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Monitoring variations of inland lakes in the arid region of Central Asia

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Frontiers of Earth Science 2012年第2期6卷 147-156页

作者： jie bai Xi CHEN Liao YANG Hui FANG State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Inland lakes are the major surface water resource in the arid regions of Central Asia. Therefore, the surface area changes in inland lakes have been a sensitive indicator of climate changes and human activ- ities, and have often been the focus of ecological and environmental research. This study aimed to monitor the changes in surface area of nine major lakes over a 32-year period. The water body was extracted from MSS images from the mid-1970s, TM images from the early 1990s, ETM ＋ images in the late 1990s, and TM images in 2007. The results indicated that the total surface area of these nine lakes had decreased over time to 50.38% of the area, from 91402.06km^2 in 1975 to 46049.23 km^2 in 2007. As the surface area of lakes in the western part of Central Asia was larger than that in the eastern part, the shrinking trend of lake area was more significant in the west than in the east. There was a varied reduction of closed lakes in flat regions. The most substantial decrease was in the surface area of closed lakes in flat regions. Most significantly, the area of the Aral Sea was reduced by 75.7% from its original area in 1975. The area of alpine lakes remained relatively stable; the change in surface area was less than 0.7% during the period 1975-2007. The area change in opened lakes with outlets was notably different from the other two types. The area of Zaysan had increased sharply by 5.85%, and that of Bosten had decreased by 9.1%. Sasykkol had hardly any changes in this period. Due to global climate wanning, vapor transfer to the south via westerly winds had been blocked, resulting in a decrease of much-needed precipitation in the western parts of Turkmenistan, Uzbekistan, and Kazakhstan between 1970 and 2000. The decrease in precipitation and the increase in water consumption for agricultural irrigation resulted in the decrease of fiver runoff. Consequently, thearea of inland lakes in Central Asia shrank over the past 32 years.

关键词： Central Asia inland lake area change climatechange

基于网络药理学结合多指标正交实验优选颈眩宁方的提取工艺

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中国新药杂志 2024年第5期33卷 469-478页

作者：胡晓红杨雪颖叶津宏肖五庆白洁杜守颖北京中医药大学中药学院北京102488

目的:通过网络药理学结合多指标正交实验优选颈眩宁方的提取工艺。方法:采用网络药理学结合分子对接筛选颈眩宁方的潜在活性成分及靶点,并参考《中华人民共和国药典》2020年版确定指标成分。运用信息熵权法赋权及正交实验设计,以加水倍... 详细信息

目的:通过网络药理学结合多指标正交实验优选颈眩宁方的提取工艺。方法:采用网络药理学结合分子对接筛选颈眩宁方的潜在活性成分及靶点,并参考《中华人民共和国药典》2020年版确定指标成分。运用信息熵权法赋权及正交实验设计,以加水倍量、提取时间、提取次数为影响因素,以指标成分转移率为评价指标,确定颈眩宁方最佳提取工艺。结果:确定指标成分为天麻素、对羟基苯甲醇及葛根素,最佳提取方法为提取2次,每次提取时间1.5 h,第1次加水12倍,第2次加水10倍。结论:通过网络药理学及分子对接技术,确定工艺评价指标,优选的颈眩宁方提取工艺合理、稳定、重复性良好,可为后续深入研究提供参考。

关键词：颈眩宁提取工艺网络药理学分子对接信息熵权法正交实验

Highly Porous Amidoximed Carbon Nanofibers Supported Palladium（0） Nanoparticle Catalyzed Heck Reaction

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Chemical Research in Chinese Universities 2015年第6期31卷 1072-1077页

作者： MENG Qingrun bai jie GUO Shoujun LI Chunping Chemical Engineering College Inner Mongolia University of Technology Hohhot 010051 P. R. China

