Constructing osteo-inductive bio-ink for 3D printing through hybridization of gelatin with maleic acid modified bacterial cellulose by regulating addition volumes of maleic acid solution
作者机构：Co-Innovation Center for Efficient Processing and Utilization of Forest ResourcesCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Pharmaceutical BiotechnologyDepartment of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNahanjing 210008China Children's Hospital of Nanjing Medical UniversityNanjing 210008China Jiangsu Institute of MetrologyNanjing 210023China Department of Forest BiomaterialsCollege of Natural ResourcesNorth Carolina State UniversityRaleigh NC 27695USA
出 版 物：《Journal of Bioresources and Bioproducts》 (生物质资源与工程（英文）)
年 卷 期：2024年第9卷第3期
页 面：336-350页
核心收录：
学科分类：07[理学] 0822[工学-轻工技术与工程] 0701[理学-数学] 070101[理学-基础数学]
基 金：supported by National Basic Research Program of China(No.2021YFA1201404) National Natural Science Foundation of China(No.32271413) Science program of Jiangsu Province Administration for Market Regulation(No.KJ2024010)
主 题：Bacterial cellulose Maleic acid Osteogenic activity Printability
摘 要：Bacterial cellulose(BC)is an exopolysaccharide with unique properties that has been applied in various ***,the dense and intertwined nature of BC fibers limits its use in certain applications,including 3D printing scaffolds for bone *** this work,a controllable BC-based bio-ink for 3D printing was successfully prepared by modifying the neat BC through maleic acid(MA)treatment,aiming to promote bone tissue *** achieve homogeneous BC dispersions while preserving its crystalline and chemical properties,BC was modified by MA solution(60%,w/V)with solid-liquid ratio from 1꞉5 to 1꞉50(w/V)to obtain MA-BC *** analysis results from microstructure,chemical group,crystallinity,and wettability indicated that the BC/MA solution with ratio of 1꞉30 demonstrated the best pre-treatment performance to obtain ***,by combining MA-BC with gelatin,we successfully formulated MA-BC-GEL gels with favorable rheological properties and compression modulus,which can be used as promising bio-inks for 3D bioprinting *** vitro tests demonstrated 1꞉30 MA-BC possessed excellent biocompatibility,a significant ability to express the alkaline phosphatase gene and osteogenic-related genes,and facilitated the formation of mineralized *** utilization of this novel bio-ink in scaffold preparation for bone regeneration highlights the promising application of modified BC in bone tissue engineering field.
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