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Large-Scale Preparation of Mechanically High-Performance and Biodegradable PLA/PHBV Melt-Blown Nonwovens with Nanofibers

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Engineering 2024年第8期39卷 244-252页

作者： Gaohui Liu jie guan Xianfeng Wang Jianyong Yu Bin Ding Shanghai Frontier Science Research Center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620China College of Materials Science and Engineering Qingdao UniversityQingdao 266071China

Biodegradable polylactic acid(PLA)melt-blown nonwovens are attractive candidates to replace nondegradable polypropylene melt-blown ***,it is still an extremely challenging task to prepare PLA melt-blown nonwovens with sufficient mechanical properties for practical ***,we report a simple strategy for the large-scale preparation of biodegradable PLA/poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV)melt-blown nonwovens with high strength and excellent *** this process,a small amount of PHBV is added to PLA to improve the latter’s crystallization rate and *** addition,when the PHBV content increases from 0 to 7.5 wt%,the diameters of the PLA/PHBV melt-blown fibers decrease significantly(with the proportion of nanofibers increasing from 7.7%to 42.9%).The resultant PLA/PHBV(5 wt%PHBV)melt-blown nonwovens exhibit the highest mechanical *** tensile stress,elongation,and toughness of PLA/PHBV(5 wt%PHBV)melt-blown nonwovens reach 2.5 MPa,45%,and 1.0 MJm3,*** importantly,PLA/PHBV melt-blown nonwovens can be completely degraded into carbon dioxide and water after four months in the soil,making them environmentally friendly.A general tensile-failure model of melt-blown nonwovens is proposed in this study,which may shed light on mechanical performance enhancement for nonwovens.

关键词： PLA PHBV Melt-blown Biodegradable Strength Toughness

Evaluation of development potential of pumped hydroelectric storage and geothermal utilization system in abandoned coal mine

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Journal of Central South University 2024年第8期31卷 2872-2890页

作者： Wang, Meng Guo, Ping-ye Jin, Xin Dang, guan-jie Guo, Yi-chen Li, Yi State Key Laboratory for Tunnel Engineering China University of Mining and Technology-Beijing Beijing China School of Mechanics and Civil Engineering China University of Mining and Technology-Beijing Bgijing China

Every year in China, a significant number of mines are closed or abandoned. The pumped hydroelectric storage (PHS) and geothermal utilization are vital means to efficiently repurpose resources in abandoned mine. In this work, the development potentials of the PHS and geothermal utilization systems were evaluated. Considering the geological conditions and meteorological data available of Jiahe abandoned mine, a simple evaluation model for PHS and geothermal utilization was established. The average efficiency of the PHS system exceeds 70% and the regulatable energy of a unit volume is over 1.53 kW·h/m3. The PHS system achieves optimal performance when the wind/solar power ratio reaches 0.6 and 0.3 in daily and year scale, respectively. In the geothermal utilization system, the outlet temperature and heat production are significantly affected by the injection flow rate. The heat production performance is more stable at lower rate flow, and the proportion of heat production is higher in the initial stage at greater flow rate. As the operating time increases, the proportion of heat production gradually decreases. The cyclic heat storage status has obvious advantages in heat generation and cooling. Furthermore, the energy-saving and emission reduction benefits of PHS and geothermal utilization systems were calculated.

关键词： abandoned mine underground reservoir wind/solar energy pumped hydroelectric storage geothermal

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-jie guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

Dramatic Difference Between Cu_(20)H_(8)and Cu_(20)H_(9)Clusters in Catalysis

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CCS Chemistry 2024年第6期6卷 1581-1590页

作者： Chun-Yu Liu Tong-Yu Liu Zong-jie guan Song Wang Yuan-Yuan Dong Feng Hu De-en Jiang Quan-Ming Wang Department of Chemistry Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education)Tsinghua UniversityBeijing 100084 Jiangsu Engineering Research Centre for Digital Textile Inkjet Printing Key Laboratory of Eco-Textile Jiangnan UniversityMinistry of EducationWuxiJiangsu 214122 Department of Chemical and Biomolecular Engineering Vanderbilt UniversityNashvilleTennessee 37235 Department of Chemistry Vanderbilt UniversityNashvilleTennessee 37235 College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082 Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026

