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A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance

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Food Science and Human Wellness 2022年第6期11卷 1441-1454页

作者： Forough Jahandideh jianping wu Department of Agricultural Food and Nutritional ScienceFaculty of AgriculturalLife and Environmental SciencesUniversity of AlbertaEdmontonABT6G 2P5Canada Cardiovascular Research Centre Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABT6G 2S2Canada

Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion and *** resistance plays a key role in the pathophysiology of type 2 diabetes and metabolic *** on the mechanisms of action of bioactive peptides on glucose homeostasis and insulin resistance are *** recent discoveries of pathways and target cells in the management of glucose and energy metabolism have opened up new opportunities for identification of novel bioactive peptides on enhancing adipocyte differentiation and insulin signaling,glucose uptake,cholecystokinin receptor expression and activation,as well as insulin mimetics and incretin *** of food-derived bioactive peptides with glucoregulatory properties include Trp-Glu-Lys-Ala-Phe-Lys-Asp-Glu-Asp(WEKAFKDED),Gln-Ala-MetPro-Phe-Arg-Val-Thr-Glu-Gln-Glu(QAMPFRVTEQE),Glu-Arg-Tyr-Pro-Ile-Leu(ERKPIL),Val-Phe-LysGly-Leu(VFKGL),Phe-Leu-Val(FLV),Val-Pro-Pro(VPP),Ile-Arg-Trp(IRW),Ala-Lys-Ser-Pro-Leu-Phe(AKSPLF),Ala-Thr-Gln-Pro-Leu-Phe(ATNPLF),Phe-Glu-Glu-Leu-Gln(FEELN),Leu-Ser-Val-Ser-Val-Leu(LSVSVL),Val-Arg-Ileu-Arg-Leu-Leu-Gln-Arg-Phe-Asn-Lys-Arg-Ser(VRIRLLQRFNKRS),and Ala-GlyPhe-Ala-Gly-Asp-Asp-Ala-Pro-Arg(AGFAGDDAPR).However,as yet,clinical evidence on the effi cacy of such bioactive peptides is rare but is inevitable to establish their applications against glucose intolerance and insulin resistance.

关键词： Adipose tissue Bioactive peptides Glucose homeostasis Insulin resistance Metabolic syndrome

Improved Simulation of Summer Heavy Rainfall over Beijing and Henan by the YHGSM with Updated Subgrid Orographic Parameters

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Journal of Meteorological Research 2024年第3期38卷 504-529页

作者： Yingjie WANG jianping wu Kaijun REN College of Computer Science and Technology National University of Defense TechnologyChangsha410600China College of Meteorology and Oceanography National University of Defense TechnologyChangsha410600China

In numerical weather prediction(NWP),the parameterization of orographic drag plays an important role in representing subgrid orographic *** subgrid orographic parameters are the key input to the parameterization of orographic ***,the subgrid orographic parameters in most NWP models were produced based on elevation datasets generated many years ago,with a coarse resolution and low *** this paper,using the latest high-quality elevation data and considering the applicable scale range of the subgrid orographic parameters,we construct the orographic parameters,including the subgrid orographic standard deviation,anisotropy,orientation,and slope,that are required as input to the orographic gravity wave drag(OGWD)***,we introduce the newly constructed orographic parameters into the Yin-He Global Spectral Model(YHGSM),optimize the description of the orographic effect in the model,and improve the simulation of two typical heavy rainfall events in Beijing and Henan.

关键词： subgrid orographic parameters orographic drag heavy rainfall Yin-He Global Spectral Model(YHGSM) parameterization

Pea-derived tripeptide LRW fails to reduce blood pressure in spontaneously hypertensive rats due to its low gastrointestinal stability and transepithelial permeability

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Food Bioscience 2022年第5期49卷 853-862页

作者： Hongbing Fan Kaiyu wu jianping wu Department of Agricultural Food and Nutritional Science4-10 Ag/For BuildingUniversity of AlbertaEdmontonAlbertaT6G 2P5Canada Cardiovascular Research Centre University of AlbertaEdmontonAlbertaT6G 2R7Canada

Leu-Arg-Trp(LRW),a pea-derived tripeptide,is an isomer of Ile-Arg-Trp(IRW),an egg-derived tripeptide possessing various health benefits including antihypertensive *** LRW and IRW are structural analogs,we hypothesized that LRW can significantly reduce blood pressure in spontaneously hypertensive *** showed a more potent in vitro ACE-inhibitory activity(IC50 value of 0.45±0.06μM)than that of IRW(1.65±0.14μM);molecular docking results also verified that LRW could form a more stable complex with ACE than that of *** addition,LRW could inhibit tumor necrosis factor alpha-induced endothelial inflammation in similar manners to ***,oral administration of LRW at a dose of 15 mg/kg/day body weight over 12 days did not cause any blood pressure reduction(p>0.05).Subsequent tissue analyses revealed no changes in the vascular renin-angiotensin system components and vascular inflammation,which are the primary targets of IRW,indicating that LRW might not be able to reach the blood circulation and exert in vivo ***,LRW demonstrated significantly lower gastrointestinal stability(p<0.001)and lower permeability(p<0.001)across human Caco-2 cell monolayers than those of *** findings indicated the low oral bioavailability of LRW which might underlie its failure in reducing blood pressure in vivo.

