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Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： jie-zhuang huang Jian-Di Li Gang Chen Rong-Quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to *** To investigate the key genes and potential mechanisms correlated with TACE refractoriness in *** The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public *** respective differentially expressed genes(DEGs)were attained via limma R *** gene co-expression network analysis was employed for identifying the significant modules related to TACE *** refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE *** key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences *** prognostic value of the key genes was evaluated by Kaplan-Meier *** analysis was utilised to investigate the independent prognostic factor in key ***-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in *** refractoriness-related genes activity was calculated via AUCell *** CellChat R package was used for the investigation of the cell–cell communication between the identified cell *** HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were *** five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were *** five key genes were all up-regulated in the TACE non-responders group and the HCC *** expression of the five key genes predicted poor prognosis in *** the key genes,TP

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

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Distributed Nash Equilibrium Seeking on Compact Action Sets over Jointly Strongly Connected Switching Networks

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Journal of Systems Science & Complexity 2024年第1期37卷 63-81页

作者： HE Xiongnan huang jie Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China.

This paper studies the distributed Nash equilibrium seeking(DNES)problem for games whose action sets are compact and whose network graph is switching satisfying the jointly strongly connected *** keep the actions of all players in their action sets all the time,one has to resort to the projected gradient-based *** the assumption that the unique Nash equilibrium is the unique equilibrium of the pseudogradient system,an algorithm is proposed that is able to exponentially find the Nash ***,the authors also consider the distributed Nash equilibrium seeking problem for games whose actions are governed by high-order integrator dynamics and belong to some compact *** examples are used to illustrate the proposed approach.

关键词： Compact action sets jointly strongly connected switching graphs Nash equilibrium seeking projected gradient-based algorithm.

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Classifying Chinese Medicine Constitution Using Multimodal Deep-Learning Model

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Chinese Journal of Integrative Medicine 2024年第2期30卷 163-170页

作者： GU Tian-yu YAN zhuang-zhi JIANG jie-hui School of Communication&Information Engineering Shanghai UniversityShanghai(200444)China School of Life Science Shanghai UniversityShanghai(200444)China

Objective:To develop a multimodal deep-learning model for classifying Chinese medicine constitution,i.e.,the balanced and unbalanced constitutions,based on inspection of tongue and face images,pulse waves from palpation,and health information from a total of 540 ***:This study data consisted of tongue and face images,pulse waves obtained by palpation,and health information,including personal information,life habits,medical history,and current symptoms,from 540 subjects(202 males and 338 females).Convolutional neural networks,recurrent neural networks,and fully connected neural networks were used to extract deep features from the *** fusion and decision fusion models were constructed for the multimodal ***:The optimal models for tongue and face images,pulse waves and health information were ResNet18,Gate Recurrent Unit,and entity embedding,*** fusion was superior to decision *** multimodal analysis revealed that multimodal data compensated for the loss of information from a single mode,resulting in improved classification ***:Multimodal data fusion can supplement single model information and improve classification *** research underscores the effectiveness of multimodal deep learning technology to identify body constitution for modernizing and improving the intelligent application of Chinese medicine.

关键词： Chinese medicine constitution classification multimodal deep learning tongue image face image pulsewave health information

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Multi-agent reinforcement learning behavioral control for nonlinear second-order systems

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 869-886页

作者： Zhenyi ZHANG jie huang Congjie PAN College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China G+Industrial Internet Institute Fuzhou UniversityFuzhou 350108China

Reinforcement learning behavioral control(RLBC)is limited to an individual agent without any swarm mission,because it models the behavior priority learning as a Markov decision *** this paper,a novel multi-agent reinforcement learning behavioral control(MARLBC)method is proposed to overcome such limitations by implementing joint ***,a multi-agent reinforcement learning mission supervisor(MARLMS)is designed for a group of nonlinear second-order systems to assign the behavior priorities at the decision *** modeling behavior priority switching as a cooperative Markov game,the MARLMS learns an optimal joint behavior priority to reduce dependence on human intelligence and high-performance computing *** the control layer,a group of second-order reinforcement learning controllers are designed to learn the optimal control policies to track position and velocity signals *** particular,input saturation constraints are strictly implemented via designing a group of adaptive *** simulation results show that the proposed MARLBC has a lower switching frequency and control cost than finite-time and fixed-time behavioral control and RLBC methods.

