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Mercury concentrations in blood and feathers of nestling Bald Eagles in coastal and inland Virginia

Avian Research 2019年第1期10卷 36-42页

作者： David E.Kramar Bill Carstensen Steve Prisley jim campbell Department of Anthropology and Earth Science Minnesota State University Moorhead Department of Geography Virginia Tech National Council for Air and Stream Improvement

Background:Mercury(Hg) and methylmercury are widely considered significant issues for wildlife,and in particular,piscivorous birds due to their widespread availability and neurotoxic *** a substantial number of studies of Hg contamination of Bald Eagles(Haliaeetus leucocephalus) have been conducted throughout the east coast of the United States,little has been done that directly addresses Hg contamination in Bald Eagles in Virginia,particularly the inland ***:We collected blood and feather samples from nestling Bald Eagles in the coastal plain,piedmont,and western regions of Virginia in an effort to determine which areas of the state were more likely to contain populations showing evidence of Hg *** analyzed the samples for total Hg using a Milestone ***:Samples collected from individuals located in the coastal region exhibited low concentrations of Hg compared to those further inland located on freshwater rivers and *** collected from the inland population exhibited levels in some areas that are approaching what may be considered to be sub-lethal to avian health(blood:mean 0.324 mg/kg,SE = 0.13,range = 0.06-0.97 mg/kg;feather:mean = 8.433 mg/kg,SE = 0.3,range = 3.811-21.14 mg/kg).Conclusions:Even after accounting for known point-sources of Hg,the inland eagle population in Virginia is susceptible to concentrations of Hg that are significantly higher than their coastal ***,several locations besides those currently known to be impacted by point-sources are exhibiting concentrations that are approaching a sub-lethal level.

关键词： Bald Eagle Haliaeetus leucocephalus Mercury Methyl-mercury Virginia

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia jiménez-Díaz Juan D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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偏远及农村地区卫生人力留用计划成本分析技术框架

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中国卫生政策研究 2011年第12期4卷 10-17页

作者： Pascal Zurn Marko Vujicic Christophe Lemiere Maud Juquois Laura Stormont jim campbell Martin Rutten Jean-Marc Braichet 马达飞(翻译) 李秋霖(翻译) 李晓燕(翻译) 张光鹏(审校) 世界卫生组织瑞士日内瓦世界银行美国华盛顿世界银行塞内加尔达喀尔 DE Cooperacion社会研究所西班牙巴塞罗那雷瓦赫宁根大学荷兰海牙卫生部人才交流服务中心

背景:通过加强卫生人力留用以提高偏远和农村地区卫生人力的可及性,对于人口健康至关重要。然而,此类干预措施有关成本方面的信息往往零散、不全面、甚至缺失。政策措施的成本分析对于政策的选择、规划、实施和评估至关重要,但是由于缺... 详细信息

背景:通过加强卫生人力留用以提高偏远和农村地区卫生人力的可及性,对于人口健康至关重要。然而,此类干预措施有关成本方面的信息往往零散、不全面、甚至缺失。政策措施的成本分析对于政策的选择、规划、实施和评估至关重要,但是由于缺少成本分析的系统方法,为卫生政策制定和决策带来了严峻的挑战。方法:本文提出了提高偏远及农村地区卫生人力可及性政策干预措施的成本分析实施框架,旨在为卫生政策决策者提供帮助。同时,该框架也强调了确定财政的主要来源和财政资金可持续性的重要性。文章对加强边远农村地区卫生人力留用相关政策措施的成本分析进行了文献综述,为此类干预措施的成本分析提供了指导框架,并进一步调查分析了成本分析在整个卫生人力规划与管理中的角色与重要意义。结果:尽管对于人力留用相关政策措施效益的争论得到越来越多的关注,但如何对此类政策措施进行成本分析,目前仍缺乏相关的知识与证据。为了解决这个问题,文章提出了实施成本分析框架的关键要素,并对此进行讨论分析。结论:这些关键要素能够帮助决策者对政策措施有更加深入的了解,明晰与理解财政来源和运行机制,同时确保财政资金的可持续性。

关键词：卫生人力资源偏远及农村地区留用成本分析技术框架

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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SYSTEMIC PATHOLOGIES OF CONFRONTATION:DIAGNOSING SECURITY DISRUPTION

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Journal of Systems Science and Systems Engineering 2009年第4期18卷 423-436页

作者： jim BRYANT Sheffield Business School Sheffield Hallam University

The world post-9/11 is characterised by uncertainty, fear and suspicion. Psychological confrontations amplified by the mass media have even come to dominate physical engagements between warring parties. Drama theory provides a powerful framework for understanding these interactions in much the way that game theory was able to support strategy making by autonomous players in a less inter-connected era, A model of the ＇normal＇ process leading to dramatic resolution is an essential feature of the drama theory approach and is described here. However this process can be derailed or fail in many ways. This paper reviews many of these systemic pathologies and illustrates some Of them through consideration of three high-profile cases. The conclusion is that it is important to recognise and possibly to use pathological behavior as an element of a character＇s interaction strategy.

