检索结果-南通市图书馆

Deaths and adverse events from adjuvant therapy with immune checkpoint inhibitors in solid malignant tumors:A systematic review and network meta-analysis

引用

Cancer Innovation 2022年第4期1卷 293-304页

作者： Ruiyang Xie Jie Wu Bingqing Shang Xingang Bi Chuanzhen Cao Youyan Guan Hongzhe Shi jianzhong shou Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:By prolonging overall survival and reducing disease recurrence rates,immune checkpoint inhibitors(ICIs)are an emerging adjuvant therapy option for patients with resectable malignant tumors.However,the safety profile(deaths and adverse events[AEs])of adjuvant ICIs has not been fully described.Methods:We searched the literature for phase III randomized clinical trials that compared PD-1,PD-L1,and CTLA-4 inhibitors in solid malignant tumors.Incidences of death,discontinuation,AEs of any cause,treatment-related adverse events(TRAEs),and immune-related adverse events(IRAEs)were extracted for the network meta-analysis.Network meta-analyses with low incidence and poor convergence are reported as incidences with 95%confidence intervals(95%CIs).Results:Ten randomized clinical trials that included 9243 patients who received ICI adjuvant therapy were eligible.In total,21 deaths due to TRAEs were recorded,with an overall incidence of 0.40%(95%CI:0.26–0.61).The treatment-related mortality rates for ipilimumab(0.76%,95%CI:0.31–1.55)and atezolizumab(0.56%,95%CI:0.18–1.31)were higher than for pembrolizumab(0.24%,95%CI:0.10–0.56)and nivolumab(0.30%,95%CI:0.08–0.77).The most frequent causes of death were associated with the gastrointestinal(0.10%,95%CI:0.04–0.24)and pulmonary(0.08%,95%CI:0.03–0.21)systems.Compared with the control arm,we found that nivolumab(odds ratio[OR]:2.73,95%CI:0.49–15.85)and atezolizumab(OR:12.43,95%CI:2.42–78.48)caused the fewest grade≥3 TRAEs and IRAEs.Commonly reported IRAEs of special interest were analyzed,and two agents were found to have IRAEs with incidences>10%,i.e.,hepatitis for atezolizumab(14.80%,95%CI:12.53–17.32)and hypophysitis for ipilimumab(13.53%,95%CI:11.38–15.90).Conclusions:Ipilimumab and atezolizumab were correlated with higher treatment-related death rates than pembrolizumab and nivolumab,in which the gastrointestinal and pulmonary systems were mostly involved.Regarding severe TRAEs and IRAEs,nivolumab and atezolizumab are likely to be the safest agent,respectively.This stu

关键词： immune checkpoint inhibitor adjuvant therapy cancer adverse event death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids

引用

Nano Research 2023年第1期16卷 1021-1032页

作者： Dong Liu Ruirui Guo Shuangshuang Mao Yanjie Huang Bin Wang Zijian Wu Xuanjie Xia Jian Dong Yu Xin Ruiyang Xie jianzhong shou Wei Sun Yuan Pang Yuan Lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Tianjin Industrial Microbiology Key Laboratory College of BiotechnologyTianjin University of Science and TechnologyTianjin 300457China Biomanufacturing Center Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Biomanufacturing Center Dept.of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Nanocatalytic medicine triggering in situ catalytic reactions has been considered as a promising strategy for tumor-selective therapeutics.However,the targeted distribution of nanocatalysts was still low,considering the absence of targeting propulsion capability.Here,encouraged by the fast-developing controllable microrobotics for targeting delivery,a sunflower-like nanocatalytic active swarm(SNCAS)controlled by a three-dimensional(3D)magnetic field was proposed for synergistic tumorselective and magnetic-actively tumor-targeting therapeutics.Furthermore,a patient-derived renal cancer cell 3D organoid was utilized for the verification of the effective tumor therapeutic outcomes.Under the targeted control of 3D magnetic field,the multiple cascade catalytic efficiency of SNCAS based on Fenton reaction was evaluated,resulting in efficient tumor cell apoptosis and death.For the patient-derived organoid treatment,the SNCAS presented significant lethality toward 3D organoid structure to induce cell apoptosis with the collapse of organoid morphology.The targeting efficiency was further enhanced under the magnetic-controllable of SNCAS.Overall,empowered by the magnetic control technology,the synergistic therapeutic strategy based on controllable swarm combined active targeting and tumor-specific catalytic nanomedicine has provided a novel way for advanced cancer therapy.Meanwhile,3D patient-derived organoids were proved as a powerful tool for the effectiveness verification of nanocatalytic medicine.

