检索结果-南通市图书馆

Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 433-435页

作者： Lin Wang jianping Ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft *** is an intermediate metabolite within the purine degradation pathway,predominantly derived from uric acid under physiological pH *** occurs due to excessive uric acid production or insufficient excretion2.which is associated with various chronic diseases,including type 2.diabetes.

关键词： Uric acid Gout Microbiota Gut Uricase

Improved Simulation of Summer Heavy Rainfall over Beijing and Henan by the YHGSM with Updated Subgrid Orographic Parameters

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2024年第3期38卷 504-529页

作者： Yingjie WANG jianping WU Kaijun REN College of Computer Science and Technology National University of Defense TechnologyChangsha410600China College of Meteorology and Oceanography National University of Defense TechnologyChangsha410600China

In numerical weather prediction(NWP),the parameterization of orographic drag plays an important role in representing subgrid orographic *** subgrid orographic parameters are the key input to the parameterization of orographic ***,the subgrid orographic parameters in most NWP models were produced based on elevation datasets generated many years ago,with a coarse resolution and low *** this paper,using the latest high-quality elevation data and considering the applicable scale range of the subgrid orographic parameters,we construct the orographic parameters,including the subgrid orographic standard deviation,anisotropy,orientation,and slope,that are required as input to the orographic gravity wave drag(OGWD)***,we introduce the newly constructed orographic parameters into the Yin-He Global Spectral Model(YHGSM),optimize the description of the orographic effect in the model,and improve the simulation of two typical heavy rainfall events in Beijing and Henan.

关键词： subgrid orographic parameters orographic drag heavy rainfall Yin-He Global Spectral Model(YHGSM) parameterization

A Multiscale Model of Mass-Functionally Graded Beam-Fluid System Under Bending and Vibration Responses

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第2期37卷 327-340页

作者： Lei Zhang jianping Lin Jiaqing Jiang Guannan Wang Department of Civil Engineering Zhejiang University866 Yuhangtang RoadHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China College of Civil Engineering Huaqiao UniversityXiamen361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityXiamen361021China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China

In this paper,a multiscale model is developed for the mass functionally graded(FG)beam-fluid system to investigate its static and dynamic responses based on 3D printed porous beam free vibration tests,which are determined by two *** the microstructural level,the gradient variation is realized by arbitrary distribution of matrix pores,and the effective moduli under specific distribution are obtained using the micromechanics homogenization *** the meantime,at the structural level,the mechanical responses of FG porous beams subjected to mass loading are considered in a static fluid ***,the explicit expressions of local finite-element(FE)expressions corresponding to the static and dynamic responses are given in the *** present results are validated against numerical and experimental results from the literature and mechanical tests of 3D printed structures,with good agreement generally obtained,giving credence to the present *** this basis,a comprehensive parametric study is carried out,with a particular focus on the effects of boundary conditions,fluid density,and slenderness ratio on the bending and vibration of FG beams with several different gradations.

关键词： 3D printed test Mass functionally graded beam-fluid system Multiscale model Local finite-element expressions Static bending Free vibration

Study on concentration distribution and detonation characteristics for non-axisymmetric fuel dispersal

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 484-495页

作者： Linghui Zeng Zhongqi Wang Xing Chen jianping Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China College of Environment and Chemical Engineering Sichuan University of Science&EngineeringZigong643000China

The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is *** concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation *** phase and component changes of fuel cloud at different locations are *** fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 2..94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 *** highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is2..90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,*** stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 2..37% longer than cylindrical charge.

关键词： Fuel dispersal Concentration distribution Detonation characteristic Fuel loss Numerical simulation

Commentary:The central lymphatic drainage in pharmacological,surgical and physical therapies of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3291-3293页

作者： Lixuan Ren jianping Ye Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000China Tianjian Laboratory of Advanced Biomedical Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450001China

Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged *** of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease *** recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.

关键词： Ab Central lymphatic drainage Surgery NPLP AD

Mitigating gut immune adverse effects in CTLA-4 blockade for antitumor efficacy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1539-1541页

作者： Shijun He jianping Zuo Zemin Lin Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China

By creating an immune checkpoint blockade-induced colitis model,Lo et al.(2.2.)have suggested a strategy for alleviating gastrointestinal immune-related adverse events while preserving the antitumor stimulatory effect... 详细信息

关键词： immune gastrointestinal

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant S.Bhullar jianping Wu Department of Agricultural Food&Nutritional Science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic

An NMOS output-capacitorless low-dropout regulator with dynamic-strength event-driven charge pump

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第6期45卷 23-34页

作者： Yiling Xie Baochuang Wang Dihu Chen jianping Guo School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510006China School of Microelectronics University of Science and Technology of ChinaHefei 230000China

In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power *** event-driven charge pump(CP)loop with the dynamic strength control(DSC),is proposed in this paper,which overcomes trade-offs inherent in conventional *** presented design addresses and resolves the large signal stability issue,which has been previously overlooked in the event-driven charge pump *** breakthrough allows for the full exploitation of the charge-pump structure's poten-tial,particularly in enhancing transient ***,a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage,leading to favorable static characteristics.A prototype chip has been fabricated in 65 nm CMOS *** measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current(IQ)and can recover within 30 ns under 2.0 mA/10 ns loading change.

关键词： output-capacitorless low-dropout regulator fast transient low quiescent current event-driven charge pump

Parametric formation control of multiple nanosatellites for cooperative observation of China Space Station

在线全文

学校读者我要写书评

暂无评论

Astrodynamics 2024年第1期8卷 77-95页

作者： Hao Zhou Bohan Jiao Zhaohui Dang jianping Yuan School of Astronautics Northwestern Polytechnical UniversityXi’an710072China National Key Laboratory of Aerospace Flight Dynamics Northwestern Polytechnical UniversityXi’an710072China

This study proposes a parametric formation control method for the cooperative observation of the China Space Station(CSS)using multiple ***,a simplified geometrical model of the CSS is constructed using fundamental solids,such as the capsule body and ***,the spacecraft formation configuration for the observation mission is characterized by a three-dimensional(3D)Lissajous curve using related design parameters under the full-coverage observation requirements of specific parts,such as the CSS connecting section and collision avoidance ***,a double-layer control law is designed for each nanosatellite,in which the upper layer is a distributed observer for recognizing the target formation configuration parameters,and the lower layer is a trajectory-tracking controller to make the nanosatellite converge to its temporary target position calculated from the upper layer’s *** closed-loop control stability is proven under the condition that the communication network topology of the nanosatellite cluster contains a directed spanning ***,the control method is verified by numerical simulation,where the CSS connecting section is selected as the observation target,and ten small nanosatellites are assumed to perform the cooperative observation *** simulation results demonstrate that the double-layer control law is robust to single-point communication failures and suitable for the accompanying missions of large space objects with multiple nanosatellites.

关键词： China Space Station(CSS) cooperative observation parametric formation 3D Lissajous curve double-layer system