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Acta Pharmaceutica Sinica B 2024年第4期14卷 1677-1692页

作者： Dongsheng Bai Jiawei Zhao Runde Wang jiaying du Chen Zhou Chunyang Gu Yuxiang Wang Lulu Zhang Yue Zhao Na Lu State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRNA and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRNA stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

Identification of Epinephelus malabaricus and Epinephelus coioides using DNA markers

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Acta Oceanologica Sinica 2007年第1期26卷 122-129页

作者： WANG Shifeng du jiaying WANG Jun DING Shaoxiong College of Oceanography and Environment Science Xiamen University Xiamen 361005 China

Using multi-molecular marker technologies and based on morphological criteria, the genetic relationship between Epinepheelus malabaricus and E, coioides was examined in the hope of resolving the long-standing issue of identifying these two species. Results showed that：（ 1 ） E. coioides and E. malabaricus should be identified as two species, the consistency of mitochondrial DNA cytochrome b gene sequence between E. malabaricus and E. coioides is 94.4%, and the genetic similarity by AFLP was 0.753 9 ; （2） Hybridization exists between E. malabaricus and E. coioides, the specific RAPD and AFLP fragments are found to be useful in the identification of these two species, and the genetic properties （both with exterior and inheritance） of hybrid is significantly biased to the male parents ; and （3） AFLP was a potentially powerful tool in constructing the genetic linkage map for these two groupers.

关键词： Epinephelus malabaricus Epinephelus coioides hybridize molecular identification

Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

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Particuology 2024年第3期86卷 269-280页

作者： Danping Wu jiaying Zou Junyi Chen Yan Li Na Ma Wei Dai College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China College of Life Sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood *** this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward *** of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in *** the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically *** nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred ***,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres Sustained-release performance Biocompatibility

A Two-layer Framework for Mitigating the Con-gestion of Urban Power Grids Based on Flexible Topology with Dynamic Thermal Rating

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Protection and Control of Modern Power Systems 2024年第4期9卷 83-95页

作者： Yi Su Jiashen Teh Qian Luo Kangmiao Tan jiaying Yong the School of Automation and Electronic In-formation Xiangtan Universityxiangtan 411100China IEEE the School of Electrical and Electronic Engineering Universiti Sains Malaysia(USM)Penang 11800Malaysia the School of Computer Sciences Universiti Sains Malaysia(USM)Penang 11800Malaysia the Institute of Power Engineering College of EngineeringUniversiti Tenaga Nasional(UNITEN)Kajang 43000Malaysia

The urban power grid(UPG)combines transmission and distribution *** studies on UPG congestion mitigation have primarily focused on relieving local congestion while ignoring large-scale energy transfer with safety margins and load *** situation is expected to worsen with the proliferation of renewable energy and electric *** this paper,a two-layer congestion mitigation framework is proposed,one which considers the congestion of the UPG with flexible *** the upper-layer,the particle swarm optimization algorithm is employed to optimize the power supply distribution(PSD)of substation *** is known as the upper-layer *** lower-layer model recalculates the new PSD,known as the lower-layer PSD,based on the topology candidates.A candidate topology is at an optimum when the Euclidean distance mismatch between the upper-and lower-layer PSDs is the *** optimum topology is tested by standard power flow to ascertain its *** optimum transitioning sequence between the initial and optimum topologies is also determined by the two-layer framework to minimize voltage deviation and line overloading of the UPG considering dynamic thermal *** proposed framework is tested on a 56-node test *** show that the proposed framework can significantly reduce congestion,maintain safety margins,and determine the optimum transitioning sequence.