Sensitivity to structure and composition is very challenging to establish in nanocatalysis due to inadequate definition of structures that are very close in *** synthesized a pair of atomically precise copper clusters that are very close in composition,[Cu_(20)H_(9)(Tf-dpf)_(10)]·BF4(Cu_(20)H_(9))and[Cu_(20)H_(8)(Tf-dpf)_(10)]·(BF_(4))_(2)(Cu_(20)H_(8)),by using a pyridyl-functionalized flexible amidinate ligand,N,N′-di(5-trifluoromethyl-2-pyridyl)*** one-hydride difference in their composition leads to significant variation in geometric and electronic structures and,consequently,distinctly different optical and catalytic ***_(20)H_(8)exhibits 25 times higher catalytic activity than Cu_(20)H_(9)(96.7%vs 3.7%in yield)in the selective hydrogenation of anα,β-unsaturated aldehyde(cinnamaldehyde)to saturated aldehyde(3-phenylpropanal).Electrospray ionization mass spectrometry combined with density functional theory calculations reveal that the greater ease of dissociation of one Tf-dpf ligand compared to Cu_(20)H_(8)is the key to its higher *** work demonstrates a clear case of structure and composition sensitivity in nanocatalysis and that one hydride,out of∼330 atoms in the nanoclusters,can make a huge difference in the catalytic *** insights will be useful in the design and synthesis of atomically precise nanocatalysts.

关键词： copper cluster hydride amidinate ligand structural transformation hydrogenation catalysis

UDMH/NTO富氧燃气发生器预点火过程模型研究及应用

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推进技术 2024年第7期45卷 25-32页

作者：管杰刘上李斌王鹏武西安航天动力研究所陕西西安710100 航天推进技术研究院陕西西安710100

对富氧燃气发生器中偏二甲肼/四氧化二氮(UDMH/NTO)推进剂的自燃点火特性开展实验研究,结果表明,燃气发生器点火初期能量低,燃气温度缓慢爬升。基于实验结果和化学机理分析,构建了描述UDMH/NTO自燃推进剂在富氧环境下预点火过程的热力... 详细信息

对富氧燃气发生器中偏二甲肼/四氧化二氮(UDMH/NTO)推进剂的自燃点火特性开展实验研究,结果表明,燃气发生器点火初期能量低,燃气温度缓慢爬升。基于实验结果和化学机理分析,构建了描述UDMH/NTO自燃推进剂在富氧环境下预点火过程的热力学模型,并将其应用到实验系统的系统级仿真模型中。实验结果验证了仿真模型的合理性,动态相对误差小于15%,主要差异在于燃气发生器压力“平台段”的仿真值偏低。在此基础上开展仿真研究,结果表明:初始参数变化明显影响点火初期的性能参数爬升特性,其中延长点火时差至2倍、将入口压力降低0.05 MPa或者将推进剂温度降低15℃均会导致发动机起动加速性降低25~50 ms,而提高入口压力和缩短点火时差可以减轻推进剂温度变化对性能参数爬升特性的影响程度。

关键词：燃气发生器 UDMH/NTO 预点火点火实验热力学模型仿真分析

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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习近平关于党内监督重要论述探析

扬州教育学院学报 2024年第1期42卷 85-89页

作者：王观杰扬州职业大学江苏扬州225009

中国特色社会主义进入新时代以来,习近平提出了有关党内监督的一系列重要论述,涉及党内监督的地位、关键、核心、重点、基本方式、专责机关、制度性安排等诸多方面。习近平关于党内监督的重要论述开拓了马克思主义监督思想新境界,为新... 详细信息

