检索结果-南通市图书馆

Journal of Semiconductors 2024年第8期45卷 59-66页

作者： Danrui Wan jianping Zhou Guoyun meng Ning Su Dongdong Zhang Lian Duan Junqiao Ding School of Chemical Science and Technology Yunnan UniversityKunming 650091China Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Southwest United Graduate School Kunming 650092China

Boron−nitrogen doped multiple resonance(BN-MR)emitters,characterized by B−N covalent bonds,offer distinctive advantages as pivotal building blocks for facile access to novel MR emitters featuring narrowband spectra and high ***,there remains a scarcity of exploration concerning synthetic methods and structural derivations to expand the library of novel BN-MR ***,we present the synthesis of a BN-MR emitter,tCz[B−N]N,through a one-pot borylation reaction directed by the amine group,achieving an impressive yield of 94%.The emitter is decorated by incorporating two 3,6-di-tbutylcarbazole(tCz)units into a B−N covalent bond doped BN-MR parent molecule via para-C−π−D and para-N−π−D *** peripheral decoration strategy enhances the reverse intersystem crossing process and shifts the emission band towards the pure green region,peaking at 526 nm with a narrowband full-width at half maximum(FWHM)of 41 ***,organic light emitting diodes(OLEDs)employing this emitter achieved a maximum external quantum efficiency(EQEmax)value of 27.7%,with minimal efficiency *** at a practical luminance of 1000 cd·m^(−2),the device maintains a high EQE value of 24.6%.

关键词： multi-resonance narrowband emission B−N covalent bond organic light emitting diodes

Mechanobiology:A new frontier for human pluripotent stem cells

在线全文

学校读者我要写书评

暂无评论

医用生物力学 2013年第S1期28卷 17-19页

作者： jianping Fu Yubing Sun Koh meng Aw Yong Integrated Biosystems and Biomechanics Laboratory Department of Mechanical EngineeringDepartment of Biomedical EngineeringUniversity of Michigan

Our understanding of the molecular and cellular mechanisms that control self-renewal,pluripotency and differentiation of human pluripotent stem cells(hPSCs)and our progress toward harnessing the regenerative potential of these cells to treat human diseases are advancing at a rapid *** pluripotent stem cells(hPSCs)include human embryonic stem cells(hESCs)and human induced pluripotent stem cells(hiPSCs).Their unique capacity for indefinite self-renewal(unlimited proliferation)in vitro coupled with their ability to differentiate into almost any cell type present in the adult body(pluripotency)provide a potentially

关键词： pluripotent embryonic differentiate renewal potentially frontier regenerative advancing toward innovative

Mechanism of insulin resistance in obesity: a role of ATP

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第3期15卷 372-382页

作者： jianping Ye Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Obesity increases the risk of type 2 diabetes through the induction of insulin *** mechanism of insulin resistance has been extensively investigated for more than 60 years,but the essential pathogenic signal remains *** hypotheses include inflammation,mitochondrial dysfunction,hyperinsulinemia,hyperglucagonemia,glucotoxicity,and *** discoveries based on these hypotheses are unsuccessful in the development of new *** this review,multidisciplinary literature is integrated to evaluate ATP as a primary signal for insulin *** ATP production is elevated in insulin-sensitive cells under obese conditions independent of energy demand,which we have named“mitochondrial overheating.”Overheating occurs because of substrate oversupply to mitochondria,leading to extra ATP *** ATP overproduction contributes to the systemic insulin resistance through several mechanisms,such as inhibition of AMPK,induction of mTOR,hyperinsulinemia,hyperglucagonemia,and mitochondrial *** resistance represents a feedback regulation of energy oversupply in cells to control mitochondrial overloading by *** resistance cuts down the substrate uptake to attenuate mitochondrial *** downregulation of the mitochondrial overloading by medicines,bypass surgeries,calorie restriction,and physical exercise leads to insulin sensitization in ***,ATP may represent the primary signal of insulin resistance in the cellular protective response to the substrate *** prevention of ATP overproduction represents a key strategy for insulin sensitization.

关键词： type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK

Lightweight privacy-preserving truth discovery for vehicular air quality monitoring

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2023年第1期9卷 280-291页

作者： Rui Liu jianping Pan Department of Computer Science University of VictoriaVictoriaBCV8P 5C2Canada

Air pollution has become a global concern for many *** crowdsensing systems make it possible to monitor air quality at a fine *** better utilize the sensory data with varying credibility,truth discovery frameworks are ***,in urban cities,there is a significant difference in traffic volumes of streets or blocks,which leads to a data sparsity problem for truth *** the privacy of participant vehicles is also a crucial *** first present a data masking-based privacy-preserving truth discovery framework,which incorporates spatial and temporal correlations to solve the sparsity *** further improve the truth discovery performance of the presented framework,an enhanced version is proposed with anonymous communication and data *** frameworks are more lightweight than the existing cryptography-based *** also evaluate the work with simulations and fully discuss the performance and possible extensions.

