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Green light mediates atypical photomorphogenesis by dual modulation of Arabidopsis phytochromes B and A

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Journal of Integrative Plant Biology 2024年第9期66卷 1915-1933页

作者： Miqi xu Yi‐Yuan Wang Yujie Wu Xiuhong zhou Ziyan Shan Kunying Tao Kaiqiang Qian xuncheng Wang Jian Li Qingqing Wu Xing Wang Deng Jun‐jie ling National Engineering Laboratory of Crop Stress Resistance Breeding School of Life SciencesAnhui Agricultural UniversityHefei 230036China Province Key Laboratory of Resource Insect Biology and Innovative Utilization School of Life SciencesAnhui Agricultural UniversityHefei 230036China Biotechnology Center State Key Laboratory of Tea Plant Biology and UtilizationSchool of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei 230036China Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of Life Sciences Nanjing Normal UniversityNanjing 210023China State Key Laboratory of Protein and Plant Gene Research Peking–Tsinghua Center for Life SciencesSchool of Advanced Agriculture Sciencesand School of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences at WeifangPeking University Institute of Advanced Agricultural SciencesWeifang 261000China

Although green light(GL)is located in the middle of the visible light spectrum and regulates a series of plant developmental processes,the mechanism by which it regulates seedling development is largely *** this study,we demonstrated that GL promotes atypical photomorphogenesis in Arabidopsis thaliana via the dual regulations of phytochrome B(phyB)and *** the Pr-to-Pfr conversion rates of phyB and phyA under GL were lower than those under red light(RL)in a fluence rate-dependent and time-dependent manner,long-term treatment with GL induced high Pfr/Pr ratios of phyB and ***,GL induced the formation of numerous small phyB photobodies in the nucleus,resulting in atypical photomorphogenesis,with smaller cotyledon opening angles and longer hypocotyls in seedlings compared to *** abundance of phyA significantly decreased after short-and long-term GL *** determined that four major PHYTOCHROME-INTERACTING FACTORs(PIFs:PIF1,PIF3,PIF4,and PIF5)act downstream of phyB in GL-mediated cotyledon *** addition,GL plays opposite roles in regulating different *** example,under continuous GL,the protein levels of all PIFs decreased,whereas the transcript levels of PIF4 and PIF5 strongly increased compared with dark *** together,our work provides a detailed molecular framework for understanding the role of the antagonistic regulations of phyB and phyA in GL-mediated atypical photomorphogenesis.

关键词： cotyledon development green light photobody phytochrome PIF3

Side-Chain-Type Polyimide-Cu Complexes with Suppressed Activation Energy of Relaxation for Advanced High-Temperature Capacitor

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Chinese Journal of Polymer Science 2024年第8期42卷 1038-1048页

作者： bai-Yang zhou Ze-Tong Ma Shi-Long Zhong Zhen-jie Huang Qi Guo Deng-Chong Feng Zhong-Ke Yuan Shao-Lin Lu Yu-Zhao Yang Cheng Wang Ding-Shan Yu xu-Dong Chen Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Guangdong Engineering Technology Research Centre for High Performance Organic and Polymer Photoelectric Functional FilmsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Industry jieyang Centre Jieyang 515200China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China

The burgeoning growth of the new energy vehicles and aviation industry has escalated the need for energy storage capacitors capable of stable operation in harsh *** advent of metal-polyimide complexes has illuminated a novel approach for preparing tem perature-resistant ***,the general application of these metal-polyimide com plexes is impeded by the high dielectric loss and low breakdown strength,consequences of main-chain coordination and excessive metal ions ***,our study proposes a novel polyimideCu complex material(POP-Cu)predicated on side-chain-type pyridine-Cu coordination,utilizing the structural backbone PMDA-ODA of mature commercial PI(Kapton)with reliable *** to the high degree of freedom afforded by the side chain with suppressed relaxation activation energy and the long-range electron delocalization formed by d-πcoordination,the dielectric constant of this material containing merely 2.7 mol%Cu increases from 3.25(POPI)to 5.58,while maintaining a remarkably low dielectric loss of ***,this material exhibits a substantial DC breakdown strength of 436.2 MV·m^(-1)and a high energy density of 5.42 J·cm^(-3),coupled with superior mechanical and thermal *** at 150℃,it retains over 90%of its room-temperature energy density,demon strating notable dielectric stability under high *** attributes underscore its promising application for capacitors operating in harsh environments.

