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Enhancing osteogenic bioactivities of coaxial electrospinning nanoscaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration

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Nano Research 2024年第7期17卷 6430-6442页

作者： Peng wang Qianjin wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai wang jiayu Gu Hao Wu Zhihong Xu Qing Jiang School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Center of Modem Analysis Nanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China Co-Innovation Center for Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Jiangsu Institute of Metrology Nanjing 210023China

Bone tissue engineering provides a promising strategy for the treatment of bone ***,the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical strength and absence of osteo-inductive ***,we proposed to endow nano-scaffold(NS)constructed by coaxial electrospinning technique with enhanced osteogenic bioactivities and mechanical properties by incorporating biocompatible magnetic iron oxide nanoparticles(IONPs)and icaritin(ICA).Four types of nano-scaffolds(NS,ICA@NS,NS-IONPs and ICA@NS-IONPs)were *** incorporation of ICA and IONPs minimally impact their surface morphological and chemical *** enhanced the mechanical properties of NS scaffolds,including hardness,tensile strength,and elastic *** vitro assessments demonstrated that ICA@NS-IONPs exhibited enhanced osteogenic bioactivities towards mouse calvarial pre-osteoblast cell line MC3T3-E1 as evidenced by detecting the alkaline phosphatase(ALP)activity level,expressions of osteogenesis-related genes and proteins as well as mineralized nodule *** investigations revealed that MEK/ERK(MAP kinase-ERK kinase(MEK)/extracellularsignal-regulated kinase(ERK))signaling pathway could offer a plausible explanation for the osteogenic differentiation of MC3T3-E1 cells induced by ICA@***,the implantation of nano-scaffolds in rat skull defects exhibited a substantial improvement in in vivo bone ***,IONPs and ICA incorporated coaxial electrospinning nano-scaffolds present a novel strategy for the optimization of scaffolds for bone tissue engineering.

关键词： iron oxide nanoparticles icaritin coaxial electrospinning nano-scaffolds MEK/ERK signaling pathway bone regeneration

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Dynamics of an impurity ion transport in oil-paper insulation under various electric fields

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High Voltage 2024年第1期9卷 66-80页

作者： Yuanyang Ren Yang wang Qiankai Zhang jiayu Xiong Wen Cao Zepeng Lv Kai Wu State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina School of Electronics and Information Xi'an Polytechnic UniversityXi'anChina State Grid Sichuan Electric Power Research Institute ChengduChina

The ionic transport process is an important counterpart to charge transport in oil-paper insulation,and it significantly impacts oil flow electrification at the oil-paper *** this,the dynamics of this phenomenon and the underlying mechanisms remain unclear,particularly at the molecular *** understand this fundamental aspect,we conduct Molecular Dynamics study on the transport behaviour of an impurity ion in different oil-paper insulation models under various external electric *** influence factors,such as external electric fields,temperatures,and local structural characteristics,are investigated in relation to the corresponding ionic mobility in different polymer *** to the simulations,ionic mobility and its response to electric fields are higher in weaker electrostatic *** a result,mineral oil exhibits the highest ionic mobility and the most substantial enhancement of ionic mobility by external electric fields,followed by vegetable oil,oil-paper blends,and insulating *** significant deviation in ionic mobility between oil and paper leads to the formation of an electric double layer near the oil-paper *** underlying physical mechanisms of different ionic mobility and its response to the electric field in different polymer models could be explained by the different polymer structural influences in terms of interaction energy and coordination numbers in a static manner,as well as by the interactions between the impurity ion and its surrounding atoms in terms of lifetime correlation functions and velocity autocorrelation functions in a dynamic *** addition,the influence of temperature on ionic mobility in mineral and vegetable oil is examined,and their activation energies are *** in the fundamental understanding of the dynamics of the ion transport process in oil-paper insulation is vital to improving their insulating properties for oil-impregnated power transformers.

