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Candidate genes conferring ethylene-response in cultivated peanuts determined by BSA-seq and fine-mapping

The Crop Journal 2024年第3期12卷 856-865页

作者： Yanyan Tang Zhong Huang Shaohui Xu Wenjie Zhou jianjun Ren Fuxin Yu Jingshan Wang Wujun Ma Lixian qiao College of Agronomy Qingdao Agricultural UniversityQingdao 266109ShandongChina Murdoch University Food Futures InstitutePerthWA 6150Australia The Characteristic Laboratory of Crop Germplasm Innovation and Application Provincial Department of EducationCollege of AgronomyQingdao Agricultural UniversityQingdao 266109ShandongChina Academy of Dongying Efficient Agricultural Technology and Industry on Saline and Alkaline Land in Collaboration with Qingdao Agricultural University Dongying 257347ShandongChina

Ethylene plays essential roles in plant growth,development and stress responses.The ethylene signaling pathway and molecular mechanism have been studied extensively in Arabidopsis and rice but limited in peanuts.Here,we established a sand-culture method to screen pingyangmycin mutagenized peanut lines based on their specific response to ethylene(“triple response”).An ethylene-insensitive mutant,inhibition of peanut hypocotyl elongation 1(iph1),was identified that showed reduced sensitivity to ethylene in both hypocotyl elongation and root growth.Through bulked segregant analysis sequencing,a major gene related to iph1,named AhIPH1,was preliminarily mapped at the chromosome Arahy.01,and further narrowed to a 450-kb genomic region through substitution mapping strategy.A total of 7014 genes were differentially expressed among the ACC treatment through RNA-seq analysis,of which only the Arahy.5BLU0Q gene in the candidate mapping interval was differentially expressed between WT and mutant iph1.Integrating sequence variations,functional annotation and transcriptome analysis revealed that a predicated gene,Arahy.5BLU0Q,encoding SNF1 protein kinase,may be the candidate gene for AhIPH1.This gene contained two single-nucleotide polymorphisms at promoter region and was more highly expressed in iph1 than WT.Our findings reveal a novel ethylene-responsive gene,which provides a theoretical foundation and new genetic resources for the mechanism of ethylene signaling in peanuts.

关键词： Ethylene-insensitive Hypocotyl elongation AhIPH1 Candidate gene Genetic resources

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Recent progress in the structural study of ion channels as insecticide targets

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Insect Science 2022年第6期29卷 1522-1551页

作者： Hadiatullah Hadiatullah Yongliang Zhang Arthur Samurkas Yunxuan Xie Rajamanikandan Sundarraj Han Zuilhof jianjun qiao Zhiguang Yuchi Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency Collaborative Innovation Center of Chemical Science and EngineeringSchoolof Pharmaceutical Science and TechnologyTianjin UniversityTianjinChina Department of MolecularPharmacology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Laboratory of Organic Chemistry Wageningen University&Research WageningenThe Netherlands Department of Environmental Science Tianjin UniversityTianjinChina Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjinChina

Ion channels,many expressed in insect neural and muscular systems,have drawn huge attention as primary targets of insecticides.With the recent technical breakthroughs in structural biology,especially in cryo-electron microscopy(cryo-EM),many new high-resolution structures of ion channel targets,apo or in complex with insecticides,have been solved,shedding light on the molecular mechanism of action of the insecticides and resistance mutations.These structures also provide accurate templates for structure-based insecticide screening and rational design.This review summarizes the recent progress in the structural studies of 5 ion channel families:the ryanodine receptor(RyR),the nicotinic acetylcholine receptor(nAChR),the voltage-gated sodium channel(VGSC),the transient receptor potential(TRP)channel,and the ligand-gated chloride channel(LGCC).We address the selectivity of the channel-targeting insecticides by examining the conservation of key coordinating residues revealed by the structures.The possible resistance mechanisms are proposed based on the locations of the identified resistance mutations on the 3D structures of the target channels and their impacts on the binding of insecticides.Finally,we discuss how to develop“green”insecticides with a novel mode of action based on these high-resolution structures to overcome the resistance.

