检索结果-南通市图书馆

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： jiawen Zhang Sihui Yu Qiao Peng Ping wang Lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key player.The cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor microenvironment.Furthermore,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer immunotherapy.Current strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint inhibitors.These approaches have shown promise in preclinical and clinical settings,by enhancing patient survival rates.This review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and therapy.Moreover,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy strategies.Despite challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanisms of glutamate metabolic function and dysfunction in vasculardementia

引用

Neuroprotection 2024年第1期2卷 33-48页

作者： jiawen wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia Li Xiaohui Lin Bin Yang Qinghua Li Rujia Liao Laboratory of Neuroscience Afliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Neurology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Pharmacology Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Department of Geriatrics Affliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina Guangxi Clinical Research Center for NeurologicalDiseases Afiliated Hospitalof Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxiChina

As the global population ages,research on the pathogenesis and treatment options for older patients with dementia has become increasingly important.Vascular dementia(VaD),the second most frequent type of dementia,is characterized by vascular impairment caused by inadequate blood supply to the brain.VaD is a complex neurological disorder involving multiple cells and signaling pathways,and its prevention and treatment pose clinical challenges with significant behavioral implications.Glutamate,the most abundant amino acid in the brain,plays a critical role as an excitatory neurotransmitter,impacting cognitive function,learning,and memory.Abnormal glutamate metabolism has been closely linked to dementia,and reduced blood flow to the brain can lead to excessive glutamate accumulation,resulting in neuronal death.This article highlights the connection between VaD and glutamate metabolism,aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism.

关键词： glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vasculardementia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microplastics in sediment of the Three Gorges Reservoir:abundance and characteristics under different environmental conditions

引用

Journal of Oceanology and Limnology 2024年第1期42卷 101-112页

作者： wang LI Bo ZU Yiwei LIU Juncheng GUO jiawen LI College of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Chongqing Research Academy of Ecology and Environmental Sciences Chongqing 401147China

Freshwater microplastic pollution is an urgent issue of global concern,and research on the distribution in reservoirs is lacking.We investigated the microplastic pollution levels in wet sediments collected from the Three Gorges Reservoir,the largest reservoir of China.Results show that microplastics were ubiquitous in the sediments of the Three Gorges Reservoir,and their abundance ranged from 59 to 276 pp/kg(plastic particles per kg,dry weight).Economic development and total population were important factors affecting the spatial heterogeneity of microplastic abundance,and the contribution of large cities along the reservoir to microplastic pollution should be paid with more attention.Fibrous microplastics were the most abundant type of microplastic particles in reservoir sediments,whereas polystyrene,polypropylene,and polyamide were the main types of polymers.The apparent spatial heterogeneity in morphology and color of microplastics is attributed to different anthropogenic or landbased pollution sources.Moreover,the accumulation of microplastics near the inlet of tributaries reflects the role of potential contributors of tributaries.More importantly,multiple bisphenols(BPs)and heavy metals detected at the microplastic surfaces indicate that microplastics can act as carriers of these pollutants in the environment in the same way as sediments did,which may alter the environmental fate and toxicity of these pollutants.Therefore,we conclude that the Three Gorges Reservoir had been contaminated with microplastics,which posed a stress risk for organisms who ingest them along with their associated pollutants(BPs,heavy metals).

关键词： microplastics Three Gorges Reservoir sediment bisphenol heavy metal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydration Behavior and Cementitious Properties of Calcium Carbonate-aluminate Minerals Composite

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 126-133页

作者：王冲周帅 ZOU Luyao LIU jiawen ZHENG Yalin College of Materials Science and Engineering Chongqing UniversityChongqing 400045China China West Construction Group Co. Ltd.Chengdu 610015China

The purpose of this research is to investigate the hydration behavior and cementitious properties of the mixture of calcium carbonate and aluminate, and to explore whether it can be adopted as a new low-carbon cementitious material. The composite system of calcium carbonate and aluminate minerals is studied by measuring the component of hydration products, the hydration heat, setting time and compressive strength.The results prove that the composite system has certain cementitious properties and is feasible to prepare new low-carbon cement.

