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Cav3.2 channel regulates cerebral ischemia/reperfusion injury:a promising target for intervention

Neural Regeneration Research 2024年第11期19卷 2480-2487页

作者： Feibiao Dai Chengyun Hu Xue Li Zhetao Zhang Hongtao Wang Wanjun zhou jiawu Wang Qingtian Geng Yongfei Dong Chaoliang Tang Graduate School Wannan Medical CollegeWuhuAnhui ProvinceChina Department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Core Facility Center for Medical Sciences The First Affiliated Hospital of USTC(Anhui Provincial Hospital)HefeiAnhui ProvinceChina Department of Pharmacy The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury.Various calcium channels are involved in cerebral ischemia/reperfusion injury.Cav3.2 channel is a main subtype of T-type calcium channels.T-type calcium channel blockers,such as pimozide and mibefradil,have been shown to prevent cerebral ischemia/reperfusion injury-induced brain injury.However,the role of Cav3.2 channels in cerebral ischemia/reperfusion injury remains unclear.Here,in vitro and in vivo models of cerebral ischemia/reperfusion injury were established using middle cerebral artery occlusion in mice and high glucose hypoxia/reoxygenation exposure in primary hippocampal neurons.The results showed that Cav3.2 expression was significantly upregulated in injured hippocampal tissue and primary hippocampal neurons.We further established a Cav3.2 gene-knockout mouse model of cerebral ischemia/reperfusion injury.Cav3.2 knockout markedly reduced infarct volume and brain water content,and alleviated neurological dysfunction after cerebral ischemia/reperfusion injury.Additionally,Cav3.2 knockout attenuated cerebral ischemia/reperfusion injury-induced oxidative stress,inflammatory response,and neuronal apoptosis.In the hippocampus of Cav3.2-knockout mice,calcineurin overexpression offset the beneficial effect of Cav3.2 knockout after cerebral ischemia/reperfusion injury.These findings suggest that the neuroprotective function of Cav3.2 knockout is mediated by calcineurin/nuclear factor of activated T cells 3 signaling.Findings from this study suggest that Cav3.2 could be a promising target for treatment of cerebral ischemia/reperfusion injury.

关键词： calcineurin Cav3.2 channel cerebral ischemia/reperfusion hippocampus hypoxia/reoxygenation inflammatory response nuclear factor of activated T cells 3 oxidative stress primary hippocampal neurons stroke

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Metal-free two-dimensional phosphorene-based electrocatalyst with covalent P-N heterointerfacial reconstruction for electrolyte-lean lithium-sulfur batteries

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Carbon Energy 2024年第5期6卷 175-185页

作者： Jiangqi zhou Chengyong Shu jiawu Cui Chengxin Peng Yong Liu Weibo Hua Laura Simonelli Yuping Wu Shi Xue Dou Wei Tang School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghaiChina CELLS-ALBA Synchrotron BarcelonaSpain School of Energy and Environment Southeast UniversityNanjingChina

The use of lithium-sulfur batteries under high sulfur loading and low electrolyte concentrations is severely restricted by the detrimental shuttling behavior of polysulfides and the sluggish kinetics in redox processes.Two-dimensional(2D)few layered black phosphorus with fully exposed atoms and high sulfur affinity can be potential lithium-sulfur battery electrocatalysts,which,however,have limitations of restricted catalytic activity and poor electrochemical/chemical stability.To resolve these issues,we developed a multifunctional metal-free catalyst by covalently bonding few layered black phosphorus nanosheets with nitrogen-doped carbon-coated multiwalled carbon nanotubes(denoted c-FBP-NC).The experimental characterizations and theoretical calculations show that the formed polarized P-N covalent bonds in c-FBP-NC can efficiently regulate electron transfer from NC to FBP and significantly promote the capture and catalysis of lithium polysulfides,thus alleviating the shuttle effect.Meanwhile,the robust 1D-2D interwoven structure with large surface area and high porosity allows strong physical confinement and fast mass transfer.Impressively,with c-FBP-NC as the sulfur host,the battery shows a high areal capacity of 7.69 mAh cm^(−2) under high sulfur loading of 8.74 mg cm^(−2) and a low electrolyte/sulfur ratio of 5.7μL mg^(−1).Moreover,the assembled pouch cell with sulfur loading of 4 mg cm^(−2) and an electrolyte/sulfur ratio of 3.5μL mg^(−1) shows good rate capability and outstanding cyclability.This work proposes an interfacial and electronic structure engineering strategy for fast and durable sulfur electrochemistry,demonstrating great potential in lithium-sulfur batteries.

关键词： black phosphorus electronic structure high sulfur loading interfacial covalent bonds lean electrolyte

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Natural alleles of a uridine 5'-diphospho-glucosyltransferase gene responsible for differential endosperm development between upland rice and paddy rice

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Journal of Integrative Plant Biology 2022年第1期64卷 135-148页

作者： Zihao Wu Xiao Zhang Guimei Chang Jun Yang Jinpeng Wan Feijun Wang Dayun Tao jiawu zhou Lianguang Shang Peng Xu Diqiu Yu School of Life Sciences University of Science and Technology of ChinaHefei 230027China CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical Gardenthe Chinese Academy of SciencesKunming 650223China Yunnan Key Laboratory for Rice Genetic Improvement Food Crops Research InstituteYunnan Academy of Agricultural SciencesKunming 650200China The Innovative Academy of Seed Design Chinese Academy of SciencesMengla 666303China Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agricultural and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMergla 666303China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan UniversityKunming 650091China

Traditional upland rice generally exhibits insufficient grains resulting from abnormal endosperm development compared to paddy rice. However, the underlying molecular mechanism of this trait is poorly understood. Here,we cloned the uridine 5’-diphospho(UDP)-glucosyltransferase gene EDR1(Endosperm Development in Rice) responsible for differential endosperm development between upland rice and paddy rice by performing quantitative trait loci analysis and map-based cloning. EDR1 was highly expressed in developing seeds duringgrain filling. Natural variations in EDR1 significantly reduced the UDP-glucosyltransferase activity of EDR1 YZNcompared to EDR1 YD1,resulting in abnormal endosperm development in the near-isogenic line, accompanied by insufficient grains and changes in grain quality.By analyzing the distribution of the two alleles EDR1 YD1 and EDR1 YZNamong diverse paddy rice and upland rice varieties, we discovered that EDR1 was conserved in upland rice, but segregated in paddy rice. Further analyses of grain chalkiness in the alleles of EDR1 YD1 and EDR1 YZNvarieties indicated that rice varieties harboring EDR1 YZNand EDR1 YD1 preferentially showed high chalkiness, and low chalkiness,respectively. Taken together, these results suggest that the UDP-glucosyltransferase gene EDR1 is an important determinant controlling differential endosperm development between upland rice and paddy rice.

关键词： EDR1 endosperm development grain quality UDP-glucosyltransferase upland rice

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Sandwich-type composited solid polymer electrolytes to strengthen the interfacial ionic transportation and bulk conductivity for all-solid-state lithium batteries from room temperature to 120 °C

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Journal of Energy Chemistry 2024年第8期95卷 288-295页

作者： Jiewen Tan Zhen Wang jiawu Cui Zhanhui Jia Wensheng Tian Chao Wu Chengxin Peng Chengyong Shu Kang Yang Wei Tang School of Chemical Engineering and Technology Xi'an Jiaotong University Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University State Key Laboratory of Space Power-sources Technology Shanghai Institute of Space Power-Sources School of Materials Science and Engineering University of Shanghai for Science and Technology Top-Energy Digital Manufacturing Technologies(Xi'an) Co. Ltd.