中国特色社会主义进入新时代以来,习近平提出了有关党内监督的一系列重要论述,涉及党内监督的地位、关键、核心、重点、基本方式、专责机关、制度性安排等诸多方面。习近平关于党内监督的重要论述开拓了马克思主义监督思想新境界,为新时代深化党的自我革命、推进全面从严治党提供了行动指南,为世界其他政党解决党内监督难题提供了中国智慧和中国方案。

关键词：党内监督全面从严治党自我革命

匹多莫德联合吸入用布地奈德混悬液治疗反复性呼吸道感染患儿的临床研究

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中国临床药理学杂志 2024年第3期40卷 307-311页

作者：金冠杰赵焱赵晓云苏州大学附属第二医院儿科江苏苏州215004 苏州大学附属儿童医院新生儿科江苏苏州215004

目的观察匹多莫德口服溶液联合吸入用布地奈德混悬液治疗反复性呼吸道感染(RRTIs)患儿的临床疗效及安全性。方法将RRTIs患儿按队列法分为对照组和试验组。对照组给予匹多莫德口服溶液初始剂量400 mg,bid,连续治疗10 d后调整为每次400 ... 详细信息

目的观察匹多莫德口服溶液联合吸入用布地奈德混悬液治疗反复性呼吸道感染(RRTIs)患儿的临床疗效及安全性。方法将RRTIs患儿按队列法分为对照组和试验组。对照组给予匹多莫德口服溶液初始剂量400 mg,bid,连续治疗10 d后调整为每次400 mg,qd;试验组在对照组治疗的基础上,给予吸入用布地奈德混悬液0.5 mg,雾化吸入治疗,bid。2组患儿均连续治疗8周。比较2组患儿的临床症状消失时间、体液免疫[免疫球蛋白G(IgG)、IgM、IgA]、细胞因子[人胰岛素样生长因子-1(IGF-1)、单核细胞趋化蛋白-1(MCP-1)、环氧化酶-2(COX-2)]水平变化,评估2组患儿的临床疗效,统计药物不良反应发生情况。结果对照组入组47例、试验组入组53例。治疗后,试验组和对照组的总有效率分别为92.45%和76.60%,在统计学上差异有统计学意义(P0.05)。结论匹多莫德口服溶液联合吸入用布地奈德混悬液治疗可明显缓解RRTIs患儿的临床症状,改善体液免疫,提高临床疗效,安全性较高。

关键词：匹多莫德口服溶液吸入用布地奈德混悬液儿童反复性呼吸道感染治疗效果安全性

沉陷区河堤边采边复治理方式下的动态填方量预计方法

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金属矿山 2024年第2期 198-204页

作者：李思豪查剑锋关杰张民中国矿业大学环境与测绘学院江苏徐州221116 皖北煤电集团有限责任公司五沟煤矿安徽淮北235131 兖矿能源集团股份有限公司杨村煤矿山东济宁272118

煤矿开采引起的河堤变形与破坏显著降低了其防洪安全性能。“先破坏、后治理”的传统处理方式存在修复滞后、防汛压力大的问题,具有较大的安全隐患,甚至诱发溃坝、洪水等重大公共安全事故。边采边复,及时恢复河堤的防洪能力是解决这一... 详细信息

煤矿开采引起的河堤变形与破坏显著降低了其防洪安全性能。“先破坏、后治理”的传统处理方式存在修复滞后、防汛压力大的问题,具有较大的安全隐患,甚至诱发溃坝、洪水等重大公共安全事故。边采边复,及时恢复河堤的防洪能力是解决这一问题的主要技术途径。基于矿山开采沉陷动态过程特征,提出了沉陷区河堤边采边复的设计流程;构建了河堤治理过程中的动态填方量计算模型,并应用于某矿地表河流的河堤采动损害治理工程中。研究结果表明:采用边采边复的治理方式对沉陷区河堤进行治理,可以降低在采动过程中的河水外溢风险,同时减轻了采动损害对河堤的破坏程度;提出的动态填方量预计方法可实现对河堤各治理阶段土方量的准确预计,能够满足实际工程需求,为河堤治理工程设计提供了依据。

关键词：边采边复概率积分法开采沉陷预计河堤治理