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A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 77-87页

作者： jiawei ge Justin D.Opfermann Hamed Saeidi Katherine A.Huenerberg Christopher D.Badger Jaepyeong Cha Martin J.Schnermann Arjun S.Joshi Axel Krieger Department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Mechanical Engineering University of Maryland College Park MD 20742USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital WashingtonDC 20010USA Department of Pathology george Washington University WashingtonDC 20052USA Division of Otolaryngology-Head and Neck Surgery george Washington University Washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

Surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(SNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and SNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis

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Science China(Life Sciences) 2024年第9期67卷 1881-1898页

作者： Jiaxin Chen Huijuan Wang Jianbin Xu Engeng Chen Qing Meng jiawei Wang Haoyi Xiang Wei Zhou ge Shan Zhenyu Ju Zhangfa Song Department of Colorectal Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Biological Treatment of Zhejiang Province Hangzhou 310016China Department of Pulmonary and Critical Care Medicine Regional medical center for National Institute of Respiratory DiseaseSir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Aberrant expression of circular RNAs(circ RNAs)is frequently linked to colorectal cancer(CRC).Here,we identified circ ZFR as a promising biomarker for CRC diagnosis and *** ZFR was upregulated in CRC tissues and serum exosomes and its level was linked to cancer incidence,advanced-stages,and *** both in vitro and in vivo settings,circ ZFR promoted the growth and spread while suppressing apoptosis of *** with circ ZFR overexpression promoted the proliferation and migration of cocultured CRC ***,epithelial splicing regulatory protein 1(ESRP1)in CRC cells may enhance the production of circ ***2-associated transcription factor 1(BCLAF1)bound to circ ZFR,which prevented its ubiquitinated ***,circ ZFR sponged mi R-3127-5p to boost rhotekin 2(RTKN2)*** TCP1-CD-QDs nanocarrier was able to carry and deliver circ ZFR si RNA(si-circ ZFR)to the vasculature of CRC tissues and cells,which inhibited the growth of tumors in patient-derived xenograft(PDX)*** together,our results show that circ ZFR is an oncogenic circ RNA,which promotes the development and spread of CRC in a BCLAF1 and mi R-3127-5p-dependent *** ZFR is a possible serum biopsy marker for the diagnosis and a desirable target for further treatment of CRC.

关键词： circZFR exosome ESRP1 BCLAF1 miR-3127-5p nanoparticle(NP)

Ultraclean transfer of graphene by mechanically exfoliating polymer with modified crosslink density

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Nano Research 2024年第8期17卷 6795-6802页

作者： Qi Lu jiawei Yang Chaofan Zhou Zhaoning Hu Saiyu Bu Bingbing Guo Yixuan Zhao Junhao Liao Mingpeng Shang ge Chen Kaicheng Jia Jianbo Yin Qiang Zeng Li Lin Zhongfan Liu College of Science China University of Petroleum(Beijing)Beijing 102249China School of Materials Science and Engineering Peking UniversityBeijing 100871China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular ScienceCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Electronics Peking UniversityBeijing 100871China Second Clinical Division National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing 100081China

The transfer of graphene from metallic substrates onto application-specific substrates is usually inevitable for the applications of high-quality graphene films derived from chemical vapour deposition(CVD)*** used to support the graphene films during the transfer,the coating of the polymer would produce the surface contaminations and hinder the industrially compatible *** this work,through the thermal imidization of polyamide acid(PAA)to polyimide(PI)and tuning of the concentration of dangling chains,we achieved the ultraclean and crack-free transfer of graphene wafers with high electronic *** resulting contamination-free and hydrophilic surface also enabled the observed improved cell viability in a biomedical *** avoiding aqueous etching or the usage of strong bases,our proposed transfer method is industrially compatible for batch transfer of graphene films towards the real applications.

