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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： jieying wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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DESIGN OF MICROPHYSIOMETER BASED ON MULTIPARAMETER CELL-BASED BIOSENSORS FOR QUICK DRUG ANALYSIS

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 36-47页

作者： NING HU DA HA CHENGXIONG wu GONG CHENG HUI YU TIANXING WANG jieying wu HUA CAI QINGJUN LIU PING WANG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China ACEA Bioscience Inc.West Lake Technology and Economy Park Hangzhou 310030 P.R.China

Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of *** paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug *** study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and *** analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the ***,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell ***,the research explores drug analysis method of the multiparameter *** results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.

关键词： Microphysiometer multiparameter cell-based biosensor extracellular acidification cancer cells drug analysis

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Synthesis, crystal structures and electrochemical properties of two new metal-centered ferrocene complexes

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Science China Chemistry 2009年第7期52卷 930-936页

作者： WANG XuChun wu jieying ZHOU HongPing TIAN YuPeng LI Lin YANG JiaXiang JIN BaoKang ZHANG ShengYi Department of Chemistry Anhui Province Key Laboratory of Function Inorganic Material ChemistryAnhui UniversityHefei 230039China Department of Chemistry Anhui Science and Technology UniversityFengyang 233100China State Key Laboratory of Crystal Materials Institute of Crystal Materials of Shandong UniversityJinan 250100China

Two new metal-centered ferrocene complexes Ni(SCN)2(L)4 (1) and Cu(OAc)2(L)2 (2) (L = 1-[1-ferrocenylmethyl]imidazole) have been synthesized and characterized by elemental analysis, single crystal X-ray diffraction analysis, spectroscopic and cyclic voltammetric measurements. The geometry of Ni(II) in 1 is octahedral, with four ligands in the equatorial plan and two thiocyanate anions at the axial site, while that of Cu(II) in 2 is a distorted octahedron formed by two chealted OAc? and two ligands. Single crystal X-ray diffraction studies reveal that there is partial electron delocalization from ferrocene to imidazole in the two complexes. Electrochemical measurements exhibit that complexes 1 and 2 undergo similar reversible one electron redox processes, suggesting that the ferrocene moieties are equivalent and there are no interactions among them.

关键词： ferrocene imidazole complex crystal structure electrochemistry

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Synthesis of two carbazole-based dyes and application of two-photon initiating polymerization

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Science China Chemistry 2009年第8期52卷 1210-1215页

作者： HU RenTao LüLiangFei RUAN BanFeng WANG Peng ZHANG MingLiang ZHOU HongPing LI ShengLi wu jieying TIAN YuPeng Department of Chemistry and Chemical Engineering Key Laboratory of Functional Inorganic Materials Chemistry of Anhui ProvinceAnhui UniversityHefei 230039China

Two carbazole-based polymerization initiators possessing blue fluorescence emission have been synthesized via Wittig reaction in the solid phase at room ***-photon excited fluorescence(TPEF) spectra for them were investigated under 800 nm fs laser pulse and two-photon absorption cross sections were determined by the Z-scan *** two-photon initiating polymerization(TPIP) microfabrication experiments were successfully carried ***-dimensional lattice and artificial defects were gained,indicating that they were viable candidates for the two-photon polymerization initiator in practical application of microfabrication.

关键词： carbazole-based dye two-photon excited fluorescence(TPEF) two-photon initiating polymerization(TPIP) microfabrication

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A novel hydrogen peroxide biosensor based on the BPT/AuNPs/graphene/HRP composite

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Science China Chemistry 2011年第10期54卷 1645-1650页

作者： WANG Teng ZHU Yi LI Gai ZHANG ShengYi SONG JiMing MAO ChangJie wu jieying JIN BaoKang TIAN YuPeng Key Laboratory of Inorganic Materials Chemistry of Anhui Province Department of Chemistry Anhui University Hefei 230039 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

A novel hydrogen peroxide biosensor based on the BPT/AuNPs/graphene/HRP composite was developed. Firstly, graphene was prepared under the protection of polyvinylpyrrolidone (PVP), and then the AuNPs/graphene composite was synthesized via in situ decoration. Using biphenyldimethanethiol (BPT) as a connector, the AuNPs/graphene composite was immobilized on the surface of the Au electrode, and whereafter the horseradish peroxidase (HRP) was decorated on the surface of the composite by adsorption. The morphology and structure of the products were characterized by XRD, SEM, TEM and UV-visible spectroscopy. The electrocatalytic performance of the resulting BPT/AuNPs/grapheme/HRP composite (namely, biosensor) was studied by electrochemical instrument. The results show that the biosensor has high sensitivity and fast response to H2O2. In the solution of pH 7.4 with potential -0.2V, the linear response of the biosensor to H2O2 ranges from 5.0×10-6 to 2.5×10-3M with the detection limit of 1.5×10-6M.

关键词： AuNPs/grapheme biosensor horseradish peroxidase hydrogen peroxide

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A new series of two-photon polymerization initiators:Synthesis and nonlinear optical properties

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Science China Chemistry 2009年第12期52卷 2180-2185页

作者： GAN XiaoPing ZHOU HongPing SHI PengFei WANG Peng wu jieying TIAN YuPeng YANG JiaXiang XU GuiBao ZHOU YuFang JIANG MinHua Department of Chemistry Anhui University and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui ProvinceHefei 230039China Department of Applied Chemistry School of ScienceAnhui Agriculture UniversityHefei 230036China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210093China

Four photopolymerization initiators with D-π-D (D,donor; π,conjugation system) structure have been synthesized by solvent-free reaction and characterized by 1H NMR spectroscopy,IR and elemental analysis. The one-photon and two-photon excited fluorescence have been investigated in different solvents. Experimental results of the one-photon and two-photon absorption cross sections show different trends in OPA and TPA ability with different substitution groups in donor units.

