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Nano Research 2024年第6期17卷 5087-5094页

作者： Chenhao Xiao Yaxiao Guo jiayuan sun Tao Guo Xinyuan Jia Shinuo Guo Guancheng Wu Yue sun Zhaoyang Yao Yi Liu State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China Key Laboratory of Functional Polymer Materials College of ChemistryNankai UniversityTianjin 300071China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Electrocatalytic nitrate reduction to ammonia(NO3−RR)for removing nitrate from wastewater is a promising but challengeable technology that is increasingly ***,we developed an efficient CuO_(x)and CoCuO_(x)composed hybrid catalyst(CoCuO_(x)@CuO_(x)/copper foam(CF)),characteristic of distinctive shell-core nanowires grown on CF substrate with CuO_(x)core and CoCuO_(x)*** built-in electric field formed at the interface of the CoO/Cu_(2)O heterostructure promotes NO3−adsorption by modulating the charge distribution at the interface,which greatly improves the ammonia yield rate and Faradaic ***−0.2 V *** hydrogen electrode(RHE),CoCuO_(x)@CuO_(x)/CF achieves not only an excellent ammonia yield rate of up to 519.1μg·h^(−1)·cm^(−2)and Faradaic efficiency of 99.83%at 1 mM NO3−concentration,but also excellent mechanical *** study provides a novel pathway to design electrocatalyst for the removal of nitrate from dilute nitric acid solutions(≤2 mM).

关键词： CoCuO_(x)@CuO_(x)/copper foam(CF) shell-core nanowires heterostructure low concentration nitrate electroreduction to ammonia

Interventional pulmonology for chronic inflammatory airway diseases

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 171-181页

作者： Han Yang Si Chen jiayuan sun Felix J.F.Herth Department of Respiratory and Critical Care Medicine Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Respiratory Endoscopy Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Engineering Research Center of Respiratory Endoscopy Shanghai 200030China Pneumology and Critical Care Medicine ThoraxklinikUniversity of HeidelbergHeidelberg 69126Germany Translational Lung Research Center Heidelberg German Center for Lung ResearchHeidelberg 69126Germany

Chronic inflammatory airway diseases,such as chronic bronchitis,chronic obstructive pulmonary disease,emphysema,and bronchial asthma,pose significant healthcare *** treatments offer promise as valuable complements to the optimal medical therapy recommended by the Global Initiative for Chronic Obstructive Lung Disease guideline and the Global Initiative for Asthma *** directly accessing the airways,these minimally invasive procedures enable precise *** encompass a wide range of techniques including bronchial thermoplasty and targeted lung denervation for both chronic obstructive pulmonary disease and severe asthma,bronchoscopic lung volume reduction(including the use of endobronchial valves,coils,and bronchoscopic thermal vapor ablation),airway bypass and peripheral stent placement for emphysema,bronchial rheoplasty and spray cryotherapy for chronic bronchitis,and other emerging *** interventional treatments aim to improve patients’symptoms by reducing lung volume,alleviating hyperinflation,eliminating vagal innervation,disrupting hyperplastic goblet cells and thus reducing excessive mucus secretion,and weakening submucosal smooth *** review highlights the potential advantages of interventional treatments for chronic inflammatory airway diseases and discusses relevant techniques tailored to specific disease *** overall aim is to assist interventional pulmonologists in selecting the most appropriate techniques for individual patients.

关键词： Chronic inflammatory airway disease Chronic obstructive pulmonary disease Asthma Emphysema Bronchoscopic lung volume reduction Targeted lung denervation

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重视肺外周病变经支气管诊断技术

中华结核和呼吸杂志 2021年第12期44卷 1040-1042页

作者：孙加源上海市胸科医院上海交通大学附属胸科医院 200030

经支气管诊断技术作为肺外周病变的主要诊断方式之一,具有较高安全性。传统经支气管诊断技术的诊断率较低,使其应用受限。引导支气管镜技术的出现提高了其诊断效能,推动了这一技术的应用。随着肺部磨玻璃结节和实性小结节检出率的不断增... 详细信息

经支气管诊断技术作为肺外周病变的主要诊断方式之一,具有较高安全性。传统经支气管诊断技术的诊断率较低,使其应用受限。引导支气管镜技术的出现提高了其诊断效能,推动了这一技术的应用。随着肺部磨玻璃结节和实性小结节检出率的不断增高,对经支气管诊断技术也提出了更高的要求。因此,从事支气管镜诊疗操作的呼吸科医生要重视肺外周病变经支气管诊断技术。

关键词：肺外周病变支气管镜诊疗操作诊断技术诊断效能诊断率肺部磨玻璃结节诊断方式

Learning curve of a robotic-assisted bronchoscopy system in sampling peripheral pulmonary nodules

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Chinese Medical Journal 2022年第22期135卷 2753-2755页

