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Potential therapeutic effect of epigenetic therapy on Ireatment-induced neuroendocrine prostate cancer

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Asian Journal of Andrology 2017年第6期19卷 686-693页

作者： Xiang Xu Yu-Hua Huang Yan-Jing Li Alexa Cohen Zhen Li jill Squires Wei Zhang Xu-Feng Chen Min Zhang Jiao-Ti Huang School of Life Sciences Anhui University Hefei China Department of Pathology and Laboratory Medicine University of California at Los Angeles Los Angeles California USA Department of Urology The First Affiliated Hospital of SooChow University Suzhou China Department of Medical Oncology Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA Department of Pathology Beijing Hospital Beijing China

Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatment-induced neuroendocrine prostate cancer have not been characterized owing to limited biopsies/resections and the lack of a cellular model. In this study, we used a unique cellular model （LNCaP/NE1.8） to investigate the potential role of cancer stem cells in treatment-induced neuroendocrine prostate cancer with acquired resistance to hormonal therapy and chemotherapy. We also studied the role of cancer stem cells in enhancing invasion in treatment-induced neuroendocrine prostate cancer cells that recurred after long-term androgen-ablation treatment. Using an in vitro system mimicking clinical androgen-ablation, our results showed that the neuroendocrine-like subclone NE1.8 cells were enriched with cancer stem cells. Compared to parental prostate adenocarcinoma LNCaP cells, NE1.8 cells are more resistant to androgen deprivation therapy and chemotherapeutic agents and show increased cancer cell invasiveness. Results from this study also suggest a potential epigenetic therapeutic strategy using suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, as a chemotherapeutic agent for therapy-resistant treatment-induced neuroendocrine prostate cancer cells to minimize the risk of prostate cancer recurrence and metastasis.

关键词： cancer stem cell epigenetic therapy hormonal therapy neuroendocrine prostate cancer suberoylanilide hydroxamic acid

Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally- induced dry eye syndrome

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Nano Research 2015年第2期8卷 621-635页

作者： Shengyan Liu Chu Ning Chang Mohit S. Verma Denise Hileeto Alex Muntz Ulrike Stahl jill Woods LyndonW. Jones Frank X. Gu Department of Chemical Engineering University of Waterloo Waterloo N2L 3G1 Canada Waterloo Institute for Nanotechnology University of Waterloo Waterloo N2L3G1 Canada Centre for Contact Lens Research University of Waterloo Waterloo N2L3G1 Canada

Topical formulations, commonly applied for treatment of anterior eye diseases, require frequent administration due to rapid clearance from the ocular surface, typically through the lacrimal drainage system or through over-spillage onto the lids. We report on a mucoadhesive nanoparticle drug delivery system that may be used to prolong the precorneal residence time of encapsulated drugs. The nanoparticles were formed from self-assembly of block copolymers composed of poly（D, L-lactide） and Dextran. The enhanced mucoadhesion properties were achieved by surface functionalizing the nanoparticles with phenylboronic acid. The nanoparticles encapsulated up to 12 wt.% of Cyclosporine A （CycA） and sustained the release for up to five days at a clinically relevant dose, which led us to explore the therapeutic efficacy of the formulation with reduced administration frequency. By administering CycA-loaded nanoparticles to dry eye-induced mice once a week, inflammatory infiltrates were eliminated and the ocular surface completely recovered. The same once a week dosage of the nanoparticles also showed no signs of physical irritation or inflammatory responses in acute （1 week） and chronic （12 weeks） studies in healthy rabbit eyes. These findings indicate that the nanoparticles may significantly reduce the frequency of administration for effective treatment of anterior eye diseases without causing ocular irritation.

