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Journal of Environmental Sciences 2017年第8期29卷 239-249页

作者： Katherine Z.Fu jinhua li Sai Vemula Birget Moe Xing-Fang li Division of Analytical&Environmental Toxicology Department of Laboratory Medicine&PathologyFaculty of Medicine&DentistryUniversity of Alberta Alberta Centre for Toxicology Department of Physiology&PharmacologyFaculty of MedicineUniversity of Calgary

Human neural stem cells（h NSCs） are a useful tool to assess the developmental effects of various environmental contaminants; however, the application of h NSCs to evaluate water disinfection byproducts（DBPs） is scarce. Comprehensive toxicological results are essential to the prioritization of DBPs for further testing and regulation. Therefore, this study examines the effects of DBPs on the proliferation and differentiation of h NSCs. Prior to DBP treatment, characteristic protein markers of h NSCs from passages 3 to 6 were carefully examined and it was determined that h NSCs passaged 3 or 4 times maintained stem cell characteristics and can be used for DBP analysis. Two regulated DBPs, monobromoacetic acid（BAA） and monochloroacetic acid（CAA）, and two emerging DBPs, 2.6-dibromo-1,4-benzoquinone（2.6-DBBQ） and 2.6-dichloro-1,4-benzoquinone（2.6-DCBQ）, were chosen for h NSC treatment. Both 2.6-DBBQ and 2.6-DCBQ induced cell cycle arrest at S-phase at concentrations up to 1 μmol/L. Comparatively, BAA and CAA at 0.5 μmol/L affected neural differentiation. These results suggest DBP-dependent effects on h NSC proliferation and differentiation. The DBP-induced cell cycle arrest and inhibition of normal h NSC differentiation demonstrate the need to assess the developmental neurotoxicity of DBPs.

关键词： Disinfection byproducts Human neural stem cells Differentiation Halobenzoquinones Haloacetic acids Cell cycle arrest

Banach空间中太阳集对无穷序列的最佳同时逼近

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数学学报（中文版） 2002年第2期45卷 287-294页

作者：罗先发何金苏李冲吉首大学数学与计算机科学系湖南吉首416000 浙江师范大学数理信息学院浙江金华321004 东南大学应用数学系江苏南京210096

本文研究太阳集对一列无穷序列的最佳同时逼近问题，建立了特征及唯一性结果．

关键词：最佳同时逼近同时太阳集严格凸唯一性 RS集 Banach空间

ALK-TKI耐药后获得性RET融合晚期非小细胞肺癌1例报道并文献复习

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肿瘤防治研究 2024年第8期51卷 703-706页

作者：李锦华祁萍乔慧兰州大学第一临床医学院兰州730000 兰州大学第一医院肿瘤内科兰州730000 兰州大学生命科学院兰州730000

0引言间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因融合阳性是非小细胞肺癌(nonsmall cell lung cancer,NSCLC)中常见的驱动基因突变类型之一。ALK融合阳性NSCLC发生率较低,只见于约3%~5%的NSCLC,且患者接受ALKTKI靶向治疗预... 详细信息

0引言间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因融合阳性是非小细胞肺癌(nonsmall cell lung cancer,NSCLC)中常见的驱动基因突变类型之一。ALK融合阳性NSCLC发生率较低,只见于约3%~5%的NSCLC,且患者接受ALKTKI靶向治疗预后较好,因此,ALK基因突变也被称为“钻石突变”。即便如此,携带ALK基因表达的患者仍会进展[1-2.,且通常与ALK-TKI耐药相关。ALK-TKI耐药主要包括原发性耐药和获得性耐药,前者的机制目前尚不明确,初步考虑与肿瘤内在因素、患者及药物特异性因素有关。

关键词： ALK-TKI耐药 RET融合 CCDC6 非小细胞肺癌靶向治疗

Genesis of Silica-phosphatic Nodules with Small Shelly Fossils Preserved in the Lowermost Cambrian of South China

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Acta Geologica Sinica(English Edition) 2022年第4期96卷 1294-1307页

作者： QIU Hao FENG lianjun CHU Xuelei li Luoyang ZHANG Xingliang li jinhua Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdaoShandong 266100China State Key Laboratory of Continental Dynamics and Shaanxi Key Laboratory of Early life and Environments Department of GeologyNorthwest UniversityXi’an 710069China

Silica-phosphatic nodules are abundant in black shales of the Yanjiahe Formation in the Three Gorges Area of South China,which is correlated to the Fortunian Stage,Terreneuvian Series,Cambrian *** nodules are rich in small shelly fossils and hence attract the attention of numerous paleontologists and sedimentary ***,the genesis of the nodules and the preservation of the small shelly fossils are poorly *** we analyze morphological,structural,mineralogical and chemical features of the nodules in multiscale using a combination of micro-X-ray fluorescence spectroscopy,X-ray diffraction,scanning electron microscopy and confocal laser Raman *** reveal that nodules are concentric in chemical and mineralogical compositions,comprising a silica-phosphatic core encrusted sequentially by a phosphatic zone,a siliceous zone and a very thin pyrite outer *** black shales hosting the nodules demonstrate a laminated texture of alternating clayey and silty laminae,which were respectively deposited in sulfidic/less sulfidic,high/low production,intense/weak chemical weathering *** phosphogenesis of the nodules resulted in the phosphatization of small shelly fossils,which prevented the fossils from being dissolved during diagenesis,whereas the silica encrustation sealed the fossils within the nodules and thus protected the fossils from alteration by deep burial and surface weathering.

