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Altered functional connectivity networks of hippocampal subregions in remitted late-onset depression:a longitudinal resting-state study

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Neuroscience Bulletin 2015年第1期31卷 13-21页

作者： Zan Wang Yonggui Yuan Feng Bai Hao Shu jiayong you Lingjiang Li Zhijun Zhang Neurology Department Affiliated ZhongDa HospitalNeuropsychiatric Institute and Medical School of Southeast University Department of Psychosomatics and Psychiatry Affiliated ZhongDa HospitalMedical School of Southeast University Department of Psychiatry Nanjing Brain Hospital Affiliated to Nanjing Medical University Mental Health Institute Second Xiangya Hospital of Central South University

The regional specifi city of hippocampal abnormalities in late-life depression（LLD） has been demonstrated in previous studies. In this study,we sought to examine the functional connectivity（FC） patterns of hippocampal subregions in remitted late-onset depression（r LOD）,a special subtype of LLD. Fourteen r LOD patients and 18 healthy controls underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans at baseline and at ~21 months of follow-up. Each hippocampus was divided into three parts,the cornu ammonis（CA）,the dentate gyrus,and the subicular complex,and then six seed-based hippocampal subregional networks were *** changes of the six networks over time were directly compared between the rL OD and control groups. From baseline to follow-up,the r LOD group showed a greater decline in connectivity of the left CA to the bilateral posterior cingulate cortex/precuneus（PCC/PCUN）,but showed increased connectivity of the right hippocampal subregional networks with the frontal cortex（bilateral medial prefrontal cortex/anterior cingulate cortex and supplementary motor area）. Further correlative analyses revealed thatthe longitudinal changes in FC between the left CA and PCC/PCUN were positively correlated with longitudinal changes in the Symbol Digit Modalities Test（r = 0.624,P = 0.017） and the Digit Span Test（r = 0.545,P = 0.044） scores in the r LOD group. These results may provide insights into the neurobiological mechanism underlying the cognitive dysfunction in r LOD patients.

关键词： remitted late-onset depression hippocampal subregional network functional connectivity functional magnetic resonance imaging cognitive dysfunction

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Generating Factual Text via Entailment Recognition Task

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Computers, Materials & Continua 2024年第7期80卷 547-565页

作者： Jinqiao Dai Pengsen Cheng jiayong Liu School of Cyber Science Sichuan UniversityChengdu610207China

Generating diverse and factual text is challenging and is receiving increasing *** sampling from the latent space,variational autoencoder-based models have recently enhanced the diversity of generated ***,existing research predominantly depends on summarizationmodels to offer paragraph-level semantic information for enhancing factual *** challenge lies in effectively generating factual text using sentence-level variational autoencoder-based *** this paper,a novel model called fact-aware conditional variational autoencoder is proposed to balance the factual correctness and diversity of generated ***,our model encodes the input sentences and uses them as facts to build a conditional variational autoencoder *** training a conditional variational autoencoder network,the model is enabled to generate text based on input *** upon this foundation,the input text is passed to the discriminator along with the generated *** employing adversarial training,the model is encouraged to generate text that is indistinguishable to the discriminator,thereby enhancing the quality of the generated *** further improve the factual correctness,inspired by the natural language inference system,the entailment recognition task is introduced to be trained together with the discriminator via multi-task ***,based on the entailment recognition results,a penalty term is further proposed to reconstruct the loss of our model,forcing the generator to generate text consistent with the *** results demonstrate that compared with competitivemodels,ourmodel has achieved substantial improvements in both the quality and factual correctness of the text,despite only sacrificing a small amount of ***,when considering a comprehensive evaluation of diversity and quality metrics,our model has also demonstrated the best performance.

关键词： Text generation entailment recognition task natural language processing artificial intelligence

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Apatite Fission Track Thermochronology of Granite from the Xiazhuang Uranium Ore Field,South China:Implications for Exhumation History and Ore Preservation

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 430-440页

作者： SUN Yue CHEN Zhengle PAN jiayong HUO Hailong LI Haidong SUN Junjie XU Guangchun State Key Laboratory of Nuclear Resources and Environment School of Earth SciencesEast China University of TechnologyNanchang 330013China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China No.290 Research Institute CNNCShaoguanGuangdong 512029China

