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Contrasting response of rice rhizosphere microbiomes to in situ cadmium-contaminated soil remediation

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Soil Ecology Letters 2024年第2期6卷 149-162页

作者： Zhongyi Cheng Qinyu Han Yan He Jiachun Shi Laosheng Wu jianming xu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationHangzhou310058China Department of Environmental Sciences University of CaliforniaRiversideCA92521USA

Changes in soil properties and microbial communities regulated rhizosphere protistan assemblages. • Bacterial community was more sensitive to soil amendments than protists and fungi. • Soil amendments trigger the role of specific protistan taxa Cercozoa on microbial interactions. Understanding the responses of different rhizosphere microbial lineages to soil amendments during in situ remediation of Cd-contaminated soil is of great importance in the assessment of the restoration and crop health. Here, we evaluated the effects of lime (LM), biochar (BC), pig manure (PM), and a commercial Mg-Ca-Si conditioner (CMC) on the rice rhizosphere soil physicochemical properties and community assembly of bacteria, fungi, and protists in a six-year consecutive application of soil amendments field trial. Our results indicated that among the four amendments, the BC and CMC had the best efficiency in increasing soil pH, which were 5.2% and 16.2%, respectively. Despite the differences in soil Cd concentrations is not noticeable, all the soil amendment treatments significantly decreased the proportion of available Cd in total Cd compared to the control. Soil amendments significantly altered the diversity of bacterial community, while they had no effect on fungal and protistan communities. Linear discriminant analysis effect size (LEfSe) showed that the bacteria was more sensitive to soil amendment-induced changes. For protists, treatments with LM and BC changed the groups of protistan consumers, while treatments with PM and CMC significantly increased the relative abundances of protistan phototrophs. Co-occurrence network analysis revealed that soil amendments increased microbial network complexity and triggered the role of protists, especially for the predatory protists Cercozoa, on microbial trophic interactions. Further variation partitioning analysis revealed that edaphic properties, bacterial and fungal communities compositions together explained the 77% of the total variation i

关键词： cadmium soil amendments soil protist community microbial interactions

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian Li Ye xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang jianming xu Ying Yuan Haiping Jiang Jieer Ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi Huang Xiaoping Qian Yueyin Pan Ying Cheng Sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided P<0.0001]and ORR across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 10%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor

基于STM32的步进电机加减速轨迹规划算法

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浙江工业大学学报 2024年第4期52卷 465-472页

作者：徐建明徐金辉浙江工业大学信息工程学院浙江杭州310023

针对传统步进电机开环控制下加减速过程中柔性冲击大、失步和过冲等问题,结合STM32单片机提出了一种离散化的、带有电流调节的S曲线加减速控制算法。首先,通过多项式算法构建连续光滑的S曲线,根据矩频特性拟合转速和转矩的关系,联立转... 详细信息

针对传统步进电机开环控制下加减速过程中柔性冲击大、失步和过冲等问题,结合STM32单片机提出了一种离散化的、带有电流调节的S曲线加减速控制算法。首先,通过多项式算法构建连续光滑的S曲线,根据矩频特性拟合转速和转矩的关系,联立转速和功率的关系,推导出电流计算方法;然后,对连续的S曲线进行等时间间隔采样,完成对S曲线的离散化;最后,在Keil平台进行算法代码编写,将编译后的工程文件下载到STM32中,通过步进电机的速度和位置跟踪实验验证了算法的有效性。

关键词：步进电机 S曲线加减速控制

基于CODESYS平台的移动机械臂运动控制系统设计

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浙江工业大学学报 2024年第3期52卷 237-247页

作者：徐建明陈显汉浙江工业大学信息工程学院浙江杭州310023

针对传统六关节机械臂操作空间有限的问题,以移动底盘和Elfin05机械臂为控制对象,采用ARM+CODESYS架构和PLCopen规范设计了一款移动机械臂运动控制器。首先根据MD-H参数与坐标变换思想建立移动机械臂正运动学模型,基于关节角参数化解析... 详细信息

针对传统六关节机械臂操作空间有限的问题,以移动底盘和Elfin05机械臂为控制对象,采用ARM+CODESYS架构和PLCopen规范设计了一款移动机械臂运动控制器。首先根据MD-H参数与坐标变换思想建立移动机械臂正运动学模型,基于关节角参数化解析法简化移动机械臂的冗余度进行逆运动学求解,并设计相应运动学功能块;其次采用分布式控制思想设计控制模块,以SM3_CNC库为基础设计了机械臂的点到点运动控制功能块,基于Backstepping法设计了移动底盘的跟踪控制功能块;再次以Visualization模块为基础设计人机交互界面;最后以该机器人为实验对象进行实验,实现了移动底盘与机械臂的协同运动,增加了传统六关节机械臂可操作空间,并验证了该运动控制器设计的有效性。

关键词： CODESYS 移动机械臂运动控制器运动学

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考虑时滞的中药饮片制造过程调度优化

高技术通讯 2024年第6期34卷 624-633页

作者：何德峰赵凯徐建明浙江工业大学信息工程学院杭州310023

针对中药饮片制造场景下调度求解过程中加工时间不确定以及存在工序间时滞的问题,以最小化最大完工时间为目标,建立考虑时滞的模糊柔性作业车间调度模型,并设计一种改进的遗传算法(IGA)进行求解。使用一种四层编码方法描述带时滞约束的... 详细信息

