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Acta Oceanologica Sinica 2022年第3期41卷 44-52页

作者： Konglin Zhou Yuping Gu Lu Wang Jianming Chen Institute of Oceanography College of Geography and OceanographyMinjiang UniversityFuzhou 350108China

In contrast to typical planktonic hydromedusae,Cladonema medusae are mostly benthic,with specialised adhesive branches to adhere to the substrate.In this study,a Cladonema species discovered in a laboratory aquarium in Fuzhou,China,was confirmed as a new species,based on morphological and molecular analyses.The species was named Cladonema multiramosum sp.nov.Its medusa is distinct from that of congeners possessing substantially more adhesive branches(8-24,rarely 5-7),and tiny branches on the upper radial canals.The validity of C.multiramosumum sp.***.was also supported by molecular phylogenetic analyses based on the mitochondrial 16S rDNA sequence.However,C.multiramosum sp.***.medusa also displayed considerable phenotypic plasticity with respect to its radial canals,tentacles,stinging branches per tentacle,oral tentacles,manubrium,and gonads,hindering species identification based solely on morphology.Although some morphological characteristics of hydroids(filiform tentacles and medusa buds)and nematocysts could also be used as diagnostic characters in the genus Cladonema,this information is unavailable for some Cladonema species.Thus,the taxonomy within the genus Cladonema was re-evaluated based mainly on the morphological characteristics of the medusa.Further revision of the genus Cladonema should be made when supplementary information on the life cycle and DNA barcoding are updated.

关键词： Cladonema morphology life cycle DNA barcoding 16S rDNA

Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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Chinese Chemical Letters 2024年第2期35卷 335-340页

作者： Xin Wu Xinmei chen Xinyu Wang Haisheng He Jianming Chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Shanghai Wei Er Lab Shanghai 201707China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor solubility.Liposomes are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and biodegradability.However,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal formulations.To address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14C),palmitic acid(PA,16C)and stearic acid(SA,18C),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,respectively.All liposomes show high stability and drug loadings,as well as sustained drug release.The chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal PTX.Neither rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of PTX.Among all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion rate.Witnessing its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release Chemotherapy

Label-free quantitative proteomics analysis models in vivo and in vitro reveal key proteins and potential roles in sciatic nerve injury

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生物细胞(英文) 2023年第9期47卷 2069-2080页

作者： YANG GU MINGGUANG BI DEHUI chen NING NI Jianming Chen Department of Trauma Orthopedics Surgery Ningbo No.6 HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedics Ningbo Medical CenterLihuili HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhou350001China School of Medicine Ningbo UniversityNingbo315000China

Background:The underlying mechanism of sciatic nerve injury(SNI)is a common motor functional disorder,necessitates further research.Methods:A rat model of SNI was established,with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure.An oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 cells.Following data acquisition and quality control,differentially expressed proteins(DEPs)in each model were identified through differential analysis,and enrichment analysis was used to explore the potential functions and pathways of the DEPs.Venn diagrams were drawn,and DEPs from both in vivo and in vitro SNI models were imported into the STRING database to construct a protein-protein interaction network and screen for hub proteins.Results:After the peptide segments obtained from rat nerve blockade and PC12 cells met quality requirements,258 DEPs were identified in rat nerve samples,and 119 DEPs were screened in PC12 cells.Enrichment analysis revealed that DEPs in the rat model were predominantly concentrated in biological functions such as myogenic cell proliferation and signaling related to lipid and energy metabolism.DEPs in the in vitro model were mainly enriched in biological processes such as phagocytosis and were associated with lipid transport and metabolism.Two hub proteins,amyloid precursor protein(APP)and fibronectin 1(FN1),were identified through MCC,MCODE,and Degree scoring.Both PC12 cells and external validation sets showed relatively higher expression of APP and FN1 in injured samples.Results of gene set enrichment analysis indicated that these two proteins were associated with metabolic pathways,such as biosynthesis of glycosaminoglycan chondroitin sulfate and biosynthesis of unsaturated fatty acids.Conclusion:APP and FN1 are potential key molecules involved in SNI and are associated with various metabolic pathways in nerve repair.These findings provide a theore

关键词： Oxygen glucose deprivation Proteomics Sciatic nerve injury Peripheral nerve injury

Numerical simulation of gas–liquid flow in the bubble column using Wray–Agarwal turbulence model coupled with population balance model

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Chinese Journal of Chemical Engineering 2023年第6期58卷 205-223页

作者： Hongwei Liang Wenling Li Zisheng Feng Jianming Chen Guangwen Chu Yang Xiang State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

In this paper,an improved computational fluid dynamic(CFD)model for gas-liquid flow in bubble column was developed using the one-equation Wary-Agarwal(WA)turbulence model coupled with the population balance model(PBM).Through 18 orthogonal test cases,the optimal combination of interfacial force models,including drag force,lift force,turbulent dispersion force.The modified wall lubrication force model was proposed to improve the predictive ability for hydrodynamic behavior near the wall of the bubble column.The values simulated by optimized CFD model were in agreement with experimental data,and the errors were within±20%.In addition,the axial velocity,turbulent kinetic energy,bubble size distribution,and the dynamic characteristic of bubble plume were analyzed at different superficial gas velocities.This research work could provide a theoretical basis for the extension of the CFD-PBM coupled model to other multiphase reactors..

关键词： CFD–PBM Wray–Agarwal turbulence model Gas–liquid flow Bubble column Interfacial force Wall lubrication force

Prefrontal cortical circuits in anxiety and fear:an overview

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Frontiers of Medicine 2022年第4期16卷 518-539页

作者： Yihua chen Nengyuan Hu jianming Yang Tianming Gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong−Hong Kong−Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong Province Key Laboratory of Psychiatric DisordersDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically,and it represents a major societal problem.Studies have implicated structural changes within the prefrontal cortex(PFC)and functional changes in the communication of the PFC with distal brain structures in anxiety disorders.Treatments that affect the activity of the PFC,including cognitive therapies and transcranial magnetic stimulation,reverse anxiety-and fear-associated circuit abnormalities through mechanisms that remain largely unclear.While the subjective experience of a rodent cannot be precisely determined,rodent models hold great promise in dissecting well-conserved circuits.Newly developed genetic and viral tools and optogenetic and chemogenetic techniques have revealed the intricacies of neural circuits underlying anxiety and fear by allowing direct examination of hypotheses drawn from existing psychological concepts.This review focuses on studies that have used these circuit-based approaches to gain a more detailed,more comprehensive,and more integrated view on how the PFC governs anxiety and fear and orchestrates adaptive defensive behaviors to hopefully provide a roadmap for the future development of therapies for pathological anxiety.

关键词： prefrontal cortex anxiety fear neural circuits optogenetics DREADD

Understanding of the settlements with coexisting water and earth under the background of climate change—the case of Liang Village in Pingyao County,China

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Built Heritage 2022年第3期6卷 78-97页

作者： Yong Shao Yue chen jianming Su Department of Urban Planning College of Architecture and Urban PlanningTongji University1239 Siping RoadShanghai 200092People’s Republic of China

Global climate change has caused general and serious damage to cultural heritage sites,and earthen settlements and buildings are particularly vulnerable to water-afected disasters.Thus,this paper uses Liang Village in Pingyao County,China,as a case study,linking the human–land study in the Liang Village Sino-French workshop of 2009/2010 to a disaster assessment completed after the devastating rainstorm in October 2021.We found that the village’s rain disaster resulted from the vulnerability of earthen material to rainstorms and from the earthen settlement’s evolution from a culture emphasising the coexistence of‘water and earth’to a technic fostering the disintegration of‘water and earth’.The latter is the main cause of the village’s decrease in its capacity for disaster prevention and damage reduction.Therefore,in the context of global climate change,we fnd that the reestablishment of the harmonious relationship of water and earth is critical to both rural heritage conservation and village sustainable development.In addition to repairing their relation from the technical perspective of‘planning and design’by planners and architects,it is more crucial for local people to understand and enhance their contemporary appreciation for the traditional‘coexistence of water and earth’concept.

关键词： climate change earthen settlement rural heritage coexistence of water and earth

Extraction of Stress Intensity Factors by Using the P-Version Finite Element Method and Contour Integral Method

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Acta Mechanica Solida Sinica 2020年第6期33卷 836-850页

作者： jianming Zhang Jun chen Liang Wu Department of Engineering Mechanics Kunming University of Science and TechnologyKunming 650500China Department of Water Resources and Hydropower Engineering Kunming University of Science and TechnologyKunming 650500China

The stress intensity factors(SIFs)for two-dimensional cracks are extracted using the p-version finite element method(P-FEM)and the contour integral method.Several numerical experiments,e.g.,crack initiating from the edge of a circular hole under an unidirectional uniform tension and two equal-length,unequal-length hole-edge cracks,respectively,at a rectangular plate,an inclined centered crack under uniaxial tension at a square plate and a pipeline crack model,are used to demonstrate the accuracy and effectiveness of the approaches.SIFs are presented for the effects of various crack lengths and length-width ratio.Numerical results are analyzed and compared with reference solutions and results obtained by the Voronoi cell finite element method,boundary element method,high-order extended finite element method(high-order XFEM)and commercial finite element software ABAQUS in the available literature.Numerical results are in good agreement with the benchmark problems and show faster convergence rate,higher accuracy and better numerical stability.