关键词： biocompatibility copolymer mucoadhesion nanoparticle drug delivery ophthalmology

Current status of intestinal and multivisceral transplantation

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Gastroenterology Report 2017年第1期5卷 20-28,I0001页

作者： Shishira Bharadwaj Parul Tandon Tushar D.Gohel jill Brown Ezra Steiger Donald F.Kirby Ajai Khanna Kareem Abu-Elmagd Center for Gut Rehabilitation and Transplantation the Cleveland Clinic FoundationClevelandOHUSA

Clinical-nutritional autonomy is the ultimate goal of patients with intestinal failure(IF).Traditionally,patients with IF have been relegated to lifelong parenteral nutrition(PN)once surgical and medical rehabilitation attempts at intestinal adaptation have *** the past two decades,however,outcome improvements in intestinal transplantation have added another dimension to the therapeutic armamentarium in the field of gut *** has become possible through relentless efforts in the standardization of surgical techniques,advancements in immunosuppressive therapies and induction protocols and improvement in postoperative patient *** types of intestinal transplants include isolated small bowel transplant,liver-small bowel transplant,multivisceral transplant and modified multivisceral *** guidelines restrict intestinal transplantation to patients who have had significant complications from PN including liver failure and repeated *** an experimental stage to the currently established therapeutic modality for patients with advanced IF,outcome improvements have also been possible due to the introduction of tacrolimus in the early *** have shown that intestinal transplant is cost-effective within 1–3 years of graft survival compared with *** survival and quality of life as well as resumption of an oral diet should enable intestinal transplantation to be an important option for patients with IF in addition to continued *** research should focus on detecting biomarkers of early rejection,enhanced immunosuppression protocols,improved postoperative care and early referral to transplant centers.

关键词： intestinal transplant multivisceral transplant parenteral nutrition intestinal failure gut rehabilitation

Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation

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Asian Journal of Andrology 2014年第4期16卷 541-544页

作者： Julia Lipianskaya Alexa Cohen Clark J Chen Elaine Hsia jill Squires Zhen Li Yaqun Zhang Wei Li Xufeng Chen Hua Xu Jiaoti Huang Departments of Pathology and Urology Jonsson Comprehensive Cancer Center and Broad Center of Regenerative Medicine and Stem Cell Research David Geffen School of Medicine at UCLA Los Angeles CA USA.

Most prostate cancers （PCas） are classified as acinar type （conventional） adenocarcinoma which are composed of tumor cells with luminal differentiation including the expression of androgen receptor （AR） and prostate-specific antigen （PSA）. There are also scattered neuroendocrine （NE） cells in every case of adenocarcinoma. The NE cells are quiesecent, do not express AR or PSA, and their function remains unclear. We have demonstrated that IL8-CXCR2-P53 pathway provides a growth-inhibitory signal and keeps the NE cells in benign prostate and adenocarcinoma quiescent. Interestingly, some patients with a history of adenocarcinoma recur with small cell neuroendocrine carcinoma （SCNC） after hormonal therapy, and such tumors are composed of pure NE cells that are highly proliferative and aggressive, due to P53 mutation and inactivation of the IL8-CXCR2-P53 pathway. The incidence of SCNC will likely increase due to the widespread use of novel drugs that further inhibit AR function or intratumoral androgen synthesis. A phase II trial has demonstrated that platinum-based chemotherapy may be useful for such therapy-induced tumors.

关键词： neuroendocrine prostate cancer small cell carcinoma therapy

Improved Interpretive Accuracy of Sugar Content on Beverage Labels Following an Educational Intervention for Children

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Journal of Health Science 2017年第4期5卷 198-205页

作者： Myrtle McCulloch Priscilla (Ofori) Hammond jill Chanley School of Nursing and Health Studies Georgetown University Washington DC 20057 USA Better Living for Texans Texas A &M AgriLife Extension Service Bryan 77803 USA The Campaign for Tobacco-Free Kids Washington DC 20005 USA

To address childhood obesity, it is important to help children make better choices with regards to intake of sugary drinks and snacks. The purpose of this study was to evaluate the validity of a novel educational intervention designed to convert grams of sugar into teaspoons on labeled beverages. A convenience sample of children （n = 21） at a charter elementary school in Washington, D. C was studied. A pre-test required an estimation of teaspoons of sugar on labels, followed by a practice demonstration and song. A post-test was given requiring estimation of teaspoons of sugar in on the same labels. Two weeks later, a retention test as well as qualitative questions assessed participant learning and information usage. Test scores revealed increased accuracy from pre-test （26.2%） to post-test （79.8%）. Estimations were more accurate after the demonstration, as evidenced by the decreased range in average variation of responses （＋25.6 tsp to ＋1.8 tsp）. Two-week recall maintained accuracy （66.7%）, with an average variance of ＋3.8 teaspoons. Qualitative responses revealed participants had learned and used the conversion concepts. These results suggest that the educational intervention was effective. Qualitative data suggest behavior change, increased awareness, and the potential for change extending to caregivers.

