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A Matching Algorithm with Reinforcement Learning and Decoupling Strategy for Order Dispatching in On-Demand Food Delivery

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Tsinghua Science and Technology 2024年第2期29卷 386-399页

作者： Jingfang Chen ling Wang Zixiao Pan Yuting wu jie Zheng Xuetao Ding Department of Automation Tsinghua UniversityBeijing 100084China Department of Delivery Technology MeituanBeijing 100102China

The on-demand food delivery(OFD)service has gained rapid development in the past decades but meanwhile encounters challenges for further improving operation *** order dispatching problem is one of the most concerning issues for the OFD platforms,which refer to dynamically dispatching a large number of orders to riders reasonably in very limited decision *** solve such a challenging combinatorial optimization problem,an effective matching algorithm is proposed by fusing the reinforcement learning technique and the optimization ***,to deal with the large-scale complexity,a decoupling method is designed by reducing the matching space between new orders and ***,to overcome the high dynamism and satisfy the stringent requirements on decision time,a reinforcement learning based dispatching heuristic is *** be specific,a sequence-to-sequence neural network is constructed based on the problem characteristic to generate an order priority ***,a training approach is specially designed to improve learning ***,a greedy heuristic is employed to effectively dispatch new orders according to the order priority *** real-world datasets,numerical experiments are conducted to validate the effectiveness of the proposed *** results show that the proposed algorithm can effectively solve the problem by improving delivery efficiency and maintaining customer satisfaction.

关键词： order dispatching on-demand delivery reinforcement learning decoupling strategy sequence-to-sequence neural network

Dynamic monitoring of serum liver function indexes in patients with COVID-19

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World Journal of Clinical Cases 2021年第7期9卷 1554-1562页

作者： Hao Lin ling-jie wu Shun-Qi Guo Rui-Lie Chen Jing-Ru Fan Bin Ke Ze-Qun Pan Department of Gastroenterology Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Infectious Disease Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Emergency Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Ultrasonography Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Pediatrics Shantou Central HospitalShantou 515000Guangdong ProvinceChina

BACKGROUND Some patients with the novel 2019 coronavirus disease(COVID-19)display elevated liver *** antiviral drugs that can be used against COVID-19 are associated with a risk of *** To analyze the clinical significance of the dynamic monitoring of the liver function of patients with *** This was a retrospective study of patients diagnosed with COVID-19 in January and February 2020 at the Department of Infection,Shantou Central *** exclusion criteria for all patients were:(1)History of chronic liver disease;(2)History of kidney disease;(3)History of coronary heart disease;(4)History of malignancy;or(5)History of *** serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase,and total bilirubin of patients with COVID-19 were measured on days 1,3,7 and 14 after admission,and compared to non-COVID-19 *** Twelve patients with COVID-19(seven men and five women)and twelve controls(eight men and four women)were *** were one,two,and nine patients with severe,mild,and moderate COVID-19,*** were no differences in age and sex between the two groups(both P>0.05).No significant differences were found in albumin,ALT,AST,γ-glutamyltransferase,or total bilirubin between the controls and the patients with COVID-19 on day 1 of hospitalization(all P>0.05).Serum albumin showed a decreasing trend from days 0 to 7 of hospitalization,reaching the lowest level on day *** bilirubin was higher on day 3 than on day ***,AST,andγ-glutamyltransferase did not change significantly over *** severe patient was observed to have ALT levels of 67 U/L and AST levels of 75 U/L on day 7,ALT of 71 U/L and AST of 35 U/L on day 14,and ALT of 210 U/L and AST of 123 U/L on day *** Changes in serum liver function indicators are not obvious in the early stage of COVID-19,but clinically significant changes might be observed in severe COVID-19.

关键词： COVID-19 Liver function Dynamic monitoring Disease severity Kidney disease Index

Terminal-selective C（sp3）–H borylation of unbranched alkanes enabled by intermolecular radical sampling and LMCT photocatalysis

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National Science Review 2024年第5期11卷 96-98页

作者： Zhexuan Lei jie wu Department of Chemistry National University of Singapore

The selective functionalization of C（sp3）–H bonds with subtle differences in alkanes is highly sought after due to its atom-and step-efficiency. The activation of C（sp3）–H bonds through hydrogen atom transfer （HAT） has been extensively exploited to produce a valueadded product from unfunctionalized material [1,2].

