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Functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-Cheng Lu Hai-Yang Jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang ying-jie zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory

Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

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Genes & Diseases 2023年第3期10卷 877-890页

作者： Min Chen jie-ying zhu Wang-Jing Mu Liang Guo School of Kinesiology Shanghai University of SportShanghai 200438China Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Cysteine dioxygenase type 1 (CDO1), belonging to the mammalian non-heme Fe(II) dioxygenases family, is a key enzyme for cysteine catabolism. Its activity and expression is regulated through multiple mechanisms. CDO1 is involved in a spectrum of physiological processes including lipid metabolism, adipogenesis, osteoblastic differentiation, redox homeostasis, fertility, bile acid metabolism, sulfide metabolism, and organismal growth and development. Many of these processes are regulated directly or indirectly by CDO1-mediated metabolism of cysteine. In pathophysiological processes, the degree of CDO1 promoter methylation is closely related to the progression and malignancy of tumors, and overexpression of CDO1 will promote ferroptosis of cancer cells. Moreover, CDO1 may ameliorate metabolic disorders through the taurine-mediated improvement of lipid metabolism and insulin sensitivity and improve neurodegenerative diseases by regulating cysteine level. Therefore, elucidation of the mechanisms underlying the role of CDO1 would provide a clearer view of the therapeutic potential and possible risks of targeting this important enzyme.

关键词： Anti-tumor Antioxidation Cysteine Promoter methylation Taurine

The functional role of Higd1a in mitochondrial homeostasis and in multiple disease

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Genes & Diseases 2023年第5期10卷 1833-1845页

作者： jie-ying zhu Min Chen Wang-Jing Mu Hong-Yang Luo Liang Guo School of Kinesiology Shanghai University of SportShanghai 200438China Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China

Higd1a is a conserved gene in evolution which is widely expressed in many tissues in *** evidence has revealed multiple functions of Higd1a,as a mitochon-drial inner membrane protein,in the regulation of metabolic *** plays an impor-tant role in anti-apoptosis and promotes cellular survival in several cell types under hypoxic *** the survival of porcine Sertoli cells facilitated by Higd1a helps to support *** some cases,Higd1a can serve as a sign of metabolic *** the past several years,a considerable amount of studies about how tumor fate is determined and how cancerous proliferation is regulated by Higd1a have been *** this review,we summarize the physiological functions of Higd1a in metabolic homeostasis and its pathophysiological roles in distinct diseases including cancer,nonalcoholic fatty liver disease(NAFLD),type Il diabetes and mitochondrial *** prospect of Higd1a with potential to preserve mammal health is also *** review might pave the way for Higd1a-based research andapplicationinclinicalpractice.

关键词： Apoptosis Cancer Diabetes Mitochondrial homeostasis NAFLD

Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

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Genes & Diseases 2023年第3期10卷 915-930页

作者： Hong-Yang Luo jie-ying zhu Min Chen Wang-Jing Mu Liang Guo Shanghai Frontiers Science Research Base of Exercise and Metabolic Health Shanghai University of SportShanghai 200438China School of Kinesiology Shanghai University of SportShanghai 200438China

Krüppel-like factor 10 (KLF10), also known as TGFβ-inducible early gene-1 (TIEG1), was first found in human osteoblasts. Early studies show that KLF10 plays an important role in osteogenic differentiation. Through decades of research, KLF10 has been found to have complex functions in many different cell types, and its expression and function is regulated in multiple ways. As a downstream factor of transforming growth factor β (TGFβ)/SMAD signaling, KLF10 is involved in various biological functions, including glucose and lipid metabolism in liver and adipose tissue, the maintenance of mitochondrial structure and function of the skeletal muscle, cell proliferation and apoptosis, and plays roles in multiple disease processes, such as nonalcoholic steatohepatitis (NASH) and tumor. Besides, KLF10 shows gender-dependent difference of regulation and function in many aspects. In this review, the biological functions of KLF10 and its roles in disease states is updated and discussed, which would provide new insights into the functional roles of KLF10 and a clearer view of potential therapeutic strategies by targeting KLF10.

关键词： Adipose tissue Estrogen signaling Glucose and lipid metabolism NASH Obesity Skeletal muscle TGFβ/SMAD signaling Tumor

Multifunctional Fire-Resistant Paper Based on Ultralong Hydroxyapatite Nanowires

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Chinese Journal of Chemistry 2021年第8期39卷 2296-2314页

作者： ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Ding-Xi RoadShanghai 200050China

Paper was one of the greatest inventions in ancient China,and it greatly promoted the rapid development of human *** in today's electronic information age,paper and paper-derived products are still indispensable to people's daily work and ***;the traditional paper based on cellulose fibers from plants has some *** instance:(1)papermaking consumes a large amount of precious natural resources such as trees;(2)the papermaking industry causes environmental pollution;(3)the traditional paper consisting of organic cellulose fibers is highly flammable and easy to burn;(4)the traditional paper based on cellulose fibers turns to yellow color with time;(5)the lifetime of the traditional paper is relatively short because of the degradation of cellulose *** efforts are needed to investigate and solve these problems facing the traditional *** recent years,a new kind of multifunctional fire-resistant paper based on ultralong hydroxyapatite nanowires has been developed and investigated for various applications,and many research findings have been documented in the *** review article provides a comprehensive summary and discussion on recent research advances for this new kind of multifunctional fire-resistant paper based on ultralong hydroxyapatite nanowires,including the synthesis,properties,applications,and future perspectives.