Xiazhuang uranium ore field,located in the southern part of the Nanling Metallogenic Belt,is considered one of the largest granite-related U regions in South *** this paper,we contribute new apatite fission track data and thermal history modeling to constrain the exhumation history and evaluate preservation potential of the Xiazhuang Uranium ore *** Triassic outcrop granite samples collected from different locations of Xiazhuang Uranium ore field yield AFT ages ranging from 43 to 24 Ma with similar mean confined fission track lengths ranging from 11.8±2.0 to 12.9±1.9μm and Dpar values between 1.01 and 1.51μ*** robustness time-temperature reconstructions of samples from the hanging wall of Huangpi fault show that the Xiazhuang Uranium ore field experienced a time of monotonous and slow cooling starting from middle Paleocene to middle Miocene(~60-10 Ma),followed by relatively rapid exhumation in the late Miocene(~10-5 Ma)and nearly thermal stability in the Pliocene-Quaternary(~5-0 Ma).The amount of exhumation after U mineralization since the Middle Paleogene was estimated as~4.3±1.8 km according to the integrated thermal history *** studies indicate that the ore-forming ages of U deposits in the Xiazhuang ore field are mainly before Middle Paleocene and the mineralization depths are more than 4.4±1.2 ***,the exhumation history since middle Paleocene plays important roles in the preservation of the Xiazhuang Uranium ore field.

关键词： apatite fission track exhumation history ore preservation Xiazhuang Uranium ore field South China

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Single-ended Time Domain Fault Location Based on Transient Signal Measurements of Transmission Lines

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Protection and Control of Modern Power Systems 2024年第2期9卷 61-74页

作者： Jian Luo Yao Liu Qiushi Cui jiayong Zhong Lin Zhang Chongqing University ChongqingChina Taiyuan University of Technology TaiyuanChina School of Electrical Engineering and with the Liyang Smart City Research Institute Chongqing UniversityChongqing 400044China Electrical Engineering from chongqing University ChongqingChina State Grid Chongqing Electric Power Company Research Institute ChongqingChina

Precise fault location plays an important role in the reliability of modern power *** the in-creasing penetration of renewable energy sources,the power system experiences a decrease in system inertia and alterations in steady-state characteristics following a fault *** existing single-ended phasor domain methods assume a certain impedance of the remote-end system or consistent current phases at both *** problems present challenges to the applicability of con-ventional phasor-domain location *** paper presents a novel single-ended time domain fault location method for single-phase-to-ground faults,one which fully considers the distributed parameters of the line *** fitting of transient signals in the time domain is real-ized to extract the instantaneous amplitude and ***,to eliminate the error caused by assumptions of lumped series resistance in the Bergeron model,an im-proved numerical derivation is presented for the distrib-uted parameter line *** instantaneous symmet-rical components are extracted for decoupling and inverse transformation of three-phase recording *** on the above,the equation of instantaneous phase constraint is established to effectively identify the fault *** proposed location method reduces the negative effects of fault resistance and the uncertainty of remote end pa-rameters when relying on one-terminal data for ***,the proposed fault analysis methods have the ability to adapt to transient processes in power *** comparisons with existing methods in three different systems,the fault position is correctly identified within an error of 1%.Also,the results are not affected by sampling rates,data windows,fault inception angles,and load conditions. Index Terms—Fault location,distributed parameter line model,transient signal,renewable energy,instantaneous phase.

关键词： Fault location distributed parameter line model transient signal renewable energy instantaneous phase

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Design, performance and application of a line-imaging velocity interferometer system for any reflector coupled with a streaked optical pyrometer system at the Shenguang-Ⅱ upgrade laser facility

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High Power Laser Science and Engineering 2024年第1期12卷 52-59页

作者： Dawei Yuan Shaojun Wang Huigang Wei Haochen Gu Yu Dai jiayong Zhong Yutong Li Gang Zhao Jie Zhang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina Institute of Frontiers in Astronomy and Astrophysics of Beijing Normal University BeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina Key Laboratory for Laser Plasmas(MOE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Department of Astronomy Beijing Normal UniversityBeijingChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina School of Physical Sciences University of Chinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanChina

The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock *** validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.

关键词： double-cone ignition streaked optical pyrometer velocity interferometer system for any reflector

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Multi-Resource Collaborative Service Restoration of a Distribution Network with Decentralized Hierarchical Droop Control

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Protection and Control of Modern Power Systems 2024年第1期9卷 19-37页

作者： Wei Zhang Cong Zhang jiayong Li Lipeng Zhu Shiran Cao Wen Huang Zhikang Shuai College of Electrical and Information Engineering Hunan UniversityChangshaChina Hunan University ChangshaChina CSEE Journal of Power and Energy Systems Chinese Journal of Electrical Engineerin