关键词： Privacy preserving Truth discovery Crowdsensing Vehicular networks

Full-duplex two-way AF relaying systems with imperfect interference cancellation in Nakagami-m fading channels

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2021年第8期64卷 143-155页

作者： jianping TONG Caijun ZHONG College of Science Zhejiang University of Technology Department of Information and Communication Engineering Zhejiang University

Full-duplex(FD) two-way relaying has the potential to substantially improve the spectral efficiency of the system, and is regarded as an enabling technology for the next generation wireless communication systems. Nevertheless, the joint effect of residual interference and channel fading condition on the fundamental performance of FD two-way relaying systems remains unclear. Motivated by this, this study considers a general FD two-way amplify-and-forward(AF) relaying system with imperfect interference cancellation in the versatile Nakagami-m fading channels, and presents a detailed analytical investigation on the outage performance of the system. The findings of the paper suggest that the performance of the FD two-way AF relaying system depends heavily on the residual interference strength, fading condition parameter m, and signal-to-noise ratio(SNR). The FD scheme outperforms the half-duplex(HD) two-way relaying counterpart in the low and moderate SNR regime, while becomes inferior in the high SNR regime, owing to strong residual interference. Also, compared to the channel fading condition of the information transmission channels, the impact of the channel fading condition of the interference channel on the system performance is relatively insignificant. Moreover, it is desirable to deploy the FD scheme when the channel fading condition of the information transmission channels is good, since it can effectively alleviate the detrimental effect of residual interference.

关键词： full-duplex two-way relaying Nakagami-m fading outage probability sum throughput

同方期刊数据库

The life and work of Dr. Fan Qingsheng： a pioneer in antibiotics research, agricultural microbiology, systems agriculture, and agricultural education in China

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2017年第8期8卷 551-557页

作者： jianping Xu Department of Biology McMaster University Hamilton ON L8S 4K1 Canada

Microbes are everywhere in the Earth＇s biosphere-they play crucial roles in agriculture, nutrient cycling, environmental protection, and animal and human health. However, despite the importance of microbes throughout...

关键词：

Comparisons of Two Ensemble Mean Methods in Measuring the Average Error Growth and the Predictability

在线全文

学校读者我要写书评

暂无评论

Acta meteorologica Sinica 2011年第4期25卷 395-404页

作者： DING Ruiqiang LI jianping State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029

In this paper, taking the Lorenz system as an example, we compare the influences of the arithmetic mean and the geometric mean on measuring the global and local average error growth. The results show that the geometric mean error （GME） has a smoother growth than the arithmetic mean error （AME） for the global average error growth, and the GME is directly related to the maximal Lyapunov exponent, but the AME is not, as already noted by Krishnamurthy in 1993. Besides these, the GME is shown to be more appropriate than the AME in measuring the mean error growth in terms of the probability distribution of errors. The physical meanings of the saturation levels of the AME and the GME are also shown to be different. However, there is no obvious difference between the local average error growth with the arithmetic mean and the geometric mean, indicating that the choices of the AME or the GME have no influence on the measure of local average predictability.

关键词： predictability arithmetic mean geometric mean Lorenz system

Mechanisms of insulin resistance in obesity

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2013年第1期7卷 14-24页

作者： jianping Ye Antioxidant and Gene Regulation Laboratory Pennington Biomedical Research CenterLouisiana State University SystemBaton RougeLA70808USA

Obesity increases the risk for type 2 diabetes through induction of insulin *** of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin *** those hypotheses,inflammation,mitochondrial dysfunction,hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of *** stress,endoplasmic reticulum(ER)stress,genetic background,aging,fatty liver,hypoxia and lipodystrophy are active subjects in the study of these ***,none of those concepts or views has led to an effective therapy for type 2 *** reason is that there has been no consensus for a unifying mechanism of insulin *** this review article,literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance,in which insulin resistance is a result of energy surplus in *** energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase(AMPK)signaling *** ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin *** support,many of existing insulin sensitizing medicines inhibit ATP production in *** effective therapies such as weight loss,exercise,and caloric restriction all reduce ATP in insulin sensitive *** new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity,which may apply to insulin resistance in aging and lipodystrophy.

关键词： type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase(AMPK)

Commentary: Inhibitors of mitochondrial respiratory chain in the treatment of type 2 diabetes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第6期13卷 2807-2808页

作者： jianping Ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Center for Advanced Medicine College of MedicineZhengzhou University Zhengzhou 450007China Research Center of Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450007China

Prevalence of type 2 diabetes has been increased worldwide following the high incidence of obesity and growing population of aging, which are two conditions for absolute energy excess with accumulation of TAG in the body and relative energy excess due to reduced energy expense, respectively. It appears that type 2 diabetes is a compensatory mechanism of body to energy excess through urine discharge of glucose.

关键词： Type 2 diabetes Mitochondrial respiration Metformin Berberine Mitochondrial overheating Mitochondrial inhibitors Insulin sensitization

Plant Peroxisome Multiplication:Highly Regulated and Still Enigmatic

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2007年第8期49卷 1112-1118页

作者： jianping Hu Department of Energy Plant Research Laboratory and Plant Biology Department Michigan State University East Lansing MI 48824 USA

Plant peroxisomes play a key role in numerous physiological processes and are able to adapt to environmental changes by altering their content, morphology, and abundance. Peroxisomes can multiply through elongation, constriction, and fission; this process requires the action of conserved, as well as species-specific proteins. Genetic and morphological analyses have been used with the model plant Arabidopsis thaliana to determine at the mechanistic level how plant peroxisomes increase their abundance. The five-member PEXll family promotes early steps of peroxisome multiplication with an unknown mechanism and some subfamily specificities. The dynamin-related protein （DRP）3 subfamily of dynaminrelated large guanosine triphosphatases mediates late steps of both peroxisomal and mitochondrial multiplication. New genetic and biochemical tools will be needed to identify additional, especially plant-specific, constituents of the peroxisome multiplication pathways.

关键词： Arabidopsis dynamin-related proteins peroxisome multiplication PEXl1