作者： Fangfang Xie Qin Zhang Shuaiyang Liu Lijun Yan Yongzheng Zhou jiayuan sun Department of Respiratory Endoscopy Department of Respiratory and Critical Care MedicineShanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Engineering Research Center of Respiratory Endoscopy Shanghai 200030China

To the Editor:Computed tomography(CT)has been used for the screening of lung cancer in high-risk populations,with a subsequent reduction in lung cancer-related mortality.[1]However,it has also resulted in a considerab... 详细信息

关键词： lung mortality cancer

Robotic-assisted bronchoscopy in the diagnosis of peripheral pulmonary lesions

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第1期1卷 30-35页

作者： Fangfang Xie Ajay Wagh Ruolan Wu DKyle Hogarth jiayuan sun Department of Respiratory Endoscopy Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Department of Respiratory and Critical Care Medicine Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Engineering Research Center of Respiratory Endoscopy Shanghai 200030China Department of Medicine Section of Pulmonary and Critical Care MedicineUniversity of ChicagoChicagoIL 60637USA Shanghai Jiao Tong University School of Medicine Shanghai 200001China

More peripheral pulmonary lesions(PPLs)are detected by low-dose helical computed tomography(CT)either in-cidentally or via dedicated lung cancer screening ***,using methods for safe and accurate diagnosis of these lesions has become increasingly *** needle aspiration(TTNA)and transbronchial lung biopsy(TBLB)are routinely performed during the diagnostic workup for ***,TTNA often car-ries the risk of pneumothorax,uncontrollable airway hemorrhage,and does not allow mediastinal staging in one *** contrast,traditional TBLB often has a poorer diagnostic yield despite fewer *** the ongoing development of technology applied to bronchoscopy,guided bronchoscopy has become widely used and the diagnostic yield of TBLB has ***,guided bronchoscopy continues to demonstrate a better safety profile than *** recent years,robotic-assisted bronchoscopy(RAB)has been introduced and imple-mented in the diagnosis of *** present,RAB has two platforms that are commercially available:Monarch TM and Ion TM;several other platforms are under *** systems differ in characteristics,advantages,and limitations and offer features not seen in previous guided *** studies,including cadaveric model studies and clinical trials,have been conducted to examine the feasibility and performance of RAB using these two systems;large multicenter studies are *** this review,published experimental results,focus-ing on diagnostic yield and complications of RAB,are analyzed and the potential clinical application of RAB is discussed,which will enable the operators to have a clear overview of RAB.

关键词： Robotic-assisted bronchoscopy Guided bronchoscopy Lung cancer Peripheral pulmonary lesions Diagnosis

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重视多发肺结节的适度诊疗

中华预防医学杂志 2023年第8期57卷 1181-1185页

作者：崔宁心叶霖孙加源上海交通大学医学院附属胸科医院呼吸内镜中心上海200030 上海交通大学医学院附属胸科医院呼吸与危重症医学科上海200030

随着胸部计算机断层扫描检查在体检项目中的普及,多发肺结节的检出率明显增加,但目前尚无专门针对多发肺结节的诊治指南和共识,这类患者的临床诊治常常存在不足和过度问题。因此,重视多发肺结节的适度诊疗,制订统一的临床实践标准,对肺... 详细信息

随着胸部计算机断层扫描检查在体检项目中的普及,多发肺结节的检出率明显增加,但目前尚无专门针对多发肺结节的诊治指南和共识,这类患者的临床诊治常常存在不足和过度问题。因此,重视多发肺结节的适度诊疗,制订统一的临床实践标准,对肺癌的预防和多发肺结节的诊治具有重要的临床意义。

关键词：癌症筛查肺癌预防多发肺结节多原发肺癌适度诊疗

呼吸内镜技术在慢性阻塞性肺疾病治疗中的应用进展

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中国呼吸与危重监护杂志 2021年第4期20卷 289-293页

作者：顾川佳孙加源上海交通大学附属胸科医院呼吸内镜中心呼吸与危重症医学科上海200030

慢性阻塞性肺疾病(简称慢阻肺)的发病率及死亡率逐年升高,已成为我国最为常见、疾病负担最为严重的慢性疾病种类之一。根据全国性流行病学最新调查结果,我国20岁以上人群慢阻肺患病率已达到8.6%[1]。然而,与其严重的疾病负担相比,我国... 详细信息

慢性阻塞性肺疾病(简称慢阻肺)的发病率及死亡率逐年升高,已成为我国最为常见、疾病负担最为严重的慢性疾病种类之一。根据全国性流行病学最新调查结果,我国20岁以上人群慢阻肺患病率已达到8.6%[1]。然而,与其严重的疾病负担相比,我国慢阻肺的治疗现状不容乐观,除药物治疗外,其他治疗手段有限。随着近年来呼吸内镜技术的不断发展和推陈出新,微创呼吸介入治疗方法因其创伤小、恢复快等优势逐渐成为慢阻肺治疗中的一道曙光,给广大患者带来新的希望。本文将就呼吸内镜技术在慢阻肺治疗的应用进展进行一个简单的梳理。