关键词： Dielectric performance Polyimide complexes Side-Chain-Type High-temperature capacitor

Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors

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胰腺病学杂志(英文) 2024年第2期07卷 97-105页

作者： Chen jie Wu Wenming bai Chunmei Chi Yihebali Huo Li Jiang Liming Ji Yuan Luo jie Li jie Li Jingnan Lou Wenhui Shao Chenghao Shen Lin Wang Feng Wang Yu xue ling xu Jin Yuan Chunhui Yu Xianjun Yin Xiaoyu Zhao Hong Zhu Xiongzeng Zhao Yupei Centre for Neuroendocrine Tumors Fudan University Shanghai Cancer Center Shanghai China Department of General Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Department of Medical Oncology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology Zhongshan Hospital Fudan University Shanghai China Department of Pathology China-Japan Friendship Hospital Beijing China Department of Gastroenterological Oncology Beijing Cancer Hospital Peking University Cancer Hospital &amp Institute Beijing China Department of Gastroenterology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Pancreatic Surgery Zhongshan Hospital Fudan University Shanghai China Department of Pancreatic-Biliary Surgery Second Affiliated Hospital of Naval Medical University Shanghai China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp Department of Nuclear Medicine Nanjing First Hospital Nanjing Medical University Nanjing China Depar

The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (pNECs), according to the mitotic count, Ki-67 index, and cell differentiation. As a new category, G3 pNETs remain a challenging group of tumors to manage by lacking large randomized trials and consensus to support its clinical practice. Therefore, the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association gathered experts in this field to formulate this consensus for the diagnosis and treatment of G3 pNETs.

关键词： Clinical diagnosis Grade 3 Pancreatic neuroendocrine tumors Treatment

Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus

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Science China Life Sciences 2024年

作者： Kun Zhang xu Huang Chongqing Wang Xidan xu Xiaowei xu Xiaoping Dong Qingwen Xiao Jinhai bai Yue zhou Zhengkun Liu Xinyi Deng Yan Tang Siyang Li Enkui Hu Wanjing Peng ling Xiong Qinbo Qin Shaojun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry College of Life Sciences Hunan Normal University Nansha-South China Agricultural University Fishery Research Institute Hunan Yuelu Mountain Science and Technology Co. Ltd.for Aquatic Breeding

Autotetraploid Carassius auratus is a stable hereditary autotetraploid fish resulting from the hybridization of Carassius auratus red var.(RCC, ♀) × Megalobrama amblycephala(BSB, ♂), containing four sets of RCC chromosomes. However, the molecular mechanism underlying the determination of sex in this species remains largely unknown. Currently, there lacks a full understanding of the molecular mechanisms governing sex determination and specific molecular markers to differentiate sex in this species. In this study, 25,801,677 SNPs(Singlenucleotide polymorphism) and 6,210,306 Indels(insertion-deletion) were obtained from whole-genome resequencing of 100 individuals(including 50 female and 50 male). Further identification confirmed the candidate chromosomes as Chr46B, with the sex-determining region located at Chr46B: 22,500,000-22,800,000 bp. Based on the male-specific insertion(26 bp) within the candidate sex-determining region, a pair of sex-specific molecular markers has been identified. In addition, based on the screening of candidate sex-determining region genes and RT-qPCR validation analysis, ADAM10, AQP9 and tc1a were identified as candidate sex-determining genes. These findings provide a robust foundation for investigating sex determination mechanisms in fish, the evolution of sex chromosomes, and the development of monosex populations.

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GaS/Mg(OH)_(2)异质结电子结构的第一性原理研究

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物理学报 2024年第13期73卷 251-261页

作者：刘俊岭柏于杰徐宁张勤芳盐城工学院物理系盐城224051

基于第一性原理计算方法研究了GaS/Mg(OH)_(2)异质结的稳定性、电子和光学性质.结果表明,GaS/Mg(OH)_(2)异质结具有较小的晶格失配率,负的结合能和热力学稳定性而容易构建.异质结的带隙有效降低至2.021 eV,而且具有Type-Ⅱ型能带结构,... 详细信息

基于第一性原理计算方法研究了GaS/Mg(OH)_(2)异质结的稳定性、电子和光学性质.结果表明,GaS/Mg(OH)_(2)异质结具有较小的晶格失配率,负的结合能和热力学稳定性而容易构建.异质结的带隙有效降低至2.021 eV,而且具有Type-Ⅱ型能带结构,有利于光生电子-空穴对的空间分离.层间电荷转移诱导的内建电场进一步促进载流子的分离,同时有助于抑制层间电荷的复合.在双轴应变下,异质结的导带最小值和价带最大值的位置分别产生了不同程度的平移,导致带隙发生显著的变化,变化量达到了0.5 eV.而且在拉伸应变下,异质结由间接转变为直接带隙半导体,同时异质结仍保持Type-Ⅱ型能带结构.此外,应变还可以有效地调控异质结的带边位置与水分解的氧化还原电位相匹配(pH=0—7).光吸收谱显示异质结具有较强的光吸收性能,尤其在拉伸应变为3%时,光吸收发生了明显的红移.这些结果表明,GaS/Mg(OH)_(2)异质结具有可调的电子性能而在光电领域有着广阔的应用前景.

