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面向分布式传感的散射增强光纤研究进展

光学学报 2024年第1期44卷 201-213页

作者：谭滔田野张建中哈尔滨工程大学物理与光电工程学院纤维集成光学教育部重点实验室黑龙江哈尔滨150001 哈尔滨工程大学烟台研究院先进光纤传感技术研发中心山东烟台264006

基于光纤后向散射的光纤传感技术具有全分布、长距离等特点,在诸多领域受到广泛关注,被认为是一种变革性技术。散射光随着传输距离增加逐渐减弱,信噪比降低导致感知性能下降,成为限制其在长距离应用的主要因素。通过光纤掺杂、写入弱光... 详细信息

基于光纤后向散射的光纤传感技术具有全分布、长距离等特点,在诸多领域受到广泛关注,被认为是一种变革性技术。散射光随着传输距离增加逐渐减弱,信噪比降低导致感知性能下降,成为限制其在长距离应用的主要因素。通过光纤掺杂、写入弱光栅等方式增加光纤散射强度可以有效缓解该问题。然而对于数千米的超长距应用,散射增加意味光纤损耗的增强,通过增加散射来提升信噪比的方法失效。本课题组提出一种增加光纤后向散射强度但不增加光纤本征损耗的散射收集能力增强光纤。本文分别从增强光纤散射能力和增强后向收集能力两个方向总结了散射增强光纤的几种方法,论述了各种方法的优缺点,并进行了简要展望。

关键词：光纤光学分布式传感散射增强光纤辐照光纤微结构光纤掺杂光纤超长锥形光纤

聚合物基MXene光热复合材料的应用研究进展

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精细化工 2024年第4期41卷 728-739页

作者：马莉马建中张雷陕西科技大学化学与化工学院陕西西安710021 陕西科技大学轻工科学与工程学院陕西西安710021 西安市绿色化学品与功能材料重点实验室陕西西安710021 陕西科技大学轻化工程国家级实验教学示范中心陕西西安710021

过渡金属碳/氮化物(MXene)是一种新兴的二维纳米材料,具有组成可调、结构可控和优异的光热转换性能。MXene可吸收太阳光,并将其高效转换为热能,为太阳能的有效利用提供了新途径。将MXene加入聚合物基体中,不仅可赋予聚合物基复合材料优... 详细信息

过渡金属碳/氮化物(MXene)是一种新兴的二维纳米材料,具有组成可调、结构可控和优异的光热转换性能。MXene可吸收太阳光,并将其高效转换为热能,为太阳能的有效利用提供了新途径。将MXene加入聚合物基体中,不仅可赋予聚合物基复合材料优异的光热性能,而且可提升MXene的稳定性。该文总结了MXene及聚合物基MXene光热复合材料的制备方法,介绍了聚合物基MXene光热复合材料的光热转换机理,综述了聚合物基MXene光热复合材料在海水淡化、个人热管理、光热抗菌和光热治疗方面的应用研究进展;针对聚合物基MXene光热复合材料在实际应用中所面临的MXene难以绿色安全生产、易氧化和在聚合物基体中分散性差等挑战,对其未来的发展方向进行了展望。

关键词： MXene 聚合物基光热复合材料光热转换机理应用研究前景展望

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基础胰岛素/胰高糖素样肽1受体激动剂固定比例复方制剂的药物作用机制及临床研究进展

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中国糖尿病杂志 2024年第1期32卷 70-75页

作者：肖建中清华大学附属北京清华长庚医院内分泌科 102218

T2DM是一种病理生理机制复杂的进展性疾病,随DM病程进展需要不同作用机制的降糖药物,纠正多重病理生理缺陷来控制BG。基础胰岛素/胰高糖素样肽1受体激动剂(GLP-1RA)固定比例复方制剂(FRC)每日1次注射可同时给予2种机制互补的降糖药物,纠... 详细信息

T2DM是一种病理生理机制复杂的进展性疾病,随DM病程进展需要不同作用机制的降糖药物,纠正多重病理生理缺陷来控制BG。基础胰岛素/胰高糖素样肽1受体激动剂(GLP-1RA)固定比例复方制剂(FRC)每日1次注射可同时给予2种机制互补的降糖药物,纠正T2DM已知病理生理缺陷中的7种,可全面有效地控制BG。本文对基础胰岛素/GLP-1RA的FRC药物作用机制及国内外临床研究进展作一回顾性讨论,为临床医师提供参考。

关键词：基础胰岛素 GLP-1受体激动剂固定比例复方制剂作用机制

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中国阐释学的兼性主体与话语

中国社会科学 2024年第2期 105-125,206页

作者：李建中武汉大学文学院武汉430072

“兼”之语义内蕴阐释学意味:“兼持二禾”是阐释主体(人手)与阐释对象(二禾)的相遇,而“兼”之持二禾、容三秋、倍驿程、济天下的语义递增则是阐释空间的扩展。华夏文明的兼性智慧构成中国阐释学主体及行为的文化基因及语义根抵,以“... 详细信息