The insurmountable charge transfer impedance at the Li metal/solid polymer electrolytes（SPEs） interface at room temperature as well as the ascending risk of short circuits at the operating temperature higher than the melting point,dominantly limits their applications in solid-state batteries（SSBs）.Although the inorganic filler such as CeO2nanoparticle content of composite solid polymer electrolytes（CSPEs） can significantly reduce the enormous charge transfer impedance at the Li metal/SPEs interface,we found that the required content of CeO2nanoparticles in SPEs varies for achieving a decent interfacial charge transfer impedance and the bulk ionic conductivity in CSPEs.In this regard,a sandwich-type composited solid polymer electrolyte with a 10% CeO2CSPEs interlayer sandwiched between two 50% CeO2CSPEs thin layers（sandwiched CSPEs） is constructed to simultaneously achieve low charge transfer impedance and superior ionic conductivity at 30℃.The sandwiched CSPEs allow for stable cycling of Li plating and stripping for 1000 h with 129 mV polarized voltage at 0.1 mA cm-2and 30℃.In addition,the LiFePO4/Sandwiched CSPEs/Li cell also exhibits exceptional cycle performance at 30℃ and even elevated120℃ without short circuits.Constructing multi-layered CSPEs with optimized contents of the inorganic fillers can be an efficient method for developing all solid-state PEO-based batteries with high performance at a wide range of temperatures.

关键词： All-solid-state Li metal batteries CeO2 nanoparticles Charge transfer impedance PEO-based solid electrolytes Sandwich-type composite electrolytes

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Mapping and breeding value evaluation of a semi-dominant semidwarf gene in upland rice

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Plant Diversity 2018年第5期40卷 238-244页

作者： Xiaoqian Chen Peng Xu jiawu zhou Dayun Tao Diqiu Yu Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences KunmingYunnan. 650223 China University of Chinese Academy of Sciences Beijing 100049 China Food Crops Research Institute Yunnan Academy of Agricultural Sciences (YAAS) Kunming 650200 China

Plant height is an important trait related to yield potential and plant architecture.A suitable plant height plays a crucial role in improvement of rice yield and lodging resistance.In this study,we found that the traditional upland landrace 'Kaowenghan'(KWH) showed a special semi-dwarf phenotype.To identify the semi-dwarf gene from KWH,we raised BC2 F4 semi-dwarf introgression lines(IL) by hybridization of the japonica rice cultivar 'Dianjingyou1'(DJY1) and KWH in a DJY1 background.The plant height of the homozygous semi-dwarf IL(IL-87) was significantly reduced compared with that of DJY1.The phenotype of the F1 progeny of the semi-dwarf IL-87 and DJY1 showed that the semi-dwarf phenotype was semidominant.QTL mapping indicated that the semi-dwarf phenotype was controlled by a major QTL q DH1 and was localized between the markers RM6696 and RM12047 on chromosome 1.We also developed near-isogenic lines(NIL) from the BC3 F3 population,and found that the yield of homozygous NIL(NIL-2)was not significantly different compared to DJY1.Breeding value evaluation through investigation of the plant height of the progeny of NIL(NIL-2) and cultivars from different genetic background indicate that the novel semi-dwarf gene shows potential as a genetic resource for rice breeding.

关键词：水稻植物生态系统生态建设

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A hybrid sterile locus leads to the linkage drag of interspecific hybrid progenies

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Plant Diversity 2020年第5期42卷 370-375页

作者： Mianmian Wang Jun Yang Jinpeng Wan Dayun Tao jiawu zhou Diqiu Yu Peng Xu Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming650223YunnanChina University of Chinese Academy of Sciences Beijing100049China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMenglunMengla666303YunnanChina Yunnan Key Laboratory for Rice Genetic Improvement Food Crops Research InstituteYunnan Academy of Agricultural SciencesKunming650200YunnanChina