关键词： limestone hydrated calcium carboaluminate cementitious properties mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mimotope peptide modified pompon mum-like magnetic microparticles for precise recognition,capture and biotransformation analysis of rituximab in biological fluids

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1317-1328页

作者： jiawen Yang Aixuan Zhou Minyi Li Qiaoxian He Jingwei Zhou Jacques Crommen Wentao wang Zhengjin Jiang Qiqin wang Institute of Pharmaceutical Analysis College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Laboratory for the Analysis of Medicines Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium SCIEX Shanghai 200050China

Due to low immobilized ligand density,limited binding capacity,and severe interference from serum proteins,developing ideal peptide-based biomaterials for precise recognition and in vivo analysis of biopharmaceuticals remains a huge challenge.In this study,mimotope peptide modified pompon mum-like biomimetic magnetic microparticles(MMPs,3.8μm)that mimic the specific functionalities of CD20 on malignant B cells were developed for the first time.Benefit from the numerous ligand binding sites(Ni^(2+))on the pompon mum-like MMPs,these novel materials achieved≥10 times higher peptide ligand densities(>2300 mg/g)and antibody binding capacities(1380 mg/g)compared to previous reported biomaterials.Leveraging the high specificity of the mimotope peptide,rituximab can be precisely recognized and enriched from cell culture media or serum samples.We also established an LC-MS/MS method using the MMPs for tracking rituximab biotransformation in patient serum.Intriguingly,deamidation of Asn55 and Asn33,as well as oxidation of Met81 and Met34 were observed at the key complementarity determining regions of rituximab,which could potentially influence antibody function and require careful monitoring.Overall,these versatile biomimetic MMPs demonstrate superior recognition and enrichment capabilities for target antibodies,offering interesting possibilities for biotransformation analysis of biopharmaceuticals in patient serum.

关键词： Therapeutic monoclonal antibody Mimotope peptide Precise recognition Peptide-based biomaterials Biotransformation Patient serum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous hierarchical surface engineering of minerals through coupled dissolution-precipitation chemistry

Aggregate

引用

Aggregate 2024年第1期5卷 460-472页

作者： Jinyang Jiang jiawen Zhang Lanxin wang Zeyu Lu Fengjuan wang Zhiyong Liu Hongbo Zeng Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjingChinal 2Chemical and Materials EngineeringUniversity of AlbertaEdmontonAlbertaCanada

Peculiar hierarchical microstructures in creatures inspire modern material design with distinct functionalities.Creatures can effortlessly construct sophisticated yet long-range ordered microstructure across bio-membrane through ion secretion and precipitation.However,microstructure biomimicry in current technology generally requires elaborate,point-by-point fabrication.Herein,a spontaneous yet controllable strategy is developed to achieve surface microstructure engineering through a natural surface phenomenon similar to ion secretion-precipitation,that is,coupled dissolution-precipitation.A series of hierarchical microstructures on mineral surfaces in fluids with tunable morphology,orientation,dimension,and spatial distribution are achieved by simply controlling initial dissolution and fluid chemistry.In seawater,long-range ordered film of vertically aligned brucite flakes forms through interfacial dissolution,nucleation,and confinement-induced orientation of flakes with vertically grown{110}plane,on the edge of which,fusiform aragonite epitaxially precipitates.With negligible initial surface dissolution,prismatic aragonite epitaxially grows on a calcite polyhedron-packed surface.By tuning fluid chemistry,closely packed calcite polyhedron and loosely packed calcite micro-pillars are engineered through rapid and retarded precipitation,respectively.Surprisingly,the spontaneously grown microstructures resemble those deliberately created by human or found in nature,and tremendously modulate surface functionality.These findings open new possibilities for facile and customizable engineering of microstructural surfaces,hierarchical heterostructures,and biomimetic materials.

关键词： directional crystallization dissolution-precipitation chemistry hierarchical microstructures spontaneous growth surface engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alpine grassland degradation intensifies the burrowing behavior of small mammals:evidence for a negative feedback loop

引用

Integrative Zoology 2024年第2期19卷 240-252页

作者： Zaiwei wang jiawen YAN Amy MARTIN Dianne HBRUNTON Jiapeng QU Jin-Sheng HE Weihong JI Zhibiao NAN State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhouChina Manaaki Whenua-Landcare Research LincolnNew Zealand School of Natural Sciences Massey University(Albany Campus)AucklandNew Zealand Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningChina Qinghai Haibei National Field Research Station of Alpine Grassland Ecosystem Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningChina Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijingChina

Globally,grassland degradation is an acute ecological problem.In alpine grassland on the Tibetan Plateau,increased densities of various small mammals in degraded grassland are assumed to intensify the degradation process and these mammals are subject to lethal control.However,whether the negative impact of small mammals is solely a result of population size or also a result of activity and behavior has not been tested.In this study,we use plateau pika as a model to compare population size,core area of colony,and the number of burrow entrances and latrines between lightly and severely degraded grassland.We test whether the alleged contribution of pika to grassland degradation is a result of increased population size or increased burrowing activities of individuals in response to lower food abundance.We found that grassland degradation resulted in lower plant species richness,plant height,and biomass.Furthermore,the overall population size of pika was not significantly affected by location in lightly and severely degraded grassland.However,pika core areas in severely grassland degradation were significantly larger and had significantly higher densities of burrows and latrines.Our study provides convincing evidence that habitat-induced changes in the behavior of small,burrowing mammals,such as pika,can exacerbate grassland degradation.This finding has significant implications for managing small mammals and restoring degraded grassland ecosystems.

