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长江流域建立水资源刚性约束制度的关键问题与对策研究

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中国水利 2024年第9期 34-38页

作者：许继军吴江长江水利委员会长江科学院武汉430010 流域水资源与生态环境科学湖北省重点实验室武汉430010

南方丰水地区建立水资源刚性约束制度,是为了更好地促进生态环境高水平保护和经济社会高质量发展。基于长江流域水资源开发利用、管理现状及特点,分析了长江流域建立水资源刚性约束制度需重点研究的关键问题,并从水资源和水环境承载能... 详细信息

南方丰水地区建立水资源刚性约束制度,是为了更好地促进生态环境高水平保护和经济社会高质量发展。基于长江流域水资源开发利用、管理现状及特点,分析了长江流域建立水资源刚性约束制度需重点研究的关键问题,并从水资源和水环境承载能力、用水定额标准、计量监测、水资源规划论证、监管考核和市场机制等方面,提出长江流域建立水资源刚性约束制度的对策建议。

关键词：水资源刚性约束水资源环境承载能力长江流域丰水地区

Euphoric effect induced by zolpidem:a case study of magnetoencephalography

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General Psychiatry 2022年第1期35卷 61-66页

作者： Xuechan Lyu Yegang Hu Yan Zhao Haihong Wang jiang Du jijun Wang Haifeng jiang Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina

Initially,zolpidem,a non-benzodiazepine hypnotic agent,was considered to have fewer adverse reactions than traditional benzodiazepines.However,after zolpidem was approved for medical use,an increasing number of case reports have described abuse or dependence complications.We were especially interested in the cases of dependence that presented a paradoxical‘euphoric’effect of zolpidem.This article reports the case of a female zolpidem-dependent patient who presented with 6 years of daily use of 400-1400 mg of zolpidem.She reported subjective effects of euphoria,intense craving and the inability to stop drug ingestion.Her diagnoses were zolpidem dependence and a depressive episode induced by substance abuse.To explore the neural mechanisms of the euphoric effect caused by high-dose zolpidem,we performed repeated magnetoencephalography(MEG)recordings.Before undergoing detoxification,her MEG results indicated that cerebellar electrical signal activation increased when taking high zolpidem doses.However,the prefrontal and parietal lobes’electrical signal activity showed a tendency to recover to a normal state as the withdrawal time progressed to completion.This case suggests that the cerebellum plays a role in the euphoria induced by high zolpidem doses and provides clues for further research.

关键词： effect magneto intense

Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization

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National Science Review 2023年第5期10卷 240-250页

作者： Sijie Zhou Yi Wu Yu Zhao Zhen Zhang Limin jiang Lin Liu Yan Zhang jijun Tang Ying-Jin Yuan Frontiers Science Center for Synthetic Biology (Ministry of Education) Tianjin University Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin University Institute for Systems Genetics NYU Langone Health School of Computer Science and Technology College of Intelligence and ComputingTianjin University Epigenetic Group Frasergen Bioinformatics Co.Ltd. Department of Computer Science University of South Carolina

Synthetic genome evolution provides a dynamic approach for systematically and straightforwardly exploring evolutionary processes.Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution(SCRaMbLE) is an evolutionary system intrinsic to the synthetic yeast genome that can rapidly drive structural variations.Here,we detect over 260 000 rearrangement events after the SCRaMbLEing of a yeast strain harboring 5.5 synthetic yeast chromosomes(synⅡ,synⅢ,synⅤ,circular synⅥ,synⅨR and synⅩ).Remarkably,we find that the rearrangement events exhibit a specific landscape of frequency.We further reveal that the landscape is shaped by the combined effects of chromatin accessibili and spatial contact probability.The rearrangements tend to occur in 3D spatially proximal and chromatin-accessible regions.The enormous numbers of rearrangements mediated by SCRaMbLE provide a driving force to potentiate directed genome evolution,and the investigation of the rearrangement landscape offers mechanistic insights into the dynamics of genome evolution.

关键词： synthetic biology genome rearrangement hierarchical chromatin organization synthetic yeast genome SCRaMbLE Saccharomyces cerevisiae

基于MIKE模型的山洪沟风险分析——以北京怀柔区龙泉沟为例

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中国防汛抗旱 2024年第2期34卷 68-73页

作者：姜雪娇张焜和继军胡晓静李秉南卢雪琦北京市水科学技术研究院北京100048 首都师范大学资源环境与旅游学院北京100048 河海大学水文水资源学院南京210098

山洪灾害具有影响范围广、危害严重的特点,已成为防灾减灾中突出的问题。研究以北京怀柔区龙泉沟为例,基于现场调查、地形测绘等确定控制断面和临界水位,通过构建MIKE11HD-NAM耦合模型,获取水位—流量关系、降雨—流量关系,提出将不同... 详细信息

山洪灾害具有影响范围广、危害严重的特点,已成为防灾减灾中突出的问题。研究以北京怀柔区龙泉沟为例,基于现场调查、地形测绘等确定控制断面和临界水位,通过构建MIKE11HD-NAM耦合模型,获取水位—流量关系、降雨—流量关系,提出将不同土壤含水状况下1h、3 h、6 h、12 h及24 h的雨量预警指标作为立即转移指标;采用MIKE FLOOD构建MIKE11-21耦合模型,模拟分析沟道不同土壤含水状况、降雨历时、降雨量级下的淹没风险,结果表明龙泉沟防洪能力不足。研究为确定全市其他山洪流域预警指标提供参考,并为山洪灾害预案编制、预报预警及避险转移提供依据。

关键词：山洪灾害 MIKE模型雨量预警指标淹没风险

Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy

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Neuroscience Bulletin 2017年第3期33卷 339-347页

作者： jiangling jiang jijun Wang Chunbo Li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghai 200030China

In spite of the extensive application of electroconvulsive therapy（ECT）, how it works remains unclear.So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.