关键词： two-photon absorption micro-fabrication polymerization solvent-free

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Two novel terpyridine-based chromophores with donor-acceptor structural model containing modified triphenylamine moiety: Synthesis, crystal structures and two-photon absorption properties

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Science China Chemistry 2013年第9期56卷 1315-1324页

作者： LIU Jie ZHANG Qiong DING HongJuan ZHANG Jun TAN JingYun WANG ChuanKui wu jieying LI ShengLi ZHOU HongPing YANG JiaXiang TIAN YuPeng Department of Chemistry Key Laboratory of Functional Inorganic Material Chemistry of Anhui ProvinceAnhui University Department of Physics Shandong Normal University State Key Laboratory of Coordination Chemistry Nanjing University

Two novel terpyridine-based chromophores with D-A (D = donor, A = acceptor) structural model containing modified triphenylamine moiety (L1 and L2 ) have been conveniently synthesized via formylation and reduction in satisfactory yields, and fully characterized. The single crystals of them were obtained and determined by X-ray diffraction analysis. The relationships between structure and photophysical properties of the two chromophores were investigated both experimentally and theoretically. The measured maximum TPA cross-sections per molecular weight (δmax /MW) of the chromophores are 0.63 GM/(g mol) (L1) and 0.72 GM/(g mol) (L2), respectively, in DMF as a high polar solvent. The results indicate that the value of δmax/MW could be well tuned by the intramolecular charge transfer (ICT), which could be realized by introducing additional elecron-donor/acceptor groups.

关键词： terpyridine derivatives photophysical properties structure-property relationships TD-DFT calculation two-photon-excited fluorescence

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Crystal structures,two-photon absorption and theoretical calculation of a series of bis-vinylpyridine compounds synthesized by one-step solid state reaction

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Science China Chemistry 2011年第5期54卷 730-736页

作者： LI DongMei ZHANG Qiong A.M.Showkot HOSSAIN SUN Mei wu jieying YANG JiaXiang ZHOU HongPing TAO LiMin WANG ChuanKui TIAN YuPeng Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province Department of Chemistry Anhui UniversityHefei 230039China Department of Physics Shandong Normal UniversityJinan 250014China State Key Laboratory of Crystal Materials Shandong University Jinan 250100China State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093China

Three bis-vinylpyridine compounds (4,4′-bis(2-vinylpyridine)biphenyl L1,4,4′-bis(3-vinylpyridine) biphenyl L2,and 4,4′-bis (4-vinylpyridine)biphenyl L3) were synthesized by one-step solid-state reactions at room temperature,giving nearly quantitative yields. The compounds obtained were fully characterized by IR,MS and NMR spectroscopies. The structures of L2 and L3 were determined by single crystal X-ray diffraction analysis. No noticeable solvatochromism was observed in either one-photon absorption or one-photon excited fluorescence spectra. All of the compounds have high fluorescence quantum yields and long fluorescence lifetime. The linear and nonlinear optical properties of the compounds were investigated both experimentally and theoretically. Interestingly,the position of the nitrogen atom from pyridine influences their two-photon absorption across-sections.

关键词： two-photon absorption one-step solid-state reaction high quantum yield pyridine derivatives

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Cation-induced assembly of Zn(Ⅱ),Cd(Ⅱ) and Hg(Ⅱ) coordination complexes and DFT calculations to evaluate weak interactions between the helical chains

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Science China Chemistry 2011年第1期54卷 173-179页

作者： GENG WenQian LI XianLei YIN JianHui KE WeiZai HAO FuYin XU GuoYi ZHOU HongPing wu jieying TIAN YuPeng Department of Chemistry Anhui University Hefei 230039 China State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China

Two new coordination polymers [ZnLI2]∞ （1） and [CdLI2]∞ （2）（L： 3,6-di-（1,2,4-triazole-l-yl）-N-hexylcarbazole） were syn- thesized and their crystal structures were determined by single-crystal X-ray diffraction techniques. Complexes are both constructed with the helical chains along the 2l screw axis. The coordination bond, C-H...I weak interactions and π-π interactions play significant roles in constructing their 3D or 2D frameworks. Two different DFT calculations are performed for the weak interactions between the helical chains of the three different coordination polymers （[ZnLI2]∞[CdLI2]∞, and the reported [HgLI2]∞）. The results reveal that weak interactions play important roles in these supramolecular systems of helical configuration, namely, the trend is the shorter H…I distance and π-π stacking distance, the stronger the intermolecular interactions. The photoluminescence of the complexes measured in the solid state at room temperature indicates that the emission intensity varies extensively, which can be rationalized by the heavy atom effect. helical configuration, weak interactions, DFT calculations, photoluminescence

关键词： helical configuration weak interactions DFT calculations photoluminescence

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Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives

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Science China Chemistry 2013年第1期56卷 106-116页

作者： KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong wu jieying XUE ZhaoMing TIAN YuPeng Department of Chemistry Key Laboratory of Functional Inorganic Materials of Anhui ProvinceAnhui University State Key Laboratory of Crystal Materials Shandong University State Key Laboratory of Coordination Chemistry Nanjing University

In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical *** influence of solvent polarity on the photophysical properties was *** time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed.

关键词： triphenylamine derivatives optical properties structure-property relationship TD-DFT calculation

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