Mechanisms of insulin resistance in obesity
Mechanisms of insulin resistance in obesity作者机构:Antioxidant and Gene Regulation LaboratoryPennington Biomedical Research CenterLouisiana State University SystemBaton RougeLA70808USA
出 版 物:《Frontiers of Medicine》 (医学前沿(英文版))
年 卷 期:2013年第7卷第1期
页 面:14-24页
核心收录:
学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:Jianping Ye is supported by the National Institute of Health research projects(DK085495 DK068036)
主 题:type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase(AMPK)
摘 要:Obesity increases the risk for type 2 diabetes through induction of insulin *** of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin *** those hypotheses,inflammation,mitochondrial dysfunction,hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of *** stress,endoplasmic reticulum(ER)stress,genetic background,aging,fatty liver,hypoxia and lipodystrophy are active subjects in the study of these ***,none of those concepts or views has led to an effective therapy for type 2 *** reason is that there has been no consensus for a unifying mechanism of insulin *** this review article,literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance,in which insulin resistance is a result of energy surplus in *** energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase(AMPK)signaling *** ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin *** support,many of existing insulin sensitizing medicines inhibit ATP production in *** effective therapies such as weight loss,exercise,and caloric restriction all reduce ATP in insulin sensitive *** new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity,which may apply to insulin resistance in aging and lipodystrophy.