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Commentary:The central lymphatic drainage in pharmacological,surgical and physical therapies of Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3291-3293页

作者： Lixuan Ren jianping Ye Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000China Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450001China

Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged *** of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease *** recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.

关键词： Ab Central lymphatic drainage Surgery NPLP AD

Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse Mungbean(Vigna radiata(L.)Wilczek)Genotypes

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 611-625页

作者： Fenglan Zhao Jizhi Jin Meng yang Franklin Eduardo Melo Santiago jianping Xue Li Xu Yongbo Duan Anhui Provincial Engineering Laboratory for Efficient Utilization of Featured Resource Plants College of Life SciencesHuaibei Normal UniversityHuaibei235000China Department of Soil Science Federal Institute of PiauiUruçuíPiauí64860-000Brazil The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang550003China

Seed germination with selenium(Se)is promising for producing Se-biofortiﬁed ***(Vigna radiata(L.)Wilczek)sprout is freshly eaten as a salad dressed with sauce,making it superior for Se biofortiﬁ*** the Se safety range for the human body is extremely narrow,it is imperative to evaluate the genotypic responses of mungbean sprouts to *** study evaluated the Se enrichment capacity and interaction withﬂavonoids and antioxidant systems in sprouts of 20 mungbean *** treatment was done by immersing mung-bean seeds in 20μM sodium selenite solution for 8 ***,the biomass,Se amounts,ﬂavonoid(particularly vitexin and isovitexin)contents,antioxidant capacity,and key biosynthetic gene expressions were *** Se content was 2.0-7.0μg g^(-1) DW among the 20 mungbean *** treatment differentially affected the biomass,totalﬂavonoid,vitexin,isovitexin,antioxidant enzyme activities,and antioxidant capacities of the mungbean *** germplasms showed increased biomass(p<0.05),the highest increasing by 127%,but 13 did not phenotypically respond to Se *** and six germplasms showed varied levels of vitexin and isovitexin increment after Se treatment,the highest measuring 2.67-and 2.87-folds for vitexin and isovitexin,*** mungbeanﬂavonoid biosynthesis genes,chalcone synthase(VrCHS)and chalcone isomerase(VrCHI)were signiﬁcantly up-regulated in the germplasms with increased vitexin and isovitexin levels(p<0.05).Moreover,Se enrichment capacity was signiﬁcantly correlated with the vitexin,isovitexin,and antiox-idant *** conclusion,mungbean sprouts could be a useful Se-biofortiﬁed food,but the Se enrichment capacity and nutritional response must be determined for each germplasm before commercialization.

关键词： Antioxidant capacity gene expression genotypic variation isovitexin vitexin selenium

DNA metabarcoding analysis of fungal community on surface of four root herbs

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Chinese Herbal Medicines 2024年第1期16卷 143-150页

作者： Yujie Dao Jingsheng Yu Meihua yang jianping Han Chune Fan Xiaohui Pang Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Objective: Angelicae Sinensis Radix(ASR, Danggui in Chinese), Cistanches Herba(CH, Roucongrong in Chinese), Ginseng Radix et Rhizoma(PG, Renshen in Chinese), and Panacis Quinquefolii Radix(PQ,Xiyangshen in Chinese), widely used as medicine and dietary supplement around the world, are susceptible to fungal and mycotoxin contamination. In this study, we aim to analyze their fungal community by DNA ***: A total of 12 root samples were collected from three main production areas in China. The samples were divided into four groups based on herb species, including ASR, CH, PG, and PQ groups. The fungal community on the surface of four root groups was investigated through DNA metabarcoding via targeting the internal transcribed spacer 2 region(ITS2).Results: All the 12 samples were detected with fungal contamination. Rhizopus(13.04%-74.03%),Aspergillus(1.76%-23.92%), and Fusarium(0.26%-15.27%) were the predominant genera. Ten important fungi were identified at the species level, including two potential toxigenic fungi(Penicillium citrinum and P. oxalicum) and eight human pathogenic fungi(Alternaria infectoria, Candida sake, Hyphopichia burtonii, Malassezia globosa, M. restricta, Rhizopus arrhizus, Rhodotorula mucilaginosa, and Ochroconis tshawytschae). Fungal community in ASR and CH groups was significantly different from other groups,while fungal community in PG and PQ groups was relatively ***: DNA metabarcoding revealed the fungal community in four important root herbs. This study provided an important reference for preventing root herbs against fungal and mycotoxin contamination.

关键词： Angelicae Sinensis Radix Cistanches Herba DNA metabarcoding fungi Ginseng Radix et Rhizoma ITS2 Panacis Quinquefolii Radix root herbs

Mitigating gut immune adverse effects in CTLA-4 blockade for antitumor efficacy

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Science China(Life Sciences) 2024年第7期67卷 1539-1541页

作者： Shijun He jianping Zuo Zemin Lin Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China

By creating an immune checkpoint blockade-induced colitis model,Lo et al.(2024)have suggested a strategy for alleviating gastrointestinal immune-related adverse events while preserving the antitumor stimulatory effect... 详细信息

关键词： immune gastrointestinal

A distributed runoff model for inland mountainous river basin of Northwest China

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Journal of Geographical Sciences 2003年第3期13卷 363-372页

作者： CHENRensheng KANGErsi yangjianping ZHANGJishi RemoteSensingandGISInstitute PekingUniversityBeijing100871China ColdandAridRegionsEnvironmentalandEngineeringResearchInstitute CASLanzhou730000

