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Frontiers of Structural and Civil Engineering 2024年第6期18卷 949-962页

作者： Kailing DENG Duanyi WANG Cheng TANG jianwen situ Luobin CHEN School of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510640China

Raveling is a common distress of asphalt pavements,defined as the removal of stones from the pavement *** predict and assess raveling quantitatively,a cumulative damage model based on an energy dissipation approach has been developed at the meso *** construct the model,a new test method,the pendulum impact test,was employed to determine the fracture energy of the stone-mastic-stone meso-unit,while digital image analysis and dynamic shear rheometer test were used to acquire the strain rate of specimens and the rheology property of mastic,*** of the model reveals that when the material properties remain constant,the cumulative damage is directly correlated with loading time,loading amplitude,and loading ***,damage increases with superimposed linear and cosine variations over time.A higher stress amplitude results in a more rapidly increasing rate of damage,while a lower load frequency leads to more severe damage within the same loading ***,an example of the application of the model has been presented,showing that the model can be utilized to estimate failure life due to *** model is able to offer a theoretical foundation for the design and maintenance of anti-raveling asphalt pavements.

关键词： asphalt pavement raveling cumulative damage dissipation energy theory

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戊型肝炎的肝外损伤特点及临床表现

中华实验和临床病毒学杂志 2019年第5期33卷 557-560页

作者：杨伟敏司徒健文黄芬昆明理工大学医学院 650500

戊型肝炎病毒(hepatitis E virus,HEV)是严重危害人类健康的病毒性感染病原体。戊型肝炎通常是一种自限性疾病。近年发现HEV感染器官移植患者会发展为慢性戊型肝炎。HEV曾被认为是一种嗜肝病毒,但近期研究发现该病毒能够侵犯多个器官,... 详细信息

戊型肝炎病毒(hepatitis E virus,HEV)是严重危害人类健康的病毒性感染病原体。戊型肝炎通常是一种自限性疾病。近年发现HEV感染器官移植患者会发展为慢性戊型肝炎。HEV曾被认为是一种嗜肝病毒,但近期研究发现该病毒能够侵犯多个器官,并会导致侵犯的器官产生病理损伤,表现出临床症状。本文拟对近年国内外HEV侵犯的器官的研究及临床表现的报道进行综述,为更好地了解HEV致病机制及临床HEV的诊断提供新的依据。

关键词：戊型肝炎病毒病毒侵犯的器官临床表现临床诊断

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病毒感染对男性生殖系统的影响

病毒学报 2018年第1期34卷 101-105页

作者：司徒健文龙飞燕孙鹥黄芬禹文海昆明理工大学医学院昆明650500 云南省第一人民医院昆明650032 中国医学科学院医学生物学研究所昆明650038

男性生殖系统受损是影响生殖健康的主要因素。病原体或病毒感染男性生殖系统后,会造成生殖系统不同程度的损伤。目前,感染男性生殖系统的病毒,以及病毒感染后对生殖系统的影响还没有系统的文献报道。本文将对人类免疫缺陷病毒（HIV）,... 详细信息

男性生殖系统受损是影响生殖健康的主要因素。病原体或病毒感染男性生殖系统后,会造成生殖系统不同程度的损伤。目前,感染男性生殖系统的病毒,以及病毒感染后对生殖系统的影响还没有系统的文献报道。本文将对人类免疫缺陷病毒（HIV）,寨卡病毒（ZIKV）,人类巨细胞病毒（HCMV）,人乳头瘤病毒（HPV）,肝炎病毒（HV）等病毒感染后对生殖系统的损伤情况进行综述。

关键词：病毒男性生殖系统生殖系统损伤

Long-term glacier variations and the response to climate fluctuation in Qilian Mountains, China

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Journal of Geographical Sciences 2024年第10期 1904-1924页

作者： WANG Sheng WANG jianwen ZHU Meilin YAO Tandong PU Jianchen WANG Jinfeng College of Geography Science Shanxi Normal University Center for the Pan-Third Pole Environment Lanzhou University Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research CAS State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-environment and ResourcesCAS

