检索结果-南通市图书馆

In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cel.ular & Molecular Immunology 2024年第2期21卷 103-118页

作者： S.Cankat M.u.Demael l.Swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-OC43,Nl63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

The role of a novel antibacterial substance,cyclic opine-producing lacticaseibacil.us rhamnosus lS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 778-790页

作者： Tao Wang Shuang Wang Shuchen Dong Ruiling Wang Shuxuan Wang jie Yang Xin Wang Xin lü College of Food Science and Engineering Northwest Agriculture and Forestry UniversityYangling 712100China Faculty of Food Science and Engineering Kunming University of Science and TechnologyKunming 650500China School of life Science and Technology Xinjiang UniversityUrumqi 830046China

Intestinal microbiota imbalance may worsen the progression of ulcerative colitis(uC).lacticaseibacil.us rhamnosus lS8(lR)has the potential ability to regulate microbiota through producing a novel antibacterial substance,cyclic opine:*** study aimed to investigate whether lR could ameliorate dextran sulfate sodium-induced uC in mice via modulating intestinal microbiota using fecal microbiota transplantation(FMT)*** results showed that both lR and FMT attenuated uC as evidenced by 1)alleviating disease activity index and colonic pathology;2)up-regulating MuCs and tight junction proteins;3)increasing oxidative mediators and decreasing antioxidant mediators;4)down-regulating proinflammatory cytokines and *** results were mainly attributable to the microbiota-regulating effect of lR,including increasing beneficial bacteria(like Akkermansia)and its related SCFAs,while decreasing harmful bacteria(like Proteobacteria)and its related lPS,thereby suppressing the hyperactivation of TlR4/NF-κB ***,lR can alleviate uC and is a potential dietary supplement to attenuate uC.

关键词： Gut barrier Gut microbiota Fecal microbiota transplantation lacticaseibacil.us rhamnosus Oxidative stress ulcerative colitis

Perspective on new cell-free DNA technologies for early cancer detection

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第2期21卷 139-143页

作者： jie li Xun lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China MOE Key laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for life Sciences Tsinghua UniversityBeijing 100084China

High cancer heterogeneity and aggressiveness are major factors contributing to the poor prognosis of patients with advanced cancer~(1-5).Early detection of cancer can significantly improve the prognosis of patients with early-stage cancer after standard *** traditional cancer detection technologies,such as endoscopy for gastrointestinal cancer,mammography for breast cancer。

关键词： prognosis cancer patients

在线全文

学校读者我要写书评

暂无评论

Editorial

The Journal of China universities of Posts and Telecommunications 2024年第2期31卷 1-2页

作者： Zhang jie Beijing university of Posts and Telecommunications Beijing 100876China

Integrated circuits(ICs)have become the cornerstone of the information age,driving scientific and technological revolutions and symbolizing strategic national *** the continuous adjustment of economic structure and the changing of international relationships,the pivotal role of ICs and related sectors has become increasingly *** address Chinese critical“bottleneck”challenges in this domain,it is necessary to strengthen the research on semiconductor devices,IC design,and manufacturing technologies.

关键词： corners driving symbol

Durable Ru Nanocrystal with HfO_(2)Modification for Acidic Overall Water Splitting

在线全文

学校读者我要写书评

暂无评论

Nano-Micro letters 2024年第9期16卷 462-477页

作者： Xiangkai Kong jie Xu Zhicheng Ju Changle Chen School of Materials and Physics China University of Mining and TechnologyXuzhou 221116JiangsuPeople’s Republic of China Anhui Province Key laboratory of Pol.utant Sensitive Materials and Environmental Remediation Huaibei Normal UniversityHuaibei 235000AnhuiPeople’s Republic of China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026AnhuiPeople’s Republic of China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023JiangsuPeople’s Republic of China