关键词： nanocatalytic swarm magnetic control patients-derived organoids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine learning-based prognostic and metastasis models of kidney cancer

引用

Cancer Innovation 2022年第2期1卷 124-134页

作者： Yuxiang Zhang Na Hong Sida Huang Jie Wu Jianwei Gao Zheng Xu Fubo Zhang Shaohui Ma Ye Liu Peiyuan Sun Yanping Tang Chun Liu jianzhong shou Meng Chen National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Digital Health China Technologies Co.Ltd.BeijingChina Department of public policy Cornell UniversityIthacaNew YorkUSA The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijingChina

Background:Kidney cancer originates from the urinary tubule epithelial system of the renal parenchyma,accounting for 20% of all urinary system tumors.Approximately 70% of cases are localized at diagnosis,and 30%are metastatic.Most localized kidney cancers can be cured by surgery,but most metastatic patients relapse after surgery and eventually die of kidney cancer.Therefore,accurately predicting patient survival and identifying high-risk metastatic patients will effectively guide interventions and improve prognosis.Methods:This study used the data of 12,394 kidney cancer patients from the surveillance,epidemiology,and end results database to construct a research cohort related to kidney cancer survival and metastasis.Eight machine learning models(including support vector machines,logistic regression,decision tree,random forest,XGBoost,AdaBoost,K-nearest neighbors,and multilayer perceptron)were developed to predict the survival and metastasis of kidney cancer and six evaluation indicators(accuracy,precision,sensitivity,specificity,F1 score,and area under the receiver operating characteristic[AUROC])were used to verify,evaluate,and optimize the models.Results:Among the eight machine learning models,Logistic Regression has the highest AUROC in both prediction scenarios.For 3-year survival prediction,the Logistic Regression model had an accuracy of 0.684,a sensitivity of 0.702,a specificity of 0.670,a precision of 0.686,an F1 score of 0.683,and an AUROC of 0.741.For tumor metastasis prediction,the Logistic Regression model had an accuracy of 0.800,a sensitivity of 0.540,a specificity of 0.830,a precision of 0.769,an F1 score of 0.772,and an AUROC of 0.804.Conclusion:In this study,we selected appropriate variables from both statistical and clinical significance and developed and compared eight machine learning models for predicting 3-year survival and metastasis of kidney cancer.The prediction results and evaluation results demonstrated that our model could provide decision support for early intervention for kidney ca

关键词： machine learning kidney cancer survival metastasis prognostic model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

输尿管原发滤泡性淋巴瘤1例

引用

肿瘤研究与临床 2024年第2期36卷 132-135页

作者：叶振邦吴杰邱田郭蕾王冰凝农琳寿建忠黄文亭郑闪国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院病理科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100021

目的探讨原发于输尿管的滤泡性淋巴瘤(FL)的病理诊断及鉴别诊断要点。方法回顾性分析中国医学科学院肿瘤医院2023年6月收治的1例输尿管原发FL患者的临床病理资料,并复习相关文献。结果患者为老年男性,因体检发现左侧输尿管中上段占位半... 详细信息

目的探讨原发于输尿管的滤泡性淋巴瘤(FL)的病理诊断及鉴别诊断要点。方法回顾性分析中国医学科学院肿瘤医院2023年6月收治的1例输尿管原发FL患者的临床病理资料,并复习相关文献。结果患者为老年男性,因体检发现左侧输尿管中上段占位半个月就诊。既往有尿路结石病史。因术前影像资料难以明确诊断而行左肾及输尿管全长膀胱部分切除术。镜下形态学与结内滤泡淋巴瘤相同,表现为排列紧密的淋巴滤泡,生发中心极向消失,肿瘤细胞以中心细胞为主,可见散在分布的中心母细胞,未见星空现象;免疫表型示B细胞标志阳性,表达CD10、bcl-6及bcl-2,CD21和CD23显示滤泡树突细胞网存在;抗原受体基因克隆性重排聚合酶链反应显示有B细胞受体克隆性重排;荧光原位杂交显示存在bcl-2基因易位。术后PET-CT检查未发现其他病灶,支持输尿管原发FL诊断。术后行膀胱灌注治疗、局部放疗。结论输尿管原发FL临床表现无特异性,与输尿管癌在影像学上不能鉴别。肿瘤的形态学观察辅以免疫表型、抗原受体基因克隆性重排及荧光原位杂交检测可明确诊断。需行全身检查除外系统性FL累及输尿管可能。

关键词：淋巴瘤,滤泡性输尿管原位杂交,荧光抗原受体基因克隆性重排免疫表型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Temporal properties of pattern adaptation of relay cells in the lateral geniculate nucleus of cats