关键词：异质结电子结构应变第一性原理

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Green light mediates atypical photomorphogenesis by dual modulation of Arabidopsis phytochromes B and A

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Journal of Integrative Plant Biology 2024年第09期 1915-1933页

作者： Miqi xu Yi-Yuan Wang Yujie Wu Xiuhong zhou Ziyan Shan Kunying Tao Kaiqiang Qian xuncheng Wang Jian Li Qingqing Wu Xing Wang Deng Jun-jie ling National Engineering Laboratory of Crop Stress Resistance Breeding School of Life Sciences Anhui Agricultural University Province Key Laboratory of Resource Insect Biology and Innovative Utilization School of Life Sciences Anhui Agricultural University Biotechnology Center State Key Laboratory of Tea Plant Biology and Utilization School of Tea and Food Sciences and TechnologyAnhui Agricultural University Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry Sciences College of Life Sciences Nanjing Normal University State Key Laboratory of Protein and Plant Gene Research Peking–Tsinghua Center for Life Sciences School of Advanced Agriculture Sciences and School of Life Sciences Peking University State Key Laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences at Weifang Peking University Institute of Advanced Agricultural Sciences

Although green light(GL) is located in the middle of the visible light spectrum and regulates a series of plant developmental processes, the mechanism by which it regulates seedling development is largely unknown. In this study, we demonstrated that GL promotes atypical photomorphogenesis in Arabidopsis thaliana via the dual regulations of phytochrome B(phy B) and phy A. Although the Pr-to-Pfr conversion rates of phy B and phy A under GL were lower than those under red light(RL) in a fluence rate-dependent and time-dependent manner, long-term treatment with GL induced high Pfr/Pr ratios of phy B and phy A. Moreover, GL induced the formation of numerous small phy B photobodies in the nucleus, resulting in atypical photomorphogenesis, with smaller cotyledon opening angles and longer hypocotyls in seedlings compared to RL. The abundance of phy A significantly decreased after short-and long-term GL treatments. We determined that four major PHYTOCHROME-INTERACTING FACTORs(PIFs:PIF1, PIF3, PIF4, and PIF5) act downstream of phy B in GL-mediated cotyledon opening. In addition, GL plays opposite roles in regulating different PIFs. For example, under continuous GL, the protein levels of all PIFs decreased, whereas the transcript levels of PIF4 and PIF5 strongly increased compared with dark treatment. Taken together, our work provides a detailed molecular framework for understanding the role of the antagonistic regulations of phy B and phy A in GL-mediated atypical photomorphogenesis.

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan bai Jiang‑Bo bai jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑jie Jiang Zheng‑Yao Jin ling Kang Bo Li Gong Li Xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

新型PARP1/2抑制剂YHP-836与替莫唑胺联用的抗脑胶质瘤研究

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药学学报 2024年第6期59卷 1656-1663页

作者：邓佳玲杜婷婷周洁徐柏玲陈晓光季鸣中国医学科学院药物研究所天然药物活性物质与功能国家重点实验室/创新药物非临床药物代谢及PK/PD研究北京市重点实验室北京100050

本文研究和评价一种新型多聚(ADP-核糖)聚合酶[poly(ADP-ribose)polymerase,PARP]-1和PARP2抑制剂YHP-836与替莫唑胺(temozolomide,TMZ)联用的抗脑胶质瘤(glioblastoma,GBM)作用。体外采用MTT、蛋白免疫印迹法、流式细胞术,测定化合物单用和与TMZ联用对多株脑胶质瘤细胞的细胞杀伤活性和DNA损伤修复标志物磷酸化组蛋白H2AX(histone H2AX phosphorylation,γH2AX)水平以及细胞周期的影响。通过脑胶质瘤异体移植模型和原位移植瘤模型,评价YHP-836与TMZ联用的体内药效。动物实验按照中国医学科学院、北京协和医学院药物研究所实验动物伦理委员会操作规范严格执行(00009138)。结果显示,YHP-836与TMZ联用增加了对人脑胶质瘤细胞的细胞杀伤活性和γH2AX的表达水平,使细胞周期阻滞在S期。体内动物模型结果表明,单独使用YHP-836对U251/TMZ肿瘤的治疗作用较差,而在与TMZ联用时,发现其能显著增加TMZ的抗肿瘤作用,且未显著增加化疗药物毒性。综上所述,新型PARP1/2抑制剂YHP-836可以增敏化疗药物TMZ的作用,并为下一步研究其作用机制奠定了基础。提示PARP1/2抑制剂YHP-836可能成为TMZ耐药患者联合TMZ治疗的候选药物之一。

关键词：替莫唑胺 PARP抑制剂脑胶质瘤多聚(ADP-核糖)聚合酶药物联用

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan bai Jiang‑Bo bai jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑jie Jiang Zheng‑Yao Jin ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping zhou Zhi‑Hao zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons