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Effects of pentachlorophenol on the detoxification system in white-rumped munia(Lonchura striata)

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Journal of Environmental Sciences 2016年第6期28卷 224-234页

作者： Peng Jiang jianshe wang Jinguo Zhang Jiayin Dai Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Beijing Zoo Beijing 100044 China

Pentachlorophenol（PCP）, a priority pollutant due to its persistence and high toxicity, has been used worldwide as a pesticide and biocide. To understand the adverse effects of PCP, adult male white-rumped munias（Lonchura striata） were orally administrated commercial PCP mixed with corn oil at dosages of 0, 0.05, 0.5, and 5 mg/（kg·day） for 42 day. Gas chromatography–mass spectrometry（GC–MS） analysis found that PCP was preferentially accumulated in the kidney rather than in the liver and muscle in all exposure groups. To examine the function of CYP1A in pollutant metabolism, we isolated two full-length cDNA fragments（designated as CYP1A4 and CYP1A5） from L. striata liver using reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends. PCP induced the expression of CYP1A5, although no obvious change was observed in CYP1A4 expression. Furthermore, PCP significantly elevated the activities of ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase and decreased the activity of benzyloxy-trifluoromethyl-coumarin, with no significant responses observed in benzyloxyresorufin O-debenzylase. PCP induced significant changes in antioxidant enzyme（superoxide dismutase and catalase） activities and malondialdehyde content, but decreased glutathione peroxidase（GSH-Px） and glutathione S-transferase activities and GSH content in the liver of L. striata. The present study demonstrated that PCP had hepatic toxic effects by affecting CYP1As and anti-oxidative status.

关键词： CYP1A4 CYP1A5 Alkoxyresorufin O-dealkylase Antioxidant enzyme Lonchura striata

Electrospun porous carbon nanofibers derived from bio-based phenolic resins as free-standing electrodes for high-performance supercapacitors

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Frontiers of Chemical Science and Engineering 2023年第5期17卷 504-515页

作者： Yongsheng Zhang Xiaomeng Yang Jinpan Bao Hang Qian Dong Sui jianshe wang Chunbao Charles Xu Yanfang Huang School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China School of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang 471934China Department of Chemical and Biochemical Engineering Western UniversityLondonN6A 3K7Canada

Phenolic resins were employed to prepare electrospun porous carbon nanofibers with a high specific surface area as free-standing electrodes for high-performance ***,the sustainable development of conventional phenolic resin has been challenged by petroleum-based phenol and *** with abundant phenolic hydroxyl groups is the main non-petroleum resource that can provide renewable aromatic ***,lignin,phenol,and furfural were used to synthesize bio-based phenolic resins,and the activated carbon nanofibers were obtained by electrospinning and one-step carbonization *** transform infrared and differential scanning calorimetry were used to characterize the structural and thermal *** results reveal that the apparent activation energy of the curing reaction is 89.21 kJ·mol–1 and the reaction order is *** activated carbon nanofibers show a uniform diameter,specific surface area up to 1100 m^(2)·g^(-1),and total pore volume of 0.62 cm^(3)·g^(-1).The electrode demonstrates a specific capacitance of 238 F·g^(-1)(0.1 A·g^(-1))and good rate *** symmetric supercapacitor yields a high energy density of 26.39 W·h·kg^(-1)at 100 W·kg^(-1)and an excellent capacitance retention of 98%after 10000 *** results confirm that the activated carbon nanofiber from bio-based phenolic resins can be applied as electrode material for high-performance supercapacitors.

关键词： lignin bio-based phenolic resins electrospinning activated carbon nanofibers supercapacitors

Distribution of polybrominated diphenyl ethers and decabromodiphenylethane in surface sediments from Fuhe River and Baiyangdian Lake,North China

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Journal of Environmental Sciences 2010年第12期22卷 1833-1839页

作者： Guocheng Hu Zhencheng Xu Jiayin Dai Bixian Mai Hong Cao jianshe wang Zhimin Shi Muqi Xu Metropolitan Environment Center South China Institute of Environmental Sciences Ministry of Environmental Protection Guangzhou 510655 China Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Organic Chemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river （Fuhe River） in North China were analyzed for polybrominated diphenyl ethers （PBDEs） and decabromodiphenylethane （DBDPE）. The concentrations of PBDEs and DBDPE in sediments ranged from 5.5 to 300.7 ng/g dry weight （dw） and 1.1 to 68.2 ng/g dw, respectively. Their levels in sediments in Fuhe River were significantly higher than those in Balyandian Lake. Compared to data from other regions, the PBDE levels in surface sediments from Baiyangdian Lake and Fuhe River were in the medium to lower range. Among the PBDE congeners, BDE209 was predominant, with contributions to the total PBDEs ranging from 79.4% to 97.3% in sediment samples. For the lowly brominated congeners （tri- to hepta-BDE）, BDE47 and BDE99 were the most abundant, which contributed 52.1% and 44.1% to the sum of tri- to hepta-BDEs in the sediments from Baiyangdian Lake and Fuhe River, respectively. The compositional patterns of PBDEs in Baiyangdian Lake sediments indicated that technical deca-BDE mixture was the major pollutant sources with a minor contribution of penta-BDE mixture. The present study suggested that the importance of Fuhe River as a possibly potential sources of PBDEs contamination in Baiyangdian Lake.

