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Novel methods by using non-vacuum insulated tubing to extend the lifetime of the tubing

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Frontiers in Energy 2015年第2期9卷 142-147页

作者： Chenglong ZHOU Guojin ZHU Yongxiang XU jifei YU Xiaoliang ZHANG Hongzhi SHENG Institute of Mechanics Chinese Academy of Sciences Beijing 100190China CNOOC Research Center Beijing 100028 China

失败力学的分析，也就是，真空的氢浸透绝缘管料(VIT ) ，显示 VIT 的失败能被减少，但是不能被避免。解决这个问题，由使用非真空材料的一些措施在这被求婚并且分析纸。结果显示那用泡沫眼镜祷告填满管料或高压力氩可以导致好表演。

关键词：真空绝缘管材寿命真空隔热油管力学分析真空材料氢渗透维生素

Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer

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eScience 2022年第5期2卷 509-517页

作者： Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu jifei Sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen Department of Applied Chemistry School of Chemistry and Materials ScienceHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhui230026China

Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications.

关键词： Aqueous Zn anode Anti-corrosion Replacement reaction Dendrite-free Bismuth-based energizer

Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice

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Virologica Sinica 2016年第2期31卷 150-159页

作者： Xinxin Chen jifei Yang Yanhong Ji Edward Okoth Bin Liu Xiaoyang Li Hong Yin Qiyun Zhu State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou 225009 China International Livestock Research Institute Nairobi 00100 Kenya

African swine fever(ASF) is a lethal hemorrhagic disease that affects wild and domestic swine. The etiological agent of ASF is African swine fever virus(ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries. No commercial vaccines are available to prevent ASF. In this study, we generated a recombinant Newcastle disease virus(r NDV) expressing ASFV protein 72(p72) by reverse genetics and evaluated its humoral and cellular immunogenicity in a mouse model. The recombinant virus, r NDV/p72, replicated well in embryonated chicken eggs and was safe to use in chicks and mice. The p72 gene in r NDV/p72 was stably maintained through ten passages. Mice immunized with r NDV/p72 developed high titers of ASFV p72 specific Ig G antibody, and had higher levels of Ig G1 than IgG2 a. Immunization also elicited T-cell proliferation and secretion of IFN-γ and IL-4. Taken together, these results indicate that r NDV expressing ASFV p72 might be a potential vaccine candidate for preventing ASF.

关键词：病毒蛋白非洲猪瘟重组病毒免疫原性小鼠模型安全体内出血性疾病

Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity

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Neural Regeneration Research 2013年第22期8卷 2069-2077页

作者： Xinxin Guo jifei Chen Yuan Lu Luyi Wu Zhijun Weng Ling Yang Yuhu Xin Xianming Lin Yi Liang Jianqiao Fang Third Affiliated Hospital of Zhejiang Chinese Medical University Department of Orthopedics Zhongshan Hospital of Fudan University Shanghai Institute for Traditional Chinese Medicine Cancer Hospital Fudan University

Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,

关键词： neural regeneration traditional Chineseture irritable bowel syndrome visceralported paper neuroregenerationmedicine combination of He-Mu points electroacupunc-hypersensitivity P2X4 receptor acupuncture grants-sup-

重度地中海贫血患者接受基因治疗后出现HIV-1核酸检测结果假阳性1例

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中华检验医学杂志 2024年第4期47卷 451-454页

作者：钟一帆牛姬飞李越刘静王晓辉李浩甘永霞黎桂连郑陈丽李诚龙蔡一凡杨梓杰谭唯陈小珍冯铁建金聪赵锦圳市疾病预防控制中心深圳518055 深圳市福田区疾病预防控制中心深圳518040 深圳市儿童医院血液肿瘤科深圳518034 中国疾病预防控制中心性病艾滋病预防控制中心北京102211 深圳市儿童医院防保科深圳518034

患者女,11岁,因患重度β型地中海贫血于2022年7月27日在深圳市儿童医院接受细胞与基因治疗(CGT)。出院后2次随访检测均发现患者的HIV-1病毒抗原及抗体筛查实验(化学发光法)结果呈阳性,2次HIV-1核酸定量试验病毒载量结果均>5000拷贝/ml,... 详细信息

患者女,11岁,因患重度β型地中海贫血于2022年7月27日在深圳市儿童医院接受细胞与基因治疗(CGT)。出院后2次随访检测均发现患者的HIV-1病毒抗原及抗体筛查实验(化学发光法)结果呈阳性,2次HIV-1核酸定量试验病毒载量结果均>5000拷贝/ml,按照《全国艾滋病检测技术规范(2020年修订版)》可判定为HIV/AIDS感染。但经深入调查与比对实验发现:该患者HIV-1核酸检测结果异常,系其CGT治疗过程中自体造血干祖细胞基因组整合的慢病毒载体片段与现用HIV-1核酸检测试剂盒检测靶位点存在交叉反应所致,提示在对接受过CGT的人群进行HIV-1核酸检测时,需根据其所用基因工程载体选择合适的、不会引起交叉反应的检测平台。同时建议设计开发专门用于HIV核酸补充试验的采用多靶点不同荧光标记的检测平台,以降低艾滋病病毒感染的假阳性诊断风险。

关键词： HIV-1 慢病毒载体基因治疗核酸检测

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胆管内乳头状肿瘤手术切除的临床回顾性分析

中华普通外科学文献（电子版） 2024年第2期18卷 92-98页

作者：梁倚华廖冰陆世旬蔡木炎王霁朏张仲平叶伟佳赖佳明梁力建殷晓煜陈东中山大学附属第一医院肝胆胰外科中心广州510080 中山大学附属第一医院病理科广州510080 中山大学肿瘤防治中心病理科广州510060 中山大学附属第一医院放射科广州510080

目的通过大样本手术切除病例分析,探讨胆管内乳头状肿瘤(IPNB)的临床特征和治疗策略。方法回顾性分析2006年9月至2022年10月,国内2个大型医疗中心收治的94例手术切除IPNB患者资料。结果(1)IPNB术前仅21.3%(20/94)正确诊断,38.3%(36/94)... 详细信息

目的通过大样本手术切除病例分析,探讨胆管内乳头状肿瘤(IPNB)的临床特征和治疗策略。方法回顾性分析2006年9月至2022年10月,国内2个大型医疗中心收治的94例手术切除IPNB患者资料。结果(1)IPNB术前仅21.3%(20/94)正确诊断,38.3%(36/94)术前诊断为胆管癌,MRI(MRCP)术前诊断正确性相对较高(24.1%,13/54)。典型影像学表现为胆管扩张合并胆管内肿物,新发现胆总管末端鸟嘴样狭窄也是一个重要特征。(2)38例(40.4%)肿瘤位于左半肝,为最常见发病部位;IPNB伴低级别、高级别上皮内瘤变各15例(16.0%)、33例(35.1%),为良性肿瘤;浸润性癌46例(48.9%),为恶性肿瘤;肿瘤部位、多发肿瘤、分泌黏液与IPNB良恶性无关。(3)患者均手术切除,其中肝切除72例,肝外胆管切除合并胆肠吻合9例,Whipple 13例,R0切除率为95.7%;61例行淋巴结清扫,淋巴结阳性率3.3%(2/61)。(4)术后1、3、5、10年生存率分别为91.1%、82.0%、73.5%、44.0%;单因素分析显示体质量是否下降、CA125是否升高、肿瘤良恶性与患者远期预后有关(P<0.05);多因素分析显示恶性肿瘤是远期预后的独立危险因素(OR=2.479,95%CI:1.127~5.453,P=0.024)。与良性IPNB相比,恶性IPNB的中位生存时间更短(14.3年vs 8.4年,P<0.05)。结论IPNB术前难以正确诊断,近半数为浸润性癌,淋巴结阳性率低;术前需明确胆管内肿物位置及病变范围,必要时术中胆道镜检查;注意留取胆管切缘术中冰冻活检,以达到根治性切除;术后可选择性辅助治疗;IPNB远期预后良好,恶性肿瘤是其独立危险因素。