“兼”之语义内蕴阐释学意味:“兼持二禾”是阐释主体(人手)与阐释对象(二禾)的相遇,而“兼”之持二禾、容三秋、倍驿程、济天下的语义递增则是阐释空间的扩展。华夏文明的兼性智慧构成中国阐释学主体及行为的文化基因及语义根抵,以“兼”为词根,墨子标举“兼士”“兼君”,庄子感言“兼怀万物”,《尔雅》并列“我”的14种兼称,《诗经》“嗟我怀人”兼怀“你”“我”。中国阐释学主体的“兼”,包容穷达兼善的身份主体、三教兼宗的思想主体和四部兼备的知识主体,较之西方现象学主体的“间”更为宽裕广博。兼性主体创生兼性话语,汉语的语义兼训与语用兼类,指向汉语阐释的寓象、重言和随境,形成兼性话语的“诗”兼三训、“文”兼三性和“语”兼三言。关于“兼”的语义训话和知识考古,或可为中国阐释学主体及话语的概念标识提供可行性路径。

关键词：兼兼性主体兼性话语中国阐释学

Investigation of the Oral Health Status of Patients Based on Rehabilitation Nursing

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Health 2024年第7期16卷 565-577页

作者： Xiuying Guan Jing Ao Peng Jia Deping Zou Mengcan Li jianzhong Huang Fuzhou Medical College of Nanchang University Fuzhou China Fuzhou First Peoples Hospital Fuzhou China

Objective: To investigate the current situation of knowledge, attitude, and practice (KAP) of oral health among rehabilitation nursing patients, and provide some reference for implementing oral health intervention measures for rehabilitation nursing patients. Method: A total of 231 nursing patients in the rehabilitation department of a tertiary hospital in this city from January 2023 to October 2023 were selected as the research subjects. Their oral health knowledge, attitudes, and behaviors were investigated, and the oral health behavior habits of patients with different genders, education levels, and disease situations were compared. Result: The total awareness rate of oral health knowledge among patients was 73.16%, and the average score of oral health knowledge was 6.58 ± 1.25 points. The overall positive rate of oral health attitude among patients is 55.70%, and the average score of oral health attitude is 5.01 ± 1.04 points. The average score for oral health behavior is 16.87 ± 5.23 points. Only 8.48%, 3.3%, 1.3%, 2.6%, and 0.87% of patients seek timely medical treatment for bleeding tooth roots, gum swelling and pain, gum bleeding, tooth pain, and dental calculus, respectively;Only 5.19% of people change their toothbrush every 3 months, and only 10.39% use the vertical brush method to brush their teeth. The scores of oral health knowledge, attitudes, and behaviors of patients are related to age, educational level, disease type, and smoking situation. The oral health knowledge and attitude scores of elderly patients were lower than those of younger patients, and the difference was statistically significant (P P P P P < 0.05). Conclusion: The oral health status of rehabilitation nursing patients is not optimistic, with a moderate level of oral health knowledge, weak awareness of oral health, and a low qualification rate of oral health behaviors. Strengthening oral health education for rehabilitation nursing patients and incorporating oral health care procedures

关键词： Oral Health Questionnaire Survey Knowledge Attitude Behavior

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中国深海考古三部曲

科技导报 2024年第14期42卷 48-60页

作者：宋建忠国家文物局考古研究中心北京100013

梳理了国外深海考古发展情况,介绍了中国深海考古的发展历程。从2018年4月西沙北礁海域深海考古调查,到2022年8月西沙海槽深海考古调查,再到2023年5月南海西北陆坡一号、二号沉船深海考古调查,中国深海考古经历了从零的突破,到沉船遗物... 详细信息

梳理了国外深海考古发展情况,介绍了中国深海考古的发展历程。从2018年4月西沙北礁海域深海考古调查,到2022年8月西沙海槽深海考古调查,再到2023年5月南海西北陆坡一号、二号沉船深海考古调查,中国深海考古经历了从零的突破,到沉船遗物集中发现,再到古代沉船重大发现的3个阶段。中国深海科学与技术在人文科学领域的应用使中国的深海考古迅速达到世界先进水平。提出3点建议:尽快完成南海西北陆坡一号、二号沉船考古调查与综合评估,为该沉船遗址后续的研究、保护、阐释和利用提供重要依据;根据初步形成的深海考古调查技术、方法与流程,未来有计划、有目标地对已发现水下文化遗存较多的礁盘周边海域和古代重要航线节点海域开展系统的区域调查;结合南海西北陆坡一号、二号沉船遗址,进一步开展中国深海考古专用技术与装备的研发。

关键词：中国南海深海考古载人深潜深海科技

The Application of Nicotiana benthamiana as a Transient Expression Host to Clone the Coding Sequences of Plant Genes

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American Journal of Molecular Biology 2024年第2期14卷 54-65页

