2-adrenergic receptor(β2-AR) single molecule imaging

Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway

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Science China(Life Sciences) 2021年第2期64卷 242-254页

作者： Mingzhe Li jimin wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital/NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides/Key Laboratory of Molecular Cardiovascular ScienceMinistry of Education/Beijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Division of Cardiovascular Sciences Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139PTUK Institute of Cardiovascular Sciences Health Science CenterPeking UniversityBeijing 100191China

Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)*** increased stiffness further promotes CF differentiation and ***,the molecular mechanism is still *** used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer *** staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and *** expression of these fibrosis repressors was inhibited on pathological substrate *** of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF *** conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis *** work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment.

关键词： fibroblast differentiation matrix stiffness POU2F1 cardiac fibrosis transcription factor

Insult of gastroesophageal reflux on airway： clinical significance of pharyngeal nozzle

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Frontiers of Medicine 2015年第1期9卷 117-122页

作者： Zhonggao Wang Zhiwei Hu jimin wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu Center for GER the Second Artillery General Hospital of PLA Beijing 100088 China Xuanwu Hospital Capital Medical University Beijing 100053 China Center for GER the First Ajfiliated Hospital of Zhengzhou University Zhengzhou 450052 China Center for GER the Fourth Affiliated Hospital of Zhengzhou University Zhengzhou 450044 China

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux （GER） insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team＇s work and would call attention to the public so as to recognize this relatively unknown entity -- a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

关键词： gastroesophageal reflux airway pharyngeal nozzle micro-aspiration asthma

环己烯水合制环己醇分子筛催化剂的失活和再生

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石油炼制与化工 2005年第9期36卷 31-33页

作者：吴济民河南神马尼龙化工有限责任公司平顶山467013

采用气相色谱、重量法、低温氮吸附等分析方法,对水合催化剂(MH)失活的原因进行了研究。结果表明:MH表面有机物的积累是MH失活的主要原因,MH表面有机物越多,MH活性下降越多;碱性物质可以破坏分子筛部分微孔,造成MH活性下降;铁等金属的存... 详细信息

采用气相色谱、重量法、低温氮吸附等分析方法,对水合催化剂(MH)失活的原因进行了研究。结果表明:MH表面有机物的积累是MH失活的主要原因,MH表面有机物越多,MH活性下降越多;碱性物质可以破坏分子筛部分微孔,造成MH活性下降;铁等金属的存在,分子筛的脱铝也能造成MH活性降低。对MH再生过程中除油温度、除油操作等进行优化后,MH的流失和消耗显著降低,环己醇产量上升。

关键词：环己烯环己醇水合分子筛催化剂失活再生优化分子筛催化剂环己烯水合再生过程环己醇失活活性下降气相色谱碱性物质有机物

Gu︺ret花岗岩内黑云母粒径分析的图像开操作法

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岩石学报 1999年第1期15卷 124-128页

作者：吴继敏河海大学土木工程学院

应用图像分析原理中的开操作特征，利用岩石薄片作为样品，进行法国Ｇｕéｒｅｔ花岗岩内黑云母粒径分析，得到了极为理想的效果。这一方法的特点是只要制作某目标矿物的二值图像，即可评价体现每一矿物的粒径和分布特征，其精度取决与... 详细信息

应用图像分析原理中的开操作特征，利用岩石薄片作为样品，进行法国Ｇｕéｒｅｔ花岗岩内黑云母粒径分析，得到了极为理想的效果。这一方法的特点是只要制作某目标矿物的二值图像，即可评价体现每一矿物的粒径和分布特征，其精度取决与构成图像的像素数。该方法操作方便，成果可靠，在地学领域，尤其是在岩石结构定量分析方面，应该有很宽广的前景。

关键词：黑云母图像开操作粒径分析花岗岩

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胃食管反流病外科治疗术式的演变和展望

中华外科杂志 2020年第9期58卷 677-682页

作者：吴继敏陈冬火箭军特色医学中心胃食管外科北京100088

胃食管反流病的外科手术治疗在国外已开展近70年,在我国尚处于起步阶段。Allison于1951年最早尝试使用外科手段控制反流,但单纯性的食管裂孔修补疗效欠佳。Nissen于1955年开创胃底折叠术,经Rossetti改良减少了游离范围和手术损伤,提升... 详细信息

胃食管反流病的外科手术治疗在国外已开展近70年,在我国尚处于起步阶段。Allison于1951年最早尝试使用外科手段控制反流,但单纯性的食管裂孔修补疗效欠佳。Nissen于1955年开创胃底折叠术,经Rossetti改良减少了游离范围和手术损伤,提升了抗反流疗效,但术后吞咽困难和气体相关并发症高发。Toupet、Dor等提出部分胃底折叠术,Donahue和DeMeester提出"短松"Nissen手术,在一定程度上保留了手术疗效并降低了术后吞咽困难和气体相关并发症发生率,形成了目前三大主流胃底折叠术式。此外,其他医师也对抗反流术式进行了探索,形成了Belsey MarkⅣ、Hill、Collis等术式,但由于种种原因上述术式未获得广泛开展。与此同时,手术途径也从传统的开胸开腹,发展到腹腔镜及机器人手术系统辅助,降低了并发症发生率,减少了住院时间。尽管抗反流术式众多,但各种术式各有优缺点,长期疗效不稳定及各种并发症至今仍然是其获得广泛开展的主要障碍,人们仍然在不断探索更好更微创的抗反流手术方法。

关键词：胃食管反流胃底折叠术腹腔镜检查

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