关键词： insulation transport fields

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Dose-dense paclitaxel plus carboplatin *** and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer

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Chinese Journal of Cancer Research 2020年第4期32卷 485-496页

作者： Qing Li Jiani wang Yuxin Mu Tongtong Zhang Ying Han jiayu wang Qiao Li Yang Luo Fei Ma Ying Fan Pin Zhang Binghe Xulj Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The objective of this open-label,randomized study was to compare dose-dense paclitaxel plus carboplatin(PCdd)with dose-dense epirubicin and cyclophosphamide followed by paclitaxel(ECdd-P)as an adjuvant chemotherapy for early triple-negative breast cancer(TNBC).Methods:We included Chinese patients with high recurrence risk TNBC who underwent primary breast cancer *** were randomly assigned to receive PCdd[paclitaxel 150 mg/m2 on d 1 and carboplatin,the area under the curve,(AUC)=3 on d 2]or ECdd-P(epirubicin 80 mg/m2 divided in 2 d and cyclophosphamide 600 mg/m2 on d 1 for 4 cycles followed by paclitaxel 175 mg/m2 on d 1 for 4 cycles)every 2 weeks with granulocyte colony-stimulating factor(G-CSF)*** primary endpoint was 3-year disease-free survival(DFS);the secondary endpoints were overall survival(OS)and ***:The intent-to-treat population included 143 patients(70 in the PCdd arm and 73 in the ECdd-P arm).Compared with the ECdd-P arm,the PCdd arm had significantly higher 3-year DFS[93.9%vs.79.1%;hazard ratio(HR)=0.310;95%confidence interval(95%CI),0.137-0.704;log-rank,P=0.005]and OS(98.5%vs.92.9%;HR=0.142;95%CI,0.060-0.825;log-rank,P=0.028).Worse neutropenia(grade 3/4)was found in the ECdd-P than the PCdd arm(47.9%V5.21.4%,P=0.001).Conclusions:PCdd was superior to ECdd-P as an adjuvant chemotherapy for early TNBC with respect to improving the 3-year DFS and *** also yielded lower hematological ***,PCdd might be a preferred regimen for early TNBC patients with a high recurrence risk.

关键词： Triple-negative breast cancer dose-dense adjuvant chemotherapy carboplatin paclitaxel

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Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer

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Cancer Biology & Medicine 2021年第3期18卷 849-859页

作者： Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao jiayu wang Yang Luo Fei Ma Binghe Xu Peng Yuan Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Nanjing Geneseeq Technology Inc. Nanjing 210032China Cancer Hospital of Huanxing Chaoyang District Beijing Beijing 100021China

Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking *** study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast ***:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were *** was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity ***,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment *** primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and ***:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)*** median follow-up time was 10.5 *** ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 *** changes in the detectable ct DNA variant allele frequency were consistent with the tumor *** most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast *** dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response.

关键词： Anlotinib angiogenesis HER2-negative breast cancer ct DNA

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Enhanced photocatalytic nitrogen fixation performance via in situ constructing BiO_(2-x)/NaNbO_(3) heterojunction

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Chinese Journal of Chemical Engineering 2024年第5期69卷 92-100页

作者： jiayu Zhang Zhihao Zeng Lin Yue Chunran Zhao Xin Hu Leihong Zhao Xiuwen wang Yiming He Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China Heilongjiang Provincial Key Laboratory of Surface Active Agent and Auxiliary School of Chemistry and Chemistry EngineeringQiqihar UniversityQiqihar 161006China Department of Materials Science and Engineering Zhejiang Normal UniversityJinhua 321004China

The fabrication of heterojunction catalysts is an effective strategy to enhance charge separation efficiency,thereby boosting the performance of *** this study,BiO_(2-x)nanosheets were synthesized through a hydrothermal process and loaded onto NaNbO_(3) microcube to construct a series of BiO_(2-x)/NaNbO_(3) heterojunctions for photocatalytic N_(2) *** indicated that 2.5%BiO_(2-x)/NaNbO_(3) had the highest photocatalytic *** NH_(3) production rate under simulated solar light reached 406.4μmol·L^(-1)·g^(-1)·h^(-1),which reaches 2.6 and 3.8 times that of NaNbO_(3) and BiO_(2-x),***_(2-x)nanosheets primarily act as electron trappers to enhance the separation efficiency of charge *** strong interaction between BiO_(2-x)and NaNbO_(3) facilitates the electron migration between ***,the abundant oxygen vacancies in BiO_(2-x)nanosheets may facilitate the adsorption and activation of N_(2),which may be another possible reason of the high photocatalytic activity of the BiO_(2-x)/NaNbO_(3).This study may offer new insights for the development of semiconductor materials in photocatalytic nitrogen fixation.