关键词： Congestion mitigation urban power grid two-layer framework transitioning sequence dynamic thermal rating

Composition analysis of Compound Shenhua Tablet,a seven-herb Chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

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Chinese Journal of Natural Medicines 2024年第2期22卷 178-192页

作者： ZHANG Haiyan WANG Qiuyue WANG Jianan ZHANG Sichao JIA Weiwei HE Ning XIA Xiaoyan WANG Ting LAI Liyu LI jiaying du Jing OLALEYE Olajide E CHEN Xiangmei YANG Junling LI Chuan Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Zhongshan Institute for Drug Discovery Zhongshan 528400China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA *** study aimed to meticulously analyze its chemical *** on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the *** analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was *** identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 283 constituents,classified into 12 distinct categories,were identified and characterized in the Compound Shenhua *** constituents exhibited content levels of 1−10982μg·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid C,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,126,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),*** combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the *** comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

关键词： Compound Shenhua Tablet Composition analysis Analyte-capacity

Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes

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Optoelectronics Letters 2024年第6期20卷 339-345页

作者： WU Qiulin FENG Xinkai CHEN jiaying MA Lei CHEN Huaixi LIANG Wanguo Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350108China University of Chinese Academy of Sciences Beijing 100059China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China1

Thin-film lithium niobate electro-optical modulator will become the key device in the future optical communication,which has the advantages of high modulation rate,low half-wave voltage,large bandwidth,and easy integration compared with conventional bulk lithium niobate ***,because the electrode gap of the lithium niobate film modulator is very narrow,when the microwave frequency gets higher,it leads to higher microwave loss,and the electro-optical performance of the modulator will be greatly ***,we propose a thin film lithium niobate electro-optic modulator with a bimetallic layer electrode structure to achieve microwave loss less than 8 dB/cm in the range of 200 GHz,exhibiting a voltage-length product of 1.1 V·cm and a 3 dB electro-optic bandwidth greater than 160 ***-speed data transmission test has been performed,showing good performance.

关键词： Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes

Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease

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Neural Regeneration Research 2024年第3期19卷 583-590页

作者： Yingying Gu jiaying Zhang Xinru Zhao Wenyuan Nie Xiaole Xu Mingxuan Liu Xiaoling Zhang College of Pharmacy Nantong UniversityNantongJiangsu ProvinceChina

Changes in olfactory function are considered to be early biomarkers of Parkinson’s *** dysfunction is one of the earliest non-motor features of Parkinson’s disease,appearing in about 90%of patients with early-stage Parkinson’s disease,and can often predate the diagnosis by ***,olfactory dysfunction should be considered a reliable marker of the ***,the mechanisms responsible for olfactory dysfunction are currently *** this article,we clearly explain the pathology and medical definition of olfactory function as a biomarker for early-stage Parkinson’s *** the basis of the findings of clinical olfactory function tests and animal model experiments as well as neurotransmitter expression levels,we further characterize the relationship between olfactory dysfunction and neurodegenerative diseases as well as the molecular mechanisms underlying olfactory dysfunction in the pathology of early-stage Parkinson’s *** findings highlighted in this review suggest that olfactory dysfunction is an important biomarker for preclinical-stage Parkinson’s ***,therapeutic drugs targeting non-motor symptoms such as olfactory dysfunction in the early stage of Parkinson’s disease may prevent or delay dopaminergic neurodegeneration and reduce motor symptoms,highlighting the potential of identifying effective targets for treating Parkinson’s disease by inhibiting the deterioration of olfactory dysfunction.

关键词： biomarker early-stage olfactory disorders olfactory dysfunction Parkinson’s disease

Challenges and Strategies for Influenza Response After COVID-19 Pandemic

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Infectious Diseases & Immunity 2024年第2期4卷 51-55页

作者： jiaying Yang Shuxia Lin Yuelong Shu School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Pathogen Infection Prevention and Control(MOE) State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 102629China.