To improve the resilience of distribution networks(DNs)in the event of extreme natural disasters such as typhoons and rainstorms,it is imperative to efficiently implement distribution service restoration(DSR)to restore loads as soon as *** previous studies,DSR has mainly adopted the distributed resource model with droop or PQ *** inhibits the exploitation of the potential of distributed generators(DGs)in load restoration when the DN loses support from the upstream transmission ***,this paper proposes a multi-resource collaborative service restoration(MRCSR)approach for DNs incorporating local soft open points,DGs,and tie *** MRCSR model is developed by integrating a decentralized hierarchical droop control(DHDC)strategy and incorporating the frequency and voltage features of the load demand.A two-stage iterative feedback optimization(TSIFO)algorithm is then developed to analyze the MRCSR model in an accurate and efficient ***,the proposed model and algo-rithm are tested on the modified IEEE 33-bus system and a practical distribution system of the Taiwan Power Company to verify their effectiveness and advantages over existing approaches.

关键词： service Service integrating

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Homogenous coating of Li^(+)conductive Li_(5)AlO_(4)on single-crystalline nonstoichiometric Li_(1.04)Ni_(0.92)Al_(0.04)O_(2)for rechargeable lithium-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 651-659,I0014页

作者： Guoyu Ding Shizhou Wang Jinhan Li Ziyan Wu Jiayu Chen jiayong Du Xinhui Huang Kuiming Liu Yudong Zhang Zhonghan Wu Yiyang Peng Qiancheng Zhao Meng Yu Fangyi Cheng Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Engineering Research Center of High-efficiency Energy Storage(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Advanced Chemical Power Sources Nankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Cobalt-free,nickel-rich LiNi_(1-x)Al_(x)O_(2)(x≤0.1)is an attractive cathode material because of high energy density and low cost but suffers from severe structural degradation and poor rate *** this study,we propose a molten salt-assisted synthesis in combination with a Li-refeeding induced aluminum segregation strategy to prepare Li_(5)AlO_(4)-coated single-crystalline slightly Li-rich Li_(1.04)Ni_(0.92)Al_(0.04)O_(2).The symbiotic formation of Li_(5)AlO_(4)from reaction between molten lithium hydroxide and doped aluminum in the bulk ensures a high lattice matching between the Ni-rich oxide and the homogenous conductive Li_(5)AlO_(4)that permits high Li^(+)*** from mitigated undesirable side reactions and phase evolution,the Li_(5)AlO_(4)-coated single-crystalline Li_(1.04)Ni_(0.92)Al_(0.04)O_(2)delivers a high specific capacity of220.2 mA h g^(-1)at 0.1 C and considerable rate capability(182.5 mA h g^(-1)at 10 C).Besides,superior capacity retention of 90.8%is obtained at 1/3 C after 100 cycles in a 498.1 mA h pouch full ***,the particulate morphology of Li_(1.04)Ni_(0.92)Al_(0.04)O_(2)remains intact after cycling at a cutoff voltage of 4.3 V,whereas slightly Li-deficient Li_(0.98)Ni_(0.97)Al_(0.05)O_(2)features intragranular cracks and irreversible lattice *** results highlight the value of molten salt-assisted synthesis and Li-refeeding induced elemental segregation strategy to upgrade Ni-based layered oxide cathode materials for advanced Li-ion batteries.

关键词： Aluminum segregation Surface coating Nonstoichiometric oxides Molten synthesis Cathode materials

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氟伏沙明治疗抑郁症对照研究

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临床心身疾病杂志 2011年第6期17卷 519-520页

作者：张建尤加永徐州精神病医院江苏·徐州221006

目的探讨氟伏沙明治疗抑郁症的临床疗效和安全性.方法将80例抑郁症患者随机分为两组,每组40例,研究组口服氟伏沙明治疗,对照组口服阿米替林治疗,观察8周.于治疗前及治疗第1周、2周、4周、8周末采用汉密顿抑郁量表、汉密顿焦虑量表及... 详细信息

目的探讨氟伏沙明治疗抑郁症的临床疗效和安全性.方法将80例抑郁症患者随机分为两组,每组40例,研究组口服氟伏沙明治疗,对照组口服阿米替林治疗,观察8周.于治疗前及治疗第1周、2周、4周、8周末采用汉密顿抑郁量表、汉密顿焦虑量表及副反应量表评定临床疗效和不良反应.结果治疗后两组汉密顿抑郁量表、汉密顿焦虑量表评分均较治疗前显著下降（P＜0.01）,同期研究组均较对照组下降显著;治疗8周末,研究组显效率77.5%、有效率85.0%,对照组分别为75.0%、90.0%,两组差异均无显著性（χ2=0.069、0.457,P＞0.05）.研究组口干、便秘、头晕发生率,心电图异常率及治疗各时段副反应量表评分均显著低于对照组（P＜0.01）.结论氟伏沙明治疗抑郁症疗效显著,与阿米替林相当,但氟伏沙明具有明显的抗焦虑作用,更适用于伴发焦虑症状的抑郁症,且起效快,安全性更高,依从性更好.