关键词： Catalyst Solar energy Hydrothermal BiO_(2-x)/NaNbO_(3) Photocatalytic N_(2)-fixation

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Fracture behavior and mechanism of highly fragmented steel cylindrical shell under explosive loading

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Defence Technology（防务技术） 2024年第6期36卷 122-132页

作者： Kang wang Peng Chen Xingyun Sun Yufeng Liu jiayu Meng Xiaoyuan Li Xiongwei Zheng Chuan Xiao Xi'an Modern Chemistry Research Institute Xi'an 710065China Shanxi Jiangyang Chemical Company Limited Taiyuan 030051China Central Iron&Steel Research Institute Company Limited Beijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments *** study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery *** with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution *** fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high *** the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell *** the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical *** results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation.

关键词： Projectile fragmentation Fragment mass distribution Fracture mode Metallographic structure Damage power

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Enhancing photovoltaic performance via aggregation dynamics control in fused-ring electron acceptor

Aggregate

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Aggregate 2021年第3期2卷 1-8页

作者： jiayu wang Runyu Zhu Shijie wang Yawen Li Boyu Jia Jiadong Zhou Peiyao Xue Susanne Seibt Yuze Lin Zengqi Xie Wei Ma Xiaowei Zhan Department of Materials Science and Engineering College of EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationPeking UniversityBeijingChina State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’anChina Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingChina Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouChina Australian Synchrotron ClaytonVictoriaAustralia

A new fused-ring electron acceptor FNIC3 with dynamics controlled aggregation behavior was ***3 shows strong absorption in 600–900 nm,HOMO/LUMO energy levels of−5.59/−4.04 eV,and electron mobility of 1.2×10^(−3) cm^(2) V^(−1) s^(−1).The aggregation of FNIC3 shows strong dependency on film formation *** of film formation time promotes the crystallization of FNIC3,leading to improved crystallinity and enlarged aggregate *** of FNIC3 significantly influences the photovoltaic device *** aggregation red-shifts the absorption and improves the mobilities of the blend,which contributes to high photocurrent and fill factor thus high power conversion efficiency(PCE).Overaggregation leads to increased nonradiative energy loss and insufficient charge generation,resulting in decreased open-circuit voltage and short-circuit current *** blends based on PM6:FNIC3 fabricated under proper film formation time exhibit a PCE of 12.3%,higher than those fabricated under short and long film formation time(10.0–10.5%).

关键词： aggregation dynamics fused-ring electron acceptor nonfullerene acceptor organic solar cell

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Use of evergreen and deciduous plants by nocturnal-roosting birds:A case study in Beijing

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Avian Research 2024年第2期15卷 211-218页

作者： Yexi Zhao jiayu Zhang Zihan Li Qinmijia Xie Xin Deng Chenxi Zhang Nan wang School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China

With continually increasing urbanization,the land cover in urban areas continues to change,resulting in the loss of *** are highly sensitive to changes in *** forest birds perch on plants that provide increased safety to reduce the risk of predation,and small birds may also consider insulation when using roosting plants in winter because of cold *** plants thus shape the nocturnal roosting environment of urban birds,and proper planting is essential for the survival of birds at *** use of roosting plants by urban birds should therefore be studied to provide a reference for *** the current study,we observed 1865 nocturnal roosting birds in Beijing from 2021 to 2022,with 23 species of birds from 12 families and 45 species of plants from 22 families *** chinensis exhibited the highest bird rarity-weighted richness,followed by Fraxinus pennsylvanica,Phyllostachys propinqua,Pinus tabuliformis,and Ulmus *** diameter at breast height,tree height,and crown width of plants used by birds was largest in summer and smallest in winter,and the perch height of birds was the highest in spring and summer and the lowest in *** used the highest proportion of deciduous plants in summer and the highest proportion of evergreen plants in winter.A significant seasonal difference in the use of evergreen and deciduous plants by small birds was noted,with a preference for deciduous plants in summer and evergreen plants in winter,while this preference was not found in large *** findings indicate that evergreen plants provide a vital nocturnal roosting environment for small birds in *** provide a better nocturnal roosting habitat for urban birds,we recommend paying attention to the combination of evergreen and deciduous plants when carrying out landscape construction.

