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Construction of algal-bacterial consortia using green microalgae Chlorella vulgaris and As(Ⅲ)-oxidizing bacteria:As tolerance and metabolomic profiling

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Journal of Environmental Sciences 2024年第5期139卷 258-266页

作者： Xiaoman He Guobing Lin jiayuan zeng Zhaoguang Yang Lin Wang College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Central South UniversityChangsha 410083China

Bioremediation became a promising technology to resolve arsenic(As)contamination in aquatic environment.Since monoculture such as microalgae or bacteria was sensitive to environmental disturbance and vulnerable to contamination,green microalgae Chlorella vulgaris and arsenite(As(Ⅲ))-oxidizing bacteria Pseudomonas sp.SMS11 were co-cultured to construct algal-bacterial consortia in the current study.The effects of algae-bacteria(A:B)ratio and exposure As(Ⅲ)concentration on algal growth,As speciation and metabolomic profile were investigated.Algal growth arrested when treated with 100 mg/L As(Ⅲ)without the co-cultured bacteria.By contrast,co-cultured with strain SMS11 significantly enhanced As tolerance in C.vulgaris especially with A:B ratio of 1:10.All the As(Ⅲ)in culture media of the consortia were oxidized into As(Ⅴ)on day 7.Methylation of As was observed on day 14.Over 1% and 0.5% of total As were converted into dimethylarsinic acid(DMA)after 21days cultivation when the initial concentrations of As(Ⅲ)were 1 and 10 mg/L,respectively.Metabolomic analysis was further performed to reveal the response of consortia metabolites to external As(Ⅲ).The enriched metabolomic pathways were associated with carbohydrate,amino acid and energy metabolisms.Tricarboxylic acid cycle and glyoxylate and dicarboxylate metabolism were upregulated under As stress due to their biological functions on alleviating oxidative stress and protecting cells.Both carbohydrate and amino acid metabolisms provided precursors and potential substrates for energy production and cell protection under abiotic stress.Alterations of the pathways relevant to carbohydrate or amino acid metabolism were triggered by energy requirement.

关键词： Microalgae Algal-bacterial consortia As(Ⅲ)-oxidizing bacteria Metabolomics Energy metabolism

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Ionome profiling and arsenic speciation provide evidence of arsenite detoxification in rice by phosphate and arsenite-oxidizing bacteria

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Journal of Environmental Sciences 2023年第6期128卷 129-138页

作者： Guobing Lin Xiaoman He jiayuan zeng Zhaoguang Yang Lin Wang College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Central South UniversityChangsha 410083China

Arsenite(As(III))as the most toxic and mobile form is the dominant arsenic(As)species in flooded paddy fields,resulting in higher accumulation of As in paddy rice than other terrestrial crops.Mitigation of As toxicity to rice plant is an important way to safeguard food production and safety.In the current study,As(III)-oxidizing bacteria Pseudomonas sp.strain SMS11 was inoculated with rice plants to accelerate conversion of As(III)into lower toxic arsenate(As(V)).Meanwhile,additional phosphate was supplemented to restrict As(V)uptake by the rice plants.Growth of rice plant was significantly inhibited under As(III)stress.The inhibition was alleviated by the introduction of additional P and SMS11.Arsenic speciation showed that additional P restricted As accumulation in the rice roots via competing common uptake pathways,while inoculation with SMS11 limited As translocation from root to shoot.Ionomic profiling revealed specific characteristics of the rice tissue samples from different treatment groups.Compared to the roots,ionomes of the rice shoots were more sensitive to environmental perturbations.Both extraneous P and As(III)-oxidizing bacteria SMS11 could alleviate As(III)stress to the rice plants through promoting growth and regulating ionome homeostasis.

关键词： As(III)-oxidizing bacteria Ionomics Ionome homeostasis Paddy rice Stress alleviation

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Review of intelligent diagnosis methods for imaging gland cancer based on machine learning

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Virtual Reality & Intelligent Hardware 2023年第4期5卷 293-316页

作者： Han JIANG Wenjia SUN Hanfei GUO jiayuan zeng Xin XUE Shuai LI State key Laboratoty of Virtual Reality Technogy and Systems Beihang UniversityBeijing 100083China