关键词： Pea ACE Caco-2 cells Endothelial inflammation Gastrointestinal digestion Molecular docking Spontaneously hypertensive rats

Secure DHCPv6 Mechanism for DHCPv6 Security and Privacy Protection

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Tsinghua Science and Technology 2018年第1期23卷 13-21页

作者： Lishan Li Gang Ren Ying Liu jianping wu Institute for Network Sciences and Cyberspace Tsinghua University Beijing 100084 China

With the rapid developmen of the Internet, the exhaustion of IPv4 address limited the development of the Internet for years. IPv6, as the core technology of the next generation Internet, has since been rapidly deployed around the world. As the widely deployed address configuration protocol, DHCPv6 is responsible for allocating globally unique IPv6 addresses to clients, which is the basis for all the network services. However, the initial design of the DHCPv6 protocol gave little consideration to the privacy and security issues, which has led to a proliferation of privacy and security accidents breaches in its real deployment. In this paper, to fundamentally solve a range of possible security and privacy issues, we propose a secure DHCPv6 mechanism, which adds authentication and encryption mechanisms into the original DHCPv6 protocol. Compared with other proposed security mechanisms for the DHCPv6, our method can achieve all-around protection for the DHCPv6 protocol with minimal change to the current protocol, easier deployment, and low computing cost.

关键词： DHCPv6 security privacy IETF authentication encryption

Predicting vehicle fuel consumption patterns using floating vehicle data

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Journal of Environmental Sciences 2017年第9期29卷 24-29页

作者： Yiman Du jianping wu Senyan Yang Liutong Zhou Department of Civil Engineering Tsinghua University Department of Civil Engineering Columbia University

The status of energy consumption and air pollution in China is serious. It is important to analyze and predict the different fuel consumption of various types of vehicles under different influence factors. In order to fully describe the relationship between fuel consumption and the impact factors, massive amounts of floating vehicle data were *** fuel consumption pattern and congestion pattern based on large samples of historical floating vehicle data were explored, drivers＇ information and vehicles＇ parameters from different group classification were probed, and the average velocity and average fuel consumption in the temporal dimension and spatial dimension were analyzed *** fuel consumption forecasting model was established by using a Back Propagation Neural Network. Part of the sample set was used to train the forecasting model and the remaining part of the sample set was used as input to the forecasting model.

关键词： Vehicle fuel consumption Prediction Floating vehicle data

Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats

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Food Science and Human Wellness 2024年第5期13卷 2562-2572页

作者： Nan Shang Xiaoyu Bao Michael Doschak jianping wu Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada College of Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthyChina Agricultural UniversityBeijing 100193China Faculty of Pharmacy&Pharmaceutical Sciences University of AlbertaEdmonton T6G 2H5Canada

Ovotransferrin,an iron-binding glycoprotein,accounting for approximately 12%of egg white protein,is a member of transferrin fam *** previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts,while inhibits osteoclastogenesis and resorption *** work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized(OVX)Sprague-Dawley *** administration of ovotransferrin showed no negative effect on body weight,food intake and organ *** 12-week treatment,feeding ovotransferrin at a dose of 1%(1 g ovotransferrin/100 g diet)prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone *** serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups,while the bone resorption biomarkers were *** feeding also decreased the production of serum cytokine TNF-αand IL-6,which are two stimulators for osteoclast *** addition to its direct regulatory role on bone turnover,ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis,and regulating immune *** results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.

关键词： Ovotransferrin Ovariectomized(OVX)rats Bone mineral density Bone microarchitecture Bone resorption Inflammation

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food Science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant S.Bhullar jianping wu Department of Agricultural Food&Nutritional Science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic

Chicken collagen hydrolysates differentially mediate anti-inflammatory activity and type I collagen synthesis on human dermal fibroblasts

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Food Science and Human Wellness 2018年第2期7卷 138-147页

作者： Marina Offengenden Subhadeep Chakrabarti jianping wu Department of Agricultural Food&Nutritional Science and the Cardiovascular Research CentreUniversity of AlbertaEdmontonABCanada

Collagen is a major extracellular matrix *** the potential anti-inflammatory and antioxidant profiles of these bioactive compounds,there has been increasing interest in using collagen derived peptides and peptide-rich collagen hydrolysates for skin health,due to their immunomodulatory,antioxidant and proliferative effects on dermal ***,all hydrolysates are not equally effective in exerting the beneficial effects;hence,further research is needed to determine the factors that improve the therapeutic applicability of such *** used different enzymatic conditions to generate a number of different collagen hydrolysates with distinct peptide *** found that the use of two rather than one enzyme for hydrolysis generates a greater abundance of low molecular weight peptides with consequent improvement in bioactive *** these hydrolysates on human dermal fibroblasts showed distinct actions on inflammatory changes,oxidative stress,type I collagen synthesis and cellular *** findings suggest that different enzymatic conditions affect the peptide profile of hydrolysates and differentially regulate their biological activities and potential protective responses on dermal fibroblasts.

关键词： Chicken collagen Collagen peptides Antioxidant activity Anti-inflammatory activity Human dermal fibroblasts

Dietary peptides in aging:Evidence and prospects

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Food Science and Human Wellness 2020年第1期9卷 1-7页

作者： Khushwant S.Bhullar jianping wu Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmontonABCanada Department of Pharmacology University of AlbertaEdmontonABCanada

With improvements in healthcare and lifestyle,the proportion of the aging population is rising steadily across the *** physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial ***,there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related *** reports indicate that in geroscience,dietary interventions such as bioactive peptides to slow aging are a matter of’when’rather than’if’.Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient *** of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related *** derived bioactive peptides are characterized modulators of these pathways,while some verified in vivo and even clinically approved,and numerous others are under *** brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process.

关键词： Dietary peptides Anti-aging Aging biomarkers