关键词： cryo-electron microscopy structure crystal structure insecticide ion chan-nel resistance

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Quorum sensing-based interactions among drugs,microbes,and diseases

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Science China(Life Sciences) 2023年第1期66卷 137-151页

作者： Shengbo Wu Shujuan Yang Manman Wang Nan Song Jie Feng Hao Wu Aidong Yang Chunjiang Liu Yanni Li Fei Guo jianjun qiao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China School of Computer Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Key Laboratory of Systems Bioengineering Ministry of Education(Tianjin University)Tianjin 300072China School of Computer Science and Technology College of Intelligence and ComputingTianjin UniversityTianjin 300350China Department of Engineering Science University of OxfordOxford OX13PJUK Institute of Shaoxing Tianjin UniversityShaoxing 312300China

Many diseases and health conditions are closely related to various microbes,which participate in complex interactions with diverse drugs;nonetheless,the detailed targets of such drugs remain to be elucidated.Many existing studies have reported causal associations among drugs,gut microbes,or diseases,calling for a workflow to reveal their intricate interactions.In this study,we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease(QSDMD)database(http://***/),which includes diverse interactions for more than 8,000 drugs,163 microbes,and 42 common diseases.Potential interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental validations.Furthermore,we have constructed a QS-based drug-receptor interaction network,proposed a systematic framework including various drug-receptor-microbe-disease connections,and mapped a paradigmatic circular interaction network based on the QS-DMD,which can provide the underlying QS-based mechanisms for the reported causal associations.The QS-DMD will promote an understanding of personalized medicine and the development of potential therapies for diverse diseases.This work contributes to a paradigm for the construction of a molecule-receptor-microbe-disease interaction network for human health that may form one of the key knowledge maps of precision medicine in the future.

关键词： quorum sensing drugs microbe-disease association microbe-host interaction gut microbiota personalized medicine

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Bacterial Diversity of Anshun Sufu, A Traditional Fermented Tofu in Guizhou Province of China

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Transactions of Tianjin University 2019年第5期25卷 497-503页

作者： Shanna Liu jianjun qiao School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China College of Food Science and Bioengineering Tianjin Agricultural UniversityTianjin 300384China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China

Samples of sufu, a traditional food product made by fermenting soybeans, were collected in the city of Anshun in Southwest China and their bacterial diversity was investigated. Nine samples were divided into groups A C, according to the markets in which they were collected, and the samples were subjected to pyrosequencing of the 16S rRNA V3 V4 regions for evaluation of the bacterial community. A total of 342 operational taxonomic units (OTUs) were determined. One of the samples (B2) included as many as 286 OTUs, and it also displayed the greatest bacterial richness. The most abundant bacterial diversity was shown in group B. F irmicutes was the dominant phylum in groups A and B, while P roteobacteria was the dominant phylum in group C. L actobacillus was the prevailing genus in group A, T etragenococcus in group B, and E mpedobacter in group C. The bacterial composition of sufu depends, to a large degree, on the manufacturer. The obtained results showed regional di erences in the bacterial community patterns of sufu products, which could contribute to a better understanding of the fermentation and ripening bioprocesses of sufu.

关键词： Sufu Bacteria Biodiversity Sequencing

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医用多位姿辅助支撑外骨骼机构设计与支撑性能评估

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生物医学工程学杂志 2024年第2期41卷 295-303页

作者：戚开诚尹智扬张建军宋井科乔高昆河北工业大学机械工程学院天津300401 河北省机器人感知与人机融合重点实验室天津300401 智能康复装置与检测技术教育部工程研究中心天津300401

针对外科医生长时间保持手术姿态而造成的肌肉和关节损伤的现状,本文通过分析手术姿态,分别对不同关节进行构型研究,设计了一种具有多关节机构的医用多位姿辅助支撑外骨骼。然后通过建立人机静力学模型,本研究得到人体穿戴外骨骼前后的... 详细信息

针对外科医生长时间保持手术姿态而造成的肌肉和关节损伤的现状,本文通过分析手术姿态,分别对不同关节进行构型研究,设计了一种具有多关节机构的医用多位姿辅助支撑外骨骼。然后通过建立人机静力学模型,本研究得到人体穿戴外骨骼前后的关节扭矩、关节力,并用有限元分析软件对外骨骼强度校核。结果表明,外骨骼最大应力小于材料强度要求,整体形变小,外骨骼结构强度满足使用需求。最后,本研究选取受试者参与足底压力试验,并结合人机静力学模型进行生物力学仿真,从足底压力、关节扭矩和关节力、肌肉力和肌肉总体代谢三个方面进行结果分析,以评估外骨骼支撑性能。结果表明,外骨骼对全身有较好的支撑性,能够减轻肌肉骨骼负担。本研究的外骨骼机构更匹配外科医生的实际工作需求,为医用支撑外骨骼机构设计提供了一种新的范例。

关键词：支撑外骨骼医用多位姿机构设计静力学分析支撑性能

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Phase-Selective Gelators Based on p-Alkoxybenzoyl for Oil Spill Recovery and Dye Removal

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Transactions of Tianjin University 2019年第6期25卷 586-594页

作者： Hongmei Qu Jie Zhang Yunxia Ma Zhongxuan Li jianjun qiao Key Laboratory of Systems Bioengineering (Ministry of Education) Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Tianjin University

Oil spills result in tremendous damage to the environment and ecosystem.In this study,several p-alkoxybenzoyl-based gelators(1,2a,2b,2c,3)synthesized from commercially available materials were designed for recovering oil from an oil–water mixture.Gels with remarkable gelation ability in various oils were characterized by nuclear magnetic resonance,Fourier transform infrared spectroscopy and X-ray diffraction to study the driving forces of self-assembly.Notably,these gelators could achieve the goal of recycling oil from the oil–water mixture at room temperature.In addition,gelator 2b could be used to remove toxic dyes from aqueous solutions with high efficiency.Therefore,these compounds were considered promising materials for oil spill recovery and dye removal due to their practicality and high efficiency.

关键词： Organogelator p-Alkoxybenzoyl Phase selectivity Oil spills recovery Dye removal

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Optimization of the main liming process for inulin crude extract from Jerusalem artichoke tubers

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Frontiers of Chemical Science and Engineering 2012年第3期6卷 348-355页

作者： Huandong LI Hongji ZHU jianjun qiao Junhu DU Hua ZHANG Key Laboratory of Systems Bioengineering Ministry of EducationSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

A three-stage homogenate extraction was used as a new method for inulin extraction from Jerusalem artichoke tubers. Compared with the results from conventional hot water extraction, the three-stage homogenate extraction gave higher yields and caused less degradation of the inulin. The inulin crude extract was then clarified by a carbonate-precipitation method, during which three variables -- the quicklime mass, the reaction temperature and the reaction time were optimized for the main liming process to give the best clarification effect. A Plackett- Burman design, the path of steepest ascent method, a Box- Behnken design and response surface methodology （RSM） were employed in the experimental design. The optimal conditions for the main liming process were determined to be 12.0g/L, 71.4℃ and 8min. The confirmatory tests proved that the best clarification efficiency （92.74%） was achieved at these conditions and this was approximately equal to the value predicted by the model.

