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Significantly enhanced performance and conductivity mechanism in Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)ferroelectrics

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Journal of Materiomics 2024年第3期10卷 652-669页

作者： Jiageng Xu Shaoxiong Xie Qian Xu jie xing Qingyuan Wang Jianguo Zhu School of Aeronautics and Astronautics Sichuan UniversityChengdu610000China Institute for Advanced Study Chengdu UniversityChengdu610106China Department of Mechanical Engineering Kyushu UniversityFukuoka819-0395Japan College of Architecture and Environment Sichuan UniversityChengdu610065China College of Material Science and Engineering Sichuan UniversityChengdu610065China

With the rapid development of high-end industries,the demand for high-temperature piezoelectric materials is significantly ***,realizing the ultra-high performance to meet more ap-plications still faces major scientific and engineering challenges of our ***,a new Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)(CBT)high-temperature piezoelectric material system of CaBi_(4)Ti_(4-x)(Nb_(2/3)Mn_(1/3))_(x)O_(15)was synthesized by the conventional solid-state sintering *** results show that the addition of the dopants tends to break the long-range ferroelectric chain and soften the flexibility of polarization,resulting in more distorted crystal structure and better ferroelectric properties of CBT *** ultra-high piezoelectric constant(d_(33)=26.8 pC/N)is thus attained in CBT-based ceramics with x=0.12,which is about several times larger than that of pure CBT ***,numerous nano-sized layered domain structures that lie on the lateral plane of grains are observed in ceramics,with lower domain wall energy and better dynamic features under electric fields,mainly responsible for the origin of enhanced ***,excess dopants could make the conductivity mechanism of CBT ceramics transform from p-type to n-type,and also result in a shift of conduction relaxation mechanism from defect dipole rotation polarization to electron relaxation *** work not only provides a promising candidate for high-temperature piezoelectric materials,but also opens a window for opti-mizing performance by tailoring domain structures using chemical modification.

关键词： CaBi_(4)Ti_(4)O_(15) Lattice distortion Electrical performance Domain structure Conductivity mechanism

pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 781-794页

作者： Shuai Guo Chunhui Li Changrong Wang Xiaowen Cao Xinyue Liu xing-jie Liang Yuanyu Huang Yuhua Weng School of Medical Technology Advanced Research Institute of Multidisciplinary ScienceSchool of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Pharmacy Shandong New Drug Loading&Release Technology and Preparation Engineering LaboratoryBinzhou Medical UniversityYantai 264003China School of Ophthalmology and Optometry School of Biomedical EngineeringThe Eye HospitalWenzhou Medical UniversityWenzhou 325027China Chinese Academy of Sciences(CAS) Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

Small interfering RNA(siRNA)has a promising future in the treatment of ocular diseases due to its high efficiency,specificity,and low toxicity in inhibiting the expression of target genes and ***,due to the unique anatomical structure of the eye and various barriers,delivering nucleic acids to the retina remains a significant *** this study,we rationally design PACD,an A-B-C type non-viral vector copolymer composed of a hydrophilic PEG block(A),a siRNA binding block(B)and a pH-responsive block(C).PACDs can self-assemble into nanosized polymeric micelles that compact siRNAs into polyplexes through simple *** evaluating its pH-responsive activity,gene silencing efficiency in retinal cells,intraocular distribution,and anti-angiogenesis therapy in a mouse model of hypoxia-induced angiogenesis,we demonstrate the efficiency and safety of PACD in delivering siRNA in the *** are surprised to discover that,the PACD/siRNA polyplexes exhibit remarkable intracellular endosomal escape efficiency,excellent gene silencing,and inhibit retinal *** study provides design guidance for developing efficient nonviral ocular nucleic acid delivery systems.

关键词： SiRNA Oculardeliverysystem Block polymer Endosomalescape Retinal neovascularization Blood-retinal barrier VEGFA Safety

Arnold Bennett’s Hotel Space and Modernity

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Journal of Literature and Art Studies 2024年第7期14卷 584-591页

作者： DU xing-jie Hangzhou Dianzi University HangzhouChina

Arnold Bennett is well-known for his regional novels that mainly represent domestic quotidian lives of his pottery town,especially the lower and middle ***,his infatuation with the hotel space implicates his ambition to re-situate his characters within the parameters of hotel and create new types of characters,representing in new ways the subjectivity of characters and their relations with material *** on his hotel writing,this article intends to re-conceive the historical reasons of his obsession with hotel space and further probe the modernity deflected by his representation of domestic selves and modern public identities in hotel space.