Gland cancer is a high-incidence disease that endangers human health,and its early detection and treatment require efficient,accurate,and objective intelligent diagnosis methods.In recent years,the advent of machine learning techniques has yielded satisfactory results in intelligent gland cancer diagnosis based on clinical images,significantly improving the accuracy and efficiency of medical image interpretation while reducing the workload of doctors.The focus of this study is to review,classify,and analyze intelligent diagnosis methods for imaging gland cancer based on machine learning and deep learning.This paper briefly introduces some basic imaging principles of multimodal medical images,such as the commonly used computed tomography(CT),magnetic resonance imaging(MRI),ultrasound(US),positron emission tomography(PET),and pathology.In addition,the intelligent diagnosis methods for imaging gland cancer were further classified into supervised learning and weakly supervised learning.Supervised learning consists of traditional machine learning methods,such as K-nearest neighbor algorithm(KNN),support vector machine(SVM),and multilayer perceptron,and deep learning methods evolving from convolutional neural network(CNN).By contrast,weakly supervised learning can be further categorized into active learning,semisupervised learning,and transfer learning.State-of-the-art methods are illustrated with implementation details,including image segmentation,feature extraction,and optimization of classifiers.Their performances are evaluated through indicators,such as accuracy,precision,and sensitivity.In conclusion,the challenges and development trends of intelligent diagnosis methods for imaging gland cancer were addressed and discussed.

关键词： Gland cancer Intelligent diagnosis Machine learning Deep learning Multimodal medical images

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预浓缩-GC-MS/FID同时测定环境空气中104种挥发性有机物

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山西化工 2024年第1期44卷 59-61页

作者：张晓淳曾家源张颖姬高缨红广东省中山生态环境监测站广东中山528400

建立了预浓缩-GC-MS/FID双检测器同时测定环境空气中104种挥发性有机物(VOCs)的分析方法。利用中心切割,将C2~C3低沸点组分与其他组分切割到不同极性色谱柱分离,分别用FID和MS检测,提高了低碳组分的分析灵敏度。方法线性良好,相关系数... 详细信息

建立了预浓缩-GC-MS/FID双检测器同时测定环境空气中104种挥发性有机物(VOCs)的分析方法。利用中心切割,将C2~C3低沸点组分与其他组分切割到不同极性色谱柱分离,分别用FID和MS检测,提高了低碳组分的分析灵敏度。方法线性良好,相关系数均大于0.99,检出限为0.01×10^(-9)~0.12×10^(-9),RSD为0.5%~15.6%,加标回收率为83.4%~106%。

关键词：预浓缩 GC-MS/FID 挥发性有机物

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Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1359-1388页

作者： Qian Zhou Yu Meng Daishi Li Lei Yao jiayuan Le Yihuang Liu Yuming Sun Furong zeng Xiang Chen Guangtong Deng Department of Dermatology Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Furong Laboratory 87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya Hospital87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of General Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Plastic and Cosmetic Surgery Xiangya HospitalCentral South University87 Xiangya RoadChangsha 410008 Hunan ProvinceChina Department of Oncology Xiangya HospitalCentral South University87Xiangya RoadChangsha 410008Hunan ProvinceChina

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membranelocalized lipid peroxides.It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors.Intriguingly,mesenchymal and dedifferentiated cancer cells,which are usually resistant to apoptosis and traditional therapies,are exquisitely vulnerable to ferroptosis,further underscoring its potential as a treatment approach for cancers,especially for refractory cancers.However,the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor cells.Ferroptosis induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer immunity.Thus,a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical applications.In this review,we provide an overview of the recent advancements in understanding ferroptosis in cancer,covering molecular mechanisms,biological functions,regulatory pathways,and interactions with the tumor microenvironment.We also summarize the potential applications of ferroptosis induction in immunotherapy,radiotherapy,and systemic therapy,as well as ferroptosis inhibition for cancer treatment in various conditions.We finally discuss ferroptosis markers,the current challenges and future directions of ferroptosis in the treatment of cancer.

关键词： cancer mechanisms treatment

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基于广义意见动态模型的社交信任网络意见最大化问题

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上海理工大学学报 2023年第2期45卷 198-204页

作者：曾佳媛张广上海理工大学理学院上海200093 上海理工大学管理学院上海200093

提出了一种广义意见动态模型(GODM),此模型可以通过动态计算每个人的表达意见来解决社交信任网络中的意见最大化问题。在模型中提出了一个新的、合理的、可解释的自信指数αi,αi由个人的社会地位与其周围人的评价共同决定。并且利用对... 详细信息

提出了一种广义意见动态模型(GODM),此模型可以通过动态计算每个人的表达意见来解决社交信任网络中的意见最大化问题。在模型中提出了一个新的、合理的、可解释的自信指数αi,αi由个人的社会地位与其周围人的评价共同决定。并且利用对角占优理论,得到模型达到纳什均衡状态时的最优解析解。设计了一种具有l1形式的交替方向乘子法来最大化现有的总体意见。进行了一系列实验,实验结果表明,此方法在4个数据集上都有较好的结果。在4个数据集上,解决内部意见问题的平均效益分别提升了66.4%,88.7%,47.8%和34.1%。实验结果充分验证了所提模型的优越性。