关键词：胆管肿瘤胆管内乳头状肿瘤诊断淋巴结转移手术原则预后

Development of Cementitious Materials Utilizing Alkali-activated Yellow River Silt

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Journal of Wuhan University of Technology(Materials Science) 2021年第3期36卷 364-373页

作者：王宝民 WANG Wanli 梁晓霞刘慧 HAN Junnan ZHAO Lu YANG Xingxing YAN jifei School of Civil Engineering Dalian University of TechnologyDalian 116024China Yellow River Institute of Hydraulic Research Zhengzhou 450003China

The possibility of preparing cementitious materials by the alkali-activated method using Yellow River sediment(The second largest river in China)as raw material and the modification effect on different slag addition were investigated.Sodium silicate and calcium hydroxide were used as the activator,and the specimens were prepared by the press molding method.The hydration process,hydration products,pore characteristics,and mechanical properties were investigated using SEM/EDS,FTIR,TG/DTG,XRD,MIP,and uniaxial compressive strength experiments,respectively.The results showed that the compressive strength of the modified yellow river silt-based cementitious material was significantly increased when the water glass dosage was 12 wt%(Ms=1.8)and the slag dosage was 40%,and its 90-day maximum compressive strength could reach 53 MPa.

关键词： yellow river silt alkali-activation blast-furnace slag compression molding

小视野弥散加权成像对直肠癌的诊断价值研究进展

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现代肿瘤医学 2022年第14期30卷 2629-2632页

作者：邓吉飞付旷哈尔滨医科大学附属第二医院核磁共振科黑龙江哈尔滨150086

直肠癌是一种死亡率较高的恶性消化道肿瘤。小视野弥散加权成像作为一种新兴的核磁共振(magnetic resonance imaging,MRI)技术,为直肠癌的术前分期及新辅助治疗疗效预测和评估提供了更精细的解剖结构、更高的图像质量和更精准定量评估... 详细信息

直肠癌是一种死亡率较高的恶性消化道肿瘤。小视野弥散加权成像作为一种新兴的核磁共振(magnetic resonance imaging,MRI)技术,为直肠癌的术前分期及新辅助治疗疗效预测和评估提供了更精细的解剖结构、更高的图像质量和更精准定量评估参数。本文就小视野弥散加权成像技术的成像原理及其对直肠癌的诊断价值进行综述。

关键词：磁共振弥散加权成像直肠肿瘤

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基于生成对抗网络的雷达脉内信号去噪与识别

西安电子科技大学学报 2023年第6期50卷 133-147页

作者：杜明洋杜蒙潘继飞毕大平国防科技大学电子对抗学院安徽合肥230037

近年来,深度神经网络在计算机视觉等领域取得了突破性进展,然而在射频信号处理领域,如电子支援侦察系统中的雷达辐射源识别任务,相关技术的发展仍处于起步阶段。在实际军事应用场景中,噪声的存在是影响深度神经网络性能发挥的关键因素... 详细信息

近年来,深度神经网络在计算机视觉等领域取得了突破性进展,然而在射频信号处理领域,如电子支援侦察系统中的雷达辐射源识别任务,相关技术的发展仍处于起步阶段。在实际军事应用场景中,噪声的存在是影响深度神经网络性能发挥的关键因素。例如,在高信噪比环境下训练至收敛的深度模型分类器在处理低信噪比数据时往往性能下降严重。为了解决上述问题,提出了一种生成对抗式的去噪网络,实现了端到端的雷达信号去噪和脉内调制类型识别。该模型由生成器、鉴别器和分类器三部分组成,其中,生成器为编解码器结构,通过对称的上采样和下采样操作提取输入雷达信号中高阶特征向量,从噪声中恢复出干净信号;鉴别器则用来判断生成器输出去噪结果的真伪;在此基础上,将分类器与上述两者级联,使得去噪结果符合分类所需的语义信息。实验结果表明,所提算法在密集噪声环境下具备高质量的信号去噪效果和较高的分类准确度;与已有算法相比,算法在低信噪比环境数据上的迁移能力具有一定的优越性。

关键词：雷达辐射源信号识别卷积神经网络生成对抗网络信号去噪