关键词： Arnold Bennett hotel writing space modernity

The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells

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Science China(Life Sciences) 2024年第9期67卷 1867-1880页

作者： Weixiao Yan Xiaotong Wang Wenjing Wang Qi Guo Na Huang Hao Chen xing-jie Liang Yu Han Dandan Liu Jinchao Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients/Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education/College of Chemistry and Materials Science Chemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Cancer stem cells(CSCs)play an important role in metastasis development,tumor recurrence,and treatment resistance,and are essential for the eradication of ***,therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape,which leads to enhanced aggressive behaviors compared with CSCs that have never been ***,the underlying mechanisms regulating the therapeutic escape remain *** this end,we established a model to isolate the therapeutic escaped CSCs(TSCSCs)from breast CSCs and performed the transcription profile to reveal the ***,we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway,resulting in TSCSCs exhibiting enhanced motility and ***,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo,which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and *** obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy.

关键词： therapeutic escape breast cancer stem cells motility p38/MAPK signaling pathway molecular mechanism

Enhanced electrical properties and Vickers hardness of calcium bismuth niobate ceramics by W/Co substituted at B-site

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Journal of Advanced Dielectrics 2024年第4期14卷 92-103页

作者： Fei Wang Jia Yang Qing Yang Ning Chen Xinji Yang Mingyue Mo jie xing Zhi Tan Zhongqing Tian Fancheng Meng Yuheng Guo Huixing Lin Jianguo Zhu College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054P.R.China College of Materials Science and Engineering Sichuan UniversityChengdu 610064P.R.China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730P.R.China Key Laboratory of Inorganic Functional Material and Device Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899P.R.China

Calcium bismuth niobate(CBN)ceramic,as a core element of high-temperature piezoelectric sensors,has attracted widespread attention due to its high Curie temperature within the class of Aurivillius ***,CBN usually faces two *** piezoelectric constant and low *** this work,CBN-based ceramics with donor–acceptor ions(W/Co)co-substituted at B-site were prepared by solid-state reaction method,and structure–property relationship of ceramics was studied in ***-substitution of W/Co ions effectively improved the electrical property and hardness of CBN ***_(2)Nb_(1.91)(W_(2/3)Co_(1/3)T_(0.09)O_(9))exhibits enhanced electrical and mechanical properties including high resistivity of-10^(7)Ω·cm at 500℃,piezoelectric constant of-15.3 pC/N and hardness value of-3.57 *** values are two orders of magnitude,over two times,and 1.36 times higher than those of pure CBN ceramic,*** work provides a reference for exploring other bismuth-layered structural ceramics.

关键词： Calcium bismuth niobate ceramics donor and acceptor ions B-site electrical properties Vickers hardness

Modifiable risk factors for esophageal cancer in endoscopic screening population:A modeling study

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Chinese Medical Journal 2024年第3期137卷 350-352页

作者： Qian Zhang Fan Wang Hao Feng jie xing Shengtao Zhu Hao Zhang Yang Li Wenqiang Wei Shutian Zhang Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing 100050China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China Statistical Consulting Center Renmin University of ChinaBeijing 100872China National Cancer Center National Clinical Research Center for CancerCancer InstituteChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Jizhong Energy Fengfeng Group HospitalHandanHebei 056000China RSS and China-Re Life Joint Lab on Public Health and Risk Management Renmin University of ChinaBeijing 100872China

To the Editor:Esophageal cancer,one of the most common cancer types in China,with an estimated 346,633 new cases and 323,600 deaths in 2022,is becoming an increasingly serious clinical and public health problem.^([1])The successful promotion of the self-management strategy has indicated that lifestyle modifications can be valuable in the primary prevention of cancer *** a healthy lifestyle has become a novel strategy for primary prevention and risk reduction in high-risk *** epidemiological studies have identified several lifestyle-related risk factors for esophageal cancer,including smoking and diet.^([2])Each factor can typically explain a modest proportion of cancer ***,when combined,these known risk factors may substantially affect the risk of esophageal ***,some risk factors for esophageal cancer are non-modifiable,including age,low socioeconomic status,and family *** and how these non-modifiable risk factors affect primary cancer prevention by intervening with modifiable risk factors remain unclear.

