The Effects of Vitamin D Supplementation on Lipid Profile in Pregnant Women: A Meta-Analysis of Randomized Controlled Trials
作者单位：Department of Obstetrics and Gynecology Wenzhou people's Hospital the Third Clinical Institute Affiliated to Wenzhou Medical University Department of Obstetrics Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Department of Cardiovascular Medicine Research Center for Translational Medicine Shanghai East Hospital Tongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's Hospital The Third Clinical Institute Affiliated to Wenzhou Medical University
会议名称：《2019长三角围产医学学术会议暨浙江省围产医学学术大会》
会议日期：2019年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
摘 要：BACKGROUND/OBJECTIVES: An abnormal lipid profile during gestation may result in maternal and neonatal adverse outcome. Vitamin D has been identified as a major contributing factor for dyslipidemia, insulin resistance, obesity and metabolic syndrome. The present meta-analysis evaluated the effect of vitamin D supplementation on lipid profile in pregnant ***/METHODS: A literature search was identified using PubMed, EMBASE, MEDLINE, Web of Science and Cochrane databases. The quality of each study was evaluated using a revised Jadad’s scale. A funnel plot(Begg’s test) was used to examined publication biasdsd. The pooled effect was calculated by a random effects ***/METHODS: All study were regarded as high quality trials. A total of 132 participants from 9 studies were pooled in this meta-analysis(intervention group: 66, control group: 66). As for low dosage of vitamin D group, there was a significant effect for TC, TG, LDL [SMD=-1.44,-1.04,-0.76, 95%CI:(-2.03,-0.84),(-1.45,-0.63),(-1.16,-0.36), z= 4.74, 4.91, 3.69, P = 0.00, 0.00, 0.00, respectively]. Moderate dosage of vitamin D supplementation significantly decreased TC, LDL[ SMD =-0.49,-0.44, 95%CI :(-0.79,-0.19),(-0.83,-0.05), z= 3.21, 2.18, P = 0.00, 0.03, respectively]. High dosage of vitamin D supplementation significantly increased TC and HDL [SMD=0.752, 0.821, 95%CI:(0.08, 1.43),(0.45, 1.19), z= 2.19, 4.31, P = 0.03, 0.00, respectively]. According to different population(with GDM and without GDM), vitamin D supplementation significantly decreased LDL in pregnant women with GDM(SMD=-0.51, 95%CI:-0.87,-0.14, z= 2.73, P =0.01). The overall SMD and its 95% CI were-0.47,-0.39,-0.35, 0.27 mg/dl and(-0.89,-0.05),(-0.69,-0.09),(-0.76, 0.07),(-0.03, 0.58) for TG, LDL, TG and HDL, respectively. CONCLUSIONS: Vitamin D supplementation had effect on lipid prolife in pregnant women.