Interspecific hybridization plays an important role in rice breeding by broadening access to desirable traits such as disease resistance and improving yields.However,interspecific hybridization is often hindered by hybrid sterility,linkage drag,and distorted segregation.To mine for favorable genes from Oryza glaberrima,we cultivated a series of BC4 introgression lines(ILs)of O.glaberrima in the japonica rice variety background(Dianjingyou 1)in which the IL-2769(BC4F10)showed longer sterile lemmas,wider grains and spreading panicles compared with its receptor parent,suggesting that linkage drag may have occurred.Based on the BC5F2 population,a hybrid sterility locus,S20,a long sterile lemma locus,G1-g,and a new grain width quantitative trait locus(QTL),qGW7,were mapped in the linkage region about 15 centimorgan(cM)from the end of the short arm of chromosome 7.The hybrid sterility locus S20 from O.glaberrima eliminated male gametes of Oryza sativa,and male gametes carrying the alleles of O.sativa in the heterozygotes were aborted completely.In addition,the homozygotes presented a genotype of O.glaberrima,and homozygous O.sativa were not produced.Surprisingly,the linked traits G1-g and qGW7 showed similar segregation distortion.These results indicate that S20 was responsible for the linkage drag.As a large number of detected hybrid sterility loci are widely distributed on rice chromosomes,we suggest that hybrid sterility loci are the critical factors for the linkage drag in interspecific and subspecific hybridization of rice.

关键词： Interspecific hybridization Linkage drag Hybrid sterility Segregation distortion

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退火对FeCoNi2-xMnGax高熵合金微观组织、力学性能和磁性能的影响

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金属热处理 2024年第1期49卷 22-31页

作者：朱嘉武欧阳晟南昌航空大学材料科学与工程学院江西南昌330063

利用非自耗真空电弧熔炼炉制备FeCoNi2-xMnGax(x=0, 0.5, 0.75, 1.0, 1.25)高熵合金铸锭,然后在800℃和1000℃退火8 h,研究了退火对高熵合金微观组织、力学性能和磁性能的影响。结果表明,随着Ga含量的增加,铸态合金组织由未添加Ga时(x=0... 详细信息

利用非自耗真空电弧熔炼炉制备FeCoNi2-xMnGax(x=0, 0.5, 0.75, 1.0, 1.25)高熵合金铸锭,然后在800℃和1000℃退火8 h,研究了退火对高熵合金微观组织、力学性能和磁性能的影响。结果表明,随着Ga含量的增加,铸态合金组织由未添加Ga时(x=0)的FCC单相过渡到FCC+BCC双相,最终在Ga含量为25at%时(即x=1.25)转变为BCC单相。经过800℃和1000℃退火后,在FCC相内产生了棒状的析出物。双相组织的FeCoNi2-xMnGax合金具有较好的磁性能和压缩性能,退火后合金的力学性能和磁性能均有所提高。FeCoNi1.25MnGa0.75合金1000℃退火后的力学性能最优,在形变量约为20%时的抗压强度为1852.5 MPa。FeCoNi1.0MnGa1.0合金1000℃退火后的饱和磁化强度最大,为121.8 emu/g。

关键词：高熵合金退火处理显微组织力学性能磁性能

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基于深度学习和双域融合的红外成像制导系统复杂背景噪声去除方法

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兵工学报 2024年第6期45卷 1747-1760页

作者：栗苹周宇曹荣刚李发栋曹宇曦李佳武张安琪北京理工大学机电学院北京100081 北京理工大学机电动态控制重点实验室北京100081 北京理工大学唐山研究院河北唐山063611

红外成像制导系统受到严苛运行环境影响,其成像过程伴随复杂背景噪声干扰,严重影响系统制导跟踪精度。为减少复合噪声对红外成像效果的影响,在分析多种常见噪声的成因和特性的基础上,提出一种基于加性成分和乘性成分的噪声特性先验设定... 详细信息