Highly porous amidoximed carbon nanofibers（AOCNFs）, which were fabricated via a conventional elec- trospinning technique followed by chemically modification, impregnation-reduction and carbonization process, had been used for the immobilization of palladium nanoparticles（Pd NPs） catalyst. During the carbonization process, po- lystyrene（PS） was selectively decomposed from bicomponent fibers, generating porous fibers. Fourier transform infrared spectroscopy（FTIR） result revealed the functional groups on PAN-PS fibers（PAN=polyacrylonitrile）, AOPAN-PS fibers and AOCNFs; scanning electron microscopy（SEM） was used to observe the morphology of all stages of nanofibers; transmission electron microscopy（TEM） result gave the structure of through-hole morphology clearly visible and the dispersion ofPd NPs on the surface of nanofibers; and X-ray photoelectron spectra（XPS） con- firmed that Pd nanoparticles on the surface of AOCNFs was of the metallic state. Moreover, the as-prepared catalyst exhibited high catalytic activity and efficient recycle for Heck coupling reactions between iodobenzene and acrylates.

关键词： Pd nanoparticle Carbon nanofiber Heck reaction

Modified ADM1 for modeling free ammonia inhibition in anaerobic acidogenic fermentation with high-solid sludge

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Journal of Environmental Sciences 2017年第2期29卷 58-65页

作者： jie bai He Liu Bo Yin Huijun Ma Xinchun Chen School of Environmental and Civil Engineering Jiangnan UniversityWuxi 214122China

Anaerobic acidogenic fermentation with high-solid sludge is a promising method for volatile fatty acid（VFA） production to realize resource recovery. In this study, to model inhibition by free ammonia in high-solid sludge fermentation, the anaerobic digestion model No. 1（ADM1） was modified to simulate the VFA generation in batch, semicontinuous and full scale sludge. The ADM1 was operated on the platform AQUASIM *** kinds of inhibition forms, e.g., simple inhibition, Monod and non-inhibition forms,were integrated into the ADM1 and tested with the real experimental data for batch and semi-continuous fermentation, respectively. The improved particle swarm optimization technique was used for kinetic parameter estimation using the software MATLAB 7.0. In the modified ADM1, the Ksof acetate is 0.025, the km,acis 12.51, and the KI_NH3is 0.02,respectively. The results showed that the simple inhibition model could simulate the VFA generation accurately while the Monod model was the better inhibition kinetics form in semi-continuous fermentation at pH 10.0. Finally, the modified ADM1 could successfully describe the VFA generation and ammonia accumulation in a 30 m^3full-scale sludge fermentation reactor, indicating that the developed model can be applicable in high-solid sludge anaerobic fermentation.

关键词： High-solid sludge ADM1 Semi-continuous Full scale Free ammonia inhibition

HPLC法同时测定3种滑膜炎制剂中9种成分的含量

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中成药 2024年第3期46卷 729-734页

作者：彭紫薇黄嘉怡李花花宋扬杜守颖白洁北京中医药大学中药学院北京100029

目的建立HPLC法同时测定滑膜炎颗粒、胶囊、片剂中迷迭香酸、丹酚酸B、丹酚酸A、丹参素、原儿茶醛、绿原酸、隐绿原酸、新绿原酸、咖啡酸的含量。方法分析采用Xselect■HSS T3色谱柱(250 mm×4.6 mm, 5μm);流动相乙腈-0.1%磷酸,梯度... 详细信息

目的建立HPLC法同时测定滑膜炎颗粒、胶囊、片剂中迷迭香酸、丹酚酸B、丹酚酸A、丹参素、原儿茶醛、绿原酸、隐绿原酸、新绿原酸、咖啡酸的含量。方法分析采用Xselect■HSS T3色谱柱(250 mm×4.6 mm, 5μm);流动相乙腈-0.1%磷酸,梯度洗脱;体积流量1 mL/min;柱温30℃;检测波长280、287、327 nm。结果 9种成分在各自范围内线性关系良好(r>0.999 0),平均加样回收率97.05%~102.14%,RSD 0.91%~2.59%。不同制剂中丹酚酸B含量均符合2020年版《中国药典》要求,各成分综合含量依次为颗粒>胶囊>片剂(B公司)>片剂(E公司)>片剂(D公司)>片剂(C公司)。结论该方法简便、快速、稳定,结果准确可靠,可为滑膜炎制剂质量标准提升提供参考依据。