针对中药饮片制造场景下调度求解过程中加工时间不确定以及存在工序间时滞的问题,以最小化最大完工时间为目标,建立考虑时滞的模糊柔性作业车间调度模型,并设计一种改进的遗传算法(IGA)进行求解。使用一种四层编码方法描述带时滞约束的染色体,构建具有模糊加工时间和模糊时滞的作业析取图获取关键路径,使用基于变邻域下降法(VND)的禁忌搜索(TS)增强算法局部搜索能力,再使用一种精英拓展选择策略提高算法迭代效率。以某企业的生产调度数据为例进行仿真实验,结果表明,改进算法在求解中药饮片生产调度问题中具备较好的性能。

关键词：中药饮片生产调度时滞约束模糊时间局部搜索遗传算法(GA)

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财政补助、农民养老金替代率与经济增长率

通化师范学院学报 2024年第7期45卷 62-68页

作者：魏思予许建明浙江农林大学浙江杭州311300

在一般均衡框架下采用世代交叠模型,研究了城乡居民基本养老保险财政支出中社会保障部分对养老金替代率和经济增长率的影响程度以及影响机制,构建了一个三期叠代模型,并在模型中引入人力资本,经过参数模拟对其进行量化分析。研究发现:... 详细信息

在一般均衡框架下采用世代交叠模型,研究了城乡居民基本养老保险财政支出中社会保障部分对养老金替代率和经济增长率的影响程度以及影响机制,构建了一个三期叠代模型,并在模型中引入人力资本,经过参数模拟对其进行量化分析。研究发现:财政支出中社保比例与养老金替代率呈现正相关关系;财政支出中社保比例与经济增长率呈现“U”型关系。得出如下政策建议:应辩证调整财政补贴筹资结构;村集体要充分发挥主观能动性和释放经济潜能;考虑适当增加公共教育支出以提高人力资本水平。

关键词：城乡居保养老金替代率财政负担世代交叠模型

社会养老保险对农村老年人社会适应的影响——基于中国老年社会追踪调查的实证研究

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安徽农业大学学报（社会科学版） 2024年第1期33卷 88-99页

作者：许建明吕良瑞浙江农林大学经济管理学院浙江杭州311300

基于中国老年社会追踪调查(CLASS)2016年和2018年两期数据,运用固定效应模型、工具变量法和渠道分析法,实证分析社会养老保险对农村老年人社会适应的影响。研究发现:社会养老保险显著提高了农村老年人的生活满意度和人际交往,对社会适... 详细信息

基于中国老年社会追踪调查(CLASS)2016年和2018年两期数据,运用固定效应模型、工具变量法和渠道分析法,实证分析社会养老保险对农村老年人社会适应的影响。研究发现:社会养老保险显著提高了农村老年人的生活满意度和人际交往,对社会适应具有明显的改善效应,在对内生偏误进行有效处理后,所得结论依然稳健;社会养老保险对农村老年人社会适应的改善效用具有性别、年龄和居住方式差异;经济支持和情感支持是社会养老保险影响农村老年人社会适应的重要路径。因此,应提高社会养老保障水平并建立稳定持续的增长模式、强化社会养老公共服务均等化并精准施策、积极建设老年友好型社会并重视农村老年人的社会需求,以期进一步提高农村老年人的社会养老保障水平和社会适应能力。

关键词：社会养老保险农村老年人生活满意度人际交往社会适应

Current progress in cancer treatment by targeting FGFR signaling

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Cancer Biology & Medicine 2023年第7期20卷 490-499页

作者： Sicheng Du Ying Zhang jianming xu Department of Graduate Administration Chinese People’s Liberation Army(PLA)General HospitalBeijing 100853China Department of Oncology The Fifth Medical Center of the PLA General HospitalBeijing 100071China

Fibroblast growth factor receptors(FGFRs),a family of transmembrane receptors with intracellular tyrosine kinase domains,and fibroblast growth factors(FGFs)form the FGF/FGFR signaling pathways,which participate in cel... 详细信息

关键词： carcinogenesis treatment cancer

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浙江省农地规模化的空间潜力与减氮增效研究

农业资源与环境学报 2024年第1期41卷 27-35页

作者：黄璐瑶段佳堃邬奇峰虞轶俊徐建明谷保静浙江大学环境与资源学院杭州310058 浙江大学政策仿真实验室杭州310058 浙江省耕地质量与肥料管理总站杭州310016 杭州市临安区农林技术推广中心杭州311300 浙江省农业资源与环境重点实验室杭州310058

我国农业以小农经营为主,为解决浙江省细碎化经营带来的收益和资源利用效率低、面源污染严重等问题,本研究通过分析浙江耕地分布格局,量化浙江农地规模化潜力和空间优化路径,结合农田氮平衡和成本收益分析,评估农地规模化对浙江农业生... 详细信息

我国农业以小农经营为主,为解决浙江省细碎化经营带来的收益和资源利用效率低、面源污染严重等问题,本研究通过分析浙江耕地分布格局,量化浙江农地规模化潜力和空间优化路径,结合农田氮平衡和成本收益分析,评估农地规模化对浙江农业生产和环境效应的影响。结果表明:浙江耕地平均田块面积为0.4 hm^(2),面积低于0.6 hm^(2)的耕地占70%。通过土地整理,73%的耕地连片面积在16 hm^(2)以上。耕地连片规模化经营可以使氮肥投入减少53%,促进氮素利用效率从38%增加至56%。农业劳动力需求从每公顷4人减少至1人,农业投入成本降低77%,劳动力农业年均收入可提高9 457元。浙江省推动实施农地规模化具备良好的资源条件,在全省范围内推行有助于发挥农业生产提质增效和环境资源保护作用。政府应当加强政策引导、加大财政支持、推动农业转型,以农地规模化提升浙江农业可持续发展潜力。

关键词：农地规模化氮素利用效率农业收益浙江可持续发展

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