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On-chip ultra-high rejection and narrow bandwidth filter based on coherency-broken cascaded cladding-modulated gratings

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Photonics Research 2024年第5期12卷 979-985页

作者： JINZHAO WANG TING li YANG FENG jiewen li WANXIN li LUWEI DING YONG YAO JIANAN DUAN WEI liU FENG HE YI ZOU XIAOCHUAN XU Guangdong Provincial Key Laboratory of Integrated Photonic-Electronic Chip Guangdong Provincial Key Laboratory of Aerospace Communication and Networking TechnologyHarbin Institute of TechnologyShenzhenShenzhen 518055China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China

Bragg filters are of essential importance for chip-scale photonic ***,the implementation of filters with sub-nanometer bandwidth and rejection beyond 70 dB is hindered by the high index contrast of the siliconon-insulator platform,which makes filters prone to fabrication *** this paper,we propose to combine coherency-broken cascading architecture and cladding modulation to circumvent the intrinsic *** cascading architecture effectively prevents the accumulation of phase errors,while the cladding modulation offers additional design freedom to reduce the coupling coefficient.A bimodal Bragg filter with a testingequipment-limited rejection level of 74 dB and a 40 dB bandwidth of 0.44 nm is experimentally *** minimum feature size is 90 nm,which significantly relieves the fabrication constraints.

关键词： filter cladding narrow

HOG-VGG: VGG Network with HOG Feature Fusion for High-Precision PolSAR Terrain Classification

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Journal of Harbin Institute of Technology(New series) 2024年

作者： jiewen li Zhicheng Zhao Yanlan Wu Jiaqiu Ai Jun Shi School of Software， Hefei University of Technology School of Computer Science and Information Engineering， Hefei University of Technology School of Artificial Intelligence， Anhui University Information Materials and Intelligent Sensing Laboratory of Anhui Province， Anhui University Intelligent Interconnected Systems Laboratory of Anhui Province (Hefei University of Technology)

This article proposes a VGG network with histogram of oriented gradient (HOG) feature fusion (HOG-VGG) for polarization synthetic aperture radar (PolSAR) image terrain classification. VGG-Net has a strong ability of deep feature extraction， which can fully extract the global deep features of different terrains in PolSAR images， so it is widely used in PolSAR terrain classification. However， VGG-Net ignores the local edge & shape features， resulting in incomplete feature representation of the PolSAR terrains， as a consequence， the terrain classification accuracy is not promising. In fact， edge and shape features play an important role in PolSAR terrain classification. To solve this problem， a new VGG network with HOG feature fusion was specifically proposed for high-precision PolSAR terrain classification. HOG-VGG extracts both the global deep semantic features and the local edge & shape features of the PolSAR terrains， so the terrain feature representation completeness is greatly elevated. Moreover， HOG-VGG optimally fuses the global deep features and the local edge & shape features to achieve the best classification results. The superiority of HOG-VGG is verified on the Flevoland， San Francisco and Oberpfaffenhofen datasets. Experiments show that the proposed HOG-VGG achieves much better PolSAR terrain classification performance， with overall accuracies of 97.54%， 94.63%， and 96.07%， respectively.

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城市空间同质化问题的思辨与超越——以上海武康路项目为例

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城市规划 2024年第1期48卷 79-89页

作者：李杰文王红扬南京大学建筑与城市规划学院

城镇化下半场和中国式现代化目标对城市空间高质量及特色化发展提出了更紧迫、更高的要求。但我国经过城市设计、旧城更新、多元主体协同创新等方面的长期研究和实践,对城市空间同质化问题的解决仍不尽人意。本文研究了上海武康路“同... 详细信息

城镇化下半场和中国式现代化目标对城市空间高质量及特色化发展提出了更紧迫、更高的要求。但我国经过城市设计、旧城更新、多元主体协同创新等方面的长期研究和实践,对城市空间同质化问题的解决仍不尽人意。本文研究了上海武康路“同质化—特色化—再同质化”的历程,提出将同质化和特色化分别作为空间发展要突破的问题和要追求的目标是走入了本末倒置的误区。应回归城市空间发展的根本目标——满足人民对美好生活的需求。这一目标要求合理的同质化,排斥不合理的异质化,追求增益人类福祉的过程性的和永久性的特色。规划师尤其要围绕这一目标突破思维的贫乏和范式化。

关键词：城市空间同质化再同质化武康路贫乏

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一种基于时空棱柱的乘车行程可拼性判断模型

武汉大学学报（信息科学版） 2024年第9期49卷 1702-1711页

作者：李杰文康朝贵武汉大学遥感信息工程学院湖北武汉430079 中国地质大学(武汉)国家地理信息系统工程技术研究中心湖北武汉430078

拼车是城市共享出行的重要组成部分,量化分析行程间的可拼性程度对推广拼车服务和提高乘客的出行效率具有重要意义。现有研究大多依据车辆在多个上、下车点间是否满足特定时空约束条件下的先后到达顺序来判断可否拼车,缺少有效建模行程... 详细信息

