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Maternal and neonatal viromes indicate the risk of offspring's gastrointestinal tract exposure to pathogenic viruses of vaginal origin during delivery

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mLife 2022年第3期1卷 303-310页

作者： Jinfeng Wang Liwen Xiao Baichuan Xiao Bing Zhang Zhenqiang Zuo Peifeng Ji jiayong zheng Xiaoqing Li Fangqing Zhao College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina Beijing Institutes of Life Science Chinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Gynecology and Obstetrics Wenzhou People's HospitalWenzhouChina

A cumulative effect of enterovirus and gluten intake on the risk of celiac disease autoimmunity in infants highlights the significance of viral exposure in early life on the health of ***,pathogenic viruses may be transmitted to the offspring in an earlier period,raising the possibility that women whose vaginas are inhabited by such viruses may have had their babies infected as early as the time of delivery.A high‐resolution intergenerational virome atlas was obtained by metagenomic sequencing and virome analysis on 486 samples from six body sites of 99 mother–neonate *** found that neonates had less diverse oral and enteric viruses than *** delivered newborns seconds after birth had a more similar oral virome and more viruses of vaginal origin than cesarean‐section(C‐section)newborns(56.9%vs.5.8%).Such viruses include both Lactobacillus phage and potentially pathogenic viruses,such as herpesvirus,vaccinia virus,and hepacivirus,illustrating a relatively high variety of the pioneer viral taxa at the time of delivery and a delivery‐dependent mother‐to‐neonate transmission along the vaginal–oral–intestinal *** are exposed to vaginal viruses as they pass through the reproductive tract,and viruses of vaginal origin may threaten their *** findings challenge the conventional notion that vaginal delivery is definitely better than cesarean delivery from the perspective of microbial *** for vaginal virome before delivery is a worthwhile step to advocate in normal labor to eliminate the risk of intergenerational transmission of pathogenic viruses to offspring.

关键词： bacteriophage gastrointestinal tract newborn virus

CRISPRs provide broad and robust protection to oral microbial flora of gingival health against bacteriophage challenge

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Protein & Cell 2015年第7期6卷 541-545页

作者： Huiyue Zhou (1) (2) Hui Zhao (3) jiayong zheng (3) Yuan Gao (1) (2) Yanming Zhang (1) Fangqing Zhao (1) Jinfeng Wang (1) 1.Computational Genomics Lab Beijing Institutes of Life Science Chinese Academy of Sciences Beijing 100101 China 2.University of Chinese Academy of Sciences Beijing 100049 China 3.Wenzhou People’s Hospital Wenzhou 325000 China

Dear Editor,Clustered regularly interspaced short palindromic repeats （CRISPR）, which are widely present in prokaryotic genomes （Grissa et al., 2007）, belong to a family of DNA sequences characterized as short direct repeats （DR） separated by spacers （Jansen et al., 2002）. CRISPR and CRISPR-asso- ciated （cas） genes are involved in resistance against exogenous sequences, and recognition of infected bacte- riophages depends on the sequence similarity between spacers and targeted phage DNA segments （Barrangou et al., 2007）. CRISPRs exhibited diversity in different microbial communities, and that may be the response to different phaqe infections （Tyson and Banfield, 2008）.

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The Effects of Vitamin D Supplementation on Lipid Profile in Pregnant Women: A Meta-Analysis of Randomized Controlled Trials

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The Effects of Vitamin D Supplementation on Lipid Profile in...

The Effects of Vitamin D Supplementation on Lipid Profile in Pregnant Women:A Meta-Analysis of Randomized Controlled Trials

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Jianqiong zheng Liang zheng Zuo Wang Congcong Sun Jie Yang jiayong zheng Zhenzhen zheng Bingbing zheng Meimei Lin Jingjing Chen Haiying Chen Hongping Zhang Hao Ying Department of Obstetrics and Gynecology Wenzhou people's Hospital the Third Clinical Institute Affiliated to Wenzhou Medical University Department of Obstetrics Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Department of Cardiovascular Medicine Research Center for Translational Medicine Shanghai East Hospital Tongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's Hospital The Third Clinical Institute Affiliated to Wenzhou Medical University