红外成像制导系统受到严苛运行环境影响,其成像过程伴随复杂背景噪声干扰,严重影响系统制导跟踪精度。为减少复合噪声对红外成像效果的影响,在分析多种常见噪声的成因和特性的基础上,提出一种基于加性成分和乘性成分的噪声特性先验设定,结合空间域和变换域的双域融合去噪思想,设计了一种基于深度卷积神经网络的多类型噪声去除方法。该方法将富梯度流卷积模块引入UNet++结构以缩减梯度信息冗余并提升多感受野特征提取能力;针对噪声形态特性提出维度注意力机制以实现双域噪声估计;引入高阶双树复小波变换作为域变换方法,提升在不同尺度和方向上对噪声成分的识别能力。通过消融实验验证了噪声先验设定以及双域融合去噪思想的有效性和优越性,通过对比实验证明了所提方法对多种类型噪声均具有优秀的去噪能力。所提方法对高斯噪声的去噪峰值信噪比和结构相似度指标分别达到29.57和0.85,优于其他典型噪声抑制方法;对多类型混合噪声则分别达到27.84和0.82,达到良好的去噪水平。此外,也验证了所提方法对真实图像噪声具有优秀的去噪能力。

关键词：红外成像图像去噪深度学习空间域去噪变换域去噪

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Several basic problems in plastic theory of geomaterials

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Frontiers of Structural and Civil Engineering 2009年第1期3卷 81-84页

作者： Yuanxue LIU jiawu zhou Zhongyou LI Chen CHEN Yingren ZHENG The Institute of Geotechnical Engineering Department of Architecture and Civil EngineeringLogistical Engineering UniversityChongqing 400041China

Based on the basic mechanical properties of geomaterials,it was proven that the Drucker Postulate and the classical theory of plasticity can not be applied to geomaterials.Moreover,several basic problems of plastic theory of geomaterials were discussed.Based on the strict theoretical analysis,the following have been proven:the single yield surface model based on the classical theory of plasticity is unsuitable for geomaterials whether the rule of associated flow is applied or not;the yield surface of geomaterials is not unique,and its number is the same as the freedoms of plastic strain increment;the yield surface is not convex;and the rule of associated flow is unsuitable for geomaterials.

关键词： constitutive relation geomaterials classial plastic theory Drucker Postulate yield surface flow rule

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90Y树脂微球治疗在临床应用中的放射防护研究

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中华放射医学与防护杂志 2024年第1期44卷 36-40页

作者：冯加武孙敬智王韶佳张力周旋凌瑞杰湖北省中西医结合医院(湖北省职业病医院)职业卫生科武汉430015

目的探讨90Y树脂微球治疗在临床应用中的放射防护措施。方法模拟90Y树脂微球治疗手术流程,通过监测术前药物分装准备、药物转运、术中药物操作和输注、术后患者住院观察各个阶段周围剂量当量率水平,分析临床应用中所应采取的放射防护措... 详细信息

目的探讨90Y树脂微球治疗在临床应用中的放射防护措施。方法模拟90Y树脂微球治疗手术流程,通过监测术前药物分装准备、药物转运、术中药物操作和输注、术后患者住院观察各个阶段周围剂量当量率水平,分析临床应用中所应采取的放射防护措施。结果活性室周围剂量当量率水平为0.12~0.42μSv/h,通风橱周围剂量当量率为1.04~3.32μSv/h。数字减影血管造影(DSA)室在90Y+DSA扫描时最高为0.78μSv/h,在99 Tc^(m)+DSA时最高为0􀆰36μSv/h;透视防护区在90Y药物时在第一术者位155 cm高度为13.19μSv/h,而在90Y+DSA扫描时最高为80 cm高度处315.01μSv/h。第二术者位在90Y药物时最高为155 cm高度为6􀆰28μSv/h,90Y+DSA扫描时最高为155 cm高度处291.03μSv/h。患者病房周围剂量当量率为0.11~0.58μSv/h。结论核医学科及介入室等原有屏蔽措施能够满足90Y树脂微球治疗的放射防护要求,但仍需根据实际情况进行科学评估,同时应加强药物操作中的放射防护及表面污染处理措施。

关键词： 90Y树脂微球放射防护周围剂量当量率

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