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Bioprinting of inorganic-biomaterial/neural-stem-cell constructs for multiple tissue regeneration and functional recovery

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National Science Review 2024年第4期11卷 228-244页

作者： Hongjian Zhang chen Qin Zhe Shi Jianmin Xue jianxin Hao Jinzhou Huang Lin Du Hongxu Lu chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Tissue regeneration is a complicated process that relies on the coordinated effort of the nervous, vascular and immune systems. While the nervous system plays a crucial role in tissue regeneration, current tissue engineering approaches mainly focus on restoring the function of injury-related cells, neglecting the guidance provided by nerves. This has led to unsatisfactory therapeutic outcomes. Herein, we propose a new generation of engineered neural constructs from the perspective of neural induction, which offers a versatile platform for promoting multiple tissue regeneration. Specifically, neural constructs consist of inorganic biomaterials and neural stem cells(NSCs), where the inorganic biomaterials endows NSCs with enhanced biological activities including proliferation and neural differentiation. Through animal experiments, we show the effectiveness of neural constructs in repairing central nervous system injuries with function recovery. More importantly, neural constructs also stimulate osteogenesis, angiogenesis and neuromuscular junction formation, thus promoting the regeneration of bone and skeletal muscle, exhibiting its versatile therapeutic performance. These findings suggest that the inorganic-biomaterial/NSC-based neural platform represents a promising avenue for inducing the regeneration and function recovery of varying tissues and organs.

关键词： 3D bioprinting neural stem cells inorganic biomaterials neural constructs multiple tissue regeneration

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RNA ac^(4)C modification in cancer biology:from regulatory mechanisms to clinical applications

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Science China(Life Sciences) 2024年第4期67卷 832-835页

作者： Lijun Tao Yunqing Lu Zhuojia chen Lichen Ge Junming He jianxin Peng Hongsheng Wang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Hepatobiliary Surgery Guangdong Province Traditional Chinese Medical HospitalGuangzhou 510120China

RNA modifications are increasingly recognized for their significance in diverse physiological and pathological processes,with over 170 types of chemical modifications having been discovered since *** these modifications,N4-acetylcytidine(ac^(4)C)is the first acetylated modification identified on eukaryotic RNAs,previously reported in transfer RNA(t RNA)and ribosomal RNA(rRNA)。

关键词： clinical (4) modification

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Achieving Negatively Charged Pt Single Atoms on Amorphous Ni(OH)_(2)Nanosheets with Promoted Hydrogen Absorption in Hydrogen Evolution

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Nano-Micro Letters 2024年第10期16卷 213-224页

作者： Yue Liu Gui Liu Xiangyu chen Chuang Xue Mingke Sun Yifei Liu jianxin Kang Xiujuan Sun Lin Guo School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringKey Laboratory of Bio-inspired Smart Interfacial Science and TechnologyBeihang UniversityBeijing 100191People's Republic of China School of Chemistry Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of EducationXiangtan UniversityXiangtan 411105HunanPeople'Republic of China

Single-atom(SA)catalysts with nearly 100%atom utilization have been widely employed in electrolysis for decades,due to the outperforming catalytic activity and ***,most of the reported SA catalysts are fixed through the strong bonding between the dispersed single metallic atoms with nonmetallic atoms of the substrates,which greatly limits the controllable regulation of electrocatalytic activity of SA *** this work,Pt-Ni bonded Pt SA catalyst with adjustable electronic states was successfully constructed through a controllable electrochemical reduction on the coordination unsaturated amorphous Ni(OH)_(2)nanosheet *** on the X-ray absorption fine structure analysis and first-principles calculations,Pt SA was bonded with Ni sites of amorphous Ni(OH)_(2),rather than conventional O sites,resulting in negatively charged Pt^(δ-).In situ Raman spectroscopy revealed that the changed configuration and electronic states greatly enhanced absorbability for activated hydrogen atoms,which were the essential intermediate for alkaline hydrogen evolution *** hydrogen spillover process was revealed from amorphous Ni(OH)_(2)that effectively cleave the H-O-H bond of H_(2)O and produce H atom to the Pt SA sites,leading to a low overpotential of 48 mV in alkaline electrolyte at-1000 mA cm^(-2)mg^(-1)_(Pt),evidently better than commercial Pt/C *** work provided new strategy for the control-lable modulation of the local structure of SA catalysts and the systematic regulation of the electronic states.

关键词： Hydrogen evolution reaction Amorphous Pt single atoms Hydrogen spillover

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Changes on Stroke Burden Attributable to Ambient Fine Particulate Matter in China

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Biomedical and Environmental Sciences 2024年第8期37卷 823-833页

作者： Jingyu Wang Yan Wang Xiaohua Liang Keyong Huang Fangchao Liu Shufeng chen Xiangfeng Lu jianxin Li Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Department of Clinical Epidemiology and Biostatistics Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Pediatric Metabolism and Inflammatory DiseaseChongqing 400016China

Objective In recent decades,China has implemented a series of policies to address air *** aimed to assess the health effects of these policies on stroke burden attributable to ambient fine particulate matter(PM_(2.5)).Methods Joinpoint regression was applied to explore the temporal tendency of stroke burden based on data from the Global Burden of Disease 2019 *** The age-standardized rates of disability-adjusted life year(DALY)for stroke attributable to ambient PM2.5 in China,increased dramatically during 1990-2012,subsequently decreased at an annual percentage change(APC)of-1.98[95% confidence interval(CI):-2.26,-1.71]during *** ischemic stroke(IS),the age-standardized DALY rates doubled from 1990 to 2014,and decreased at an APC of-0.83(95%CI:-1.33,-0.33)during *** hemorrhage(ICH)showed a substantial increase in age-standardized DALY rates from 1990 to 2003,followed by declining trends,with APCs of-1.46(95%CI:-2.74,-0.16)during 2003-2007 and-3.33(95%CI:-3.61,-3.06)during 2011-2019,***,the age-standardized DALY rates for subarachnoid hemorrhage(SAH)generally declined during *** Our results clarified the dynamic changes of the ambient PM_(2.5)-attributable stroke burden in China during 1990-2019,highlighting the health effects of air quality improvement policies.

关键词： Ambient fine particulate matter Stroke Disease burden Temporal trend Policy

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Highly efficient and broad electromagnetic wave absorbers tuned via topology-controllable metal-organic frameworks

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Science China Materials 2020年第10期63卷 2050-2061页

作者： Peng Miao jianxin chen Yusheng Tang Kai-Jie chen Jie Kong MOE Key Laboratory of Materials Physics and Chemistry in Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Advanced electromagnetic(EM)wave absorbing materials with strong absorption and broad bandwidth are important for military stealth and elimination of microwave pollution in consumers’*** organic framework(MOF)-derived metal/carbon hybrids with ordered structure are significantly urgent in this *** this contribution,we presented a design strategy of hollow cage-like or solid box-like magnetic/dielectric Fe/Co/C and dielectric Fe/Mn/C EM wave absorbing nanomaterials via pyrolyzing Prussian blue’s analogs with controllable topology and phase *** solid box-like Fe/Co/C and hollow cage-like Fe/Mn/C showed favorable absorption property with a broad effective absorption bandwidth(EAB)and a low reflection loss(RL).Especially,the EAB of 8.8 GHz at a thickness of 2.5 mm for solid box-like Fe/Co/C nanocomplex prepared at 900℃is a new record for this type of *** design and tuning strategy for EM wave absorbers derived from topology-controllable MOF is important for EM functional materials possessing great potential in military stealth and consumers’electronics.

关键词： electromagnetic wave absorber MOF Prussian blue's analogs topology pyrolysis

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Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice

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Food Science and Human Wellness 2024年第1期13卷 90-100页

作者： Xiaoxiang Gao chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian jianxin Zhao Wei chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most *** date,microbiota-directed foods selectively promote the targeted human gut microbes,providing a strategy for *** *** studies have indicated the potential regulation of the polyphenol on ***,a polyphenol screening based on *** upregulation was performed in *** acid(CGA)exhibited a greater response to *** ***,we found that CGA did not directly promote *** growth or mucin *** and metabolomics revealed that the increased abundance of *** resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid,β-hydroxybutyrate,and ***,to confirm the regulation of CGA on *** under disease conditions,high-fat diet-fed mice were *** results showed CGA promoted *** growth,and we expectedly found that CGA suppressed the augment in body weight of mice,significantly attenuated adipose tissue abnormality,provided liver protection and improved gut barrier *** results suggest that CGA inhibits the development of ***,our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.

关键词： Akkermansia muciniphila polyphenol chlorogenic acid obesity

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基于藻菌共生废水处理技术的MBRM反应模型

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南昌大学学报（理科版） 2024年第4期48卷 352-359页

作者：周玮钰熊川懿陈姝灿高梦嘉王锌针万瀚宇王圣智田茂芝陈建新李昆南昌大学资源与环境学院南昌330031 南昌大学鄱阳湖环境与资源利用教育部重点实验室南昌330031

将藻菌共生的微生物代谢体系用在废水的水质处理中,能快速同步去除碳氮磷等易造成水体富营养化的污染物,因此藻菌共生水处理技术具有广阔的应用前景。而数学模型能够对相关的藻菌水处理过程进行精准的抽象描述,发掘其中的变化规律,总结... 详细信息

将藻菌共生的微生物代谢体系用在废水的水质处理中,能快速同步去除碳氮磷等易造成水体富营养化的污染物,因此藻菌共生水处理技术具有广阔的应用前景。而数学模型能够对相关的藻菌水处理过程进行精准的抽象描述,发掘其中的变化规律,总结适宜的参数优化策略,对于工艺后续的效果强化和扩大应用具有重要意义。尽管已有许多基于生化处理的数学模型作为基础,藻菌模型在应对水质更为复杂的情况下的表现较少,需要在原有的模型体系中针对不同的水质特性和应用场景加以改良。本研究是基于藻菌共生水处理技术应用在畜禽养殖废水处理中的一系列物理化学反应和生长代谢过程,针对其反应器开发了一个MBRM数学模型。通过30 d连续运行实验研究对模型进行验证和校准,验证了该模型能根据反应器的运行参数条件和进出水水质,并且准确地模拟其中的微生物处理过程中的相关的水质变化和微生物的生长情况。

关键词：藻菌共生数学模型运行优化污水深度处理

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Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul Ross Catherine Stanton jianxin Zhao Bo Yang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

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Bilateral Breast Cancer with a Unilateral Lipid-rich Carcinoma:A Case Report

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Chinese Journal of Clinical Oncology 2007年第5期4卷 376-377页

作者： Jinsong chen jianxin Zhang Qingmo Liang Zheng Bao Zigui Zheng Nie Hu Hongfei Yan Nanhua Hospital of Nanhua University Hengyang 421002 Hunan China

Case ReportA 38-year old female patient was hospitalized on the 10th of December, 2006 as she had noted a lump in her right breast for 3 months. Her past medi. cal history indicated that, because of a left-breast carcinoma complex, she had undergone a radical operation for a left-sided mastocarcinoma on the 20th, October, 2002, in Xiangya Hospital, Chasha. She received 5-course postoperative chemotherapy （i.e. CAF regimen）, and one course of radiotherpy on the left supraclavicular and left parasternal region. There was no medical record of breast cancer in her familv.

关键词： Breast tumor lipid-rich carcinoma

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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

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Food Science and Human Wellness 2024年第4期13卷 1951-1961页

作者： Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu jianxin Zhao Gang Wang Wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Institute of Food Biotechnology(Yangzhou) Jiangnan UniversityYangzhou 225004China

Gut microbiome is indispensable for maintaining normal brain ***,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive *** this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived ***1025 improved the body weight and food and water intake of the *** also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related ***1025 significantly altered the gut microbial composition and genome *** microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the *** metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator ***,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its *** findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

关键词： Bifidobacterium Sleep Circadian rhythm Purine Gut microbiome

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