BACKGROUND/OBJECTIVES: An abnormal lipid profile during gestation may result in maternal and neonatal adverse outcome. Vitamin D has been identified as a major contributing factor for dyslipidemia, insulin resistance, obesity and metabolic syndrome. The present meta-analysis evaluated the effect of vitamin D supplementation on lipid profile in pregnant ***/METHODS: A literature search was identified using PubMed, EMBASE, MEDLINE, Web of Science and Cochrane databases. The quality of each study was evaluated using a revised Jadad’s scale. A funnel plot(Begg’s test) was used to examined publication biasdsd. The pooled effect was calculated by a random effects ***/METHODS: All study were regarded as high quality trials. A total of 132 participants from 9 studies were pooled in this meta-analysis(intervention group: 66, control group: 66). As for low dosage of vitamin D group, there was a significant effect for TC, TG, LDL [SMD=-1.44,-1.04,-0.76, 95%CI:(-2.03,-0.84),(-1.45,-0.63),(-1.16,-0.36), z= 4.74, 4.91, 3.69, P = 0.00, 0.00, 0.00, respectively]. Moderate dosage of vitamin D supplementation significantly decreased TC, LDL[ SMD =-0.49,-0.44, 95%CI :(-0.79,-0.19),(-0.83,-0.05), z= 3.21, 2.18, P = 0.00, 0.03, respectively]. High dosage of vitamin D supplementation significantly increased TC and HDL [SMD=0.752, 0.821, 95%CI:(0.08, 1.43),(0.45, 1.19), z= 2.19, 4.31, P = 0.03, 0.00, respectively]. According to different population(with GDM and without GDM), vitamin D supplementation significantly decreased LDL in pregnant women with GDM(SMD=-0.51, 95%CI:-0.87,-0.14, z= 2.73, P =0.01). The overall SMD and its 95% CI were-0.47,-0.39,-0.35, 0.27 mg/dl and(-0.89,-0.05),(-0.69,-0.09),(-0.76, 0.07),(-0.03, 0.58) for TG, LDL, TG and HDL, respectively. CONCLUSIONS: Vitamin D supplementation had effect on lipid prolife in pregnant women.

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2019浙江省妇产科医师大会及妇产科学学术年会

作者： Jianqiong zheng Liang zheng Zuo Wang Congcong Sun Jie Yang jiayong zheng Zhenzhen zheng Bingbing zheng Meimei Lin Jingjing Chen Haiying Chen Hongping Zhang Hao Ying Department of Obstetrics and Gynecology Wenzhou people's Hospitalthe Third Clinical Institute Affiliated to Wenzhou Medical University Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of Medicine Department of Cardiovascular Medicine Research Center for Translational MedicineShanghai East HospitalTongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's HospitalThe Third Clinical Institute Affiliated to Wenzhou Medical University

BACKGROUND/OBJECTIVES:An abnormal lipid profile during gestation may result in maternal and neonatal adverse *** D has been identified as a major contributing factor for dyslipidemia,insulin resistance,obesity and metabolic *** present meta-analysis evaluated the effect of vitamin D supplementation on lipid profile in pregnant ***/METHODS:A literature search was identified using PubMed,EMBASE,MEDLINE,Web of Science and Cochrane *** quality of each study was evaluated using a revised Jadad’s scale.A funnel plot(Begg’s test) was used to examined publication *** pooled effect was calculated by a random effects ***/METHODS:All study were regarded as high quality trials.A total of 132 participants from 9 studies were pooled in this meta-analysis(intervention group:66,control group:66).As for low dosage of vitamin D group,there was a significant effect for TC,TG,LDL [SMD=-1.44,-1.04,-0.76,95%CI:(-2.03,-0.84),(-1.45,-0.63),(-1.16,-0.36),z= 4.74,4.91,3.69,P = 0.00,0.00,0.00,respectively].Moderate dosage of vitamin D supplementation significantly decreased TC,LDL[ SMD =-0.49,-0.44,95%CI :(-0.79,-0.19),(-0.83,-0.05),z= 3.21,2.18,P = 0.00,0.03,respectively].High dosage of vitamin D supplementation significantly increased TC and HDL [SMD=0.752,0.821,95%CI:(0.08,1.43),(0.45,1.19),z= 2.19,4.31,P = 0.03,0.00,respectively].According to different population(with GDM and without GDM),vitamin D supplementation significantly decreased LDL in pregnant women with GDM(SMD=-0.51,95%CI:-0.87,-0.14,z= 2.73,P =0.01).The overall SMD and its 95% CI were-0.47,-0.39,-0.35,0.27mg/dl and(-0.89,-0.05),(-0.69,-0.09),(-0.76,0.07),(-0.03,0.58) for TG,LDL,TG and HDL,***:Vitamin D supplementation had effect on lipid prolife in pregnant women.