关键词： polybrominated diphenyl ethers decabromodiphenylethane contamination profile Baiyangdian Lake Fuhe River

Investigation on the electrochemical behaviours of Mg_(2-x)Cr_xNi negative electrode

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Rare Metals 2003年第2期22卷 144-149页

作者： XUE jianshe, wang Lijun, LUO Yuanhui, LI Guoxun, DU Jun, HU Guangyong, and wang ChaoqunGeneral Research Institute for Non-ferrous Metals, Beijing 100088, China (Received 2002-09-01) Generald Research Institute for Non-ferrous Metals 北京 100088

A series of Mg_(2-x)Cr_xNi alloy powder has been produced by combination ofsolid-state diffusion with mechanical grinding (MG). X-ray diffraction patterns show that the alloypowders have an amorphous structure and great increase in the specific surface. Electrochemicaldetection results indicate that the partial substitution of Mg by Cr in Mg_2Ni alloy improves thecycle life of this alloy greatly, which gets up to 100 cycles at 200 mA/g mass discharge current,keeping its mass discharge capacity over 200 mA.h/g. In the meanwhile, partial replacement of Mg byCr also increases the mass discharge capacity compared with Mg_2Ni alloy. With the increasing ofmass discharge current and content of Cr in Mg_(2-x)Cr_xNi, the cycle life of the alloys areincreased and the decay of mass discharge capacity slows down.

关键词： electrochemistry hydrogen storage alloy Ni-MH battery mechanicalgrinding Mg_2Ni

Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children

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Virologica Sinica 2020年第6期35卷 803-810页

作者： Jiehao Cai Xiangshi wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning wang jianshe wang Qirong Zhu Xiaowen Zhai Mei Zeng Department of Infectious Diseases Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Shanghai Public Health Clinical Center of Fudan UniversityShanghai 201102China Department of Clinical Laboratory Children’s Hospital of Fudan UniversityShanghai 201102China Department of Infectious Diseases Xiamen Children’s HospitalChildren’s Hospital of Fudan University Xiamen BranchShanghai 201102China Department of Hematology Children’s Hospital of Fudan UniversityShanghai 201102China

To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported ***(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological ***-eight(57.1%)were symptomatic and 21(42.9%)were *** asymptomatic nor symptomatic cases progressed to severe *** mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in *** mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with *** conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic *** cases shed viral RNA in a similar pattern as symptomatic cases *** is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control.

关键词： SARS-CoV-2 infection Children Epidemiology Viral shedding Seropositivity

Etiologic diagnosis for children with liver foam cells or vacuolated hepatic macrophages

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Etiologic diagnosis for children with liver foam cells or va...

Non-invasive biomarkers for identification of vanishing bile duct syndrome among children with acute cholestatic hepatitis

第12届全国疑难及重症肝病大会

作者： Nengli wang jianshe wang Children’s Hospital of Fudan University

Objectives & Aims: Liver foam cells or vacuolated hepatic macrophages are frequently detected in children with liver diseases. This study tried to explore etiologic diagnosis of liver foam cells or vacuolated hepatic macrophages among children with liver ***: Between January 2018 and December 2021, liver foam cells were detected in liver-biopsy material from 14 children by hematoxylin-eosin (HE) staining. Vacuolated hepatic macrophages were detected by CD68 immunostaining in 77 other children, including 23 aged <3mo and 54 aged ≥ 3mo, without detectable liver foam cells in HE-stained sections. The patients were referred for signs of liver disease. Clinical data were collected retrospectively.

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Non-invasive biomarkers for identification of vanishing bile...

第12届全国疑难及重症肝病大会

作者： Nengli wang jianshe wang Children’s Hospital of Fudan University

Background & Aims:Vanishing bile duct syndrome (VBDS) have been reported in children as isolated cases and its diagnosis is still challenging before liver biopsy. This study tried to summarize the clinical characteris...

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遗传性胆汁淤积症诊疗

中华肝脏病杂志 2023年第9期31卷 901-904页

作者：刘腾王建设复旦大学附属儿科医院感染传染科上海201102

随着我国在病毒性肝炎防治方面取得巨大成就,由基因缺陷引起的遗传性胆汁淤积症已逐渐成为儿童期肝病死亡或移植的重要原因。不断发现新的致病基因拓展了疾病谱和人们对疾病的认知。不同基因缺陷引起的遗传性胆汁淤积症的疾病特点和临... 详细信息

随着我国在病毒性肝炎防治方面取得巨大成就,由基因缺陷引起的遗传性胆汁淤积症已逐渐成为儿童期肝病死亡或移植的重要原因。不断发现新的致病基因拓展了疾病谱和人们对疾病的认知。不同基因缺陷引起的遗传性胆汁淤积症的疾病特点和临床表现各异,同一基因缺陷引起疾病的严重程度和对治疗的反应也差异显著,早期基因诊断对改善患者的临床管理具有重要价值。治疗方面,除了传统药物和手术外,靶向治疗和基因治疗等也逐步走向临床应用。代谢组学、基因编辑技术和结构生物学的发展使得未来对遗传性胆汁淤积病患儿的个体化精准治疗成为可能,这也给相关从业人员提出了更高要求。

关键词：遗传儿童基因胆汁淤积

论民主集中制中“民主虚泛”现象及其治理对策

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理论前沿 2007年第1期 16-18页

作者：王建社中共宁波市委政策研究室

文章深入分析了现实生活中党内“民主虚泛”的四种表现,认为坚持和完善民主集中制,核心在于加强“一把手”监督,关键在于以民主平衡权力,基础在于推行党务公开。

关键词：民主集中制民主虚泛权力监督党务公开