关键词：疾病负担慢性阻塞性肺疾病慢阻肺呼吸内镜流行病学慢性疾病药物治疗治疗现状

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稠油热采辅助剂的试验研究

石油钻采工艺 2004年第B10期26卷 28-29页

作者：孙加元辽河油田公司钻采工艺研究院辽宁盘锦124010

蒸汽吞吐是辽河油田稠油开采的重要方式,针对有些蒸汽吞吐区块存在综合含水上升较快、油层近井地带污染严重、综合吞吐效果差等问题,进行了稠油热采辅助剂的试验性研究。系统分析了油藏物性和油层流体性质在注汽开采过程中的变化情况,... 详细信息

蒸汽吞吐是辽河油田稠油开采的重要方式,针对有些蒸汽吞吐区块存在综合含水上升较快、油层近井地带污染严重、综合吞吐效果差等问题,进行了稠油热采辅助剂的试验性研究。系统分析了油藏物性和油层流体性质在注汽开采过程中的变化情况,对蒸汽添加剂进行了配伍性试验、物理分散溶解性能试验、提高蒸汽驱油率试验、原油降黏性能评价等。试验结果表明,该辅助剂能与原油高效反应,有效改善原油界面性质,改善油层岩石润湿状况。

关键词：稠油热采油层蒸汽吞吐原油黏度近井地带蒸汽驱油注汽辅助剂分散含水

电磁导航支气管镜系统在呼吸系统疾病诊治中的应用现状与展望

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中国癌症杂志 2015年第10期25卷 832-837页

作者：孙加源韩宝惠陈海泉上海交通大学附属胸科医院内镜科上海200030 上海交通大学附属胸科医院呼吸科上海200030 上海交通大学附属胸科医院胸外科上海200030

支气管镜为获取肺外周病变(peripheral pulmonary lesions,PPL)的一种微创技术。传统支气管镜引导的经支气管肺活检(transbronchial lung biopsy,TBLB)在X线透视指导下进行,诊断率相对较低。电磁导航支气管镜(electromagnetic navigation bronchoscopy,ENB)是近年来出现的一项新的微创诊断技术。其对PPL诊断率优于传统经支气管镜。多项研究已显示出ENB诊断PPL具有的可行性和安全性,并且显示出ENB在PP定位和治疗领域具有潜在的应用前景。该文就这一技术临床应用现状作一综述。

关键词：支气管镜电磁导航诊断肺外周病变

支气管内超声引导下经支气管针吸活检诊断胸内结核

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中华胸心血管外科杂志 2014年第11期30卷 653-656页

作者：孙加源滕家俊钟润波李志夫张杰赵珩韩宝惠上海交通大学附属胸科医院内镜室 200030 上海交通大学附属胸科医院呼吸内科 200030 上海交通大学附属胸科医院检验科 200030 上海交通大学附属胸科医院病理科 200030 上海交通大学附属胸科医院胸外科 200030

目的评价支气管内超声引导下经支气管针吸活检（EBUS-TBNA）对胸内结核的诊断价值.方法回顾性分析2009年10月至2013年3月上海市胸科医院行EBUS-TBNA检查,最终确诊为胸内结核患者的资料,观察EBUS-TBNA对胸内结核病理学和微生物学诊断... 详细信息

目的评价支气管内超声引导下经支气管针吸活检（EBUS-TBNA）对胸内结核的诊断价值.方法回顾性分析2009年10月至2013年3月上海市胸科医院行EBUS-TBNA检查,最终确诊为胸内结核患者的资料,观察EBUS-TBNA对胸内结核病理学和微生物学诊断效果和安全性.结果 75例患者确诊为胸内淋巴结结核或肺结核,EBUS-TBNA诊断率为80％（60/75）,其中完整行EBUS-TBNA病理、抗酸染色和分支杆菌培养检查的60例患者中,EBUS-TBNA诊断52例,诊断率86.67％;病理发现支持结核诊断者77.33％（58/75）,抗酸染色涂片阳性率20.31％（13/64）,培养阳性率46.67％（28/60）;75例患者穿刺淋巴结129组,肺内肿块10个,平均1.85组（个）/例,病理显示结核表现者66.19％（92/139）,抗酸染色涂片阳性率13.91％（16/115）,培养阳性率38.32％（41/107）.多因素回归分析发现阳性病理、涂片、培养均与病灶的短径大小呈正相关,阳性病理又与穿刺次数呈正相关,病理显示坏死和抗酸染色涂片阳性者的培养阳性率更高.结论 EBUS-TBNA是诊断胸内结核的一种安全、有效方法.

关键词：支气管内超声经支气管针吸活检结核