Glaciers are considered to be ‘climate-sensitive indicators' and ‘solid reservoirs',and their changes significantly impact regional water security. The mass balance（MB） from 2011 to 2020 of the Qiyi Glacier in the northeast Tibetan Plateau is presented based on field observations. The glacier showed a persistent negative balance over 9 years of in-situ observations, with a mean MB of-0.51 m w.e. yr-1. The distributed energy-mass balance model was used for glacier MB reconstruction from 1980 to 2020. The daily meteorological data used in the model were from HAR v2 reanalysis data, with automatic weather stations located in the middle and upper parts of the glacier used for deviation correction. The average MB over the past 40 years of the Qiyi Glacier was-0.36 m w.e. yr-1with the mass losses since the beginning of the 21st century, being greater than those in the past. The glacier runoff shows a significant increasing trend, contributing ～81% of the downstream river runoff. The albedo disparity indicates that the net shortwave radiation is much higher in the ablation zone than in the accumulation zone, accelerating ablation-area expansion and glacier mass depletion. The MB of the Qiyi Glacier is more sensitive to temperature and incoming shortwave radiation variation than precipitation. The MB presented a non-linear reaction to the temperature and incoming shortwave radiation. Under future climate warming, the Qiyi Glacier will be increasingly likely to deviate from the equilibrium state, thereby exacerbating regional water balance risks. It is found that the mass losses of eastern glaciers are higher than those of western glaciers, indicating significant spatial heterogeneity that may be attributable to the lower altitude and smaller area distribution of the eastern glaciers.

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Long-term glacier variations and the response to climate fluctuation in Qilian Mountains,China

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Journal of Geographical Sciences 2024年第10期34卷 1904-1924页

作者： WANG Sheng WANG jianwen ZHU Meilin YAO Tandong PU Jianchen WANG Jinfeng College of Geography Science Shanxi Normal UniversityTaiyuan 030000China Center for the Pan-Third Pole Environment Lanzhou UniversityLanzhou 730000China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchCASBeijing 100101China State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-environment and ResourcesCASLanzhou 730000China

Glaciers are considered to be‘climate-sensitive indicators'and‘solid reservoirs',and their changes significantly impact regional water *** mass balance(MB)from 2011 to 2020 of the Qiyi Glacier in the northeast Tibetan Plateau is presented based on field *** glacier showed a persistent negative balance over 9 years of in-situ observations,with a mean MB of-0.51 m ***^(-1).The distributed energy-mass balance model was used for glacier MB reconstruction from 1980 to *** daily meteorological data used in the model were from HAR v2 reanalysis data,with automatic weather stations located in the middle and upper parts of the glacier used for deviation *** average MB over the past 40 years of the Qiyi Glacier was -0.36 m ***^(-1)with the mass losses since the beginning of the 21st century,being greater than those in the *** glacier runoff shows a significant increasing trend,contributing~81% of the downstream river *** albedo disparity indicates that the net shortwave radiation is much higher in the ablation zone than in the accumulation zone,accelerating ablation-area expansion and glacier mass *** MB of the Qiyi Glacier is more sensitive to temperature and incoming shortwave radiation variation than *** MB presented a non-linear reaction to the temperature and incoming shortwave *** future climate warming,the Qiyi Glacier will be increasingly likely to deviate from the equilibrium state,thereby exacerbating regional water balance *** is found that the mass losses of eastern glaciers are higher than those of western glaciers,indicating significant spatial heterogeneity that may be attributable to the lower altitude and smaller area distribution of the eastern glaciers.

关键词： glacier mass balance energy-mass balance model hydrology Qilian Mountains

天然免疫抗病毒因子RIG-I过表达对HEV复制的抑制作用

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昆明理工大学学报（自然科学版） 2019年第3期44卷 86-92页

作者：曹文涛郝先辉赵勇琴司徒健文何秋霞纪汉斌杨伟敏黄芬昆明理工大学医学院

视黄酸诱导基因I(retinoic acid inducible gene-I, RIG-I)在宿主天然免疫过程中具有抑制多种RNA病毒复制的作用.为了探究HEV感染过程中宿主天然免疫抗病毒因子RIG-I是否能够抑制HEV的复制,本文采用A549细胞及Huh7.5.1细胞接种HEV;瞬时... 详细信息

视黄酸诱导基因I(retinoic acid inducible gene-I, RIG-I)在宿主天然免疫过程中具有抑制多种RNA病毒复制的作用.为了探究HEV感染过程中宿主天然免疫抗病毒因子RIG-I是否能够抑制HEV的复制,本文采用A549细胞及Huh7.5.1细胞接种HEV;瞬时转染RIG-I真核表达质粒;通过荧光显微镜、Real-time qPCR及Western-blot方法,分析细胞中RIG-I、IRF3和I型干扰素等细胞因子及HEV表达水平变化.结果显示细胞感染HEV后,RIG-I的表达水平显著上升;当细胞中RIG-I过表达时,可显著抑制HEV的复制;RIG-I可上调IRF3的表达,进而刺激I型干扰素的产生进行抗HEV作用.本研究明确了RIG-I过表达具有抑制HEV复制的作用,为今后进一步探究宿主天然免疫防御HEV感染提供了依据.

关键词：抗病毒因子 HEV复制天然免疫 RIG-I

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纸筒构件受压及受拉力学性能研究

实验技术与管理 2021年第2期38卷 30-35页

作者：林静聪李国鹏陈庆军陈飞豪曾庆瀚方淇臻黄国贤司徒坚文伍良富华南理工大学土木与交通学院广东广州510641 亚热带建筑科学国家重点实验室广东广州510641

纸筒作为一种轻质材料,具有绿色环保、运输方便等优点,在临建结构中具有良好的应用前景。该文通过力学试验,研究了在受压和受拉荷载下不同几何参数对纸筒构件关键力学性能的影响;明确了纸筒构件的抗压、抗拉破坏形态,给出了极限强度及... 详细信息

纸筒作为一种轻质材料,具有绿色环保、运输方便等优点,在临建结构中具有良好的应用前景。该文通过力学试验,研究了在受压和受拉荷载下不同几何参数对纸筒构件关键力学性能的影响;明确了纸筒构件的抗压、抗拉破坏形态,给出了极限强度及峰值应变的数值区间;通过建立有限元模型,对试验进行了补充验证,进一步明确纸筒构件的受力机理,并分析了参数对纸筒构件关键力学性能的影响;最后提出一种可实现绿色生产的空间桁架纸筒结构,这种结构应用了3D节点打印技术。研究结果可为纸筒结构的实际应用提供数据支持。

关键词：纸筒临建结构受压受拉力学性能有限元分析

肾母细胞瘤1p/16q杂合性缺失和1q获得与临床病理特征及预后的关系

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中华病理学杂志 2024年第3期53卷 257-263页

作者：贾超姚兴凤张朦管晓星王建文宋宏程何乐健国家儿童医学中心、首都医科大学附属北京儿童医院病理科北京100045 国家儿童医学中心、首都医科大学附属北京儿童医院泌尿外科北京100045

目的探讨肾母细胞瘤1p/16q杂合性缺失(loss of heterozygosity,LOH)、1q获得与临床病理特征及预后的关系。方法回顾性分析2019年9月至2022年8月北京儿童医院病理科接收的肾母细胞瘤样本共175例。经由2名病理医师明确组织学分型和淋巴结... 详细信息

目的探讨肾母细胞瘤1p/16q杂合性缺失(loss of heterozygosity,LOH)、1q获得与临床病理特征及预后的关系。方法回顾性分析2019年9月至2022年8月北京儿童医院病理科接收的肾母细胞瘤样本共175例。经由2名病理医师明确组织学分型和淋巴结受累情况。查阅临床资料,对儿童性别、年龄、肿瘤部位、手术前化疗情况及临床分期进行汇总分析。采用病历查询和电话方式进行随访,了解患儿预后情况。荧光原位杂交法(fluorescence in situ hybridization,FISH)检测肿瘤1p/16q杂合性缺失、1q获得情况,并探究其异常与临床病理特征及预后的关系。结果175例样本中,男性86例(49.1%),女性89(50.9%)。平均年龄(3.5±2.9)岁,中位年龄为2.6岁。1p缺失26例(14.9%),16q缺失28例(16.0%),1p、16q共缺失10例(5.7%);1q获得53例(30.3%)。1q获得与1p缺失(P<0.001)及16q缺失(P<0.01)显著相关。在不同年龄组患儿中,1q获得、1p缺失及16q缺失率差异均有统计学意义(P<0.01)。高危病理组织学类型16q缺失率(50.0%)显著高于中危型(13.6%,P<0.05)。临床分期晚期(Ⅲ、Ⅳ)患儿1q获得、1p缺失及16q缺失率均显著高于临床分期早期(Ⅰ、Ⅱ)患儿(P<0.01)。1q获得、1p缺失及16q缺失异常与性别、单双侧发病、是否化疗、淋巴结是否转移无显著相关性。1q获得、1p缺失肾母细胞瘤患儿的无进展生存时间(progress-free survival,PFS)较1q、1p正常患儿显著缩短(P<0.05),16q缺失患儿的无进展生存时间略短于16q正常患儿,但差异无统计学意义。在晚期肾母细胞瘤患儿中,伴随1q获得、1p缺失具有相对更高的复发转移死亡相对危险度。结论肾母细胞瘤1p/16q杂合性缺失、1q获得情况与年龄、高危病理组织学类型及临床分期相关。1q获得、1p缺失与肾母细胞瘤患儿预后显著相关。

关键词：基因,肾母细胞瘤杂合子缺失病理学,临床预后

Chemo-damage modeling and cracking analysis of AAR-affected concrete dams

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Science China(Technological Sciences) 2013年第6期56卷 1449-1457页

作者： PAN jianwen FENG YunTian XU YanJie JIN Feng ZHANG ChuHan ZHANG BingYin State Key Laboratory of Hydroscience and Engineering Tsinghua University Civil and Computational Engineering Centre College of EngineeringSwansea University

A chemo-damage model for cracking analysis of concrete dams affected by alkali-aggregate reaction (AAR) is proposed, which combines the plastic-damage model for concrete with the AAR kinetics law. The chemo-damage model is first verified by a stress-free AAR expansion test. The expansion deformation obtained from the simulation is in good agreement with the measurement, demonstrating that the proposed model has a sufficient accuracy to predict the expansion of AAR-affected concrete. Subsequently, the expansion deformation and cracking process of the AAR-affected Fontana gravity dam is analyzed. It shows that permanent displacements in the upstream direction and the vertical direction are gradually increased during the long-term operation period, and that their maximal values reach 1.6 and 3.6 cm, respectively. A crack is observed on the wall in the foundation drainage gallery, and extends towards the downstream face of the dam. With the further development of AAR, another crack forms on the downstream face, and then intersects with the gallery crack to penetrate the downstream side profile of the dam. The third crack occurs in the upstream side wall of the gallery and propagates a short distance towards the upstream face of the dam. The simulated cracking pattern in the dam due to AAR is similar to the in situ observation.

关键词： concrete dams alkali-aggregate reaction (AAR) expansion deformation cracking

Confined synthesis of MoS_(2) with rich co-doped edges for enhanced hydrogen evolution performance

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Journal of Energy Chemistry 2022年第7期31卷 18-26,I0002页

作者： Zongge Li Chenlei Li jianwen Chen Xu Xing Yaqun Wang Ying Zhang Miaosen Yang Guoxin Zhang Al-ion Battery Research Center Department of Energy Storage TechnologyShandong University of Science and TechnologyQingdao 266590ShandongChina State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580ShandongChina School of Chemical Engineering Northeast Electric Power UniversityJilin 132012JilinChina

Activating MoS_(2) with atomic metal doping is promising to harvest desirable Pt-matched hydrogen evolution reaction(HER)catalytic ***,we developed an efficient method to access edgerich lattice-distorted MoS_(2) for highly efficient HER via in-situ sulphuration of atomic Co/Mo species that were well-dispersed in a formamide-derived N-doped carbonaceous(f-NC)*** from others,pre-embedding Co/Mo species in f-NC controls the release of metal sources upon annealing in S vapor,grafting the as-made MoS_(2) with merits of short-range crystallinity,distorted lattices,rich defects,and more edges *** content of atomic Co species embedded in MoS_(2) reaches up to 2.85 at.%,and its atomic dispersion has been systematically confirmed by using XRD,HRTEM,XPS,and XAS *** Co-doped MoS_(2) sample exhibits excellent HER activity,achieving overpotentials of 67 and155 m V at j=10 m A cm^(-2) in 1.0 M KOH and 0.5 M H_(2)SO_(4),*** functional theory simulations suggest that,compared with free-doping MoS_(2),the edged Co doping is responsible for the significantly improved HER *** method,in addition to providing reliable Pt-matched HER catalysts,may also inspire the general synthesis of edge-rich metal-doped metal chalcogenide for a wide range of energy conversion applications.

关键词： Molybdenum sulfide Metal doping Formamide Carbon material Hydrogen evolution reaction