检索结果-南通市图书馆

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

使用合规农药能确保农产品“地头”质量安全吗?——基于豇豆农户的扎根理论分析

引用

海南大学学报（人文社会科学版） 2025年第1期43卷 119-128页

作者：樊孝凤张娇朱月季海南大学国际商学院海南海口570228

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析... 详细信息

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析了访谈资料。研究发现:农户施药环节是一个复杂的行为选择过程,即使施用合规农药也不能确保农产品在产地的质量安全。在合规农药视角下影响农户施药行为选择的最重要因素是信息渠道,其次是农产品质量安全管理的政策强度、农产品市场价格和农村劳动用工成本。同时,邻里效应在农户施药行为选择中的作用越来越弱。在此基础上提出,要增加农户用药信息的有效供给渠道,加强农产品质量安全的全面检测,坚持为农户提供形式多样的有针对性的有效培训,增加重要食用农产品质量安全关键技术供给与推广,加强农产品“优质优价”市场建设的政策建议,并进一步指出海南自贸港建设和RECP协议实施背景下提升海南农产品质量安全水平的紧迫性。

关键词：合规农药施药行为农产品质量安全扎根理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

引用

Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation and improvement of pearlite microstructure and mechanical properties in 45Cr4NiMoV and 50Cr5NiMoV steels

引用

Journal of Iron and Steel Research International 2022年第12期29卷 1995-2005页

作者： Kai-quan Liu Xue-jiao zhang Xiao-yang Song lin Zhao lin Zhu State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina Tianjin Heavy Industries Research&Development Co. Ltd.CFHITianjin 300457China China First Heavy Industry Qiqihar 161042HeilongjiangChina Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China

The microstructure and mechanical properties of pearlite in 45Cr4NiMoV and 50Cr5NiMoV steels were studied and *** microstructural characteristics of pearlite of two steels were carefully examined by optical microscopy,scanning electron microscopy and transmission electron microscopy(TEM),and the type,size and relative amount of extracted carbide particles were analyzed by X-ray diffraction and TEM coupled with selected area electron *** hardness,tensile property,impact and fracture toughness of pearlite of two steels were also ***,the carbide dissolution kinetics of 45Cr4NiMoV and 50Cr5NiMoV steels were *** results indicated that the carbides in 50Cr5NiMoV steel exhibited higher dissolution temperature than those in 45Cr4NiMoV steel,which induced different morphologies of pearlite after eutectoid *** to the pearlite with lamellar M_(23)C_(6)carbides in 45Cr4NiMoV steel,the pearlite with the mixture of spheroidized M_(7)C_(3)and lamellar M_(23)C_(6)carbides in 50Cr5NiMoV steel possessed higher impact and plane-strain fracture toughness but lower hardness and strength,because different pearlite morphologies led to different mechanical *** order to further improve the comprehensive properties of the steels,the fraction of M_(7)C_(3)for the material with acceptable properties was examined and dissolution kinetic of M_(7)C_(3)was ***,the austenitizing temperature and holding time could be appropriately selected to keep enough undissolved M_(7)C_(3)in the steels.

关键词： Microstructure Carbide Back-up roll Mechanical property Toughness Spheroidization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SCStore： Managing Scientific Computing Packages for Hybrid System with Containers

引用

Tsinghua Science and Technology 2017年第6期22卷 675-681页

作者： Wusheng zhang jiao lin Weiping Xu Haohuan Fu Guangwen Yang Department of Computer Science and Technology Tsinghua University Beijing 100084 China National Supercomputing Center in Wuxi Wuxi 210008 China Department of Computer Science and Technology Tsinghua University Beijing 100084 China. Department of Earth System Science Tsinghua University Beijing 100084 China

Managing software packages in a scientific computing environment is a challenging task, especially in the case of heterogeneous systems. It is error prone when installing and updating software packages in a sophisticated computing environment. Testing and performance evaluation in an on-the-fly manner is also a troublesome task for a production system. In this paper, we discuss a package management scheme based on containers. The newly developed method can ease the maintenance complexity and reduce human mistakes. We can benefit from the self-containing and isolation features of container technologies for maintaining the software packages among intricately connected clusters. By deploying the Super Computing application Strore（SCStore） over the WAN connected world-largest clusters, it proved that it can greatly reduce the effort for maintaining the consistency of software environment and bring benefit to achieve automation.