关键词： silica-phosphatic nodule small shelly fossils Yanjiahe Formation taphonomy Cambrian

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 408-416页

作者： li Zhenxuan WANG Xuerui Luis Ulloa Ayman Youssef BAI Yunjing XU Xiaolong liU Qingquan department of Infectious Diseases Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases Beijing 100010China Infection immunity laboratory Beijing Institute of Traditional Chinese MedicineBeijing 100010China Clinical College of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Perioperative Organ Protection Department of AnesthesiologyDuke University Medical CenterDurhamNorth Carolina 27710USA

Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep *** is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive *** mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial *** evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after ***,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

关键词： sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review

Functional MRI activation of primary and secondary motor areas in healthy subjects

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Neural Regeneration Research 2008年第2期3卷 138-141页

作者： Donghai li Honghan Gong Xiangzuo Xiao jinhua Wan department of Neurosurgery the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China department of Radiology the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China

BACKGROUND： Functional MRI （fMRI） demonstrates the localization of hand representation in the motor cortex, thereby providing feasible noninvasive mapping of functional activities in the human brain. OBJECTIVE： To observe cortical activation within different cortical motor regions during repetitive hand movements in healthy subjects through the use of fMRI. DESIGN： An observational study, with each subject acting as his own control. SETTING： department of Radiology, the First Affiliated Hospital of Nanchang university. PARTICIPANTS： Seven healthy volunteers, 4 males and 3 females, aged 19 to 38 years, participated in the study. All subjects were right-handed, with no neurological or psychological disorders. Informed written consent was obtained from all subjects, and the study was approved by the Institutional Review Board of the First Affiliated Hospital of Nanchang university. METHODS： The study was performed at the department of Radiology between June-August 2.05. A 1.5 Tesla Siemens MRI scanner （Symphony, Germany） was used to acquire T1-weighted structural images, which were oriented parallel to the line running through the anterior and the posterior commissures. Subjects were instructed on a task and were allowed to practice briefly prior to the imaging procedure. The motor activation task consisted of the right hand performing a clenching movement. The T1-W images were acquired from six alternating epochs of rest and activation from all seven healthy subjects. Data were collected with echoplanar imaging of brain oxygen level dependent （BOLD） sequence. Each series comprised six cycles of task performance （30 seconds）, alternating with rest （30 seconds） periods, and 3-second time intervals. The differences between active and baseline fMRI imaging were calculated using the student t-test. Differential maps were overlaid on the high resolution TI-W structural image for neuroanatomical correlation of activation areas. MAIN OUTCOME MEASURES： The omega-sh

关键词： functional MRI cerebral cortex motor area

基于生物信息学筛选卵巢癌转移相关的基因及预后风险模型的构建

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现代妇产科进展 2024年第10期33卷 721-727页

作者：朱顺鹏李倩周金华苏州大学附属第一医院妇产科苏州215006

目的:研究卵巢癌转移相关分子亚型和肿瘤微环境(TME)细胞浸润。方法:通过四个GEO数据集筛选转移相关基因,并以此在TCGA队列中探索转移相关分子亚型,以及相关的TME细胞浸润。使用Lasso回归构建预后模型,检测对预后评估及免疫治疗的预测... 详细信息

目的:研究卵巢癌转移相关分子亚型和肿瘤微环境(TME)细胞浸润。方法:通过四个GEO数据集筛选转移相关基因,并以此在TCGA队列中探索转移相关分子亚型,以及相关的TME细胞浸润。使用Lasso回归构建预后模型,检测对预后评估及免疫治疗的预测作用。结果:在TCGA队列中鉴定出三类转移相关亚型,具有不同的预后。TME细胞浸润分析揭示了3种亚型的免疫异质性。建立含14个基因的预后模型,可预测预后及免疫治疗效果。结论:该模型所得转移评分是一种有前景的生物标志物,对确定卵巢癌患者的预后、TME细胞浸润特征和免疫治疗效果具有重要意义。

关键词：转移卵巢癌肿瘤微环境免疫治疗分子亚型

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Iron-catalyzed benzylation of 1,3-dicarbonyl compounds by simple toluene derivatives

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Chinese Science Bulletin 2012年第19期57卷 2382-2386页

作者： PAN ShiGuang liU jinhua li YuanMing li ZhiPing department of Chemistry Renmin University of ChinaBeijing 100872China

An iron-catalyzed oxidative C-C bond formation by the reactions of simple toluene derivatives with 1,3-dicarbonyl compounds is developed.A benzylic radical addition to a benzoylmethanato iron species is proposed for t... 详细信息

关键词：二羰基化合物苯衍生物催化氧化苄基铁自由基

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全员参与学生发展性心理辅导研究

心理科学 2002年第6期25卷 697-701页

作者：边玉芳李绍才祝新华浙江大学教育系金华市江滨小学金华320017 香港大学教育学院

本研究借鉴美国、英国和我国香港地区的一些实践经验 ,力图发展和形成一种具有综合性的集体心理辅导模式 ,即学校教师全员参与学生的发展性心理辅导。研究提出了辅导模式的基本理念、操作步骤及主要内容 ,并采用教育实验的方法在金华南... 详细信息

本研究借鉴美国、英国和我国香港地区的一些实践经验 ,力图发展和形成一种具有综合性的集体心理辅导模式 ,即学校教师全员参与学生的发展性心理辅导。研究提出了辅导模式的基本理念、操作步骤及主要内容 ,并采用教育实验的方法在金华南苑小学进行了实证研究 ,结果证明该模式有助于提高学生的心理健康水平 ,能促进学生更好地发展。

关键词：集体心理辅导发展性心理辅导阿肯巴克儿童行为量表辅导模式教育实验学生心理健康