关键词：意见最大化社交信任网络自信指数有限预算

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye Yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu Xing jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

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中山市石歧河喹诺酮类抗生素污染特征研究

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山西化工 2023年第8期43卷 204-206页

作者：陈弘丽张晓淳曾家源广东省中山生态环境监测站广东中山528400

本文选取石歧河水体作为研究对象,采用超高效液相色谱-三重四级杆质谱法分析河水中典型抗生素喹诺酮类的污染特征。结果表明,石歧河水体中喹诺酮类抗生素以克林沙星、噁喹酸为主,其检出率均为100%;喹诺酮类抗生素质量浓度范围为9.56~348... 详细信息

本文选取石歧河水体作为研究对象,采用超高效液相色谱-三重四级杆质谱法分析河水中典型抗生素喹诺酮类的污染特征。结果表明,石歧河水体中喹诺酮类抗生素以克林沙星、噁喹酸为主,其检出率均为100%;喹诺酮类抗生素质量浓度范围为9.56~348.44 ng/L;就空间分布而言,喹诺酮类抗生素浓度在17#最高(348.44 ng/L),而在1#最低(9.56 ng/L)。

关键词：河水喹诺酮类抗生素污染特征

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英德野生茶树叶片表型性状的遗传多样性分析

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热带亚热带植物学报 2024年第2期32卷 219-228页

作者：郑佳嫄谢曼卫曾贞黄亚辉晏嫦妤华南农业大学园艺学院广州510642

为了解英德野生茶树的叶片表型性状的遗传多样性及进化特点,对英德89份野生茶树资源的表型性状的变异系数、遗传多样性指数、表型分化系数进行分析。结果表明,89份资源的18项叶片性状的变异系数为12.90%~43.11%,平均27.86%;平均遗传多... 详细信息

为了解英德野生茶树的叶片表型性状的遗传多样性及进化特点,对英德89份野生茶树资源的表型性状的变异系数、遗传多样性指数、表型分化系数进行分析。结果表明,89份资源的18项叶片性状的变异系数为12.90%~43.11%,平均27.86%;平均遗传多样性指数为1.12,表型分化系数为17.07%~45.51%,平均33.40%。聚类分析结果表明,当欧氏距离为21.5时,所有材料可分为4大类,分类结果与地域分布有一定相关性。巢氏方差分析表明,在不同种群间和种群内,数量性状均有极显著差异。相关性分析表明,叶长与叶宽、叶面积、叶脉对数、叶长宽比、叶形呈极显著相关;叶形与叶长宽比、叶脉对数之间呈极显著相关;叶基与叶宽之间呈极显著相关;叶长宽比与叶尖、着生状态呈极显著负相关。因此,英德野生茶树资源存在丰富的遗传多样性,茶树种质资源类型原始型、进化型以及中间类型并存,但以中间类型和进化型为主。

关键词：野生茶树叶片形态学表型性状遗传多样性

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超声弹性成像技术与常规超声在前列腺癌和前列腺增生诊断中的应用对比研究

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中国男科学杂志 2016年第1期30卷 25-29页

作者：娄小嫣曾家元张名均重庆市九龙坡区第一人民医院重庆400050

目的探寻早期诊断前列腺癌的方法。方法应用超声弹性成像(UE)技术,对56例前列腺增生伴PSA增高或正常患者,同时行经直肠前列腺二维超声及UE检查,比较普通经直肠超声检查联合PSA与UE联合PSA对前列腺癌诊断的敏感性和特异性。结果以穿刺活... 详细信息

目的探寻早期诊断前列腺癌的方法。方法应用超声弹性成像(UE)技术,对56例前列腺增生伴PSA增高或正常患者,同时行经直肠前列腺二维超声及UE检查,比较普通经直肠超声检查联合PSA与UE联合PSA对前列腺癌诊断的敏感性和特异性。结果以穿刺活检为判断前列腺癌的标准,UE联合PSA无论是敏感性(75.0%)、特异性(85.0%)和符合率(82.1%)均高于普通经直肠超声检查联合PSA敏感性(62.5%)、特异性(15.0%)和符合率(28.6%),差异具统计学意义(P<0.05)。结论 UE无痛无创,简便易行,其与PSA相结合对前列腺癌的诊断,比经直肠超声检查联合PSA更具有临床价值,值得推广。

关键词：前列腺肿瘤前列腺增生弹性成像技术

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