After the World Health Organization(WHO)declared the coronavirus disease 2019(COVID-19)pandemic in March 2020,the implementation of the most effective interventions became a paramount public health priority in the global response to the COVID-19 pandemic,especially before vaccines were *** studies have demonstrated that nonpharmaceutical interventions(NPIs),such as social distancing,wearing facemasks,and school closures,can substantially control the transmission of respiratory infections,including severe acute respiratory syndrome,pandemic H1N1 in 2009,and the COVID-19 pandemic.[1–3]However,various respiratory infections have become more prevalent since the COVID-19 *** 2021,the incidence of respiratory syncytial virus(RSV)has rapidly increased in numerous countries,including the United States,[4]Australia,[5]England,[6]Italy,[7]Germany,[8]and Switzerland.[9]In December 2022,5 European countries,including France and the United Kingdom。

关键词： respiratory acute closure

Aggregation-induced Emission Probe for Fluorescence/Photoacoustic dual-modality Imaging and Photodynamic/Photothermal Treatment

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Chemical Research in Chinese Universities 2024年第2期40卷 293-304页

作者： CHEN Peiyu ZHANG Guoyang LI Jiguang MA Lijun ZHOU jiaying ZHU Mingguang LI Shuo WANG Zhuo State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing100029P.R.China

The combination of near-infrared(NIR)fluorescence imaging(FLI)and photoacoustic imaging(PAI)can effectively compensate for each other’s inherent limitations,which can provide reliable and rich information on tumor ***,the development of FL/PA dual-modality imaging probes is beneficial for achieving precision cancer diagnosis and ***,we designed an efficient phototherapy agent methoxy bithiophene indene(OTIC),which was based on aggregation-induced emission(AIE)active *** improve the water dispersion and enrichment of OTIC at the tumor site,OTIC nanoparticles(OTIC NPs)were prepared by a nanoprecipitation *** balance between radiation and non-radiation energy dissipation was regulated by the strong donor-acceptor interaction and intramolecular *** OTIC NPs exhibited bright NIR fluorescence,photoacoustic signals,efficient generation of reactive oxygen species,and high photothermal conversion efficiency under NIR *** imaging of the tumor and mice sentinel lymph nodes(SLNs)with OTIC NPs was visualized by NIR FL/PA dual-modal *** the comprehensive imaging information provided by OTIC NPs in vivo,tumors were ablated under laser irradiation,which greatly improved the therapeutic *** NPs would be possible to realize the precise guidance of FL/PA imaging for tumor treatment in the future clinical application.

关键词： Aggregation-induced emission dual-modality imaging Photodynamic/photothermal treatment

Facilitating prelithiation of silicon carbon anode by localized high-concentration electrolyte for high-rate and long-cycle lithium storage

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Carbon Energy 2024年第6期6卷 216-233页

作者： Yuanxing Zhang Borong Wu jiaying Bi Xinyu Zhang Daobin Mu Xin-Yu Zhang Ling Zhang Yao Xiao Feng Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Chongqing Innovation Center Beijing Institute of TechnologyChongqingChina College of New Energy Xi′an Shiyou UniversityXi′anChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjinChina

The commercialization of silicon-based anodes is affected by their low initial Coulombic efficiency(ICE)and capacity decay,which are attributed to the formation of an unstable solid electrolyte interface(SEI)***,a feasible and cost-effective prelithiation method under a localized highconcentration electrolyte system(LHCE)for the silicon-silica/graphite(Si-SiO_(2)/C@G)anode is designed for stabilizing the SEI layer and enhancing the *** thin SiO_(2)/C layers with-NH2 groups covered on nano-Si surfaces are demonstrated to be beneficial to the prelithiation process by density functional theory calculations and electrochemical *** SEI formed under LHCE is proven to be rich in ionic conductivity,inorganic substances,and flexible organic ***,faster Li+transportation across the SEI further enhances the prelithiation effect and the rate performance of Si-SiO_(2)/C@G *** also leads to uniform decomposition and high stability of the SEI with abundant organic *** a result,the prepared anode shows a high reversible specific capacity of 937.5 mAh g^(-1)after 400 cycles at a current density of 1 *** 811‖Li-SSGLHCE full cell achieves a high-capacity retention of 126.15 mAh g^(-1)at 1 C over 750 cycles with 84.82%ICE,indicating the great value of this strategy for Si-based anodes in large-scale applications.

关键词： localized high-concentration electrolytes prelithiation SEI layer silicon anode