关键词： children obesity sugar-sweetened beverages education

Disaster preparedness, pediatric considerations in primary blast injury, chemical, and biological terrorism

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World Journal of Critical Care Medicine 2014年第1期3卷 15-23页

作者： Mitchell Hamele William Bradley Poss jill Sweney Division of Pediatric Critical Care Department of Pediatrics School of Medicine University of Utah Salt Lake City UT 84108 United States

Both domestic and foreign terror incidents are an unfortunate outgrowth of our modern times from the Oklahoma City bombings, Sarin gas attacks in Japan, the Madrid train bombing, anthrax spores in the mail, to the World Trade Center on September 11 th, 2001. The modalities used to perpetrate these terrorist acts range from conventional weapons to high explosives, chemical weapons, and biological weapons all of which have been used in the recent past. While these weapons platforms can cause significant injury requiring critical care the mechanism of injury, pathophysiology and treatment of these injuries are unfamiliar to many critical care providers. Additionally the pediatric population is particularly vulnerable to these types of attacks. In the event of a mass casualty incident both adult and pediatric critical care practitioners will likely be called upon to care for children and adults alike. We will review the presentation, pathophysiology, and treatment of victims of blast injury, chemical weapons, and biological weapons. The focus will be on those injuries not commonly encountered in critical care practice, primary blast injuries, category A pathogens likely to be used in terrorist incidents, and chemical weapons including nerve agents, vesicants, pulmonary agents, cyanide, and riot control agents with special attention paid to pediatric specific considerations.

关键词： Terrorism Bioterrorism Chemical terrorism Blast injuries Mass casualty incidents Disasters Pediatrics

探索新冠肺炎流行期间在家工作时间长短对工作-家庭冲突和睡眠质量的影响

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探索新冠肺炎流行期间在家工作时间长短对工作-家庭冲突和睡眠质...

作者： jill Ivy Komugisa 浙江工商大学

学位级别：硕士

Many people opinionate that working from home during the Covid-19 pandemic is good for employees' health and sleep quality because they may have flexible work schedules and can take rests anytime as they *** this true? This study is premised on unraveling the effects of working from home during the covid-19 pandemic on work-family conflict and sleep quality and determine the role of family support and *** a quantitative research design and random sampling approach a questionnaire was prepared and administered to the study population who comprised of employees from four companies in *** questionnaire was distributed through online portals(Whats App and Telegram).A total of 151 questionnaires were shared,144 were completed and the same adopted for the study representing a response rate of 95%.The sample size of 144 was processed and analyzed using the Statistical Package for Social Sciences(SPSS version 26).The descriptive,correlation analysis,ordinary least square regression,the SPSS Process Macro,and the hierarchical regression was used to determine the direct,mediating,and moderating *** outcome of the study showed that length of time spent working from home positively and significantly influence work-family *** so,work-family conflict has a negative and significant effect on sleep ***,length of time spent working from home negatively and significantly indirectly influenced sleep quality through work-family ***,the moderating role of family support and gender on the relationship between length of time spent working from home and work-family conflict was not *** outcome of the study implies that the length of time spent working from home can have implications for work-family conflict and sleep quality during the COVID-19 *** mitigate these challenges,it is important for individuals to establish clear boundaries between work and family life,maintain a regular work schedule,pri

关键词： Length of time spent working from home Work-family conflict Sleep quality Covid-19 Working from home

Wildflowers Wildflowers have become a;travel destination

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空中英语教室（高级版．彭蒙惠英语） 2013年第4期 10-11页

作者： by jill Schensul PAGE DESIGN VICKY TSUNG

SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green Stephen A.Shaw Lauren J.Bonilla Shannon E.Ronca Maria Elena Bottazzi Farrah Kheradmand jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of Medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

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