关键词：滑膜炎制剂化学成分含量测定 HPLC

Impact of Phenanthrene on Denitrification Activity and Transcription of Related Functional Genes in Estuarine and Marine Sediments

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Journal of Ocean University of China 2020年第1期19卷 124-134页

作者： SUN Pengfei bai jie LI Kuiran ZHAO Yangguo TIAN Weijun bai Xiaoyan TIAN Yanzhao College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China The Key Laboratory of Marine Environmental Science and Ecology Ministry of EducationOcean University of ChinaQingdao 266100China College of Marine Life Science Ocean University of ChinaQingdao 266003China

The effects of phenanthrene(Phe)on the denitrification activity and denitrifying genes(narG,nirS and nosZ)were evaluated by dose-response experiments in sediments of Dagu River Estuary(DRE)and Jiaozhou Bay(JZB).The results showed that potential denitrification activity(PDA),N2O,NO3−and NO2−reduction rates of both areas were inhibited with an increase of Phe *** PDA,N2O,NO3−and NO2−reduction rates of both areas was highest and lowest in the control(DRE:0.453,0.427,7.439 and 3.222mgNkg−1 h−1,JZB:0.592,0.555,8.470 and 3.793mgNkg−1 h−1)and highest Phe amended treatments(DRE:0.069,0.001,4.486,and 1.563 mgNkg−1 h−1;JZB:0.114,0.024,5.527 and 2.200 mgNkg−1 h−1).The inhibition rate of PDA was highest,follow by NO2−reduction and then NO3−***,with the increasing of Phe concentrations,total bacteria count and the abundance of denitrifying genes were *** N2O accumulation was promoted with the addition of Phe for both *** on the comparison of EC50 values,denitrifiers harboring three genes were more sensitive to Phe than PDA,and denitrifiers harboring nirS gene were more sensitive,followed by nosZ gene,and then narG ***,according to correlation analysis,the relative abundance of denitrifying genes was much more positively correlated with PDA,NO3−and NO2−reduction than total bacteria *** addition,the denitrification activity and total bacteria count in JZB were more inhibited than that of *** study is useful for understanding the impact of Phe pollution on denitrification in estuary and marine sediments,with profound implications for the management of aquatic ecosystems regarding eutrophication(N-removal)and greenhouse effect.

关键词： phenanthrene effect denitrification denitrifying genes estuarine sediment marine sediment

老年2型糖尿病患者自我感知老化的潜在剖面及影响因素

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中国健康心理学杂志 2024年第9期32卷 1339-1346页

作者：白洁袁曼曼刘惠萍河南省职工医院消化内分泌科(郑州) 450001

目的:探究老年2型糖尿病患者自我感知老化的潜在剖面及其影响因素。方法:采用基本人口学特征调查表、健康状况调查表、老年抑郁评定量表、一般疏离感量表及简版自我感知老化量表对某医院就诊及住院的337例老年2型糖尿病患者进行调查,运... 详细信息

目的:探究老年2型糖尿病患者自我感知老化的潜在剖面及其影响因素。方法:采用基本人口学特征调查表、健康状况调查表、老年抑郁评定量表、一般疏离感量表及简版自我感知老化量表对某医院就诊及住院的337例老年2型糖尿病患者进行调查,运用潜在剖面分析探究其自我感知老化的类别及特征,并通过单因素分析和多项式logistic回归分析不同类别的影响因素。结果:老年2型糖尿病患者自我感知老化可被分为“高自我感知老化组”(35.90%)、“积极结果突出组”(14.48%)以及“低自我感知老化组”(49.26%)3个潜在剖面。多项式logistic回归分析显示,婚姻状况(OR=0.136,95%CI:0.070~0.262)、有无子女(OR=0.266,95%CI:0.116~0.611)、自评健康状况为非常好/比较好(OR=0.289,95%CI:0.123~0.681)、糖尿病合并症(OR=0.378,95%CI:0.196~0.731)、抑郁症状(OR=0.512,95%CI:0.273~0.960)、社会疏离感(OR=1.065,95%CI:1.039~1.092)是高自我感知老化组的影响因素;年龄(OR=0.253,95%CI:0.118~0.545)、婚姻状况(OR=0.397,95%CI:0.187~0.845)、自评健康状况为非常好/比较好(OR=0.215,95%CI:0.066~0.699)、糖尿病合并症(OR=0.331,95%CI:0.151~0.722)、合并慢性病数(OR=0.243,95%CI:0.083~0.710)、社会疏离感(OR=1.037,95%CI:1.008~1.067)是积极结果突出组的影响因素(P<0.05)。结论:老年2型糖尿病患者自我感知老化存在3种潜在剖面,且高自我感知老化组受婚姻状况、有无子女、自评健康状况、糖尿病合并症、抑郁症状、社会疏离感影响,积极结果突出组受年龄、婚姻状况、自评健康状况、糖尿病合并症、合并慢性病数、社会疏离感影响。未来应根据不同剖面的老年2型糖尿病患者的特征和影响因素制定针对性的干预措施,以改善患者自我感知老化水平,促进患者生命质量和健康状况的不断提高。