引用

Chinese Science Bulletin 2001年第17期46卷 1463-1465页

作者： YANG Yupeng JIN jianzhong ZHOU Yifeng shou Tiande Vision Research Laboratory School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Vision Research Laboratory and Liren Laboratory Center for Brain Science ResearchSchool of Life SciencesFudan UniversityShanghai 200433China Laboratory of Visual Information Processing Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

The temporal properties of pattern adaptation of relay cells induced by repeated sinusoidal drifting grating were investigated in the dorsal lateral geniculate nucleus (dLGN) of cats. The results showed that the response amplitude declined and the response latency prolonged when relay cells were pattern-adapted in dLGN, like the similar findings in visual cortex. However, in contrast to the result in cortex, the response phase of relay cells advanced. This implies that an inhibition with relatively long latency may participate in the pattern adaptation of dLGN cells and the adaptation in dLGN may be via a mechanism different from that of visual cortex.

关键词： pattern adaptation temporal properties latency phase lateral geniculate nucleus cat.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

聚焦2019年欧洲泌尿外科学会年会肾癌研究进展及带来的思考

引用

中华泌尿外科杂志 2019年第5期40卷 321-324页

作者：寿建忠国家癌症中心/北京协和医学院中国医学科学院肿瘤医院泌尿外科北京100021

作为欧洲泌尿外科学会(EAU)规模最大、最具影响力的科学盛会——第34届EAU年会已经圆满落下帷幕.大会期间所公布的全部研究数据、指南更新乃至争议都一如既往地在全球泌尿外科医生的心中激起层层涟漪.其中在肾癌领域,本次年会共收录相... 详细信息

作为欧洲泌尿外科学会(EAU)规模最大、最具影响力的科学盛会——第34届EAU年会已经圆满落下帷幕.大会期间所公布的全部研究数据、指南更新乃至争议都一如既往地在全球泌尿外科医生的心中激起层层涟漪.其中在肾癌领域,本次年会共收录相关研究超过百篇,几乎囊括肾癌诊疗的全部热点,特别是在某些研究领域带来了理念上的冲击,产生了深远的甚至是里程碑式的影响,必将指引未来肾癌研究与治疗的方向。

关键词：泌尿外科学会肾癌年会欧洲聚焦外科医生 EAU

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

系统联合认知融合靶向穿刺提高有临床意义前列腺癌的诊断率

引用

中国肿瘤临床 2023年第21期50卷 1081-1085页

作者：胡林军陈永海王怿忱寿建忠北京市朝阳区桓兴肿瘤医院泌尿外科北京市100122 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院影像科

目的:探讨静脉麻醉下经会阴的前列腺系统穿刺(systematic biopsy,SB)、认知融合靶向穿刺(cognitive fusion targeted biopsy,CF-TB)和系统联合认知融合靶向穿刺即联合穿刺(combined biopsy,CB)对有临床显著意义前列腺癌(clinically significant prostate cancer,csPCa)和无临床显著意义前列腺癌(clinically insignificant prostate cancer,incsPCa)诊断阳性率的差异。方法:分析2019年1月至2021年11月151例于北京市朝阳区桓兴肿瘤医院和中国医学科学院北京协和医学院肿瘤医院行首次前列腺穿刺且前列腺特异性抗原(prostate-specific antigen,PSA)≤50 ng/mL患者的临床资料,行3.0 T标准前列腺多参数磁共振成像(multi-parametric magnetic resonance imaging,mpMRI)检查显示有161个符合前列腺影像报告和数据系统(prostate imaging reporting and data system,PI-RADS)评分≥3分的结节,每个结节行2~4针CF-TB后再行SB 12针,分别分析SB、CF-TB和CB对csPCa和incsPCa的诊断阳性率,同时对年龄、PSA、CF-TB针数、PI-RADS评分和直肠指诊结果进行分层分析。结果:患者的中位PSA为11.50(0.52~49.37)ng/mL,161个结节的PI-RADS评分≥3分,151例患者均行12针SB,结节行2、3和4针CF-TB患者分别47、52和52例。SB、CF-TB和CB诊断csPCa阳性率分别为54.3%(82/151)、53.0%(80/151)和58.9%(89/151),CB阳性率高于SB阳性率(P=0.016)和CF-TB阳性率(P=0.004);SB、CF-TB和CB诊断incsPCa阳性率分别为7.9%(12/151)、9.3%(14/151)和11.3%(17/151),CB阳性率与SB阳性率和CF-TB阳性率比较差异均无统计学意义(均P>0.05)。按年龄、PSA、CF-TB针数、PI-RADS评分和直肠指诊结果分层分析显示,行2针CF-TB对csPCa诊断差于CB(P=0.031),3针和4针CF-TB与CB诊断csPCa阳性率比较差异无统计学意义。结论:经会阴的前列腺CB诊断csPCa阳性率最高,同时不增加incsPCa检出,每个结节行3针CF-TB诊断csPCa是高效的。