拼车是城市共享出行的重要组成部分,量化分析行程间的可拼性程度对推广拼车服务和提高乘客的出行效率具有重要意义。现有研究大多依据车辆在多个上、下车点间是否满足特定时空约束条件下的先后到达顺序来判断可否拼车,缺少有效建模行程可拼性强度的手段,在应对大规模拼车请求时无法快速全面地发现所有潜在可拼机会。提出了一种基于时空棱柱的乘车行程可拼性判断模型,首先基于时间地理学中的时空棱柱建模方法和乘客共乘意愿的时空表达,构建行程的潜在时空可达范围表达模型;然后,基于行程时空棱柱间的拓扑关系判断行程的可拼性,量化行程的可拼性强度;最后,提出两种拼车匹配策略,模拟真实出行环境下的拼车匹配结果。实验结果表明,所提模型能够准确和有效地发现潜在可拼行程。对美国纽约市曼哈顿岛内行程可拼性能力的可视化分析结果呈现出明显的时空分布规律,能为车辆资源调度和乘客拼车出行规划提供一定的决策支持。

关键词：共享出行时空棱柱道路网络可拼性判断模型拼车匹配策略

基于点云的运动数据采集平台在评估足踝多关节运动中的应用研究

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中华创伤骨科杂志 2024年第4期26卷 319-323页

作者：黎杰文茹添泓王旭陈立耿翔马昕陈文明复旦大学工程与应用技术研究院上海200438 复旦大学生物医学工程技术研究所上海200438 复旦大学附属华山医院骨科上海200040 上海交通大学附属第六人民医院上海200233

目的分析自主研发的基于点云的足踝运动数据采集平台采集正常足踝部多关节在运动中的关节角度变化。方法使用基于点云的足踝运动数据采集平台对招募的12位年轻健康受试者分别进行左足和右足步态站立相的数据采集测试,然后根据点云足部... 详细信息

目的分析自主研发的基于点云的足踝运动数据采集平台采集正常足踝部多关节在运动中的关节角度变化。方法使用基于点云的足踝运动数据采集平台对招募的12位年轻健康受试者分别进行左足和右足步态站立相的数据采集测试,然后根据点云足部分析模型将足部进行多节段分割以配对出后足关节、前足关节、趾关节、中足关节,计算各关节的角度变化。结果后足关节在站立相早期呈跖屈、内收和内翻的状态,随后均在末期发生改变。矢状面上,前足关节在站立相末期跖屈运动;而在冠状面上可以观察到前足关节内翻,但是内翻程度逐渐减小。趾关节的最大变化来自矢状面:先出现大程度的背屈运动,然后不断减小,直至末期又增加背屈。而中足关节由于跗骨关节韧带的约束机制导致其在步态站立相早期和中期的关节角度运动范围比较小。结论基于点云的足踝运动数据采集平台能够对步态中足踝部多关节角度变化数据进行采集和分析,后足关节在各视角平面下的旋转角度变化相对复杂,且趾关节在矢状面下的背屈运动幅度较大。

关键词：足关节步态生物力学关节运动角度

刺梨果醋发酵过程中理化特性和风味特征的变化

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食品工业科技 2024年第4期45卷 238-249页

作者：莫梅清曾健李洁雯魏悦佳江梓仪包爱明秦伟军高向阳华南农业大学食品学院广东省功能食品活性物重点实验室广东广州510642 粤黔科技协作发酵食品重点实验室贵州安顺561002 华南农业大学广州都柏林国际生命科学与技术学院广东广州510642 贵州南山婆食品加工有限公司贵州安顺561000

为探究刺梨果醋发酵过程中成分变化,本文以刺梨为原料,采用全液态发酵技术,经酒精发酵和醋酸发酵制备果醋,动态监测发酵过程中的理化特性,并采用固相微萃取-气相色谱-质谱联用技术(Headspace solid-phase microextraction-gaschromatogr... 详细信息