关键词： inulin homogenate extraction Jerusalem artichoke main liming process

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噬菌体与细菌基于群体感应的双向互作

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中国生物工程杂志 2024年第1期44卷 107-117页

作者：孙舒扬吴胜波张欣乔梁畅畅乔建军天津大学化工学院天津300072 天津大学浙江研究院(绍兴) 绍兴312300 天津大学系统生物工程教育部重点实验室天津300072 天津化学化工协同创新中心合成生物学平台天津300072

在长期的共同进化过程中,噬菌体与细菌宿主之间产生了复杂的相互作用关系。群体感应(quorum sensing,QS)机制在噬菌体和细菌的双向相互作用中扮演了重要角色。综述细菌宿主对群体感应机制的利用,群体感应对生物被膜调节、噬菌体吸附过... 详细信息

在长期的共同进化过程中,噬菌体与细菌宿主之间产生了复杂的相互作用关系。群体感应(quorum sensing,QS)机制在噬菌体和细菌的双向相互作用中扮演了重要角色。综述细菌宿主对群体感应机制的利用,群体感应对生物被膜调节、噬菌体吸附过程以及调控CRISPR-Cas系统等方面所起到的效果,从噬菌体对群体感应机制的介入,总结群体感应机制在噬菌体溶原-裂解性调节以及噬菌体对群体感应机制的抑制,探讨对噬菌体QS机制的挖掘和解析,以期为群体感应机制在噬菌体治疗等领域的应用提供理论依据。

关键词：群体感应噬菌体-细菌宿主溶原-裂解微生物相互作用

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S波段永磁式相对论磁控管设计及实验研究

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强激光与粒子束 2024年第3期36卷 41-45页

作者：张颜颜陈宏许建军邓坤刘东升刘巧中国电子科技集团公司第二十九研究所电磁空间安全全国重点实验室成都610036 北京真空电子技术研究所大功率微波电真空器件技术国防科技重点实验室北京100016

对S波段永磁式全腔提取相对论磁控管进行了理论设计和数值模拟研究,并对其进行了实验研究。通过理论分析初步获取相对论磁控管结构参数,并采用三维电磁仿真软件对模型进行粒子仿真优化,根据引导磁场需求设计永磁磁场产生结构。该永磁式... 详细信息

对S波段永磁式全腔提取相对论磁控管进行了理论设计和数值模拟研究,并对其进行了实验研究。通过理论分析初步获取相对论磁控管结构参数,并采用三维电磁仿真软件对模型进行粒子仿真优化,根据引导磁场需求设计永磁磁场产生结构。该永磁式相对论磁控管在500 kV电压输入条件下,输出微波功率1.978 GW,效率49.2%。利用实验室小型脉冲功率驱动源平台开展了初步实验研究。实验中,该永磁式相对论磁控管在脉冲驱动源驱动下获得GW级输出功率,功率转换效率约40%,实验结果与模拟结果吻合得较好。

关键词：稀土永磁相对论磁控管高功率微波矩形波导脉冲驱动源

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细菌sRNA来源、作用机制及调控网络研究进展

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食品与发酵工业 2024年第3期50卷 290-297页

作者：赵子墨乔建军袁琳龙映鹏任书江吴昊天津大学化工学院天津300072 天津大学浙江研究院(绍兴) 浙江绍兴312300 天津农学院食品科学与生物工程学院天津300384 天津农学院动物科学与动物医学学院天津300384

通过发酵生产工业产品一直是细菌等微生物的研究热点,但是发酵过程中存在的代谢副产物和环境胁迫等问题,限制了工业菌株的发展。sRNA是细菌中普遍存在的一类调控性非编码RNA,它们与核糖开关、双组分系统、转录因子等其他调控元件共同构... 详细信息

通过发酵生产工业产品一直是细菌等微生物的研究热点,但是发酵过程中存在的代谢副产物和环境胁迫等问题,限制了工业菌株的发展。sRNA是细菌中普遍存在的一类调控性非编码RNA,它们与核糖开关、双组分系统、转录因子等其他调控元件共同构成了细菌中的复杂调控网络,在代谢调控和抗胁迫中都发挥着异常重要的作用。文章对细菌中sRNA的来源、作用机制以及在调控网络中的角色进行了详细总结,有助于更好地解析细菌的代谢途径及发酵过程中受到的环境限制,对构建低毒力、高鲁棒性菌株,助力工业产品的发酵生产有重要参考意义。

关键词： sRNA 非编码小RNA 机制代谢调控网络

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