Durable and efficient bi-functional catalyst,that is capable of both oxygen evolution reaction and hydrogen evolution reaction under acidic condition,are highly desired for the commercialization of proton exchange membrane water ***,we report a robust l-Ru/HfO_(2)heterostructure constructed via confining crystalline Ru nanodomains by HfO_(2)*** assembled with a proton exchange membrane,the bi-functional l-Ru/HfO_(2)catalyst-based electrolyzer presents a voltage of 1.57 and 1.67 V to reach 100 and 300 mA cm^(-2)current density,prevailing most of previously reported Ru-based materials as well as commercial Pt/C||RuO_(2)*** is revealed that the synergistic effect of HfO_(2)modification and small crystalline domain formation significantly alleviates the over-oxidation of *** importantly,this synergistic effect facilitates a dual-site oxide path during the oxygen evolution procedure via optimization of the binding configurations of oxygenated *** a result,the Ru active sites maintain the metallic state along with reduced energy barrier for the rate-determining step(^(*)O→^(*)OOH).Both of water adsorption and dissociation(Volmer step)are strengthened,while a moderate hydrogen binding is achieved to accelerate the hydrogen desorption procedure(Tafel step).Consequently,the activity and stability of acidic overall water splitting are simultaneously enhanced.

关键词： Ruthenium Hafnium dioxide Oxygen evolution catalysis Anti-oxidation

3D simulation of image-defined complex internal features using the numerical manifold method

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第4期67卷 1023-1039页

作者： Wu jie MA GuoWei School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China Tianjin Key laboratory for Prefabricated Building and Intelligent Construction Tianjin 300401China

The numerical simulation of internal features,such as inclusions and voids,is important to analyze their impact on the performance of composite ***,the complex geometries of internal features and the induced continuous-discontinuous(C-D)deformation fields are challenges to their numerical *** this study,a 3D approach using a simple mesh to simulate irregular internal geometries is developed for the first *** the help of a developed voxel crack model,image models that are efficient when recording complex geometries are directly imported into the *** reconstructions,which are usually labor-intensive,are excluded from this ***,using image models as the geometric input,image processing techniques are applied to detect material interfaces and develop contact ***,the C-D deformations of the complex internal features are directly cal.ulated based on the numerical manifold *** accuracy and convergence of the developed3D approach are examined based on multiple *** 3D C-D simulation of sandstones with naturally formed complex microfeatures demonstrates the capability of the developed approach.

关键词： 3D continuous-discontinuous simulation image-based simulation complex internal features numerical manifold method voxel crack model structured mesh

Eigenstate properties of the disordered Bose-Hubbard chain

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第4期19卷 57-72页

作者： jie Chen Chun Chen Xiaoqun Wang Key laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Many-body localization(MBl)of a disordered interacting boson system in one dimension is studied numerically at the filling faction *** von Neumann entanglement entropy Svn is commonly used to detect the MBl phase transition but remains challenging to be directly *** on the u(1)symmetry from the particle number conservation,Svn can be decomposed into the particle number entropy S_(n) and the configuration entropy *** light of the tendency that the eigenstate's S_(c) nears zero in the localized phase,we introduce a quantity describing the deviation of S from the ideal thermalization distribution;finite-size scaling analysis il.ustrates that it shares the same phase transition point with Sv but displays the better critical *** observation hints that the phase transition to MBl might largely be determined by S and its fluctuations Notably,the recent experiments[***,et al.,Science 364,256(2019);***,et al.,***.19,481(2023)]demonstrated that this deviation can potentially be measured through the Sn ***,our investigations reveal that the thermalized states primarily occupy the low-energy section of the spectrum,as indicated by measures of localization length,gap ratio,and energy density *** low-energy spectrum of the Bose model closely resembles the entire spectrum of the Fermi(or spin XXZ)model,accommodating a transition from the thermalized to the localized ***,owing to the bosonic statistics,the high-energy spectrum of the model allows the formation of distinct clusters of bosons in the random potential *** analyze the resulting eigenstate properties and briefly summarize the associated *** distinguish between the phase regions at the low and high energies,a probing quantity based on the structure of S_(VN) is also *** work highlights the importance of symmetry combined with entanglement in the study of *** this regard,for the disordered Heisenberg XXZ

关键词： entanglement entropy decomposition u(1)symmetry thermalization-to-localization transition

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha l.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2730-2738页

作者： Jin-Hang Xue Qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-jie Xu Qi-Peng li Jin-jie Qian College of life and Environmental Science Wenzhou UniversityWenzhou 325000China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China College of Chemistry and Chemical Engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·l^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·l·cm^(-2),a limit of detection of 100nmol·l^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation