检索结果-南通市图书馆

Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第11期33卷 4886-4890页

作者： Yingjie Yu Aiyao Liu Jingrui He Chengting Wang Haibo Mei jianlin han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular cyclization.This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good yields.This reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.

关键词： Visible-light-irradiation Sulfonylation Tetrahydrocarbazoles Indoles Tandem radical reaction Sulfonyl chlorides

Facile synthesis of ( β -chlorodifluoroethyl)phosphonates via chlorination reaction of difluoroalkyl diazo derivatives with HCl

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2429-2432页

作者： Jiang Liu Romana Pajkert Li Wang Haibo Mei Gerd-Volker Röschenthaler jianlin han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Life Sciences and Chemistry Jacobs University Bremen gGmbHCampus Ring 1Bremen 28759Germany

An efficient chlorination reaction of in situ generated(β-diazo-α,α-difluoroethyl)phosphonates has been achieved with hydrochloric acid as a chlorine source under mild and operationally convenient conditions.The reaction does not need any catalyst and tolerates a wide scope of substrates,which affords the(β-chlorodifluoroethyl)phosphonate products in good to excellent yields.This reaction represents the first example of the halogenation of difluoroalkyl diazo compounds,and also provides an easy way for the synthesis of difluoromethylenephosphonate-containing compounds.

关键词： Difluorodiazoethane (β-Diazo-α,α-difluoroethyl)phosphonates Halogenation reaction Difluoroalkyl diazo Hydrochloric acid Masked carbene

Recent advances on the synthesis and application of tetrahydro-y-carbolines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第12期34卷 93-110页

作者： Haibo Mei Klara Aradi Lorand Kiss jianlin han jiangsu Co-lnnovation Center of Eficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Institute of Organic Chemistry Research Centre for Natural SciencesStereochemistry Research GroupMagyar Tudsok krt.2117 BudapestHungary

Tetrahydro-y-carbolines(THyCs)constitute one of the most important subtypes of indole alkaloids.In addition to being substructures of natural products,these structural motifs and moieties can often be found in pharmaceuticals due to their diverse bioactivities such as antiviral,antibacterial,antifungal,antiparasitic,antitumor,anti-inflammatory,and neuropharmacological activities.Beyond the pharmacological and biological aspects of these scaffolds,they have considerable synthetic applications for the construction of further bioactive compounds,too.The aim of this review is to summarize recent developments in the synthesis of this compound class.

关键词： Tetrahydro-y-carbolines Synthetic methods Bioactive molecuels Asymmetric synthesis Indole Polycyclic compounds

Fluorine-containing drugs approved by the FDA in 2021

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第1期34卷 29-38页

作者： Jingrui He Ziyi Li Gagan Dhawan Wei Zhang Alexander E.Sorochinsky Greg Butler Vadim A.Soloshonok jianlin han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Biomedical Science Acharya Narendra Dev CollegeUniversity of DelhiNew Delhi 110019India Department of Chemistry University of Massachusetts BostonBostonMA 02125United States V.P.Kukhar Institute of Bioorganic Chemistry and Petrochemistry The National Academy of Sciences of UkraineKyiv 02094Ukraine Oakwood Chemical Inc.EstillSC 29918United States Department of Organic Chemistry I Faculty of ChemistryUniversity of the Basque Country UPV/EHU20018 San SebastiánSpain IKERBASQUE Basque Foundation for SciencePlaza Bizkaia48013 BilbaoSpain

Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl and chlorodifluoro groups.The therapeutic areas of these fluorine-containing drugs include multiple myeloma,lymphoma,HIV,chronic heart failure,chronic myeloid leukemia,(ANCA)-associated vasculitis,migraines,von Hippel-Lindau disease,and non-small cell lung cancer.The brief biological activities and the synthetic methods have been discussed in this review for each of these nine drugs.

关键词： Fluorine-containing compounds Blockbuster drugs Pharmaceuticals Anti-cancer Drug design and development Asymmetric synthesis

Global dispersal and adaptive evolution of domestic cattle:a genomic perspective

在线全文

学校读者我要写书评

暂无评论

Stress Biology 2023年第1期3卷 98-110页

作者： Xiaoting Xia Kaixing Qu Yan Wang Mikkel-Holger SSinding Fuwen Wang Quratulain hanif Zulfiqar Ahmed Johannes A.Lenstra jianlin han Chuzhao Lei Ningbo Chen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Academy of Science and Technology Chuxiong Normal UniversityChuxiong 675000China Qingdao Municipal Bureau of Agriculture and Rural Affairs Qingdao 266000China Section for Computational and RNA Biology Department of BiologyUniversity of CopenhagenCopenhagen 1350Denmark National Institute for Biotechnology and Genetic Engineering FaisalabadPakistan Faculty of Veterinary and Animal Sciences University of Poonch RawalakotAzad Jammu and Kashmir 12350Pakistan Faculty of Veterinary Medicine Utrecht UniversityUtrechtThe Netherlands Livestock Genetic Program International Livestock Research Institute(ILRI)Nairobi 00100Kenya CAAS-ILRI Joint Laboratory On Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural Sciences(CAAS)Beijing 100193China

Domestic cattle have spread across the globe and inhabit variable and unpredictable environments.They have been exposed to a plethora of selective pressures and have adapted to a variety of local ecological and management conditions,including UV exposure,diseases,and stall-feeding systems.These selective pressures have resulted in unique and important phenotypic and genetic differences among modern cattle breeds/populations.Ongoing efforts to sequence the genomes of local and commercial cattle breeds/populations,along with the growing availability of ancient bovid DNA data,have significantly advanced our understanding of the genomic architecture,recent evolution of complex traits,common diseases,and local adaptation in cattle.Here,we review the origin and spread of domestic cattle and illustrate the environmental adaptations of local cattle breeds/populations.

关键词： Cattle Origin Domestication Migration route Environmental adaptation Selective pressure

Recent Advances on the Electrochemical Difunctionalization of Alkenes/Alkynes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2019年第3期37卷 292-301页

作者： Haibo Mei Zizhen Yin Jiang Liu Hailong Sun jianlin han College of Chemical Engineering Nanjing Forestry UniversityNanjingJiangsu 210037China Nanjing Research Institute of Sinopec Yangzi Petrochemical Co. Ltd.NanjingJiangsu 210048China Nanjing University University of Oklahoma Texas Tech University

Electroorganic synthesis is an emerging area of high impact research in organic chemistry, which is considered as one of the green and efficient methods and attracts growing research attention. In this review, we summarized comprehensively the recent literature reports on the electrochemical oxidative difunctionalization of unsaturated C—C bonds. The reaction types described in this review included electrochemical intermolecular cyclization, electrochemical intramolecular cyclization, and electrochemical difunctionalization of alkenes/alkynes. This review focuses on the discussion of its synthetic generality for the preparation of functionalized compounds and the related electrochemical oxidative reaction mechanism.

关键词： Electrochemical Difunctionalization Alkenes/Alkynes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

对休闲运动鞋设计要素的再探讨

皮革科学与工程 2024年第2期34卷 73-76,83页

作者：崔同占韩建林温州职业技术学院浙江温州325035 惠州学院广东惠州516007 陕西科技大学陕西西安710016

首先对休闲运动鞋的分类进行生产工艺、帮面结构、穿着场景等视角权属分析,以此为主线,分别探讨了休闲运动鞋的外观造型设计、结构设计和功能性设计要素及其应用技术。通过论证提出在造型形式美设计上一是要理解工艺结构,注重整体设计... 详细信息

首先对休闲运动鞋的分类进行生产工艺、帮面结构、穿着场景等视角权属分析,以此为主线,分别探讨了休闲运动鞋的外观造型设计、结构设计和功能性设计要素及其应用技术。通过论证提出在造型形式美设计上一是要理解工艺结构,注重整体设计感的塑造,二是要理解设计中的空间要义,三是要理解时代变迁下相同人群的差异化设计;在功能性设计要素上提出一是要厘清大底选配的方法,二是要对标具体使用场景的功能性要素展开设计,案例化讨论了运动生物力学以及矫形、康复学的融入。文章还提出在设计中要关注如当下的碳中和概念、乡村振兴、非遗传承概念等社会热点,力求在设计研发领域为从业者提供一个技术性参标。

关键词：休闲运动鞋造型设计结构设计功能性应用技术

Fluorine-containing pharmaceuticals approved by the FDA in 2020:Synthesis and biological activity

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第11期32卷 3342-3354页

作者： Yingjie Yu Aiyao Liu Gagan Dhawan Haibo Mei Wei Zhang Kunisuke Izawa Vadim A.Soloshonok jianlin han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Biomedical Science Acharya Narendra Dev CollegeUniversity of DelhiIndia Department of Chemistry University of Massachusetts Boston100 Morrissey BoulevardBostonMA 02125United States Hamari Chemical Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Department of Organic Chemistry I Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for ScienceMaría Díaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this review.Therapeutic areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various cancers.Molecules of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)groups.For each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.

关键词： Fluorine and compounds Blockbuster drugs Modern pharmaceuticals Synthesis Drug design and development Asymmetric synthesis

Fluorine-containing drugs approved by the FDA in 2019

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第9期31卷 2401-2413页

作者： Haibo Mei Attila Mario Remete Yupiao Zou Hiroki Moriwaki Santos Fustero Lorand Kiss Vadim ASoloshonok jianlin han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China University of Szeged Institute of Pharmaceutical Chemistry6720 SzegedEotvos u.6Hungary Hamari Chemicals Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Departamento de Quimica Organica Universidad de Valencia46100 BurjassotValenciaSpain Department of Organic Chemistry 1 Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for Science.Maria Diaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed.Therapeutic areas include schizophrenia,migraine,multiple sclerosis,insomnia,rheumatoid arthritis,anti-tuberculosis,breast cancer,lymphoma kinase inhibitor,serotonin receptor antagonist.New pharmaceuticals feature four examples of aromatic fluorine,three aromatic CF3 group,three aliphatic CF3 and one compound with aromatic CF3O group.Furthermore,among the new compounds,six are chiral and seven are derived from tailor-made amino acids.

关键词： Fluorine Pharmaceuticals Synthesis Medicinal chemistry Marketed medicinal drugs