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3D simulation of image-defined complex internal features using the numerical manifold method

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Science China(Technological Sciences) 2024年第4期67卷 1023-1039页

作者： wu jie MA GuoWei School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China Tianjin Key Laboratory for Prefabricated Building and Intelligent Construction Tianjin 300401China

The numerical simulation of internal features,such as inclusions and voids,is important to analyze their impact on the performance of composite ***,the complex geometries of internal features and the induced continuous-discontinuous(C-D)deformation fields are challenges to their numerical *** this study,a 3D approach using a simple mesh to simulate irregular internal geometries is developed for the first *** the help of a developed voxel crack model,image models that are efficient when recording complex geometries are directly imported into the *** reconstructions,which are usually labor-intensive,are excluded from this ***,using image models as the geometric input,image processing techniques are applied to detect material interfaces and develop contact ***,the C-D deformations of the complex internal features are directly calculated based on the numerical manifold *** accuracy and convergence of the developed3D approach are examined based on multiple *** 3D C-D simulation of sandstones with naturally formed complex microfeatures demonstrates the capability of the developed approach.

关键词： 3D continuous-discontinuous simulation image-based simulation complex internal features numerical manifold method voxel crack model structured mesh

Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

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Protein & Cell 2024年第1期15卷 6-20页

作者： Ning wu ling Wei Zhipeng Zhu Qiang Liu Kailong Li Fengbiao Mao jie Qiao Xiaolu Zhao State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyCenter for Reproductive MedicinePeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Institute of Medical Innovation and Research Peking University Third HospitalBeijing 100191China Cancer Center Peking University Third HospitalBeijing 100191China Department of Biochemistry and Biophysics Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Beijing Advanced Innovation Center for Genomics Beijing 100191China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100191China

Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular *** biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are *** advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research *** mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification *** tumors and disorders of embryonic and fetal development are major threats to human reproductive *** roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer *** present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and *** also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic *** review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

关键词： extrachromosomal circular DNAs gynecologic tumors reproduction liquid biopsy non-invasive prena-tal testing

Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-onchronic liver failure

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World Journal of Gastroenterology 2024年第8期30卷 881-900页

作者： Yu Zhang Xiao-ling Tian jie-Qun Li Dong-Sheng wu Qiang Li Bin Chen Department of Hepatology Institute of HepatologyThe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Department of Liver Transplant Transplant Medical Research CenterThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Surgery The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina

BACKGROUND Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).However,the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are *** To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic *** Liver samples were collected from 16 healthy donors(HDs)and 17 advanced HBV-ACLF patients who were eligible for liver *** mitochondrial ultrastructure,metabolic characteristics,and immune microenvironment of the liver were *** focus was given to organic acid metabolism as well as the function and subpopulations of macrophages in patients with *** Compared with HDs,there was extensive hepatocyte necrosis,immune cell infiltration,and ductular reaction in patients with *** patients,the liver suffered severe hypoxia,as evidenced by increased expression of hypoxia-inducible factor-1α.Swollen mitochondria and cristae were observed in the liver of *** number,length,width,and area of mitochondria were adaptively increased in *** metabolomics analysis revealed that mitochondrial oxidative phosphorylation decreased,while anaerobic glycolysis was enhanced in patients with *** findings suggested that,to a greater extent,hepa-tocytes used the extra-mitochondrial glycolytic pathway as an energy *** with HBV-ACLF had elevated levels of chemokine C-C motif ligand 2 in the liver homogenate,which stimulates peripheral monocyte infiltration into the *** and functional analysis of macrophage subsets revealed that patients with ACLF had a high abundance of CD68^(+)HLA-DR^(+)macrophages and elevated levels of both interleukin-1βand transforming growth factor-β1 in their *** abundance of CD206^(+)CD163^(+)macrophag

关键词： Acute-on-chronic liver failure Hypoxia-inducible factor-1α Mitochondria Metabolic phenotype Immune cells