关键词： Fracture mechanics Stress intensity factors P-version finite element method Contour integral method

Probability Density Analysis of Nonlinear Random Ship Rolling

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中国海洋大学学报:英文版 2023年第5期22卷 1227-1242页

作者： chen Jia YANG jianming SHEN Kunfan CHANG Zongyu ZHENG Zhongqiang College of Engineering Ocean University of ChinaQingdao 266100China Faculty of Engineering and Applied Science Memorial University of NewfoundlandSt.John’sNLA1B3X5Canada Shandong Provincial Key Laboratory of Ocean Engineering Qingdao 266100China

Ship rolling in random waves is a complicated nonlinear motion that contributes substantially to ship instability and capsizing.The finite element method(FEM)is employed in this paper to solve the Fokker Planck(FP)equations numerically for homoclinic and heteroclinic ship rolling under random waves described as periodic and Gaussian white noise excitations.The transient joint probability density functions(PDFs)and marginal PDFs of the rolling responses are also obtained.The effects of stimulation strength on ship rolling are further investigated from a probabilistic standpoint.The homoclinic ship rolling has two rolling states,the connection between the two peaks of the PDF is observed when the periodic excitation amplitude or the noise intensity is large,and the PDF is remarkably distributed in phase space.These phenomena increase the possibility of a random jump in ship motion states and the uncertainty of ship rolling,and the ship may lose stability due to unforeseeable facts or conditions.Meanwhile,only one rolling state is observed when the ship is in heteroclinic rolling.As the periodic excitation amplitude grows,the PDF concentration increases and drifts away from the beginning location,suggesting that the ship rolling substantially changes in a cycle and its stability is low.The PDF becomes increasingly uniform and covers a large region as the noise intensity increases,reducing the certainty of ship rolling and navigation safety.The current numerical solutions and analyses may be applied to evaluate the stability of a rolling ship in irregular waves and capsize mechanisms.

关键词： ship rolling homoclinic rolling heteroclinic rolling finite element method Fokker Planck equation probability density function

A Construction Method of Arbitrary-Length Polar Codes

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中国通信:英文版 2023年第10期20卷 153-162页

作者： Xiaojun Zhang chengguan chen Rongcai Zhang jianming Cui Qingtian Zeng Shandong University of Science and Technology Qingdao 266590China State Key Laboratory of High-End Server and Storage Technology Jinan 250101China

To remove the restriction on code length of polar codes,this paper proposes a construction scheme,called stepwise polar codes,which can gen-erate arbitrary-length polar codes.The stepwise polar codes are generated by sub-polar codes with different code lengths.To improve coding performance,sub-polar codes are united by polarization effect priority algorithm,which can reduce the number of in-completely polarized channels.Then,the construction method of the generator matrix of the stepwise po-lar code is presented.Furthermore,we prove that the proposed scheme has lower decoding complexity than punctured,multi-kernel polar codes.Simulation results show that the proposed method can achieve similar decoding performance compared with the conventional punctured polar codes,rate-compatible punctured polar code,PC-short and asymmetric polar codes(APC)when code length N=48 and 72,respectively.

关键词： code construction polar codes arbitrary-length channel polarization union encoding

Memristive cyclic three-neuron-based neural network with chaos and global coexisting attractors

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Science China(Technological Sciences) 2022年第11期65卷 2582-2592页

作者： BAO Han chen ZhuGuan CAI jianming XU Quan BAO Bocheng School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China

It has been documented that a cyclic three-neuron-based neural network with resistive synaptic weights cannot exhibit chaos.Towards this end,a memristive cyclic three-neuron-based neural network is presented using a memristive weight to substitute a resistive weight.The memristive cyclic neural network always has five equilibrium points within the parameters of interest,and their stability analysis shows that they are one index-2 saddle-focus,two index-1 saddle-foci,and two stable node-foci,respectively.Dynamical analyses are performed for the memristive cyclic neural network by several numerical simulation methods.The results demonstrate that the memristor synapse-based neural network with the simplest cyclic connection can not only exhibit chaos,but also present global coexisting attractors composed of stable points and unstable periodic or chaotic orbits under different initial conditions.Besides,with the designed implementation circuit,Multisim circuit simulations and hardware experiments are executed to validate the numerical simulations.

关键词： memristive weight cyclic neural network chaos coexisting attractors hardware experiment