关键词： Nocturnal roosting Roosting plant Seasonal variation Urban bird

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高效液相色谱法测定枸橼酸芬太尼注射液有关物质含量

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中国药业 2024年第3期33卷 15-19页

作者：宋文涛曾令高高梓真王佳瑜冯旭许向阳江苏恩华药业股份有限公司药物研究院·江苏省中枢神经药物研究重点实验室江苏徐州221000 重庆市食品药品检验检测研究院·国家药品监督管理局麻醉精神药品质量监测重点实验室重庆401121

目的建立测定枸橼酸芬太尼注射液中有关物质含量的高效液相色谱(HPLC)法。方法色谱柱为Shim-packscepter C_(18)-120柱(150 mm×4.6 mm,5μm),流动相为0.01 mol/L氯化铵溶液-乙腈(950∶50,V/V)-0.01 mol/L氯化铵溶液-乙腈(400∶600,V/V),梯度洗脱,流速为1.0 mL/min,检测波长为210 nm,柱温为40℃,进样量为100μL。结果杂质Ⅰ、杂质Ⅱ、杂质Ⅲ、杂质Ⅺ的质量浓度分别在0.02~0.50μg/mL、0.02~0.50μg/mL、0.02~0.49μg/mL、0.02~0.50μg/mL范围内与峰面积线性关系良好(r>0.993);检测限分别为1.00,1.00,0.98,1.00 ng,定量限分别为2.01,2.00,1.97,2.01 ng;重复性试验结果各杂质的RSD均小于2.0%(n=6);中间精密度试验结果各杂质的RSD均小于3.0%(n=12);平均加样回收率分别为98.03%,100.04%,97.94%,101.03%,RSD分别为1.61%,1.09%,0.98%,1.36%(n=9);2种规格(各3批)的中试样品中各特定杂质及未知杂质的含量均小于0.05%(忽略限)。结论该方法操作简便,专属性强,灵敏度、耐用性好,准确度、精密度较高,各杂质分离度优于《中国药典》《英国药典》中的方法,可用于枸橼酸芬太尼注射液中有关物质的含量测定。拟订样品中含杂质Ⅰ、杂质Ⅱ和杂质Ⅺ不得过标示量的0.5%,最大未知杂质不得过0.2%,总未知杂质不得过0.75%。

关键词：高效液相色谱法枸橼酸芬太尼注射液有关物质含量测定

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Constructing osteo-inductive bio-ink for 3D printing through hybridization of gelatin with maleic acid modified bacterial cellulose by regulating addition volumes of maleic acid solution

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Journal of Bioresources and Bioproducts 2024年第3期9卷 336-350页

作者： Xucai wang Dengxian Wu Wei Liao Yaxuan Liu Wenhui Pei Jixian wang jiayu Gu Peng wang Kai Lan Caoxing Huang Co-Innovation Center for Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNahanjing 210008China Children's Hospital of Nanjing Medical University Nanjing 210008China Jiangsu Institute of Metrology Nanjing 210023China Department of Forest Biomaterials College of Natural ResourcesNorth Carolina State UniversityRaleigh NC 27695USA

Bacterial cellulose(BC)is an exopolysaccharide with unique properties that has been applied in various ***,the dense and intertwined nature of BC fibers limits its use in certain applications,including 3D printing scaffolds for bone *** this work,a controllable BC-based bio-ink for 3D printing was successfully prepared by modifying the neat BC through maleic acid(MA)treatment,aiming to promote bone tissue *** achieve homogeneous BC dispersions while preserving its crystalline and chemical properties,BC was modified by MA solution(60%,w/V)with solid-liquid ratio from 1꞉5 to 1꞉50(w/V)to obtain MA-BC *** analysis results from microstructure,chemical group,crystallinity,and wettability indicated that the BC/MA solution with ratio of 1꞉30 demonstrated the best pre-treatment performance to obtain ***,by combining MA-BC with gelatin,we successfully formulated MA-BC-GEL gels with favorable rheological properties and compression modulus,which can be used as promising bio-inks for 3D bioprinting *** vitro tests demonstrated 1꞉30 MA-BC possessed excellent biocompatibility,a significant ability to express the alkaline phosphatase gene and osteogenic-related genes,and facilitated the formation of mineralized *** utilization of this novel bio-ink in scaffold preparation for bone regeneration highlights the promising application of modified BC in bone tissue engineering field.

关键词： Bacterial cellulose Maleic acid Osteogenic activity Printability

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