关键词： burrowing behavior grassland degradation plateau pika population size small mammals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interfacial charge redistribution to promote the catalytic activity of Vs-CoP-CoS_(2)/C n-n heterojunction for oxygen evolution

引用

Chinese Chemical Letters 2024年第2期35卷 611-616页

作者： jiawen Sun Hui Xue Jing Sun Niankun Guo Tianshan Song Yi-Ru Hao Qin wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Modulating surface charge redistribution based on interface and defect engineering has been considered as a resultful means to boost electrocatalytic activity.However,the mechanism of synergistic regulation of heterojunction and vacancy defects remains unclear.Herein,a Vs-CoP-CoS_(2)/C n-n heterojunction with sulfur vacancies is successfully constructed,which manifests superior electrocatalytic activity for oxygen evolution,as demonstrated by a low overpotential of 170 mV to reach 10 mA/cm^(2).The experimental results and density functional theory calculations testify that the outstanding OER performance of Vs-CoP-CoS_(2)/C heterojunction is owed to the synergistic effect of sulfur vacancies and built-in electric field at n-n heterogeneous interface,which accelerates the electron transfer,induces the charge redistribution,and regulates the adsorption energy of active intermediates during the reaction.This study affords a promising means to regulate the electrocatalytic performance by the construction of heterogeneous interfaces and defects,and in-depth explores the synergistic mechanisms of n-n heterojunction and vacancies.

关键词： Charge redistribution n-n Heterojunction Built-in electric field Sulfur vacancy Oxygen evolution reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergy of phosphorus vacancies and build-in electric field into NiCo/NiCoP Mott-Schottky integrated electrode for enhanced water splitting performance

引用

Chinese Chemical Letters 2024年第2期35卷 604-610页

作者： Xiaochen Zhang Hui Xue Jing Sun Niankun Guo Tianshan Song jiawen Sun Yi-Ru Hao Qin wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Vacancy engineering and Mott-Schottky heterostructure can accelerate charge transfer,regulate adsorption energy of reaction intermediates,and provide additional active sites,which are regarded as valid means for improving catalytic activity.However,the underlying mechanism of synergistic regulation of interfacial charge transfer and optimization of electrocatalytic activity by combining vacancy and Mott-Schottky junction remains unclear.Herein,the growth of a bifunctional NiCo/NiCoP Mott-Schottky electrode with abundant phosphorus vacancies on foam nickel(NF)has been synthesized through continuous phosphating and reduction processes.The obtained NiCo/NiCoP heterojunctions show remarkable OER and HER activities,and the overpotentials for OER and HER are as low as 117 and 60 mV at 10 mA/cm^(2) in 1 mol/L KOH,respectively.Moreover,as both the cathode and anode of overall water splitting,the voltage of the bifunctional NiCo/NiCoP electrocatalyst is 1.44 V at 10 mA/cm^(2),which are far exceeding the benchmark commercial electrodes.DFT theoretical calculation results confirm that the phosphorus vacancies and build-in electric field can effectively accelerate ion and electron transfer between NiCo alloy and NiCoP semiconductor,tailor the electronic structure of the metal centers and lower the Gibbs free energy of the intermediates.Furthermore,the unique self-supported integrated structure is beneficial to facilitate the exposure of the active site,avoid catalyst shedding,thus improving the activity and structural stability of NiCo/NiCoP.This study provides an avenue for the controllable synthesis and performance optimization of Mott-Schottky electrocatalysts.

关键词： Mott-Schottky Build-in electric field Phosphorus vacancies Phosphides Overall water splitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Visualization of nasal powder distribution using biomimetic human nasal cavity model

引用

Acta Pharmaceutica Sinica B 2024年第1期14卷 392-404页

作者： jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen wang Zeru Li Jianhua Lu Lulu wang Xiaofeng wang Jie Wu Lixin Sun Jiwen Zhang Zhigang wang Rui Yang Li Wu Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug Evaluation School of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201210China Nantong Haimen People’s Hospital Nantong 226199China Yangtze Delta Drug Advanced Research Institute Nantong 226126China Shenyang Pharmaceutical University Shenyang 110016China National Institutes for Food and Drug Control Beijing 100000China Nanjing University of Chinese Medicine Nanjing 210023China

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity.However,no reliable method is currently available to assess its impact on delivery performance.In this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal cavity.The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females.The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test.The experimental device produced the most satisfactory results with five spray times.Furthermore,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,respectively.Additionally,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo correlation.In conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

关键词： Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：