关键词：系统穿刺认知融合靶向穿刺联合穿刺有临床意义前列腺癌无临床意义前列腺癌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

引用

Asian Journal of Urology 2019年第1期6卷 114-121页

作者： Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma jianzhong shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang Department of Urology Peking University First HospitalBeijingChina Institute of Urology Peking UniversityBeijingChina National Urological Cancer Center BeijingChina Air Force General Hospital PLABeijingChina Department of Urology Peking Union Medical College HospitalBeijingChina Department of Urology Beijing Chao-Yang HospitalBeijingChina Department of Urology Armed-Police General HospitalBeijingChina Department of Urology Shanxi Medical University First HospitalTaiyuanChina Department of Urology Hebei Medical University Second HospitalShijiazhuangChina Department of Urology The General Hospital of the People’s Liberation ArmyBeijingChina Department of Urology First Affiliated Hospital of Jilin UniversityChangchunChina Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina Department of Urology The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Urology General Hospital of Guangzhou Military Command of PLAGuangzhouChina Department of Urology West China School of MedicineChengduChina Department of Urology Shangdong Province-owned HospitalJinanChina Department of Urology Peking University Shenzhen HospitalShenzhenChina Department of Urology The Central Hospital of Jinan CityJinanChina Department of Urology Shanghai Changzheng HospitalShanghaiChina Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Urology Beijing Anzhen Hospital of Capital Medical UniversityBeijingChina Department of Urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Urology People’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina Department of Urology Guangdong General HospitalGuangzhouChina Department of Urology The First Affil

Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors.

关键词： Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

前列腺重复穿刺研究进展

引用

中华泌尿外科杂志 2021年第1期42卷 71-74页

作者：胡林军寿建忠北京市朝阳区桓兴肿瘤医院泌尿外科 100122 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100006

前列腺穿刺存在漏诊前列腺癌的可能,重复穿刺有其必要性。本文对前列腺重复穿刺独立危险因素、穿刺途径选择和穿刺新技术进展方面进行综述,以提高临床医生对前列腺重复穿刺适应证的认识。对符合前列腺重复穿刺的患者,推荐使用mpMRI靶向... 详细信息

前列腺穿刺存在漏诊前列腺癌的可能,重复穿刺有其必要性。本文对前列腺重复穿刺独立危险因素、穿刺途径选择和穿刺新技术进展方面进行综述,以提高临床医生对前列腺重复穿刺适应证的认识。对符合前列腺重复穿刺的患者,推荐使用mpMRI靶向穿刺,以提高有临床意义前列腺癌的检出率,减少无临床意义前列腺癌的检出率。

关键词：前列腺肿瘤重复穿刺研究进展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

溶瘤病毒在膀胱癌治疗中的研究现状与进展

引用

中华泌尿外科杂志 2020年第8期41卷 633-636页

作者：尚冰清寿建忠国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100021

膀胱癌是泌尿系统最常见的恶性肿瘤。免疫治疗作为一种新型的治疗方法,在尿路上皮癌领域取得了巨大成功。溶瘤病毒作为免疫治疗的一项新兴研究热点,可以通过特异性破坏肿瘤细胞或激活特异性抗肿瘤免疫的双重作用机制来达到抗肿瘤效应。... 详细信息

膀胱癌是泌尿系统最常见的恶性肿瘤。免疫治疗作为一种新型的治疗方法,在尿路上皮癌领域取得了巨大成功。溶瘤病毒作为免疫治疗的一项新兴研究热点,可以通过特异性破坏肿瘤细胞或激活特异性抗肿瘤免疫的双重作用机制来达到抗肿瘤效应。目前,溶瘤病毒在膀胱癌的治疗中取得了重大突破,特别是在非肌层浸润性膀胱尿路上皮癌的治疗方面。包括腺病毒、柯萨奇病毒、牛痘病毒及单纯疱疹病毒等在内的溶瘤病毒,在膀胱灌注治疗膀胱癌的多项临床试验中显示出良好的安全性和有效性。特别是在重组腺病毒干扰素α治疗膀胱癌的Ⅲ期临床试验中,高达53%的患者3个月时获得完全缓解,且无Ⅳ/Ⅴ级不良反应。本文就溶瘤病毒在膀胱癌治疗中的研究现状和进展进行综述。

关键词：膀胱肿瘤膀胱癌溶瘤病毒膀胱灌注

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：