为探究刺梨果醋发酵过程中成分变化,本文以刺梨为原料,采用全液态发酵技术,经酒精发酵和醋酸发酵制备果醋,动态监测发酵过程中的理化特性,并采用固相微萃取-气相色谱-质谱联用技术(Headspace solid-phase microextraction-gaschromatography-mass spectrometry,HS-SPME-GC-MS)和气味活性值(Odoractivityvalue,OAV)分析挥发性风味成分。结果表明,随着发酵时间的进行,可溶性固形物、pH、总糖及还原糖均呈下降趋势,而总酸和V_(C)含量持续增加,由原汁到醋酸发酵结束分别从1.86 g/100 mL和956.82 mg/100 mL增加至6.79 g/100 mL和1275.88 mg/100 mL。有机酸的含量不断变化,草酸、奎宁酸、丙酮酸、抗坏血酸、乳酸、乙酸及富马酸呈现不同程度的显著增加(P<0.05),而甲酸、柠檬酸、马来酸和琥珀酸含量变化小。共检测到92种挥发性物质,结合OAV分析,10种挥发性物质被确定为刺梨果醋中OAV≥1的关键香气物质,即壬醛、乙醛、异丁酸乙酯、丁酸乙酯、2-甲基丁酸乙酯、乙醇、异戊醇、叶醇、芳樟醇及苯乙醇。其中,丁酸乙酯和叶醇对刺梨果醋香气贡献最大,是刺梨果醋具有青草香、青苹果香的特征风味物质。研究结果为有效控制发酵条件、揭示发酵刺梨果醋的理化特性和风味特征,形成刺梨果醋品质评价方法、制定质量标准提供理论基础和实践指导。

关键词：刺梨果醋发酵 V_(C) 有机酸挥发性风味成分气味活性值

Fine mapping and characterization of a major QTL for grain length,***-2D.1,that has pleiotropic effects in synthetic allohexaploid wheat

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Journal of Integrative Agriculture 2024年第9期23卷 2911-2922页

作者： Mingming Wang Jia Geng Zhe Zhang Zihan Zhang lingfeng Miao Tian Ma jiewen Xing Baoyun li Qixin Sun Yufeng Zhang Zhongfu Ni Frontiers Science Center for Molecular Design Breeding/Key Laboratory of Crop Heterosis and Utilization Ministry of Education/Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China National Plant Gene Research Centre Beijing 100193China

Grain size is one of the determinants of grain yield,and identifying the genetic loci that control grain size will be helpful for increasing grain *** our previous study,a quantitative trait locus(QTL)for grain length(GL),***-2D.1,was identified from an F2 population developed from the cross between the natural(TAA10)and synthetic(XX329)allohexaploid *** the present study,we mainly fine mapped and validated its genetic *** this end,multiple near-isogenic lines(NILs)were obtained through marker-assisted selection with TAA10 as the recurrent *** secondary populations derived from 25 heterozygous recombinants were used for fine mapping of ***-2D.1,and the allele from XX329 significantly increased GL,thousand-grain weight(TGW),total spikelet number per spike(TSN)and spike compactness(SC).Using NILs for XX329(2D+)and TAA10(2D−),we determined the genetic and pleiotropic effects of *** target sequences were aligned with the wheat reference genome RefSeq v2.1 and spanned an~0.9 Mb genomic ***2D03G0114900(ortholog of Os03g0594700)was predicted as the candidate gene based on whole-genome re-sequencing and expression *** summary,the map-based cloning of ***-2D.1 will be useful for improving grain weight with enhanced GL and TSN.

关键词： grain length total spikelet number per spike spike compactness near-isogenic lines QTL wheat

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing Cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2942-2958页

作者： Shishi He Guowei Huang Rong Lei Rurong Jia Zhanghai He jiewen Chen Hongyan Huang Zixian Huang Ailifeire Yilihamu Xun li Zilin Zhuang Mengjia Han Xueman Chen Di Huang Yan Nie Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology Shantou University Medical CollegeShantou 515041China School of Basic Medical Science Southern Medical UniversityGuangzhou 510515China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Breast Medicine Affiliated Foshan Maternity and Child Healthcare HospitalSouthern Medical UniversityFoshan 528000China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Breast phyllodes tumor(PT)is a rare fibroepithelial neoplasm with potential malignant *** non-coding RNAs(lncRNAs)play multifaceted roles in various cancers,but their involvement in breast PT remains largely *** this study,microarray was leveraged for the first time to investigate the role of lncRNA in *** identified lncRNA ZFPM2-AS1 was significantly upregulated in malignant PT,and its overexpression endowed PT with high tumor grade and adverse ***,we elucidated that ZFPM2-AS1 promotes the proliferation,migration,and invasion of malignant PT in *** ZFPM2-AS1 through nanomaterial-mediated siRNA delivery in patient-derived xenograft(PDX)model could effectively inhibit tumor progression in ***,our findings showed that ZFPM2-AS1 is competitively bound to CDC42,inhibiting ACK1 and STAT1 activation,thereby launching the transcription of *** conclusion,our study provides evidence that ZFPM2-AS1 plays a pivotal role in the pathogenesis of breast PT,and suggests that ZFPM2-AS1 could serve as a prognostic indicator for patients with PT as well as a promising novel therapeutic target.

关键词： LncRNA Phyllodes tumor ZFPM2-AS1 Cell division cycle 42 Activated cdc42 kinase 1 Signal transducer and activator of transcription 1 TNF receptor superfamily member 19 Nano particles