Current status of intestinal and multivisceral transplantation
肠道移植和多脏器联合移植的现状作者机构：Center for Gut Rehabilitation and Transplantationthe Cleveland Clinic FoundationClevelandOHUSA
出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)
年 卷 期：2017年第5卷第1期
页 面：20-28,I0001页
核心收录：
学科分类：1011[医学-护理学（可授医学、理学学位）] 10[医学]
主 题：intestinal transplant multivisceral transplant parenteral nutrition intestinal failure gut rehabilitation
摘 要：Clinical-nutritional autonomy is the ultimate goal of patients with intestinal failure(IF).Traditionally,patients with IF have been relegated to lifelong parenteral nutrition(PN)once surgical and medical rehabilitation attempts at intestinal adaptation have *** the past two decades,however,outcome improvements in intestinal transplantation have added another dimension to the therapeutic armamentarium in the field of gut *** has become possible through relentless efforts in the standardization of surgical techniques,advancements in immunosuppressive therapies and induction protocols and improvement in postoperative patient *** types of intestinal transplants include isolated small bowel transplant,liver-small bowel transplant,multivisceral transplant and modified multivisceral *** guidelines restrict intestinal transplantation to patients who have had significant complications from PN including liver failure and repeated *** an experimental stage to the currently established therapeutic modality for patients with advanced IF,outcome improvements have also been possible due to the introduction of tacrolimus in the early *** have shown that intestinal transplant is cost-effective within 1–3 years of graft survival compared with *** survival and quality of life as well as resumption of an oral diet should enable intestinal transplantation to be an important option for patients with IF in addition to continued *** research should focus on detecting biomarkers of early rejection,enhanced immunosuppression protocols,improved postoperative care and early referral to transplant centers.
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