关键词： 2型糖尿病老年人自我感知老化社会疏离潜在剖面

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m^(6)A修饰与肿瘤免疫逃逸的研究进展

海南医学院学报 2024年第15期30卷 1194-1200页

作者：苏夏艺张百红朱志博董亚玲白洁西北民族大学医学部甘肃兰州730030 中国人民解放军联勤保障部队第九四〇医院甘肃兰州730050 甘肃中医药大学第一临床医学院甘肃兰州730000

RNA的N6-甲基腺苷(m^(6)A)修饰是真核生物mRNA中最常见的内部表观遗传修饰方式,已被认为是肿瘤和免疫系统的关键调节因子,可广泛参与肿瘤治疗抵抗、肿瘤微环境、肿瘤免疫逃逸(TIE)和肿瘤代谢的调节,但m^(6)A修饰与TIE具体调控机制尚需... 详细信息

RNA的N6-甲基腺苷(m^(6)A)修饰是真核生物mRNA中最常见的内部表观遗传修饰方式,已被认为是肿瘤和免疫系统的关键调节因子,可广泛参与肿瘤治疗抵抗、肿瘤微环境、肿瘤免疫逃逸(TIE)和肿瘤代谢的调节,但m^(6)A修饰与TIE具体调控机制尚需进一步探究,主要可能通过直接调节免疫细胞或间接调节肿瘤细胞影响免疫反应发挥TIE调节剂作用,本文就m^(6)A修饰在TIE过程中可能发挥的作用机制进行综述,旨在为m^(6)A修饰及相关调节剂在肿瘤免疫治疗中的提供参考。

关键词：肿瘤免疫逃逸 m^(6)A修饰肿瘤微环境肿瘤免疫治疗

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基于CIM的城市地下空间安全预警系统研究

价值工程 2024年第22期43卷 123-125页

作者：郝佳宁蔡白洁李清四川建筑职业技术学院德阳618000 西华大学土木建筑与环境学院成都610039

为了有效防范和应对地下空间可能发生的火灾、水灾、气体泄漏、结构破坏、人员踩踏等事故,通过提出了一种基于城市信息模型(CIM)的地下空间安全预警系统方法研究了城市地下空间安全风险及其分析规律。结果表明:该系统可利用CIM技术整合... 详细信息

为了有效防范和应对地下空间可能发生的火灾、水灾、气体泄漏、结构破坏、人员踩踏等事故,通过提出了一种基于城市信息模型(CIM)的地下空间安全预警系统方法研究了城市地下空间安全风险及其分析规律。结果表明:该系统可利用CIM技术整合地下空间的三维模型、属性数据和监测数据,实现对地下空间的实时感知、动态分析和智能预警。该系统还可利用云计算和物联网技术,实现与上层平台和应急部门的数据共享和联动处置,可对提高城市安全风险综合监测预警平台的效能和水平提供支持。本文以某城市地铁站地下空间为例,可见该系统前沿的设计思路、完善的功能模块和良好的预期效果,为基于CIM技术的安全预警研究提供理论依据和研究思路。

关键词：城市信息模型 CIM 地下空间安全预警