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人工智能技术下中国古代家具形态谱系研究

包装工程 2024年第22期45卷 183-192页

作者：苏晨刘品卓郑佳勇郑晓如湖北工业大学武汉430068

目的以人工智能技术为工具,挖掘中国古代家具形态演变及发展脉络,借助智能技术完成家具形态谱系的整理、提取与归纳,解决传统人工收集分类效率低下问题。方法以宋代以来的椅类家具为例,首先利用机器视觉技术完成宋元时期,明代时期和清... 详细信息

目的以人工智能技术为工具,挖掘中国古代家具形态演变及发展脉络,借助智能技术完成家具形态谱系的整理、提取与归纳,解决传统人工收集分类效率低下问题。方法以宋代以来的椅类家具为例,首先利用机器视觉技术完成宋元时期,明代时期和清代时期的椅类家具形态特征度量分析;然后综合特征度量结果,应用人工智能图像分类技术开展古代家具图像分类工作;最后引入知识图谱与数据库的技术,构建古代家具形态知识网络,建立起中国古代家具形态谱系数据库。结论针对宋元、明代、清代时期的椅类家具进行特征提取与分类,并建立相对应的家具形态谱系库,多维度呈现古代家具形态嬗变历程,为我国古代家具的研究、传承与数字化保护提供参考,拓展人工智能在传统文化领域研究的应用。

关键词：人工智能中国古代家具形态谱系数据库知识图谱

母婴床旁护理对新生儿早期发育及产妇抑郁焦虑、泌乳量的影响

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中国基层医药 2016年第19期23卷 2911-2915页

作者：罗隽郑加永温州市人民医院产科浙江省温州325000 温州市人民医院妇产科浙江省温州325000

目的：探讨母婴床旁护理对新生儿早期发育及产妇抑郁焦虑、泌乳量的影响。方法选择2013年1月至2015年6月收治的足月健康新生儿及产妇120例，随机分为对照组和观察组，各60例。两组新生儿及产妇均给予常规护理包括新生儿脐部护理和臀部... 详细信息

目的：探讨母婴床旁护理对新生儿早期发育及产妇抑郁焦虑、泌乳量的影响。方法选择2013年1月至2015年6月收治的足月健康新生儿及产妇120例，随机分为对照组和观察组，各60例。两组新生儿及产妇均给予常规护理包括新生儿脐部护理和臀部护理，产妇护理包括外阴或腹部刀口换药，新生儿均常规接种疫苗，对照组采用将新生儿抱到公共婴儿沐浴室进行集中沐浴。观察组在此基础上实施母婴床旁护理方式，在床旁为新生儿沐浴并进行抚触，每天带新生儿进行游泳。采用焦虑评分（SAS）量表及抑郁评分（SDS）量表对两组产妇护理前后抑郁及焦虑状态进行评价，观察两组产妇不同时间泌乳量变化，测定新生儿神经测定评分（NBNA）及身高、体质量指数、头围的增长情况。结果护理后，两组产妇 SAS 及 SDS 评分较护理前均有所下降，且观察组患者 SAS 及 SDS 评分下降程度高于对照组，差异均有统计学意义（t ＝3．46、4．21，均 P ＜0．05）。护理后两组产妇泌乳量开始增长，观察组产妇泌乳量增长情况始终优于对照组，差异均有统计学意义（χ2＝9．34、4．53，χ2＝6．79，均 P ＜0．05）．观察组新生儿的 NBNA 评分、头围、身高、提质量指数的增长均优于对照组，差异均有统计学意义（t ＝1．98、1．65、2．73、3．63，均 P ＜0．05）。结论母婴床旁护理可显著改善产妇抑郁焦虑评分，增加产妇泌乳量，并在新生儿早期发育中具有一定促进作用，因此值得临床推广应用。