关键词： Electroconvulsive therapy Neurotransmitters Neurotrophins Inflammatory factors Epigenetics Neuroimaging

基于绿色化学理念的自由基聚合制备聚丙烯酸实验新探索

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大学化学 2024年第5期39卷 315-324页

作者：赵子健史延新李世成阮文红朱芳江继军中山大学化学学院

自由基聚合制备聚丙烯酸实验是高分子化学实验课程中重要且经典的教学内容，其单体易得、反应条件温和，作为掌握自由基聚合反应和多孔吸附材料制备的代表性实验，多个高等院校均有开设。但现有教材中聚丙烯酸的制备实验存在反应体系易... 详细信息

自由基聚合制备聚丙烯酸实验是高分子化学实验课程中重要且经典的教学内容，其单体易得、反应条件温和，作为掌握自由基聚合反应和多孔吸附材料制备的代表性实验，多个高等院校均有开设。但现有教材中聚丙烯酸的制备实验存在反应体系易凝胶化、产生废液多，流程耗时30.5–33 h，无法在一个教学段内完成，表征过程较繁复等问题。为此，本改进实验采用天然且廉价易得的海藻酸钠作为增稠剂，稳定反应体系粘度，防止因局部粘度剧增引起的反应体系凝胶化；采用同样天然且廉价易得的多孔硅藻土作填充剂，与自由基聚合反应制得的聚丙烯酸溶液共沉淀制备多孔树脂，大幅减少有机溶剂的使用和消耗。此外，本改进实验紧跟学术前沿，引入智能手机识别-比色分析法表征产物的吸附性能，表征手段快速便捷。新的致孔方式和表征手段使实验时长缩减至5 h内，保证了教学的连贯性，同时保留原实验特色，使得该实验更具有教学意义，有利于激发学生对本实验课程的学习兴趣。

关键词：自由基聚合聚丙烯酸绿色化学实验时长智能手机识别-比色分析法

Photoexcitation induced magnetic phase transition and spin dynamics in antiferromagnetic MnPS_(3) monolayer

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npj Computational Materials 2023年第1期9卷 1246-1252页

作者： Yinlu Gao Xue jiang Zhiyong Qiu jijun Zhao State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology116024 DalianChina Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Dalian University of Technology)Ministry of Education116024 DalianChina Key Laboratory of Energy Materials and Devices(Liaoning Province) School of Materials Science and EngineeringDalian University of Technology116024 DalianChina

Antiferromagnetic spin dynamics is the key issue to develop spintronic devices.We adopt ab initio nonadiabatic molecular dynamics with spin–orbit-coupling(SOC)to investigate photoinduced spin dynamics in an antiferromagnetic semiconductor MnPS_(3) monolayer.Optical doping triggers MnPS_(3) from Néel antiferromagnetic to ferromagnetic phase at an experimentally achievable electron–hole pair density of 1.11×10^(14) cm−2.This phase transition can be ascribed to the light-induced mid-gap states of S-p orbitals,which lower the electron excitation energy and strengthen the SOC effect between S-p and Mn-d orbitals.The excited S-p electrons first decay to the mid-gap states due to p–p electron–phonon-coupling and then relax to the spin-down Mn-d orbitals via SOC.Such a dramatic relaxation process prolongs the photogenerated carrier lifetime up to 648 fs,providing an explanation for the unusual optoelectronic performance of MnPS_(3).The reversible switching of magnetic order via optical means gives an important clue for information storage and highly efficient photocatalysts utilizing antiferromagnetic semiconductors.

关键词： dynamics excitation monolayer

Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine

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Journal of Traditional Chinese Medicine 2023年第3期43卷 588-593页

作者： QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen jiang Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology the Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology the Forth Medical Center of PLA General HospitalBeijing 100048China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Department of Endocrinology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China

OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to analyze.RESULTS:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to DN.CONCLUSIONS:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD.

关键词： diabetes mellitus type 2 renal insufficiency chronic diabetic nephropathies non-diabetic renal disease syndrome complex

Study on experiment and mechanism of thermal dissolved sulfuration of low grade lead-zinc oxide ore in lanpin

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Acta Metallurgica Sinica(English Letters) 2009年第4期22卷 291-296页

作者： Minghua jiang Bin YANG jijun WU Yuchun ZHAI Yang ZHOU Faculty of Materials and Metallurgical Engineering Kunming University of Science and Technology Kunming 650093 China Yunnan Jinding Zinc Limited Company Lanpin 671401 China School of Materials and Metallurgy Northeastern University Shenyang 110004 China

The thermal dissolved sulfuration technology is brought forward and performed based on the characteristic of low grade lead-zinc oxide ore in lanpin. Using sulfur as the sulphidizing agent in the experiment, the oxides in the sandstone and ignimbrite are changed into sulfides. The disproportionation reaction of sulfur in a solution is confirmed as 4S＋3H2O=2S^2-＋S2O3^2--＋6H^＋. The dynamics process is studied and the first-order reaction rate equation -1n（1-a）=ktt is obtained. The effects of the reactive products, stirring speed, dosage of sulfuration agent, value of pH and sulphidizing temperature on the sulfuration of oxide ore are investigated. The results indicate that the reactive apparent activation energy is 100.8 kJ/mol and the sulfuration ratio of lead-zinc oxide ore reaches 60% under the conditions of pH 5.9-7.5, the sulfuration temperature of 130 ℃, sulfuration time of 180 min and the stirring speed of 800 r/min.

关键词： Lead-zinc oxides ore Thermal dissolved sulfuration Sulphidizing ratio Disproportionation reaction First-order reaction