关键词： chemical vapour deposition(CVD)graphene films graphene transfer ultraclean transfer transfer medium crosslink density cell viability assay

Josephin domain containing 2(JOSD2)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： Tao Yuan Chenming Zeng jiawei Liu Chenxi Zhao Fujing ge Yuekang Li Meijia Qian Jiamin Du Weihua Wang Yonghao Li Yue Liu Xiaoyang Dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths *** the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC ***,the need for novel strategies addressing NSCLC remains ***(DUBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic ***,the mechanisms by which DUBs promote NSCLC remain poorly *** a global analysis of the 97 DUBs’contribution to NSCLC survival possibilities using The Cancer genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2(JOSD2)predicted the poor prognosis of *** of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in ***,we found that JOSD2 restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO25 ***,we identified the first small-molecule inhibitor of JOSD2,and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in *** findings highlight the vital role of JOSD2 in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2 in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

基于GRU-DconvLSTM的船舶轨迹预测

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船舶工程 2023年第6期45卷 124-129,139页

作者：赵琦许志远葛佳薇大连海洋大学航海与船舶工程学院辽宁大连116023

利用深度学习方法预测船舶未来航行趋势,对海上交通安全以及船舶管理具有重要意义。在船舶自动识别系统(AIS)中已知的经度、纬度、航速数据基础上,提出一种基于门控循环单元结合双卷积层长短期记忆神经网络(GRU-DconvLSTM)预测模型。根... 详细信息

利用深度学习方法预测船舶未来航行趋势,对海上交通安全以及船舶管理具有重要意义。在船舶自动识别系统(AIS)中已知的经度、纬度、航速数据基础上,提出一种基于门控循环单元结合双卷积层长短期记忆神经网络(GRU-DconvLSTM)预测模型。根据原始数据的变化趋势,采用标准差法对数据中的异常值进行处理,得到最终试验数据。该模型一方面通过门控循环单元(GRU)学习船舶历史数据上的运动规律;并采用双卷积层与长短期记忆神经网络(LSTM)结合的形式充分提取数据深层信息,提高模型对时序数据深层次特征的挖掘能力。将该模型与卷积长短期记忆神经网络(CNN-LSTM)、卷积门控循环神经网络(CNN-GRU)以及卷积层长短期记忆(Conv-LSTM)神经网络等3个模型进行对比,将均方根误差、平均绝对误差、平均绝对百分比误差作为评价标准,结果表明,GRU-DconvLSTM模型在经度和纬度预测上误差较小,精确度较高。

关键词：船舶自动识别系统数据门控循环单元双卷积层长短期记忆神经网络轨迹预测

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基于ZigBee的室内环境多因子监测系统

科技广场 2016年第4期 63-68页

作者：于丰葛佳伟沈阳建筑大学辽宁沈阳110168

本文通过ZigBee技术、传感器技术和远程无线通信技术,设计了一款能够自动监测室内环境多因子的监测系统,并运用LabView设计了一款基于该系统的上位机监控软件。该设计不仅可以减少由于建筑结构原因而提高的布线成本和维护成本,还增加了... 详细信息

本文通过ZigBee技术、传感器技术和远程无线通信技术,设计了一款能够自动监测室内环境多因子的监测系统,并运用LabView设计了一款基于该系统的上位机监控软件。该设计不仅可以减少由于建筑结构原因而提高的布线成本和维护成本,还增加了多个环境因子参数的监控,能够提升人们对于室内生活环境品质的关注,切身考虑环境对自身健康的影响,也为室内环境舒适系统提供了一个新的监测框架。设计从系统的整体架构、软件实施、硬件操作三个部分进行考量和规划,实现了多因子参数的无线传输和接收。系统的升级潜力较大,可连接多个其他外设设备,应用范围较广。

关键词： ZigBee 无线网络 LabView 监测系统

用于提高无线充电抗偏移能力的补偿参数确定方法及控制策略

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电力自动化设备 2022年第1期42卷 193-198页