关键词： Reinforcement learning Behavioral control Second-order systems Mission supervisor

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Progress on Bionic Textured Cutting Tools:A Review and Prospects

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Journal of Bionic Engineering 2024年第1期21卷 19-55页

作者： Hong Wei Guangjun Chen zhuang Chen Zhiwei Yu Jiashuai huang Tianjin Key Laboratory of High Speed Cutting and Precision Processing Tianjin 300222China School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China

Cutting tools are known as the“productivity”of the manufacturing industry,which affects the production efficiency and quality of the workpiece,and has become the focus of research and attention in academia and ***,traditional cutting tools often suffer from adhesion or wear during the cutting process,which considerably reduces the cutting efficiency and service life of the tools,and makes it difficult to meet current production *** solve the above problems,scholars have introduced bionics into the tool’s design,applying the microscopic structure of the biological surface to the tool surface to alleviate the tool’s *** paper mainly summarizes the research progress of bionic textured cutting ***,categorize whether the bionic texture design is inspired by a single organism or multiple ***,it is discussed that the non-smooth surface of the biological surface has five characteristics:hydrophilic lubricity,wear resistance,drag reduction and hydrophobicity,anti-adhesion,and arrangement,and the non-smooth structure of these different characteristics are applied to the surface of the tool is designed with bionic ***,the cutting performance of bionic textured cutting tools is *** anti-friction and wear-resisting mechanism of bionic textured cutting tools is ***,some pending problems and perspectives have been proposed to provide new inspirations for the design of bionic textured cutting tools.

关键词： Bionic textured cutting tools Biological microstructure characteristics Cutting performance Anti-friction and wear-resisting mechanism

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Review on the terahertz metasensor:from featureless refractive index sensing to molecular identification

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Photonics Research 2024年第2期12卷 194-217页

作者： JIAMING LYU LIHAO huang LIN CHEN YIMING ZHU SONGLIN zhuang THz Technology Innovation Research Institute Shanghai Key Laboratory of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 200092China

The terahertz(THz)wave is at the intersection between photonics and electronics in the electromagnetic *** the vibration mode of many biomedical molecules and the weak interaction mode inside the molecules fall in the THz regime,utilizing THz radiation as a signal source to operate substance information sensing has its unique ***,the metamaterial sensor(metasensor)has greatly enhanced the interaction between signal and substances and spectral selectivity on the subwavelength ***,most past review articles have demonstrated the THz metasensor in terms of their structures,applications,or *** recently,with the rapid development of metasensing technologies,the molecular information has paid much more attention to the platform of THz *** this review,we comprehensively introduce the THz metasensor for detecting not only the featureless refractive index but also the vibrational/chiral molecular information of *** objectives of this review are to improve metasensing specificity either by chemical material-assisted analyte capture or by physical molecular ***,to boost THz absorption features in a certain frequency,the resonant responses of metasensors can be tuned to the molecular vibrational modes of target molecules,while frequency multiplexing techniques are reviewed to enhance broadband THz spectroscopic *** chiral metasensors are also summarized to specific identification chiral ***,the potential prospects of next generation THz metasensors are *** to featureless refractive index metasensing,the specific metasensor platforms accelerated by material modification and molecular information will lead to greater impact in the advancement of trace detection of conformational dynamics of biomolecules in practical applications.

关键词： refractive index sensor

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Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang Chu-jie huang Department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World Health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(PI)*** protamine expressions(P1 and P2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both P<0.01).P1 level,P1/P2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the P2 level decreased(all P

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

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Precisely Control Relationship between Sulfur Vacancy and H Absorption for Boosting Hydrogen Evolution Reaction

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Nano-Micro Letters 2024年第4期16卷 14-24页

作者： Jing Jin Xinyao Wang Yang Hu zhuang Zhang Hongbo Liu jie Yin Pinxian Xi College of Chemistry and Chemical Engineering Frontiers Science Center for Rare IsotopesState Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000People’s Republic of China