关键词： esophageal prevention promotion

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用于常见疾病成像的纳米材料造影剂

Science China Materials 2024年第4期67卷 1288-1291页

作者：邢洁李子厚姚俊列吴爱国 Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and Application Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices Ningbo Cixi Institute of Biomedical Engineering Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Advanced Energy Science and Technology Guangdong Laboratory

生物医学精准诊断对于疾病的有效治疗十分重要.纳米基成像造影剂具有灵敏度高、特异性强、生物相容性好等特点,在生物医学成像诊断中具有巨大的临床转化潜力.目前,尽管研究者们构筑了大量的纳米基探针材料作为疾病诊断造影剂,但纳米材... 详细信息

生物医学精准诊断对于疾病的有效治疗十分重要.纳米基成像造影剂具有灵敏度高、特异性强、生物相容性好等特点,在生物医学成像诊断中具有巨大的临床转化潜力.目前,尽管研究者们构筑了大量的纳米基探针材料作为疾病诊断造影剂,但纳米材料造影剂在临床转化方面仍然面临极大的挑战.这里我们主要概述了不同生物医学成像类型的纳米基造影剂所面临的问题,并针对这些难题提出了应对方案和未来的研究重点,最后对纳米基造影剂的临床转化前景进行了展望.

关键词：造影剂生物医学成像疾病诊断应对方案生物相容性纳米材料临床转化有效治疗

基于碳配额回购融资的工程机械再制造供应链定价与协调

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运筹与管理 2024年第7期33卷 8-15页

作者：陈伟达邢洁东南大学经济管理学院江苏南京211189

研究考虑碳配额回购融资的工程机械再制造供应链定价与协调问题,建立由供应商和资金约束的制造商组成的两级工程机械再制造供应链决策模型。分别讨论了制造商是否采用碳配额回购融资两种情形,并利用Kuhn-Tucker条件求解相应模型。然后,... 详细信息

研究考虑碳配额回购融资的工程机械再制造供应链定价与协调问题,建立由供应商和资金约束的制造商组成的两级工程机械再制造供应链决策模型。分别讨论了制造商是否采用碳配额回购融资两种情形,并利用Kuhn-Tucker条件求解相应模型。然后,设计了收益分享契约对供应链进行协调。最后,通过算例仿真分析了配额回购融资金额和收益分享参数对供应链成员最优决策和利润的影响。研究表明:当制造商初始资金受限时,供应链成员采用配额回购融资可以提高新产品产量、总产量和核心零部件的批发价;当供应商愿意提供的配额回购融资金额较低时,供应链成员更愿意接受收益分享契约,且当收益分享比例一定时,供应链双方可以实现帕累托改进。

关键词：碳配额回购融资再制造供应链协调收益分享契约

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计及配网电压越限的光储协同优化运行策略

储能科学与技术 2024年第3期13卷 893-902页

作者：顾怡邢洁马洪艳高杉东华大学信息科学与技术学院上海201620

随着大量分布式光伏(distributed photovoltaic,DPV)并网,目前配电网中出现了日间过压和夜间低压并存的电压越限问题,并进一步影响了网络的经济运行。本工作基于此提出了两阶段光储系统协同运行的优化调度策略。该策略第一阶段通过计算... 详细信息

随着大量分布式光伏(distributed photovoltaic,DPV)并网,目前配电网中出现了日间过压和夜间低压并存的电压越限问题,并进一步影响了网络的经济运行。本工作基于此提出了两阶段光储系统协同运行的优化调度策略。该策略第一阶段通过计算节点的电压灵敏度来确定待调节的储能节点与充放功率,以及光伏可调节点;第二阶段建立了光储运行优化模型。该模型以储能的调度成本、购售电成本以及网损成本之和最小为目标,以网络潮流、节点电压、储能SOC(state of charge)、光伏的无功可调容量等作为约束,通过粒子群算法对该模型进行求解,可以得到光储系统日调度出力策略。最后,以某地区31节点的实际配电网作为算例,验证了本工作方法的有效性。算例结果表明,该策略可以通过光储的协同调度,有效治理电网中的电压越限问题,并且在保障配电网电压安全的同时,实现优化运行成本的目标。

关键词：分布式光伏电压越限储能装置光伏无功运行优化