关键词： high performance computing package management container hybrid system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling and Analyzing Dynamic Response for An Offshore Bottom-Fixed Wind Turbine with Individual Pitch Control

引用

China Ocean Engineering 2022年第3期36卷 372-383页

作者： XIE Shuang-yi zhang Kai-fei HE jiao GAO Jian zhang Cheng-lin College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China College of Engineering Science and Technology Shanghai Ocean UniversityShanghai 201306China

The asymmetric or periodically varying blade loads resulted by wind shear become more significant as the blade length is increased to capture more wind ***,compared with the onshore wind turbines,their offshore counterparts are subjected to additional wave loadings in addition to wind loadings within their ***,vibration control and fatigue load mitigation are crucial for safe operation of large-scale offshore wind *** view of this,a multi-body model of an offshore bottom-fixed wind turbine including a detailed drivetrain is established in this ***,an individual pitch controller(IPC)is designed using disturbance accommodating *** feedback is used to add damping in flexible modes of concern,and a state estimator is designed to predict unmeasured ***,a coupled aero-hydro-servo-elastic model is *** on this coupled model,the load reduction effect of IPC and the dynamic responses of the drivetrain are *** results showed that the designed IPC can effectively reduce the structural loads of the wind turbine while stabilizing the turbine power ***,it is found that the drivetrain dynamic responses are improved under IPC.

关键词： wind turbine individual pitch controller disturbance accommodating control multi-body modeling drivetrain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beam-beam effects and mitigation in a future proton-proton collider

引用

Nuclear Science and Techniques 2022年第10期33卷 90-105页

作者： Li-jiao Wang Tanaji Sen Jing-Yu Tang lin-Hao zhang Institute of High Energy Physics CASYuquan Road 19BBeijing 100049China University of Chinese Academy of Sciences CAS19A Yuquan RoadBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA

The beam-beam effects in a hadron collider with an unprecedented energy scale were *** effects are strongly related to the attainable luminosity of the ***-range interactions were identified as the major factor limiting the dynamic aperture,which is strongly dependent on the crossing angle,β*,and bunch *** mitigation methods of the beam-beam effects were addressed,with a focus on the compensation of long-range interactions by electric curren *** CEPC-SPPC project is a two-stage large circular collider,with a first-stage circular electron-positron collider(CEPC)and a second-stage super proton-proton collider(SPPC).The design of the SPPC aims to achieve a center-of-mass energy of 75 TeV and peak luminosity of approximately 1×10^(35) cm^(-2)s^(-1).We studied the beam-beam effects in the SPPC and tested the effectiveness of the mitigation *** found that with compensation using electric current wires,the dynamic aperture is at an acceptable ***,considering the significant emittance damping in this future proton-proton collider the beam-beam effects and compensation are more complicated and are studied using long-term *** was found that with a smaller emittance,the head-on interactions with a crossing angle become more prominent in reducing the beam stability,and combined head-on and long-range compensation is needed to improve the beam *** the reduction in population owing to burnoff was included,it was found that the coupling between the transverse and longitudinal planes at smaller emittance is the main driving source of the ***,crab cavities and emittance control are also necessary than just the compensation of the long-range interactions to improve the beam *** study serves as an example for studying the beam-beam effects in future proton-proton colliders.

关键词： Particle collider Beam-beam effects Luminosity Tune footprint Dynamic aperture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of the Mechanism of Water Inrush Geohazards in Deep-Buried Tunnels under the Complex Geological Environment of Karst Cave-Fractured Zone

引用

Journal of Earth Science 2022年第5期33卷 1204-1218页

作者： Weishe zhang Yuyong jiao Guohua zhang Xi zhang Guangzhao Ou Zhiping lin Faculty of Engineering China University of GeosciencesWuhan430074China Fujian Highway Bridge Engineering Co. Ltd.Fuzhou350000China

To study the mechanism and evolution process of water inrush geohazards under the complex geological environment of the karst cave-fractured zone,a large-scale physical threedimensional(3 D)model test was first *** the conceptual model for the evolution process of water inrush geohazards and the simplified theoretical model for the critical hydraulic pressure were both established based on the main characteristics of the water inrush geohazard in the engineering background and that in the model test.A new method was developed for modeling the geological environment of the karst cave-structural plane,and two formulae describing the critical water pressure of water inrush geohazards under two failure models of tensile-shear fracture failure and compressionshear fracture failure were also deduced based on fracture *** results showed that:(1)the evolution process of the water inrush geohazard can be divided into four stages,which include the initial balance,the propagation of original cracks,the formation of the dominant water inrush channel,and the instability of the waterproof rock mass;(2)the suddenness of water inrush geohazards becomes stronger with the increase of the hydraulic pressure;(3)the calculated critical hydraulic pressure of water inrush geohazards is similar to the measured critical hydraulic pressure in the model test,which validated the accuracies of the theoretical model,and the failure model of water inrush geohazards in this research is compression-shear fracture failure.