作者： jianzhong Huang Peng Jia Xiaoju Zhong Xiuying Guan Hongbin Zhang Honglei Ruan Key Laboratory of Chronic Diseases Fuzhou Medical University Fuzhou China

Coding sequences (CDS) are commonly used for transient gene expression, in yeast two-hybrid screening, to verify protein interactions and in prokaryotic gene expression studies. CDS are most commonly obtained using complementary DNA (cDNA) derived from messenger RNA (mRNA) extracted from plant tissues and generated by reverse transcription. However, some CDS are difficult to acquire through this process as they are expressed at extremely low levels or have specific spatial and/or temporal expression patterns in vivo. These challenges require the development of alternative CDS cloning technologies. In this study, we found that the genomic intron-containing gene coding sequences (gDNA) from Arabidopsis thaliana, Oryza sativa, Brassica napus, and Glycine max can be correctly transcribed and spliced into mRNA in Nicotiana benthamiana. In contrast, gDNAs from Triticum aestivum and Sorghum bicolor did not function correctly. In transient expression experiments, the target DNA sequence is driven by a constitutive promoter. Theoretically, a sufficient amount of mRNA can be extracted from the N. benthamiana leaves, making it conducive to the cloning of CDS target genes. Our data demonstrate that N. benthamiana can be used as an effective host for the cloning CDS of plant genes.

关键词： Coding Sequence Genomic Sequence Nicotiana benthamiana Plant Genes

In Silico Screening of Potential Inhibitors against dPLA2 from Named Chinese Herbs for Identification of Compounds with Antivenom Effects Due to Deinagkistrodon acutus Snake Bites

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American Journal of Molecular Biology 2024年第3期14卷 107-125页

作者： Xingyang Xiao Mengyi Lai Zechang Rao jianzhong Huang Yiwei Xie Hongbin Zhang Fuzhou Medical College of Nanchang University Fuzhou China Medical College Jinggangshan University Jian China

Phospholipase A2 (PLA2) is the key enzyme to the venom from Deinagkistrodon acutus which is one of the highly venomous snakes in China. In addition to being a catalyst for the hydrolysis of phospholipases A2 from snake venom, its well known that it possesses a broad spectrum of pharmacological activities, such as myotoxicity, neurotoxicity, cardiotoxicity, and hemolytic, anticoagulant and antiplatelet activities. However, snakebites are not efficiently treated by conventional serum therapy. Acute wounds can still cause poisoning and death. In order to find effective inhibitors of Deinagkistrodon venom acid phospholipase A2 (dPLA2), we obtained 385 compounds in 9 Chinese herbs from the TCMSP. These compounds were further performed to virtual screen using in silico tools like ADMET analysis, molecular docking and molecular dynamics (MD) simulation. After Pharmacokinetics analysis, we found 7 candidate compounds. Besides, analysis of small molecule interactions with dPLA2 confirmed that the amino acid residues HIS47 and GLY29 are key targets. Because they bind not only to the natural substrate phosphatidylcholine and compounds known for having inhibitory functions, but also for combining with potential antidote molecules in Chinese herbal medicine. This study is the first to report experience with virtual screening for possible inhibitor of dPLA2, such as the interaction spatial structure, binding energy and binding interaction analysis, these experiences not only provide reference for further experimental research, but also have a guideline for the study of drug molecular mechanism of action.

关键词： Chinese Herbal Medicine Phospholipase A2 Inhibitor Molecular Docking Molecular Mechanism

Structural and Functional Insights into an Arabidopsis NBS-LRR Receptor in Nicotiana benthamiana

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American Journal of Molecular Biology 2024年第2期14卷 84-96页

作者： jianzhong Huang Xiuying Guan Xiaoju Zhong Peng Jia Hongbin Zhang Honglei Ruan Key Laboratory of Chronic Diseases Fuzhou Medical University Fuzhou China

Nucleotide-binding site leucine-rich repeat receptors (NBS-LRR/NLRs) are crucial intracellular immune proteins in plants. Previous article reported a novel NLR protein SUT1 (SUPPRESSORS OF TOPP4-1, 1), which is involved in autoimmunity initiated by type one protein phosphatase 4 mutation (topp4-1) in Arabidopsis, however, its role in planta is still unclear. This study employed Nicotiana benthamiana, a model platform, to conduct an overall structural and functional analysis of SUT1 protein. The transient expression results revealed that SUT1 is a typical CNL (CC-NBS-LRR) receptor, both fluorescence data and biochemical results showed the protein is mainly anchored on the plasma membrane due to its N-terminal acylation site. Further truncation experiments announced that its CC (coiled-coil) domain possessed cell-death-inducing activity. The outcomes of point mutations analysis revealed that not only the CC domain, but also the full-length SUT1 protein, whose function and subcellular localization are influenced by highly conserved hydrophobic residues. These research outcomes provided favorable clues for elucidating the activation mechanism of SUT1.

关键词： CC-NBS-LRR Hypersensitive Response Nicotiana benthamiana Plasma Membrane Localization