关键词：抑郁症氟伏沙明阿米替林汉密顿抑郁量表汉密顿焦虑量表副反应量表

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Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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动物营养学报 2024年第1期16卷 363-375页

作者： Jinzhong Jing Jiayi Wang Xiaoyu Xiang Shenggang Yin jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian Jingyi Cai Bo Kang Lianqiang Che Hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairs of Sichuan Province Animal Nutrition Institute Sichuan Agricultural University Chengdu 611130 Sichuan China College of Animal Science and Technology Sichuan Agricultural University Chengdu 611130 Sichuan China

In the present study, the chronic heat stress (CHS) broiler model was developed to investigate the potential protection mechanism of organic selenium (selenomethionine, SeMet) on CHS-induced skeletal muscle growth retardation and poor meat quality. Four hundred Arbor Acres male broilers (680 ± 70 g, 21 d old) were grouped into 5 treatments with 8 replicates of 10 broilers per replicate. Broilers in the control group were raised in a thermoneutral environment (22 ± 2 °C) and fed with a basal diet. The other four treatments were exposed to hyperthermic conditions (33 ± 2 °C, 24 h in each day) and fed on the basal diet supplied with SeMet at 0.0, 0.2, 0.4, and 0.6 mg Se/kg, respectively, for 21 d. Results showed that CHS reduced ( P 0.05) the growth performance, decreased ( P 0.05) the breast muscle weight and impaired the meat quality of breast muscle in broilers. CHS induced protein metabolic disorder in breast muscle, which increased ( P 0.05) the expression of caspase 3, caspase 8, caspase 9 and ubiquitin proteasome system related genes, while decreased the protein expression of P-4EBP1. CHS also decreased the antioxidant capacity and induced mitochondrial stress and endoplasmic reticulum (ER) stress in breast muscle, which increased ( P 0.05) the ROS levels, decreased the concentration of ATP, increased the protein expression of HSP60 and CLPX, and increased ( P 0.05) the expression of ER stress biomarkers. Dietary SeMet supplementation linearly increased ( P 0.05) breast muscle Se concentration and exhibited protective effects via up-regulating the expression of the selenotranscriptome and several key selenoproteins, which increased ( P View The PDF

关键词： Broiler Chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

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艾司西酞普兰与舍曲林治疗抑郁症患者疗效的比较研究

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中国民康医学 2016年第23期28卷 13-14,24页

作者：束飞尤加永南京脑科医院江苏南京210029 徐州精神病院

目的:比较艾司西酞普兰与舍曲林治疗抑郁症患者的疗效及安全性。方法:58例符合CCMD-3诊断标准的例抑郁症患者随机分为艾司西酞普兰组(30例)和舍曲林组(28例)。艾司西酞普兰组患者采用可变剂量治疗;舍曲林组患者采用舍曲林治疗。两组患... 详细信息

目的:比较艾司西酞普兰与舍曲林治疗抑郁症患者的疗效及安全性。方法:58例符合CCMD-3诊断标准的例抑郁症患者随机分为艾司西酞普兰组(30例)和舍曲林组(28例)。艾司西酞普兰组患者采用可变剂量治疗;舍曲林组患者采用舍曲林治疗。两组患者的疗程均为8周。在进行治疗的第0、1、2、4、8周的周末,采用汉密尔顿抑郁量表(HAMD-17)和汉密尔顿焦虑量表(HAMA)评定两组患者的临床疗效。用治疗中出现的不良反应症状量表(TESS)及相关实验室检查评定两组患者的药物安全性。结果:治疗第8周末,艾司西酞普兰和舍曲林组患者的HAMD-17评分分别从(21.58±2.24)、(20.78±2.13)减到(6.79±3.67)、(6.94±4.30);有效率分别为86.67%(26/30)、82.14%(23/28)痊愈率为56.67%(17/30)、53.57%(15/28);两组患者的总体疗效差异无显著性(P>0.05)。1周末,两组患者的HAMD-17评分差异有显著性(P<0.05)。各时点两组患者HAMA评分无显著性差异。两组患者不良反应均较轻,且无脱落病例。结论:艾司西酞普兰和舍曲林治疗抑郁症均安全有效,艾司西酞普兰起效较舍曲林快。

关键词：艾司西酞普兰舍曲林抑郁症

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