关键词： Drama theory confrontation conflict resolution systemic pathology

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Critical role of risk management in ground engineering and opportunities for improvement

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International Journal of Mining Science and Technology 2017年第5期27卷 725-731页

作者： jim Galvin Mining Engineering University of New South WalesSydney 2283Australia

Green mining is concerned with mining in a sustainable manner, such that the needs of the present are met without compromising future generations. The achievement of this objective depends on balancing social, environmental and economic objectives and has to have regard to both active mining operations and legacy issues associated with mine closure. Ground engineering has a critical role in achieving green mining objectives but its contribution is characterised by pervasive uncertainty. Uncertainty equates to risk. This means that ground engineering should be practiced within a risk management framework that aims to both prevent unwanted outcomes and to mitigate their consequences to an acceptable level. This keynote address presents the fundamentals of risk management and demonstrates its effectiveness by reference to improvements in the safety performance of the NSW coal sector over the past three ***, ground control remains a mix of art and science, relying heavily on judgements which should be premised on knowledge, skill and experience(that is, competence). Risk management has now been enshrined in mining legislation and operating practice in Australia for over two *** this, near-hit and accident and incident investigations, commissions of inquiry and legal proceedings almost invariably identify deficiencies and opportunities for improvements necessary to achieve the objectives of sustainable mining. Three of the more important opportunities which have global application in relation to ground engineering are discussed. These relate to the vexing issue of defining competency in ground engineering; the criteria for undertaking rigorous risk assessment; and the need for ground engineers to become involved in mine rehabilitation and closure planning over the full life cycle of a mine, commencing at the prefeasibility stage.

关键词： Bow tie analysis Mine safety Mine closure Risk assessment Risk management Sustainable mining Uncertainty

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Interfacial tension studies between Fe-Cu-Ni sulfide and halo-norilsk basalt slag system

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Science China Earth Sciences 2005年第6期48卷 834-839页

作者： jim Mungall Department of Geology University of Toronto 22 Russell St Toronto Ontario M5S 3B1 Canada

The interfacial tension of the matte/halo-Norilsk basalt slag systems of FeS-Cu2S-Ni3S2 and FeO-FeS were investigated using the sessile drop technique. The results indicate that interfacial tension decreases with increasing copper and nickel contents in the matte of FeS-Cu2S-Ni3S2 system while it increases with increasing oxygen content in the matte of FeO-FeS system. It is inferred from these results that two conditions are critical for the formation of giant Cu-Ni sulfide deposits. One is that ma-fic-ultramafic parent magma of sulfide deposits should be rich in copper and nickel where due to the low interfacial tension, it is difficult to form sulfide droplet in the early stage of magma evolution. In other words, sulfide liquid conglomeration occurs more difficultly. The other condition is that the magma emplacement should be shallow; and a lot of faults occur in the magma emplacement field. Since oxygen content is high in the environment, interfacial tension is high, which helps sulfide liquid conglomeration and consequently Cu-Ni sulfide deposits form.

关键词： matte, slag, interfacial tension, Cu-Ni sulfide deposit.

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Turbulence modelling of the aerodynamic interaction ofOGV wakes and diffuser flow

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航空动力学报 2011年第10期26卷 2302-2312页

作者： Page Gary McGuirk jim Department of Aeronautical and Automotive Engineering Loughborough University

Different turbulence closures were used to predict the flow interaction between the wakes created by compressor outlet guide vanes(OGVs) and a downstream annular *** statistical turbulence models were tested based on the classical Reynolds-averaged Navier-Stokes(RANS) *** high-Re and low-Re(Launder-Sharma) versions of the k-ε model were applied to a selected test problem for OGV wake/diffuser *** test problem was specifically chosen because experimentally determined inlet conditions and both profile and performance data were available to validate predictions.A preliminary study was also reported of the more advanced large eddy simulation(LES) *** LES sub-grid-scale(SGS) model was the basic Smagorinsky eddy viscosity assumption,with a Van-Driest damping function for improved capture of near-wall viscous *** between the two RANS models showed little difference in terms of velocity contours at OGV trailing edge and diffuser *** terms of overall diffuser performance(static pressure recovery and total pressure loss coefficients),the high-Re model was shown to agree well with experimental *** preliminary LES study indicates the highly unsteady character of the OGV wake flow,but requires improved treatment of inlet conditions.

关键词： outlet guide vane(OGV) wakes diffuser flow interaction Reynolds-averaged Navier-Stokes(RANS) modelling large eddy simulation(LES) modelling

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The influence factors of NMR logging porosity in complex fluid reservoir

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Science China Earth Sciences 2008年第S2期51卷 212-217页

作者： DUNN Keh jim State Key Laboratory of Petroleum Resource and prospecting (at China University of Petroleum)

Porosity is a basic parameter for evaluating reservoir,and NMR logging is an effective method to obtain the porosity. However,we have often found that there exist significant differences between NMR po-rosities and formation core porosities in the complex reservoir. In this paper,we list the factors which affect the NMR porosity response in the complex reservoir,such as longitudinal relaxation time (T1),transverse relaxation time (T2),hydrogen index (HI) and borehole environment. We show how these factors affect the NMR porosity response and suggest methods to correct them. This should improve the accuracy of NMR logging porosity in complex reservoirs for the terrestrial formation.

关键词： NMR logging complex fluid reservoir porosity influencing factors

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A novel application of fluidization-Integrating three processes in reclaiming foundry sand

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Particuology 2010年第6期8卷 595-598页

作者： Derek Geldart jim Lewis Powder Research Ltd Leeds University UK Coastal River Technologies PLLC USA

Immersion of automotive parts in a fluidized bed of foundry sand is used to both strip the castings free from moulding sand and to heat-treat the castings at 500℃. The fluid bed is heated by hot gases from a burner directed first into a serpentine heat exchanger located near one side-wall of the rectangular tank, and then into a distributor consisting of horizontal sparger pipes having maintenance standpipes fixed into their upper surfaces.

关键词： Removal of moulding sand Castings Fluidized beds Heat transfer Foundries

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