作者：康锦萍葛佳蔚刘坤耿琪琛程少宇赵海森华北电力大学新能源电力系统国家重点实验室北京102206

电动汽车无线充电过程中,磁耦合器原、副边线圈的偏移会导致无线充电系统(WPTS)功率的剧烈波动。为了提升系统输出功率的抗偏移能力,以三线圈方形线圈结构磁耦合器为例,研究了非谐振的电容补偿参数选择方法并提出了基于品质因数的控制策... 详细信息

电动汽车无线充电过程中,磁耦合器原、副边线圈的偏移会导致无线充电系统(WPTS)功率的剧烈波动。为了提升系统输出功率的抗偏移能力,以三线圈方形线圈结构磁耦合器为例,研究了非谐振的电容补偿参数选择方法并提出了基于品质因数的控制策略,降低了工程应用中的控制难度。设计并研制了一台3 kW样机进行了实验验证,结果表明采用所提控制策略,在横向偏移距离小于250 mm和纵向偏移距离小于100 mm的情况下,WPTS输出功率均大于3 kW,输出功率的波动小于1 kW,效率仍高于90%。

关键词：无线充电系统抗偏移能力电容补偿参数控制策略

用于提升无线充电抗偏移能力的磁耦合器最优耦合系数研究

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浙江电力 2020年第11期39卷 81-87页

作者：张伟峰金正军宋书轩葛佳蔚国网浙江省电力有限公司杭州供电公司杭州310016 华北电力大学北京102206

电动汽车无线充电过程中,LCT(磁耦合器)原副边线圈错位会导致无线传输系统功率和效率显著降低。为了提升WPTS(无线充电系统)的抗偏移能力,对比了常见的两线圈和三线圈结构LCT的抗偏移特性,揭示了带中继线圈的三线圈LCT具有较好抗偏移能... 详细信息

电动汽车无线充电过程中,LCT(磁耦合器)原副边线圈错位会导致无线传输系统功率和效率显著降低。为了提升WPTS(无线充电系统)的抗偏移能力,对比了常见的两线圈和三线圈结构LCT的抗偏移特性,揭示了带中继线圈的三线圈LCT具有较好抗偏移能力;并在原副边线圈位置固定的前提下,提出基于最优耦合系数区间的中继线圈最佳位置确定方法;最后,研制了一台3 kW带中继线圈的WPTS样机并进行实验验证,结果表明在横向偏移150 mm、纵向偏移50 mm情况下,采用最优耦合系数区间的WPTS在满足输出功率前提下效率仍大于90%。文中成果可为研制具有较强抗偏移能力的商用WPTS提供重要理论支撑。

关键词：无线充电磁耦合器最优耦合系数区间抗偏移能力

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带凸台无底缸体零件的多向模锻工艺研究

热加工工艺 2024年第1期53卷 143-147,154页

作者：葛苏任杰张家伟上海第二工业大学智能制造与控制工程学院上海201209 上海电机学院高职学院上海200240 中冶重工(唐山)有限公司河北唐山063009 先进锻压成形技术与科学教育部重点实验室(燕山大学)机械学院河北秦皇岛066004

为了保证气缸、液压缸在服役过程中的可靠性和稳定性,其毛坯必须采用锻件。针对带凸台无底缸体零件内部中空、外侧带有凸起的结构特点,制定其锻件图。通过对比坯料填充模腔的成形过程、锻造载荷、锻件应变分布、锻件温度分布、模具温度... 详细信息

为了保证气缸、液压缸在服役过程中的可靠性和稳定性,其毛坯必须采用锻件。针对带凸台无底缸体零件内部中空、外侧带有凸起的结构特点,制定其锻件图。通过对比坯料填充模腔的成形过程、锻造载荷、锻件应变分布、锻件温度分布、模具温度分布,对4种多向模锻方案进行了有限元模拟研究,得出了最佳多向模锻操作方案。按照此方案设计模具和试验,成形出尺寸合格的缸体锻件。

关键词：带凸台无底缸体多向模锻无飞边斜度小