关键词： Nano wires Hydroxyapatite Fire-resistant paper Nanostructures Green chemistry

Nanowires:Synthesis and Energy/Environmental Applications

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Energy & Environmental Materials 2021年第4期4卷 544-561页

作者： Heng Li ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

As the main inorganic component of human bones and teeth,hydroxyapatite(HAP)materials have been widely investigated for various applications especially in the biomedical ***,HAP nanowires(HAP NWs)have attracted research interest in the energy and environment-related fields owing to their advantages such as excellent biocompatibility and bioactivity,high-thermal stability,surface modification and functionalization,and selfassembly to form nanoscale porous networked *** this review,we first briefly discuss the synthesis of HAP *** we focus on summarizing the foremost advances in energy and environment-related applications of HAP NWs,including the battery,solar energy-assisted water evaporation,light-driven self-propelled device,thermal insulation,fireresistant inorganic paper,water purification,air purification,molecular detection,superhydrophobic surface,and high-strength nanocomposite *** addition,the future research directions on HAP NWs and their energy and environmental applications are *** review aims to provide inspiration and stimulate extensive future studies in the energy and environmental applications of HAP NWs and other inorganic NWs.

关键词： hydroxyapatite nanowire application energy environment

Nanostructured Materials of Calcium Phosphates and Calcium Silicates： Synthesis, Properties and Applications

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Chinese Journal of Chemistry 2017年第6期35卷 769-790页

作者： ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

Calcium phosphates are a family of compounds with different chemical compositions, structures and properties containing calcium ions and functional groups of orthophosphate （ pO34- ）, metaphosphate （ PO3- ） or pyrophosphate （ P2O4-7 ） and sometimes hydrogen or hydroxide ions. Calcium phosphates can be widely found in nature as well as in hard tissues （bone and tooth） of the vertebrate. Owing to similar chemical composition and structure to the main inorganic constituents of bone and tooth, calcium phosphate-based materials are promising biomaterials with high biocompatibility, and have been investigated for applications in various biomedical areas. Calcium silicate-based materials have attracted much attention on their potential applications in various biomedical fields such as bone de- fect repair and drug delivery. In recent years, this research group has been focusing on the research in this exciting and rapidly evolving research field, and has published many papers. This article will provide a brief review on our main research work on the synthesis, characterization, properties and applications of nanostructured materials of calcium phosphates and calcium silicates. Finally, future perspectives and challenges for the research and applica- tions of nanostructured materials of calcium phosphates and calcium silicates are discussed.

关键词： calcium phosphate calcium silicate nanostructured materials biomaterials biomedical applications

Bioinspired flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure

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Nano Research 2021年第10期14卷 3643-3652页

作者： Han-Ping Yu ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The synthetic hydrogels with high water contents are promising for various applications,however,they usually exhibit low mechanical *** this work,inspired by the natural biological soft tissues,whose hierarchically ordered fibrous structures result in high strength and good flexibility,a flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure(HFMOS)is developed based on ultralong hydroxyapatite(HAP)nanowires and polyacrylic acid(PAA).The as-prepared HFMOS hydrogel has a high water content(~70 wt.%),dense structure,and excellent mechanical properties,and these properties are similar to those of the human cartilage and are superior to many hydrogels reported in the *** excellent mechanical properties of the HFMOS hydrogel originate from the combination of the fiberboard-and-mortar hierarchically ordered structure,reinforcement of ultralong HAP nanowires,strong interfacial strength,and multiple energy dissipation ***,thanks to the controllable components and injection procedure,the HFMOS hydrogel with a Janus structure is prepared for particular *** HFMOS hydrogel possesses abundant ordered water channels,and can be used for loading,release,and directed delivery of various functional ***,the as-prepared flexible,high-strength,and versatile HFMOS hydrogel possesses a great potential for various applications such as water purification,pollution treatment,biomedicine,nanofluidic devices,and high-performance structural materials.

关键词： hydrogel nanowire hydroxyapatite ordered structure

Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer’s Disease

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Neuroscience Bulletin 2022年第11期38卷 1425-1430页

作者： Yun‑Long Xu Lin zhu Zi‑Jun Chen Xiao‑Fei Deng Pei‑Dong Liu Shan Li Bing‑Chun Lin Chuan‑Zhong Yang Wei Xu Kui-Kui Zhou ying‑jie zhu Shenzhen Key Laboratory of Drug Addiction Shenzhen Neher Neural Plasticity Laboratorythe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Neonatology Shenzhen Maternity&Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518055China The First Afliated Hospital Sun Yat-sen UniversityGuangzhou 510080China Cheeloo College of Medicine Shandong UniversityJinan 250012China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyCASShenzhen 518055China CAS Center for Excellence in Brain Science and Intelligence Technology CASShanghai 200031China CAS Key Laboratory of Brain Connectome and Manipulation BCBDIShenzhen Institute of Advanced Technology(SIAT)CASShenzhen 518055China

Dear Editor,Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of *** loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Synaptic loss,un... 详细信息

关键词： Alzheimer pathology impairment