In order to predict the futuristic runoff under global warming, and to approach to the effects of vegetation on the ecological environment of the inland river mountainous watershed of Northwest China, the authors use the routine hydrometric data to create a distributed monthly model with some conceptual parameters, coupled with GIS and RS tools and data. The model takes sub-basin as the minimal confluent unit, divides the main soils of the basin into 3 layers, and identifies the vegetation types as forest and pasture. The data used in the model are precipitation, air temperature, runoff, soil weight water content, soil depth, soil bulk density, soil porosity, land cover, etc. The model holds that if the water amount is greater than the water content capacity, there will be surface runoff. The actual evaporation is proportional to the product of the potential evaporation and soil volume water content. The studied basin is Heihe mainstream mountainous basin, with a drainage area of 10,009 km 2 . The data used in this simulation are from Jan. 1980 to Dec. 1995, and the first 10 years' data are used to simulate, while the last 5 years' data are used to calibrate. For the simulation process, the Nash-Sutcliffe Equation, Balance Error and Explained Variance is 0.8681, 5.4008 and 0.8718 respectively, while for the calibration process, 0.8799, -0.5974 and 0.8800 respectively. The model results show that the futuristic runoff of Heihe river basin will increase a little. The snowmelt, glacier meltwater and the evaportranspiration will increase. The air temperature increment will make the permanent snow and glacier area diminish, and the snowline will rise. The vegetation, especially the forest in Heihe mountainous watershed, could lead to the evapotranspiration decrease of the watershed, adjust the runoff

关键词： inland river mountainous basin distributed runoff model vegetation Heihe River

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food Science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant S.Bhullar jianping Wu Department of Agricultural Food&Nutritional Science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic

Parametric formation control of multiple nanosatellites for cooperative observation of China Space Station

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Astrodynamics 2024年第1期8卷 77-95页

作者： Hao Zhou Bohan Jiao Zhaohui Dang jianping Yuan School of Astronautics Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Aerospace Flight Dynamics Northwestern Polytechnical UniversityXi’an710072China

This study proposes a parametric formation control method for the cooperative observation of the China Space Station(CSS)using multiple ***,a simplified geometrical model of the CSS is constructed using fundamental solids,such as the capsule body and ***,the spacecraft formation configuration for the observation mission is characterized by a three-dimensional(3D)Lissajous curve using related design parameters under the full-coverage observation requirements of specific parts,such as the CSS connecting section and collision avoidance ***,a double-layer control law is designed for each nanosatellite,in which the upper layer is a distributed observer for recognizing the target formation configuration parameters,and the lower layer is a trajectory-tracking controller to make the nanosatellite converge to its temporary target position calculated from the upper layer’s *** closed-loop control stability is proven under the condition that the communication network topology of the nanosatellite cluster contains a directed spanning ***,the control method is verified by numerical simulation,where the CSS connecting section is selected as the observation target,and ten small nanosatellites are assumed to perform the cooperative observation *** simulation results demonstrate that the double-layer control law is robust to single-point communication failures and suitable for the accompanying missions of large space objects with multiple nanosatellites.

关键词： China Space Station(CSS) cooperative observation parametric formation 3D Lissajous curve double-layer system

Mechanical behavior of nanorubber reinforced epoxy over a wide strain rate loading

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Nano Materials Science 2024年第1期6卷 106-114页

作者： Yinggang Miao jianping Yin Wenxuan Du Lianyang Chen Joint International Research Laboratory of Impact Dynamics and Its Engineering Applications School of AeronauticsNorthwestern Polytechnical UniversityXi'anShaanxi710072China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'anShaanxi710049China Shaanxi Key Laboratory of Impact Dynamics and Its Engineering Application School of AeronauticsNorthwestern Polytechnical UniversityXi'anShaanxi710072China

Nanorubber/epoxy composites containing 0,2,6 and 10 wt%nanorubber are subjected to uniaxial compression over a wide range of strain rate from 8×10^(-4) s^(-1) to~2×10^(4) s^(-1).Unexpectedly,their strain rate sensitivity and strain hardening index increase with increasing nanorubber *** mechanisms are proposed based on numerical simulations using a unit cell *** increase in the strain rate sensitivity with increasing nanorubber content results from the fact that the nanorubber becomes less incompressible at high strain,generating a higher hydro-static *** shear localization starts to occur in the epoxy under a strain rate of 22,000 s^(-1) when the strain exceeds *** presence of nanorubber in the epoxy reduces adiabatic shear localization by preventing it from propagating.

关键词： Strain rate Strain hardening Nano rubber Epoxy Adiabatic shearing localization

An NMOS output-capacitorless low-dropout regulator with dynamic-strength event-driven charge pump

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Journal of Semiconductors 2024年第6期45卷 23-34页

作者： Yiling Xie Baochuang Wang Dihu Chen jianping Guo School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510006China School of Microelectronics University of Science and Technology of ChinaHefei 230000China

In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power *** event-driven charge pump(CP)loop with the dynamic strength control(DSC),is proposed in this paper,which overcomes trade-offs inherent in conventional *** presented design addresses and resolves the large signal stability issue,which has been previously overlooked in the event-driven charge pump *** breakthrough allows for the full exploitation of the charge-pump structure's poten-tial,particularly in enhancing transient ***,a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage,leading to favorable static characteristics.A prototype chip has been fabricated in 65 nm CMOS *** measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current(IQ)and can recover within 30 ns under 200 mA/10 ns loading change.

关键词： output-capacitorless low-dropout regulator fast transient low quiescent current event-driven charge pump