Ef fective and robust catalyst is the core of water splitting to produce ***, we report an anionic etching method to tailor the sulfur vacancy(VS) of NiS_(2) to further enhance the electrocatalytic performance for hydrogen evolution reaction(HER). With the VS concentration change from 2.4% to 8.5%, the H* adsorption strength on S sites changed and NiS_(2)-VS 5.9% shows the most optimized H* adsorption for HER with an ultralow onset potential(68 m V) and has long-term stability for 100 h in 1 M KOH media. In situ attenuated-total-reflection Fourier transform infrared spectroscopy(ATR-FTIRS) measurements are usually used to monitor the adsorption of intermediates. The S-H* peak of the Ni S_(2)-VS 5.9% appears at a very low voltage, which is favorable for the HER in alkaline media. Density functional theory calculations also demonstrate the Ni S_(2)-VS 5.9% has the optimal |ΔG^(H*)| of 0.17 e V. This work offers a simple and promising pathway to enhance catalytic activity via precise vacancies strategy.

关键词： Hydrogen evolution reaction S vacancies Nanosheet H Adsorption

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Nanoforming of transferred metal contacts for enhanced twodimensional field effect transistors

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Nano Research 2024年第4期17卷 3210-3216页

作者： Shuoheng Xu Zheng huang jie Guan Yaowu Hu The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China School of Physics Southeast UniversityNanjing 211189China

Two-dimensional transition metal chalcogenides(2D-TMDs)have attracted much attention because of their unique layered structure and physical properties for transistor *** transferred metal contacts on these low-dimensional materials or their homogeneous and heterogeneous multilayers have generated huge interest to avoid deposition *** this paper,we show that there are large physical gaps at both the edge contact and surface contact between the transferred electrodes and the 2D materials.A method called laser shock induced superplastic deformation(LSISD)is proposed to tackle this issue and enhance the performance of the *** enhancement mechanism was investigated by molecular dynamics(MD)simulations of the nanoforming process,atomic force microscopy(AFM),scanning electron microscopy(SEM),transmission electron microscopy(TEM)characterizations of the interfaces,and density functional theory(DFT)*** force effect of laser shock can reduce the contact gap between metals and *** electrical performances of the transistors before and after LSISD,along with MD simulations,are used to find the optimal process *** addition,this paper applies the LSISD method to the short-channel MoS_(2)/graphene vertical transistors to show potential improvement in interface contact and electrical *** paper demonstrates the first report on using mechanical force induced by laser shock to enhance metal–semiconductor interfaces and transistor performances.

关键词： laser shock nanoforming metal-semiconductor contact electronics two-dimensional transistors

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Optimization of Generator Based on Gaussian Process Regression Model with Conditional Likelihood Lower Bound Search

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 32-42页

作者： Xiao Liu Pingting Lin Fan Bu Shaoling zhuang Shoudao huang CES&IEEE the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China CES

The noise that comes from finite element simulation often causes the model to fall into the local optimal solution and over fitting during optimization of ***,this paper proposes a Gaussian Process Regression(GPR)model based on Conditional Likelihood Lower Bound Search(CLLBS)to optimize the design of the generator,which can filter the noise in the data and search for global optimization by combining the Conditional Likelihood Lower Bound Search *** the efficiency optimization of 15 kW Permanent Magnet Synchronous Motor as an ***,this method uses the elementary effect analysis to choose the sensitive variables,combining the evolutionary algorithm to design the super Latin cube sampling plan;Then the generator-converter system is simulated by establishing a co-simulation platform to obtain data.A Gaussian process regression model combing the method of the conditional likelihood lower bound search is established,which combined the chi-square test to optimize the accuracy of the model ***,after the model reaches the accuracy,the Pareto frontier is obtained through the NSGA-II algorithm by considering the maximum output torque as a ***,the constrained optimization is transformed into an unconstrained optimizing problem by introducing maximum constrained improvement expectation(CEI)optimization method based on the re-interpolation model,which cross-validated the optimization results of the Gaussian process regression *** above method increase the efficiency of generator by 0.76%and 0.5%respectively;And this method can be used for rapid modeling and multi-objective optimization of generator systems.

关键词： Generator optimization Gaussian Process Regression(GPR) Conditional Likelihood Lower Bound Search(CLLBS) Constraint improvement expectation(CEI) Finite element calculation

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