Unmanned Ship Identification Based on Improved YOLOv8s Algorithm

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Computers, Materials & Continua 2024年第3期78卷 3071-3088页

作者： Chun-Ming wu Jin Lei wu-Kai Liu Mei-ling Ren ling-Li Ran Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology School of Electrical EngineeringNortheast Electric Power UniversityJilin132012China School of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030600China

Aiming at defects such as low contrast in infrared ship images,uneven distribution of ship size,and lack of texture details,which will lead to unmanned ship leakage misdetection and slow detection,this paper proposes an infrared ship detection model based on the improved YOLOv8 algorithm(R_YOLO).The algorithm incorporates the Efficient Multi-Scale Attention mechanism(EMA),the efficient Reparameterized Generalized-feature extraction module(CSPStage),the small target detection header,the Repulsion Loss function,and the context aggregation block(CABlock),which are designed to improve the model’s ability to detect targets at multiple scales and the speed of model *** algorithm is validated in detail on two vessel *** comprehensive experimental results demonstrate that,in the infrared dataset,the YOLOv8s algorithm exhibits improvements in various performance ***,compared to the baseline algorithm,there is a 3.1%increase in mean average precision at a threshold of 0.5(mAP(0.5)),a 5.4%increase in recall rate,and a 2.2%increase in mAP(0.5:0.95).Simultaneously,while less than 5 times parameters,the mAP(0.5)and frames per second(FPS)exhibit an increase of 1.7%and more than 3 times,respectively,compared to the CAA_YOLO ***,the evaluation indexes on the visible light data set have shown an average improvement of 4.5%.

关键词： Unmanned ships R_YOLO EMA CSPStage YOLOv8s

An interlaminar damage shell model for typical composite structures

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Chinese Journal of Aeronautics 2024年第1期37卷 118-137页

作者： jie ZHOU Zhen wu Zhengliang LIU Xiaohui REN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China National Key Laboratory of Strength and Structural Integrity Xi’an 710065China School of Mechanical Engineering Xi’an Aeronautical UniversityXi’an 710065China

Using the plate/shell elements in commercial software,accurate analysis of interlaminar initial damage in typical composite structures is still a challenging *** propose an accurate and efficient model for analysis of interlaminar initial damage,the following work is carried out:(A)A higher-order theory is firstly proposed by introducing the local Legendre polynomials,and then a novel shell element containing initial damage prediction is developed,which can directly predict transverse shear stresses without any postprocessing *** variables at each node are independent of number of layers,so the proposed model is more efficient than the 3D-FEM.(B)Compression experiment is carried out to verify the capability of the proposed *** results obtained from the proposed model are in good agreement with experimental data.(C)Several examples have been analyzed to further assess the capability of the proposed model by comparing to the 3D-FEM ***,accuracy and efficiency have been evaluated in different damage criterion by comparing with the selected *** numerical results show that the proposed model can well predict the initial interlaminar damage as well as other ***,the model is implemented with UEL subroutine,so that the present approach can be readily utilized to analyze the initial damage in typical composite structures.

关键词： Compression experiment Finite element method Initial damage Interlaminar stress Plate/shell element

High-stable and High-capacity Sn/SnO_(2)@C as Anode of Lithium-ion Batteries

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Journal of wuhan University of Technology(Materials Science) 2024年第4期39卷 805-813页

作者：徐天星 wu jie 李亚娟肖宏 College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science Central South UniversityChangsha 410083China Hunan Times New Energy Technology Co. LtdLuxi 416100China

We synthesized size-controllable nanoparticles with homogeneous distribution of carbon and Sn/SnO_(2)by a solvothermal *** effects of different carbon content and hydrothermal time on the composition,morphology and electrochemical properties of the materials were *** with bulk materials,nanoparticles materials not only have high specific surface area,but also can provide abundant reaction sites,thus enhancing the electrochemical activity of electrode *** importantly,the optimized microspheres Sn/8C-24 delivers a superior electrochemical performance,achieving a specific discharge capacity of 700.4 mAh·g^(-1)after 150 cycles at 0.5 A·g^(-1),and the Coulomb efficiency reaches 98.65%,which is promising for anode of LIBs.

关键词： Sn anode nanoparticles hydrothermal method