关键词： karst cave fractured zone water inrush mechanism critical hydraulic pressure model test engineering geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

富血小板血浆联合脂肪干细胞移植加速伤口愈合的临床前研究:系统评价和Meta分析

引用

中国组织工程研究 2025年第13期29卷 2753-2763页

作者：蔺莉焦琳茜于芳宁马逸朝张博徐旭英首都医科大学附属北京中医医院北京市100010

目的:研究表明,富血小板血浆和脂肪来源干细胞的组合可加速皮肤损伤的愈合,但仍缺乏二者联合治疗的系统证据。该文评价两种干预措施在临床啮齿动物皮肤创伤模型中的联合疗效。方法:检索PubMed、Embase和Cochrane及CNKI数据库,选择各数... 详细信息

目的:研究表明,富血小板血浆和脂肪来源干细胞的组合可加速皮肤损伤的愈合,但仍缺乏二者联合治疗的系统证据。该文评价两种干预措施在临床啮齿动物皮肤创伤模型中的联合疗效。方法:检索PubMed、Embase和Cochrane及CNKI数据库,选择各数据库建库至2023年7月发表的富血小板血浆与脂肪干细胞移植联合使用以及单独使用于实验动物皮肤伤口的研究,以伤口愈合及伤口中转化生长因子β、CD31、Ⅰ型胶原蛋白和血管内皮生长因子为观察指标,使用RevMan 5.3和Stata 15.0软件对数据进行Meta分析。结果:共纳入12项研究,其中8项研究使用大鼠作为实验对象,4项研究使用小鼠作为实验对象,实验组采用富血小板血浆联合脂肪干细胞移植治疗,对照组采用单独的富血小板血浆治疗。Meta分析结果显示,实验组治疗后第3,7,10天的伤口愈合率均大于对照组[SMD=2.65,95%CI(1.29,4.01),Z=3.81,P=0.0001;SMD=3.38,95%CI(2.47,4.30),Z=7.24,P<0.00001;SMD=2.62,95%CI(1.50,3.73),Z=4.61,P<0.00001],实验组伤口愈合时间短于对照组[SMD=-2.12,95%CI(-3.5,-0.74),P=0.003],实验组伤口中的转化生长因子β表达、CD31阳性率、Ⅰ型胶原蛋白及血管内皮生长因子表达均高于对照组[SMD=5.65,95%CI(1.22,10.08),Z=2.50,P=0.01;SMD=2.49,95%CI(1.96,3.02),Z=9.28,P<0.00001;SMD=3.44,95%CI(0.72,6.17),Z=2.48,P=0.01;SMD=2.38,95%CI(0.97,3.79),Z=3.30,P=0.0010]。结论:研究结果表明,富血小板血浆与脂肪干细胞联合治疗可提高伤口愈合率、缩短伤口愈合时间,同时增加转化生长因子β、CD31、Ⅰ型胶原蛋白和血管内皮生长因子的表达,加速伤口愈合。由于模型的局限性,需要进行更多的动物实验和临床试验进行进一步证实。

关键词：富血小板血浆脂肪干细胞伤口愈合临床前研究荟萃分析系统评价

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MXene-MoS_(2)nanocomposites via chemical vapor deposition with enhanced electrocatalytic activity for hydrogen evolution

引用

Nano Research 2023年第7期16卷 8937-8944页

作者： Ruijie zhang Yajing Sun Fei jiao lin Li Dechao Geng Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin University and Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China College of Chemistry Tianjin Normal UniversityTianjin 300387China

As a new paradigm of material science,two-dimensional(2D)heterostructured composites have attracted extensive interests because of combining the collective advantages and collaborative characteristics of individual building *** disulfide(MoS_(2))has demonstrated great promise as a low-cost substitute to platinum-based catalysts for electrochemical hydrogen ***,the broad adoption of MoS_(2)is hindered by its limited number of active sites and low inherent electrical *** of the promising methods to further activate MoS_(2)is coupling ***,we demonstrate for the first time the synthesis of 2D MXene-MoS_(2)nanocomposites through chemical vapor deposition(CVD)approach,thus leading to precise design in structure type and *** computational results show that nanocomposites have metallic *** to their unique 2D/2D structure,MXene-MoS_(2)nanocomposites exhibit more active catalytic sites,resulting in higher electrochemical performance,as inherited from parent excellent characteristics,and a much lower overpotential of~69 mV at a current density of 10 mA·cm^(-2) is *** work paves the way to employ CVD method by coupling engineering to construct 2D nanocomposites for energy storage applications.

关键词： MXene molybdenum disulfide(MoS_(2)) chemical vapor deposition hydrogen evolution reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：