关键词：母婴护理泌乳量婴儿,新生抑郁焦虑状态早期发育

基于Kano-FAST的瓦楞纸激光印刷设备设计研究

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包装工程 2024年第20期45卷 152-159页

作者：苏晨曾一帆郑佳勇湖北工业大学武汉430068

目的推动印刷行业朝更高效的方向迈进,提高印刷设备的易操作性和视觉识别性。方法将Kano和FAST(Function Analysis System Technique)模型引入瓦楞纸激光打印设备设计的前期应用需求分析中,通过问卷的方法获取用户的基本要求,并划分为... 详细信息

目的推动印刷行业朝更高效的方向迈进,提高印刷设备的易操作性和视觉识别性。方法将Kano和FAST(Function Analysis System Technique)模型引入瓦楞纸激光打印设备设计的前期应用需求分析中,通过问卷的方法获取用户的基本要求,并划分为几个子类型,进而建立Kano的二维功能属性模型。采用FAST法建立功能树,辅助使用Kano模型,从而更精准地分析用户需求,并更好地根据其需求进行优化设计。结果综合运用设计原理,针对性地挖掘瓦楞纸激光印刷设备在造型识别性、操作易用性、生产安全性上存在的问题,进而输出更优解。结论该设计方法的引入有助于为同类型的印刷设备设计提供参考,并引起更多相关厂家的重视,推动印刷行业向更积极的方向发展。

关键词：工业设计瓦楞纸激光印刷设备 Kano模型 FAST法

单中心经右侧腋下途径外科封堵室间隔缺损近中期结果

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中华胸心血管外科杂志 2019年第3期35卷 150-153页

作者：胡小松彭帮田张岩伟郑家永艾峰阜外华中心血管病医院郑州大学人民医院河南省人民医院心脏中心心外科 450000

目的总结单中心室间隔缺损(VSD)经右侧腋下途径微创外科封堵近中期结果。方法2014年1月至2017年12月在河南省人民医院儿童心脏中心经右腋下VSD封堵患儿624例,男304例,女320例,年龄(2.4±2.2)岁,体质量(12.3±10.2)kg;腋下3~5肋间长约2c... 详细信息

目的总结单中心室间隔缺损(VSD)经右侧腋下途径微创外科封堵近中期结果。方法2014年1月至2017年12月在河南省人民医院儿童心脏中心经右腋下VSD封堵患儿624例,男304例,女320例,年龄(2.4±2.2)岁,体质量(12.3±10.2)kg;腋下3~5肋间长约2cm切口,在食管超声引导下经右心房或右心室封堵VSD。结果患儿VSD大小(4.2±0.9)mm,封堵器大小(5.2±1.2)mm。使用偏心封堵器28例,对称封堵器596例。手术时间(58.5士20.2)min,1CU停留(19.4±6.7)ho出血量(10.4±9.5)ml:全组无死亡病例,2例封堵器移位;无ID度房室传导阻滞、新增主动脉瓣反流、大出血二次开胸、严重感染等并发症。随访6~48个月,残余分流15例,10例随访期间愈合,5例随访中,无再次手术、主动脉瓣反流、DI度房室传导阻滞、封堵器脱落等并发症。结论经腋下封堵VSD安全、有效,近中期结果满意,远期结果需要进一步随访。

关键词：室间隔缺损右侧腋下途径外科封堵

多级A/O工艺在污水处理厂提标升级改造中的应用

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水处理技术 2023年第3期49卷 134-138页

作者：杨巍宋世琨郑佳勇李亮刘波中国市政工程西南设计研究总院有限公司四川成都610213

以成都市某净水厂提标升级改造工程为例,在投资及用地受限情况下,采用多级A/O+高密度沉淀池+反硝化滤池的主体工艺,改造完成后出水水质由《城镇污水处理厂污染物排放标准》(GB 18918-2002)一级A标准提升为《四川省岷江、沱江流域水污染... 详细信息

以成都市某净水厂提标升级改造工程为例,在投资及用地受限情况下,采用多级A/O+高密度沉淀池+反硝化滤池的主体工艺,改造完成后出水水质由《城镇污水处理厂污染物排放标准》(GB 18918-2002)一级A标准提升为《四川省岷江、沱江流域水污染物排放标准》DB 51/2311-2016。本项目中采用的多级A/O改造模式及设计参数对未来类似工程具有指导意义,为推广多级A/O工艺提供现实价值。

关键词：城市污水处理厂提标改造多级A/O工艺